A Mount Sinai study found that human beliefs about nicotine can modulate brain activities in a way comparable to pharmacology, with potential implications for addiction treatment. The study used fMRI to explore the relationship between subjective beliefs and biological substrates in the human brain.
Researchers at Purdue University have developed a novel cancer immunotherapy compound that targets the enzyme TC-PTP, found in both cancer cells and T cells. Deleting this enzyme promotes antigen presentation, alerting the immune system to tumor cells, while stimulating T-cell activation enhances their ability to fight and destroy tumors.
Researchers found that metformin restores mitochondrial activity and prevents cancer progression in mice and human prostate cells, particularly those with low NKX3.1 levels. The study suggests metformin could be used to prevent further progression of cancer in patients under active surveillance with low-NKX3.1 tumors.
Researchers at the University of Arizona Health Sciences will train the next generation of translational scientists in Alzheimer's disease research through a $1.4 million grant. The program aims to develop highly trained, cross-disciplinary researchers to address the complex challenges of this devastating neurodegenerative disorder.
Researchers at Weill Cornell Medicine have discovered that a tiny chemical modification on mRNAs, known as m6A, is key to the formation of stress granules during cell stress. Longer mRNAs dominate stress granules because they have high levels of m6A, which triggers their sequestration.
Researchers at UC Davis have developed SparkMaster2, an open-source software that analyzes normal and abnormal calcium activity in human cells. The tool can identify calcium sparks associated with irregular heartbeats, or arrhythmia, enabling better understanding of the underlying biology.
Researchers found that tumors with metastasis to the brain respond better to immunotherapy due to effective priming outside the brain. Glioblastoma, an aggressive brain cancer, does not respond well due to impaired priming step.
A new study by Boston University researchers found that Serum Amyloid A (SAA) acts as a universal protein detergent to clear cell membrane debris from wounds and inflammation sites. However, high levels of SAA can also promote fibrous deposits in vital organs like the kidney and liver, leading to life-threatening disease AA amyloidosis.
Researchers have discovered how MCV initiates DNA replication in host cells, allowing the virus to make hundreds of new copies of itself. This process is different from normal cellular DNA replication and can lead to cancer if not controlled.
Researchers identified a new drug treatment option for peritonitis in patients on peritoneal dialysis, showing that a low dosage of ceftazidime and avibactam is sufficient to treat the infection. The study's findings could help gain control over peritonitis in patients with difficult-to-treat germs.
Researchers found that morphine interacts with toll-like receptor 4 to contribute to increased bone loss and pain. Blocking TLR4 prevents these effects, suggesting a new target for reducing opioid side effects.
A new study reveals the molecular mechanism behind bacterial DNA repair, showing that RNA polymerase plays a key role in identifying and fixing errors. Researchers found that RNaseHII cooperates with RNA polymerase to scan for misincorporated ribonucleotides in living bacterial cells.
Researchers at Temple University and the University of Nebraska Medical Center developed a novel dual gene-editing approach that can effectively eliminate HIV infection. The therapy targets both HIV-1, the virus responsible for AIDS, and CCR5, a co-receptor that facilitates viral entry into cells.
Scientists have discovered potential broad-spectrum antivirals that target multiple families of RNA viruses, which pose a significant threat to future pandemics. The new agents showed promise in preventing and mitigating viral arthritis caused by Chikungunya virus and rescuing cells from harmful effects of other viruses.
A study published in Clinical Pharmacology & Therapeutics has identified six single nucleotide polymorphisms associated with opioid use disorder. The findings suggest that genetics play a role in the development of OUD, but environmental factors also contribute to its progression.
Scientists at the University of Colorado Anschutz Medical Campus identified protein FAM193A as a key component of a mechanism suppressing tumor growth. The discovery offers new potential for cancer therapies targeting p53, a frequently mutated gene in human cancers.
Researchers identified a crucial molecular process involving gene expression in neurons that contributes to early memory loss and Alzheimer's disease. Genetic alterations in mice showed that lack of phosphorylation on beta-2 adrenergic receptors led to poor memory, while PDE inhibitors improved memory function.
Researchers used C-trap technology to investigate how different DNA repair proteins identify and bind to their respective forms of damage. They found that some proteins arrived at the damage site together and departed together, while others showed surprising variability in their association and dissociation patterns. The study provides...
A new study suggests that even moderate amounts of alcohol can accelerate brain atrophy and increase amyloid plaques in Alzheimer's disease. Researchers found that chronic drinking altered healthy brain function and behavior, potentially setting the stage for increased plaque proliferation.
Researchers investigated psychostimulants' effects on dopamine transporter, discovering persistent binding determines sustained effects. The study found that varying binding times between substances result in different durations and intensities of effects.
