A recent rat study identified the neural mechanism underlying chills, a cold sensation that supports the body's response to infection. The findings suggest that prostaglandin E₂ boosts cold signals from the lateral parabrachial nucleus to the central nucleus of the amygdala, triggering chills and promoting warmth-seeking behavior.
Ovarian cancer cells recruit protective mesothelial cells in abdominal fluid to form hybrid cell clusters that resist chemotherapy. These clusters use spike-like structures called invadopodia to invade surrounding tissue. The discovery opens new treatment possibilities and could help doctors monitor disease progression.
Scientists at Nagoya University identified a brain circuit that keeps mice awake in unfamiliar environments, releasing neurotensin to maintain wakefulness and protect against potential dangers. This discovery may explain the 'first night effect' in humans, where the brain remains vigilant on the first night in a new place.
A new AI-powered model predicts patient survival and risk stratification for spinal metastasis, allowing for more informed treatment decisions. The model achieved high predictive accuracy using large-scale clinical data from Japanese patients.
Researchers at Nagoya University found that about half of wood mice take time to examine nuts before selecting, potentially increasing their exposure to predators. Despite this risk, the extra time investment pays off as picky eaters are more likely to select undamaged chestnuts.
A new study from Nagoya University in Japan has found that petrolatum-based eye ointments can cause MicroShunt glaucoma implants to swell and potentially rupture. The study suggests that clinicians should avoid using these ointments on patients with the implant, particularly when it is exposed outside the conjunctiva.
The Nagoya University ISEE Award has recognized Professor Hiroyuki Yamada's pioneering work on high-altitude penetration flight observation techniques for typhoons. His research enabled scientists to observe the complete vertical structure of typhoons, providing unprecedented data on storm intensity.
Researchers identified genes controlling the switch between unicellular and multicellular life forms in marine yeast, revealing a molecular mechanism for clonal multicellularity. The study provides insights into how multicellular life may have evolved from single-celled ancestors.
Researchers at Nagoya University and Tokyo Electron Miyagi Ltd. have developed a new semiconductor etching method that significantly reduces processing time and enhances energy efficiency. The process employs plasma etching with hydrogen fluoride at very low temperatures, eliminating the need for fluorocarbon gases.
Researchers identified a gene that actively causes a decline in food-seeking behavior after reproduction, potentially benefiting the population by reducing competition for resources. This discovery challenges traditional views on aging and offers new insights into programmed mechanisms driving age-related decline.
Researchers at Nagoya University created a new aluminum alloy series optimized for high strength and heat resistance through 3D printing. The study used low-cost elements to produce recycling-friendly materials that can operate at elevated temperatures, leading to lighter vehicles and reduced emissions.
Research shows that companies with strong environmental, social, and governance track records perform better after adopting rigorous auditing standards. Investors view ESG practices as a signal of corporate quality, amplifying the benefits of transparent auditing.
Scientists have successfully replicated human neural circuits using assembloids, a type of miniature organoid derived from induced pluripotent stem cells. The study shows that the thalamus plays a crucial role in shaping cell-type specific neural circuits in the human cerebral cortex, promoting cortical growth and maturation.
Researchers have identified two proteins that allow cancer cells to evade destruction by brain immune cells, known as microglia. By removing these proteins, microglia play a key role in eliminating cancer cells during the early stage of their arrival in the brain.
Plant biologist Masatsugu Toyota receives international recognition for his discovery that plants sense danger through airborne chemicals and warn their neighbors. His work reveals advanced sensory networks rivaling animal nervous systems, challenging traditional views of passive organisms.
Researchers used historical geography to accurately measure Earth's rotation speed during a total solar eclipse in 709 BCE, providing new data about the Sun's activity. The study also supports recent solar cycle reconstructions and independently validates previous findings using radiocarbon analysis.
