Articles tagged with Infectious Diseases
The partnership aims to co-develop and evaluate next-generation self-amplifying RNA (saRNA) vaccines targeting seasonal and pandemic influenza. Apriori's Octavia platform will be combined with A*STAR IDL's saRNA delivery technology to develop improved H5 influenza vaccines that anticipate infection in humans.
Researchers discovered a 'sticky' molecule, P-selectin, that can cause blood clots and organ failure during COVID-19. A new mRNA therapy that drives P-selectin expression provides broad protection against coronavirus infection.
Approximately 1 in 30 clinical trials were disrupted due to grant funding terminations, disproportionately affecting infectious disease and prevention studies. The study emphasizes the need for sustainable financial support to ensure trial operations and participant safety.
The new book provides a comprehensive overview of medicinal chemistry and target-based drug design for diseases such as leishmaniasis, Chagas disease, malaria, and others. It highlights emerging therapeutic compounds and the integration of synthetic and computational approaches to drug discovery.
Researchers are presenting groundbreaking findings at the Association for Molecular Pathology's annual meeting, including a novel technique to study ancient DNA and rapid detection of serious fungal pathogens. The Association for Molecular Pathology is providing press materials and resources for media coverage.
Researchers have developed a molecular test capable of detecting three major pathogenic fungi at once, with a much quicker turnaround than traditional methods. The test bypasses the slow culture process by detecting genetic material directly, eliminating errors and reducing laboratory risk.
A study published in Nature found that wild birds, particularly ducks, geese, and swans, are driving the current US bird flu outbreak. The viruses were introduced to North America via migratory birds and have become better adapted to infect wild birds since 2020.
Researchers have developed a new molecular test to identify Lyme disease earlier and more accurately than traditional methods. The test can detect as few as five bacterial cells and has an estimated sensitivity of 90.9%, making it a potential new avenue for testing Lyme disease.
Researchers Andrew Gewirtz and Lanying Du from the Institute for Biomedical Sciences at Georgia State University have been recognized as Highly Cited Researchers in 2025. They are among the top 1% of globally impactful researchers, with highly cited papers in multiple fields.
A European study found that long-acting monoclonal antibody immunisation effectively prevented hospitalisation due to RSV infection among children under two years old. The overall immunisation effectiveness was 79%, with a decline in protection over time, highlighting the need for ongoing monitoring.
A 47-year-old man from New Jersey died after consuming beef due to a tick-borne meat allergy caused by the Lone Star tick's alpha-gal sugar. Researchers identified the allergy and its link to fatal anaphylaxis, urging physicians to investigate severe abdominal pain after eating red meat in areas with high Lone Star tick populations.
A new study by Sightsavers and GLIDE has found that using worn socks with yeast-generated CO2 is as effective as traditional methods for catching blackflies that spread river blindness. The research could provide an alternative to 'human bait' and reduce the risk of disease transmission, offering communities long-term protection.
The Phase 3 study demonstrated the safety and non-inferiority of EuTYPH-C Inj.® Multi-dose compared to a World Health Organization (WHO) prequalified comparator TCV, Typbar TCV®. The vaccine was shown to be well-tolerated across all age groups with no serious adverse events.
Researchers at the University of Kansas have discovered a human gene, PARP14, that plays a role in regulating interferon and boosting the immune response. The protein's antiviral activity against multiple viruses suggests it could guide the development of new therapies for viral infections.
Researchers from the University of Edinburgh have identified a new mechanism of resistance to common antibiotics, targeting a special repair system possessed by certain bacteria. This discovery could aid efforts to combat antimicrobial resistance, one of the world's most urgent health challenges.
The University of Houston is part of a statewide effort to fight the opioid epidemic by investigating opioid use disorder among people living with HIV in Harris County. Researchers aim to integrate prevention methods, including Screening, Brief Intervention, and Referral to Treatment (SBIRT), into treatment for those affected.
A study in Arequipa, Peru found that efforts to track dog-related rabies in poorer areas were lacking, despite higher disease prevalence. An active surveillance system improved data collection and analysis, revealing striking differences between risk and surveillance.