The 6th Annual Meeting of the Labroots Drug Discovery & Development Virtual Event Series will bring together specialists to discuss ongoing research in drug discovery and development. Keynote speaker Professor Kevin Pfleger will present novel pharmacology findings, while attendees can earn free CE credits.
A new protein degrader, AK-2292, shows promise against STAT5, a key player in leukemia and other cancers. By targeting the protein's degradation, researchers have overcome previous challenges in designing small molecule inhibitors.
Researchers discovered that glucose takes longer to reach the nucleus accumbens in obesity-prone rats, leading to excess glutamate levels. This defect in neurotransmitter recycling process may contribute to overeating behavior and obesity.
Angelo J. Mariotti, the new Dean of LSU Health New Orleans School of Dentistry, has a track record of success in transforming dental education, increasing fundraising, and improving facilities. He aims to enhance faculty development and expand clinics to serve Louisiana's citizens for better oral health.
Researchers discovered that female and male mouse hearts react uniformly at first to noradrenaline but exhibit differences in recovery time, affecting electrical activity. These findings may contribute to arrhythmia susceptibility between men and women, offering new insights into sex-based responses to stress hormones.
Scientists have mapped out over 300 protein kinases and their targets, which could yield new leads for cancer drugs. The comprehensive atlas helps researchers identify signaling pathways that differ between normal and cancerous cells, or between treated and untreated cancer cells.
Researchers have identified potential new lead compounds for treating depression and anxiety disorders, which display reduced risk of drug abuse and adverse effects. These substances, derived from synthetic cathinone compounds, are known to release serotonin without significantly increasing dopamine levels in the brain.
Researchers will use household dust samples to develop a receptor bioactivity component model to predict adipogenic health outcomes. The goal is to improve chemical risk assessment models to account for everyday exposures to hundreds of different chemicals.
Researchers at University of Würzburg discovered a novel phosphatase inhibitor that selectively blocks the proliferation of tumor cells. This breakthrough targets increased energy demands in diseases like cancer and autoimmune disorders, offering potential new therapies for treatment.
The West Texas Pharmacology Core laboratory at TTUHSC will focus on two primary areas: drug development and pediatric cancer. The core aims to address obstacles in drug development, including limited pharmacology expertise for small biotech companies and low profitability for pediatric cancer drugs.
A study published in The EMBO Journal reveals that the anterior cingulate cortex is activated in female mice acquiring maternal behavior through repeated experience with pups. This discovery provides a potential basis for developing therapeutic options for postpartum depression and other conditions disrupting mother-child bonding.
The Montefiore Einstein Cancer Center has received a $10 million grant from the National Cancer Institute to study lung metastasis in breast cancer. The research aims to understand the mechanisms of tumor cells seeding tumors in the lungs, a key site for triple-negative breast cancer metastasis.
The workshop will discuss recent advances, perspectives, and applications of medical cannabis and cannabinoids. Researchers will explore their chemistry, pharmacology, analysis, influence on mitochondria, and potential use as anticancer agents.
Researchers developed a new technology that can detect early-stage hepatocellular carcinoma using nanoparticles, which are released by tumor cells and can be detected in circulation. The technology, called HCC EV SPA, has the potential to enable rapid and affordable detection of the disease, leading to improved survival rates.
The WVU program trains next generation of toxicologists to collect, analyze air samples from mining, fracking sites, using the university's Inhalation Facility. Students will work with preceptors from various fields to investigate health effects of inhaling toxicants.
Researchers at UT Southwestern Medical Center identified a novel function for the TAO2 protein, which inhibits influenza virus replication. Down-regulating TAO2 levels prevents viral replication in cells without causing major toxic effects.
A new study published in Frontiers in Pharmacology found that traditional Ayurvedic medicines are effective in maintaining blood sugar levels in patients with type 2 diabetes. The review analyzed 219 articles and included 98 Ayurvedic medicines, showing benefits in glycemic control, body weight, and other diabetes-related parameters.
The Polyphenols Applications World Congress 2022 will host a cannabis symposium in Valencia, Spain, discussing recent advances on polyphenols, their applications, and innovations. The symposium aims to evaluate the constituents of cannabis and medical cannabis, mainly cannabinoids and flavonoids.
João Pedro de Magalhães, a renowned expert in aging research, will present his latest work on data-driven approaches in longevity pharmacology. The presentation aims to bridge the gap between genotype and phenotype, a major challenge in understanding the ageing process.
A study in a mouse model found that viral infections during pregnancy can affect the mother's brain and disrupt maternal care behavior after birth. The research team identified structural, molecular, and functional changes in the brains of mothers with viral-like immune activation.
