Articles tagged with Hepatocellular Carcinoma
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Researchers uncover a hypoxia–m⁶A–Gal-1 regulatory axis that fuels HCC progression by stabilizing Galectin-1 (Gal-1) mRNA, promoting malignant phenotypes. Functional experiments confirmed Gal-1's role in enhancing HCC cell proliferation, migration, invasion, and EMT-driven phenotypic plasticity.
This study investigates the prognostic value of PNI in patients receiving first-line Ate/Bev therapy for unresectable HCC. The high-PNI group showed improved treatment outcomes, including lower adverse events and longer overall survival.
PIVKA-II is a valuable tool for early detection, prognostication, and therapeutic response monitoring in HCC. Its integration into multi-parametric models enhances diagnostic accuracy and enables dynamic risk stratification.
Myosteatosis is a key predictor of poor clinical outcomes across a spectrum of liver diseases, with associations to severe disease phenotypes, hepatocellular carcinoma, and increased mortality. Nutritional intervention, exercise prescription, and potential management strategies are proposed to address this condition.
Smoking exposure induces tumor microenvironment promoting sorafenib resistance in HCC by modifying the 14-3-3η proteome. Arsenic trioxide suppresses tumor progression with synergistic effect when combined with sorafenib.
Nutrient-stimulated hormone-based therapies (NuSHs) show promise in managing MASH and preventing HCC progression. NuSHs improve metabolic parameters, reduce liver fat and fibrosis, and modulate immune-metabolic pathways that drive hepatocarcinogenesis.
Large language models (LLMs) provide treatment recommendations for early-stage hepatocellular carcinoma (HCC) that align with clinical guidelines. However, their performance is limited in late-stage disease, where they prioritize tumor factors over liver function. LLMs should be used as a supplement to clinical expertise.
A recent study reveals that over 680,000 new cases of hepatocellular carcinoma were estimated worldwide in 2022, with 78.4% attributable to nine modifiable risk factors. The majority of HCC cases are preventable, and the study emphasizes the need for targeted preventive programs.
A study has uncovered a promising three-lncRNA signature that could improve early diagnosis and treatment strategies for non-metastatic hepatocellular carcinoma. The lncRNAs HEIH, MIAT, and HOTAIR were found to be significantly elevated in cancerous tissues.
The Chinese Society of Hepatology outlines a structured framework for monitoring, diagnosing, preventing, and managing drug-induced liver injury in patients with hepatocellular carcinoma. Key risk factors include underlying liver disease, genetic predisposition, and drug-specific factors.
Researchers developed a nanoparticle system combining lenalidomide and melarsoprol to activate the cGAS-STING pathway, promoting immunotherapy for HCC. The combination therapy significantly reduced tumor growth and improved survival in mouse models.
Researchers found that tumor-associated macrophages produce acetate through a metabolic interaction involving lactate and the lipid peroxidation–ALDH2 pathway. This acetate promotes histone H3 acetylation and epithelial-mesenchymal transition in hepatocellular carcinoma cells, enhancing metastasis.
Researchers found OGT expression is higher in MASLD-HCC tissues, promoting tumor growth. OGT modifies PTEN, impairing its function and activating the PI3K/Akt pathway.
A study of over 3,000 patients identified molecular hallmarks driving hyper-progression recurrence in liver cancer, enabling tailored surgical decisions and targeted therapies. Predictive models and nomograms stratify patients before and after surgery, guiding more effective strategies.
Glypican-3 is a key driver of hepatocellular carcinoma progression, facilitating metastasis and tumor microenvironment remodeling. Immunotherapy targeting GPC3 has shown preliminary safety and antitumor activity in clinical trials, with ongoing research focusing on optimized patient selection and disease monitoring.
A new clinical model integrating CT signatures predicts HCC risk more accurately than existing models, stratifying patients into high-risk and low-risk groups. The study enhances individualized surveillance and improves patient outcomes for cirrhosis patients.
hsa_circ_101555 demonstrated high diagnostic accuracy in differentiating non-HCC CLD patients from healthy controls. Serum levels correlated with advanced liver disease scores and inflammation markers.
PANoptosis, a hybrid form of cell death, is being explored as a strategy to tackle liver cancer. By integrating apoptosis, pyroptosis, and necroptosis pathways, PANoptosis triggers both direct tumor killing and immune reprogramming.
A blood test using microbial DNA analysis can distinguish primary liver cancer from colorectal cancer that has spread to the liver, according to a new study. The test reveals distinct bacterial 'fingerprints' for each cancer type, making it a powerful tool for non-invasive diagnosis and potential future therapy guidance.
This study found that ATOX1 promotes hepatocellular carcinoma (HCC) growth by activating the c-Myb/PI3K/AKT signaling pathway. ATOX1 also reduces copper accumulation and increases reactive oxygen species (ROS) production, leading to apoptosis in HCC cells.