A new study by Nagoya University researchers found that laparoscopic surgery significantly reduces blood loss and improves jaundice recovery compared to traditional open surgery for treating biliary atresia. The study analyzed data from 356 children who had surgery at two months old, tracking their outcomes for an average of 13 years.
A new study reveals how the superstorm compressed Earth's plasmasphere, a protective layer of charged particles that encircles our planet. The plasmasphere normally extends far from Earth, but during the storm, its outer boundary moved from approximately 44,000 km above Earth's surface to just 9,600 km.
Researchers developed a probe to visualize lipid breakdown in living cells, revealing differences in breakdown rates among individual droplets. The study found that an enzyme called ATGL drives these variations, which may contribute to abnormal lipid metabolism in liver cancer cells.
Researchers at Nagoya University have developed a new technology that improves protein production efficiency in E. coli by reducing ribosome stalling. By identifying short translational-enhancing peptides, they created an AI prediction model to accurately predict translation enhancement strength for all 160,000 possible tetrapeptides.
A new system developed by researchers at Nagoya University can detect genetic mutations in brain tumors with high accuracy and speed. The system successfully identified key markers for diagnosis of diffuse glioma, a common type of brain tumor.
A recent study by Nagoya University researchers has revealed that zebrafish have enlarged areas in their spinal cords, corresponding to the paired pectoral and pelvic fins. The findings suggest an evolutionary theory: when tetrapods evolved from fish, only the paired fins transformed into limbs, while unpaired fins disappeared.
A study found that volcanic ash can enhance phytoplankton growth even at considerable distances from the volcanic site. Researchers detected a surge in phytoplankton levels around Mukojima Island, located 130 km northeast of Nishinoshima, after ash was transported by wind and ocean currents.
Researchers at Nagoya University solved the puzzle of loop current switching in kagome metals, a special group of quantum metals. Weak magnetic fields reverse tiny loop currents, changing the material's macroscopic electrical properties and reversing current flow direction.
A Japanese study has identified four distinct patterns of immune response after COVID-19 vaccines, with a 'rapid-decliner' group experiencing faster decline in antibody levels. Monitoring changes in antibody levels may help identify individuals at greater risk of infection and inform more effective vaccination strategies.
Researchers at Nagoya University have successfully developed a resonant tunnel diode that operates at room temperature using Group IV semiconductor materials. This breakthrough paves the way for terahertz wireless components that can deliver unprecedented speed and data handling capacity with superior energy efficiency.
Researchers successfully etched hafnium oxide films at atomic-level precision and smoothness without halogen gases. The new method uses nitrogen and oxygen plasmas to form volatile byproducts, resulting in reduced surface roughness and improved device performance.
A 30-year study reveals East Antarctica's interior is warming at a rate of 0.45-0.72°C per decade, faster than global average, driven by changes in the Southern Indian Ocean. This warming process may underestimate future Antarctic ice loss predictions.
A new GaN-based e-beam technology has been developed through joint research between Photo electron Soul and Nagoya University, enabling non-contact electrical inspection and metrology during semiconductor manufacturing. The technology is expected to improve yield and defect detection, leading to increased efficiency in the industry.
Researchers at Nagoya University have developed a new method to create gallium oxide semiconductors with stable p-type layers, allowing for twice the current capacity of previous devices. This breakthrough enables improved energy efficiency, reduced waste, and lower operating costs for electronics.
Researchers at Nagoya University and the Italian National Institute for Astrophysics have determined how molten rock droplets formed in Jupiter's early days. Their study shows that chondrule characteristics are influenced by the water content of impacting planetesimals, providing a clearer picture of solar system formation.
Researchers successfully transferred a gift-giving courtship behavior from Drosophila subobscura to Drosophila melanogaster by manipulating a single gene in insulin-producing neurons. This study represents the first example of transferring behavior between species through genetic manipulation.
A study by researchers at Nagoya University has found that dopamine plays a crucial role in modulating female fruit flies' sensitivity to sounds when they are eager to mate. The findings suggest that dopamine is involved in flexible auditory response modulation, a universal property shared among animals.