A recent study published in Pharmacology & Therapeutics provides an in-depth description of the anti-cancer activity of sustained release capsaicin formulations. The research team found that capsaicin displayed robust growth-inhibitory activity in a diverse array of human cancers, but its clinical applications were hindered by poor sol...
A study found that nearly half of all nursing staff made medication-related errors within the last year when administering medications to patients. Nurses who had attended medication training within the last 2 years were less likely to make these errors.
Researchers have mapped altered protein-protein interactions resulting from cancer-causing mutations, identifying potential targets for anticancer drugs. The study reveals how specific mutations can rewire the cell's interaction machinery, leading to oncogenic programs.
A team at Baylor College of Medicine found that human NANOG's 'super stickiness' enables it to form large aggregates at low concentrations, which interact with chromatin to activate a pluripotent state. This process involves reshaping the genomic landscape and turning on genes involved in pluripotency.
A clinical trial is underway to test the safety and efficacy of PhytoSERM, a dietary supplement that promotes estrogenic action in the brain without affecting reproductive tissue. The study aims to reduce menopausal symptoms and lower the risk of Alzheimer's disease in post- and perimenopausal women.
A new study at the University of Bath found that a key ingredient is missing from all sunscreens, leaving skin vulnerable to damage. The researchers identified iron-trapping extracts that can improve protection against UV rays and oxidative stress, reducing the risk of aging and cancer.
Researchers at Duke University Medical Center identified a potential new tactic to disrupt the repair mechanism that cancer cells use after treatment, blunting their ability to regenerate. This approach could present a new treatment strategy for targeted therapies.
Researchers at HKUMed found that intramuscular olanzapine is a cost-effective and safer alternative to traditional sedatives like haloperidol. IM olanzapine was shown to be more benign on the cardiovascular system and had fewer movement disorders compared to haloperidol.
A team of researchers at MedUni Vienna's Center for Physiology and Pharmacology has discovered a key building block in immune cells that promotes immunotolerance and prevents T-cell attacks on the body's own tissues. The study suggests a potential new cell-based therapeutic approach to slow down autoimmune disease progression.
Researchers at Baylor College of Medicine developed a human nose organoid model that replicates the complex interactions between human cells and viruses. The model showed divergent responses to SARS-CoV-2 and RSV infection, providing insights into disease progression and potential new therapies.
The Experimental Biology 2022 meeting will feature renowned speakers, including Nobel laureates and research pioneers, who will present the latest findings and trends in life sciences. Keynote presentations include talks on vaccine science, navigation, RNA splicing, pharmacology, and cancer classification.
Researchers will use transcriptomics and chemogenetics to identify molecular targets for pain management. The project aims to advance knowledge on pain mechanisms and develop novel therapeutic strategies.
A newly developed decoy protein has been found to be highly effective in preventing death and lung damage in humanized animal models of severe COVID-19 disease. The treatment works by competing for the spike protein of SARS-CoV-2, thereby neutralizing the virus before it can bind and enter cells.
A research team led by Youwei Zhang discovered a new protective function of the protein 53BP1 in preserving DNA structure. This mechanism involves liquid-liquid phase separation, allowing 53BP1 to stabilize proteins at condensed DNA regions, maintaining genome stability and preventing diseases like cancer and premature aging.
Researchers developed nanoparticles that activate key cancer fighters by driving up immunity at the tumor site, improving interactions with antibody therapies. The technique left six of 10 mice with lymphoma tumor-free and was effective in melanoma when combined with existing immune response amplifiers.
Vanderbilt researchers discover how a protein may treat schizophrenia, including reversing working memory deficits. Enhancing the activity of mGlu1 selectively increases the activity of specific inhibitory interneurons, restoring their ability to inhibit neuronal circuits.
Researchers at UT Southwestern Medical Center have discovered a potential cure for strongyloidiasis, a deadly tropical disease caused by Strongyloides stercoralis. Combining dafachronic acid and ivermectin increased survival rates to 85% in animal models, offering a new therapeutic target for parasitic nematode diseases.
Researchers from Istituto Italiano di Tecnologia have developed a new precision strategy to hinder coronavirus infection by blocking the ACE2 receptor. The study, published in Pharmacological Research, reveals two anti-K353 aptamers that dose-dependently inhibit viral spike protein binding to human ACE2, preventing cell infection.
Researchers developed a predictive model that maps electric activity of mouse, rabbit, and human cardiac cells, allowing translation of findings across species. The model is expected to accelerate drug development and improve understanding of disease mechanisms.
Researchers at Vanderbilt University have identified a new target for rapid antidepressant drugs using ketamine's role in synaptic effects. This breakthrough could lead to new treatments for approximately half of patients whose current antidepressants are ineffective, significantly reducing the risk of suicide.