A study found that in immune-tolerant HBV patients, a cumulative HBsAg/HBV DNA ratio below 1.791 is associated with a lower risk of disease progression, while those above this threshold face increased risk. Early antiviral treatment may improve clinical outcomes for these patients.
The Lancet commission emphasizes the need for concrete goals to reduce hepatocellular carcinoma's growing disease burden. The authors propose a 2% annual reduction in age-standardized incidence rates and recommend evidence-based strategies to tackle viral hepatitis, alcohol consumption, environmental risk factors, and disparities in he...
The Damon Runyon Cancer Research Foundation has awarded $4.2 million to five new Clinical Investigators conducting patient-oriented cancer research. The awards will support the development of new treatments for cancer patients, with a focus on enhancing efficacy and safety.
Researchers found Galectin-1, a sugar-binding protein, plays a critical role in helping hepatocellular carcinoma cells resist thermal ablation and thrive after being treated with high heat. Blocking Gal-1 can make thermal ablation more effective and reduce the risk of recurrence.
A new study published in the Journal of Hepatology shows that durvalumab plus GemCis significantly improves overall survival for patients with advanced biliary tract cancer. The three-year follow-up analysis found that over twice as many participants treated with durvalumab plus GemCis remained alive compared to those treated with a pl...
Researchers have discovered that TAF2 plays a pivotal role in the growth of liver cancer and can help promote tumor formation. The study's findings suggest that targeting TAF2 could lead to more effective treatments for liver cancer.
Research highlights the critical role of epigenetic changes in hepatocellular carcinoma development, including DNA methylation and histone modifications. Noncoding RNAs also play a key role in HCC pathogenesis and may serve as biomarkers for diagnosis and prognosis.
A study published in The Lancet Regional Health – Europe found that patients with low household income were more likely to be diagnosed late and receive less effective treatment for liver cancer. This highlights the need for targeted screening in deprived areas to improve early diagnosis and survival rates.
Recent research has focused on neddylation modification as a key driver of tumor cell proliferation, migration, and survival. Neddylation inhibitors have demonstrated significant efficacy in disrupting cancer cell growth by selectively inhibiting the neddylation pathway.
The study found that serum-derived hsa_circ_101555 showed excellent diagnostic accuracy in differentiating HCC patients from healthy controls. It also demonstrated a prognostic role in predicting tumor progression and response to therapy, with significant correlations with markers of liver inflammation and tumor features.
Hepatocellular carcinoma is the most prevalent form of liver cancer, and liver transplantation offers a curative treatment option for appropriately selected patients. Bridging therapies, such as radiofrequency ablation and transarterial chemoembolization, can improve survival outcomes post-transplant by preventing tumor progression.
A study published in Journal of Proteome Research reveals that inflammation and aging contribute to the development of non-viral liver cancer. Researchers analyzed gene expression and metabolites in normal and affected samples, identifying potential therapeutic targets for chemoprevention.
GTF3C2 expression is upregulated in HCC tissues, promoting tumor growth and poor survival outcomes. The GTF3C2/USP21/MEK2/ERK1/2 pathway regulates HCC cell proliferation and tumor growth.
A phase 3 study found that combining lenvatinib and pembrolizumab with transarterial chemoembolization significantly extended progression-free survival and showed a trend toward extending overall survival in patients with unresectable non-metastatic hepatocellular carcinoma. The treatment may lead to a complete cure.
Direct-acting antivirals have reduced HCV-related morbidity and mortality, but hepatocellular carcinoma (HCC) risk persists in certain populations. Risk factors include pre-treatment cirrhosis, metabolic disorders, and advanced fibrosis, highlighting the need for tailored surveillance strategies.
Researchers identified two immune subtypes of HCC patients with varying overall survival rates and immunity levels. Subtype 1-associated NK cells showed improved response to docetaxel and thalidomide, suggesting new hope for ICI treatment in HCC.
A recent cohort study published in JAMA Internal Medicine found that statin use was associated with a reduced risk of hepatocellular carcinoma and hepatic decompensation in patients with chronic liver disease. This suggests that statins may play a role in preventing the progression of liver disease and reducing the risk of liver cancer.
A research team developed a new system that uses spatial immune profiling to predict hepatocellular carcinoma (HCC) recurrence. The system, called TIMES, was trained on a dataset of 61 HCC patients and achieved an accuracy of 82.2% in predicting recurrence risk.
Recent developments in fluorescent probes offer improved specificity and sensitivity for detecting hepatocellular carcinoma (HCC). Next-generation probes are being developed to enhance tissue penetration depth and probe specificity, potentially improving surgical outcomes.
Research identifies six clusters of metabolic dysfunction-associated steatotic liver disease (MASLD) with varying pathophysiology and clinical outcomes. These clusters may enable personalized risk prognosis and treatment through lifestyle modification programs and targeted therapies.