A new study introduces a high-resolution melting PCR-based technique to track leishmaniasis, identifying sand fly species and detecting Leishmania parasites from a single sample. The approach reveals complex transmission patterns and ecological zones, enabling earlier intervention and targeted control strategies.
Researchers have identified three distinct immunotypes in EPTB patients, revealing new insights into disease mechanisms. Additionally, gene expression-based biomarkers have been developed to reliably diagnose both pulmonary and extrapulmonary tuberculosis.
Researchers have developed particles that can deliver an effective immune response at a much lower dose than traditional mRNA vaccines. The new particles, called AMG1541, use cyclic structures and ester groups to enhance mRNA delivery and improve biodegradability. This could potentially reduce vaccine costs and side effects.
Researchers found that early clindamycin administration significantly improved recovery rates in patients with invasive Group A Streptococcus (iGAS) infections. The study also showed that M1uk strain does not worsen prognosis in critically ill adults, but prompt treatment remains crucial.
Researchers found RSV to be of comparable severity to influenza and COVID-19, with higher death rates and intensive care admissions. Long-term cardiovascular and neurological complications were also observed up to 300 days post-hospitalisation.
Researchers have developed a novel vaccine strategy using biomaterial scaffold vaccines to protect against Staphylococcus aureus infections in orthopedic device implants. The vaccines, made with immune cell-attaching molecules and S. aureus-specific antigens, create a beneficial immune response that significantly lowers bacterial burden.
A new study identifies specific bat species carrying viruses with high epidemic potential. The research highlights that not all bats carry the same level of viral risk, and conservation efforts can help mitigate this risk by protecting habitats. Understanding which bat groups harbor deadly viruses can aid in developing therapeutics.
The editorial highlights how biological sex and gender inequities contribute to suboptimal sepsis treatment, potentially compromising outcomes for women. Hormonal fluctuations, body composition, and renal clearance all influence drug processing, yet these variables are rarely considered in dosing algorithms.
Researchers at WashU Medicine discovered central routes that deadly viruses take to invade human cells, designing decoy molecules to block infections. The studies set the stage for developing new strategies for yellow fever and tick-borne encephalitis viruses.
Pennington Biomedical researchers will participate in numerous panels and presentations during the conference, sharing their latest findings on obesity treatment and prevention. The institution is well-represented at the event, with faculty members among the experts leading courses, presentations, and speaker panels.
Researchers from the University of South Florida have used artificial intelligence and citizen science to identify what may be the first specimen of Anopheles stephensi — an invasive and deadly malaria-carrying mosquito — ever detected in Madagascar. The study demonstrates how AI-powered image recognition and public participation can t...
Scientists from Institut Pasteur identified Salmonella enterica and Borrelia recurrentis in remains of 13 soldiers who retreated from Russia in 1812. The study suggests these two pathogens may have contributed to the high number of deaths in Napoleon's army.
A new approach, epimodulation, has been developed to improve epidemiological forecasting models by incorporating critical pieces of understanding into the models. This approach increased model accuracy by up to 55% during epidemic peaks for hospital admission forecasts without reducing accuracy at non-peak times.
A recurring seasonal outbreak pattern of Salmonella Strathcona cases has been identified in Europe since 2011, with small tomatoes from Sicily being the likely source. The investigation found that almost all cases were genetically related, suggesting a common source and food vehicle.
A*STAR researchers discovered that mosquito saliva not only transmits the virus but also influences how the body's immune system responds to chikungunya infection. Sialokinin, a bioactive peptide in Aedes mosquito saliva, binds to neurokinin receptors on immune cells and suppresses monocyte activation.
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
A new human lung alveolus chip model enables investigation of viral replication, inflammatory responses, and genetic off-target effects of a novel pan-influenza CRISPR therapy. The study achieved significant reductions in virus load and host inflammatory response after a single administration.
Full-term children exposed to antenatal corticosteroids are at higher risk of infections until age 21, a new study finds. Preterm children, however, show no association between ACS and infections.
Researchers create novel compounds that kill bacteria in a new way, reducing the risk of side effects and environmental harm. The compounds have been shown to be effective in preventing bovine mastitis without affecting milk quality.