Researchers at Nagoya University developed a catalyst system that converts alcohols to valuable chemical products at lower temperatures using safer iodine compounds. The new system eliminates toxic heavy metal waste, cuts reaction temperatures by over half, and reduces energy costs.
Researchers at Nagoya University have developed a new lipid nanoparticle that delivers mRNA five times more efficiently, allowing better delivery of genetic instructions to cells. The study showed significant improvements in mRNA delivery and effective suppression of tumor growth in mice.
Researchers found that oxidative stress actually suppressed cancer development in rats with BRCA2 gene mutations, contrary to prior expectations. This discovery suggests that avoiding radiation exposure may not be the best method for people with BRCA2 pathological variants.
Scientists successfully generated lung cells similar to alveolar epithelial type 2 (AT2) cells from mouse embryonic fibroblasts without using stem cell technology. The AT2-like cells were generated in just 7 to 10 days, a significant reduction compared to conventional methods.
Researchers analyzed viral loads during early infection to predict disease progression and developed a method to identify patients at risk of severe symptoms. The study suggests that patients with high viral loads are more likely to experience long-lasting skin lesions and severe symptoms.
A Nagoya University group created a sandwich ELISA technique to accurately measure polysialic acid levels in the blood of patients with psychiatric disorders. The technique uses antibodies that minimize non-specific binding, resulting in increased accuracy.
Researchers from Nagoya University have developed a deformable mirror that changes X-ray beam size by more than 3,400 times using a single-crystal piezoelectric thin wafer of lithium niobate. This technology enhances both imaging and analysis, especially for industry applications.
Scientists at Nagoya University discovered that dying cancer cells can trigger an inflammatory feedback loop that promotes tumor growth. When macrophages consume dying cancer cells, they produce cytokines that activate growth signals in remaining cancer cells.
Researchers identified 'uncommitted' cells in neuroblastoma tumors that exhibit weaker cancer development, potentially leading to favorable outcomes for patients. These cells may help identify early diagnostic markers and novel therapeutic targets.
Researchers at Nagoya University have created CAR-T cells that recognize and target the Eva1 protein on cancer cells, effectively eliminating tumors in lab mice. The treatment is designed to be safer by ignoring healthy cells with low amounts of Eva1.
Researchers found that male mosquito brains respond to a wider range of sounds than females and have more diverse responses. This suggests that males use complex acoustic cues to locate females in noisy environments, making traditional traps less effective.
Researchers mapped electron density in the ionosphere and observed unique 3D wave patterns after the 2024 Noto Peninsula Earthquake, showing earthquakes generate waves from multiple points along the entire fault line. The study provides new insights into how earthquakes affect the upper atmosphere.
Researchers at Nagoya University developed an interface that creates programmable electric fields to sort graphene oxide without fixed microfluidic devices. The findings allow precise sorting of GO sheets, which can capture pollutants, solvents, and biomolecules based on their size-dependent properties.
Researchers at Nagoya University discovered that Cepheid variable stars in the Small Magellanic Cloud are moving in opposing directions along two distinct axes, indicating the galaxy is being stretched by multiple external gravitational forces. The findings challenge previous theories of the galaxy's structure and dynamics.
Researchers at Nagoya University discovered that combining two tiny vibrating elements can amplify their signal up to 100 million times, enabling the transmission of clear signals over long distances. This finding could innovate long-distance communications and remote medical devices without requiring high energy consumption.
A team of researchers at Nagoya University has discovered a fast-moving, high-temperature gas flow in the center of the Centaurus cluster of galaxies. This finding may solve the 'cooling flow problem', which explains why galaxy clusters appear to be warm despite emitting X-rays.
A study by Nagoya University Graduate School of Medicine found that school-age children with CDH performed worse in all tests except gait analyses, with impairments in limb muscle strength and endurance. Regular physical activity can help improve motor abilities, quality of life, and overall health for these children.