A synthetic retinoic acid-inducible gene I (RIG-I) agonist RNA has been shown to induce innate immune signaling and death of hepatocellular carcinoma cells in vitro. The addition of recombinant interferon-b potentiated this cell death, suggesting a potential new mechanism for treating patients with liver cancer.
The Wnt signaling pathway is essential for HCC development, promoting cell proliferation, migration, and immune evasion. Targeting this pathway holds significant promise for therapeutic strategies, including small molecule inhibitors, monoclonal antibodies, and gene therapies.
This article examines the molecular mechanisms underlying icaritin's anti-cancer properties and discusses recent progress in its application. Icaritin, a prenylflavonoid natural product, shows diverse pharmacological effects, including anti-inflammatory, immune-regulatory, and anti-oxidation properties.
Researchers at Osaka Metropolitan University assessed target genes in canine hepatocellular carcinoma (HCC) to develop molecular targeted therapies. The study identified potential gene targets, including PDGFB, which may improve treatment options for unresectable HCC.
Researchers at Terasaki Institute develop lipopeptide hydrogels to deliver peptide-based cancer vaccines, demonstrating sustained release and enhanced immune cell uptake. The system shows promise in overcoming limitations of traditional peptide-based vaccines.
Researchers reveal senescence's impact on liver health, from repair and regeneration to chronic disease progression. Emerging therapies, such as senolytic treatments, aim to selectively eliminate senescent cells while preserving healthy tissue.
A meta-analysis found a dose-dependent relationship between alcohol consumption and the risks of cirrhosis and HCC in HBV patients, with daily alcohol consumption exceeding 12g increasing risk by 6.2% and 11.5% respectively.
A Phase III clinical trial found that stereotactic body radiotherapy (SBRT) added to sorafenib improved progression-free survival and overall survival in patients with locally advanced hepatocellular carcinoma, particularly those with macrovascular invasion. The study also showed improvements in quality of life for these patients.
Researchers have made significant breakthroughs in treating liver cancer, with a new study revealing the potential of anti-CXCR4 therapy to reprogram the 'cold' microenvironment. The combination of anti-CXCR4 and PD1 blockades enhances intratumoral dendritic cell activation and immune responses against hepatocellular carcinoma.
HCC-derived exosomes reprogram immune and stromal cells to create an environment conducive to tumor growth. Exosome engineering holds promise for targeted therapies that enhance the efficacy of existing treatments.
Research suggests that T-cell receptor repertoire analysis can inform treatment responses and predict efficacy in combination therapies for HCC. Advances in sequencing technologies are refining our understanding of tumor-immune interactions and adaptive immune mechanisms.
Recent studies suggest HBV infection is associated with liver cancer stem cells, but the exact mechanisms are unclear. This study investigates the role of HBV infection in regulating the stemness of HCCs and its link to drug resistance.
Researchers identified plasma extracellular vesicle-derived microRNAs as potential biomarkers for AATD liver disease. They found 39 differentially expressed miRNAs, which were validated in an independent cohort for predicting AATD liver disease.
The ESMO Asia Congress 2024 will focus on multidisciplinary oncology in the Asian region, featuring novel treatment modalities, management of specific cancer types and pan-Asian trials. Key highlights include insights into genetics, biology and practice differences between West and Asia.
Researchers found that imbalances in neutrophil extracellular traps are associated with portal vein thrombosis in patients with decompensated cirrhosis. High histone-DNA levels and low DNase activity were identified as independent risk factors for PVT.
The 17-beta-hydroxysteroid dehydrogenase 13 gene plays a significant role in regulating liver lipid metabolism, with loss-of-function variants linked to reduced risk of chronic liver disease progression. HSD17B13 modulation may provide therapeutic benefits for individuals with metabolic liver disease.
This review provides a comprehensive overview of CTC detection methods, their association with HCC progression, and their role in prognostication and treatment monitoring. Studies show that the number of CTCs correlates with tumor size, grade, and overall cancer severity.
A novel ratiometric fluorescent probe was synthesized to detect native human albumin (HA) activity in patients with hepatitis B cirrhosis and hepatocellular carcinoma. Native HA activity levels were significantly higher in low albumin groups, correlating with increased severity of liver disease.
This study identifies the hsa_circ_0001726/miR-140-3p/KRAS axis as a key regulator in hepatocellular carcinoma (HCC) progression and lenvatinib resistance. The axis is involved in promoting cell proliferation and migration, and is also linked to overall survival in HCC patients.
The GALAD algorithm combines AFP, AFP-L3, and PIVKA-II for HCC detection. Combining GAAD, GALAD, or PIVKA-II with ultrasound improves diagnostic efficiency compared to recommended strategies.