A key molecular player, RfaH, has been identified as a protective shield for bacterial genes, enabling them to survive the hostile environment inside the body. The protein ensures transcription runs to completion, making it an anti-terminator that prevents premature termination of gene expression.
A new study found that breastfeeding until six months of age helps babies fight off infections and reduce chronic inflammation. The researchers identified specific lipids in breast milk, such as plasmalogens, which appear to lower inflammation and improve immune health.
Researchers at The University of Osaka have identified a previously uncharacterized subset of immune cells called preTfr that play a critical role in preventing autoantibody production. In patients with severe COVID-19, these cells are significantly reduced, correlating with increased levels of harmful autoantibodies.
Researchers found that specific bacteria, such as Haemophilus parainfluenzae and Fusobacterium species, are associated with AIG-related neuroendocrine tumors. The study suggests that changes in host metabolism occur before alterations in the gastric microbiota, potentially creating a microenvironment that favors tumor growth.
A University of Houston professor has received funding to develop effective treatments for Cryptosporidium infections, which cause severe diarrhea and have no existing cure. The team aims to design drugs that target the parasite's enzyme CDPK1 to minimize systemic exposure and maximize efficacy.
A new study reveals rising rates of invasive SDSE infections across Australia, particularly among older Australians and those from remote regions. The research highlights disparities in health outcomes between regions and populations, emphasizing the need for improved surveillance and prevention strategies.
New research from Washington University School of Medicine identifies a key step in rotavirus infection and shows that disabling this process can prevent infection. The discovery opens up new avenues for therapeutic intervention, potentially treating not only rotavirus but also other pathogens with similar infection mechanisms.
Researchers discovered that HIV embeds itself in unique DNA patterns across various tissues, including brain, blood, and digestive tract, explaining its ability to persist for decades. This knowledge can help identify targeted therapeutic approaches to eliminate infected cells or 'silence' the virus.
A historic campaign in Argentina developed antivenom for black widow spider bites, leading to a model for pharmaceutical autonomy. This approach is crucial for fighting neglected tropical diseases globally.
A new study from Karolinska Institutet reveals that postural orthostatic tachycardia syndrome (POTS) affects nearly a third of patients with severe long COVID, with middle-aged women being the most common demographic. Researchers emphasize that POTS can be detected with simple tests and treated to alleviate symptoms.
Researchers argue that AI can strengthen pandemic preparedness by detecting emerging diseases earlier. By combining data from humans, animals, and the environment, AI can reveal patterns and provide insights into potential pathogens.
A comprehensive mapping study predicts India could experience the greatest long-term impact from chikungunya, with 14.4 million people at risk globally each year. Chronic health impacts will be a major concern, with around 50% of infected individuals left with long-term disability.
A new pediatric study found that young people infected with COVID twice are twice as likely to develop long COVID, with increased risks for heart disease, damaged kidneys, cognitive issues, and more. The study analyzed data from over 407,000 patients across 40 pediatric hospitals.
A new framework for US vaccine policy aims to rebuild trust by acknowledging shared blame, abandoning absolutist tactics, and promoting community-based education. The medical community must own its share of responsibility in addressing declining vaccination rates and rising outbreaks of vaccine-preventable diseases.
The NUS Medicine will receive a S$2 million grant from Novo Nordisk Foundation and Temasek Foundation to strengthen microbiology testing for severe bacterial infections across Asia. The DETECT-Asia programme aims to combat antimicrobial resistance, which is driving socio-economic inequity and claiming millions of lives globally.
A large study found that children and adolescents are twice as likely to experience long COVID after catching COVID for the second time compared to their peers with a single previous infection. Long COVID in youth is associated with various conditions, including myocarditis, blood clots, and severe fatigue.
A study published in The Lancet Regional Health – Western Pacific found that most newborn infections in Southeast Asia are caused by bacteria unlikely to respond to current treatments, highlighting the need for updated diagnostic and treatment guidelines. Locally relevant data is crucial for guiding routine medical decisions, and new a...
Scientists introduce a new way to control when drugs are active or inactive in the body, potentially developing safer medicines. The technology was applied to create improved molecular sensors, including a rapid coronavirus sensor that responds about 70 times faster than previous protein-based tests.
Dr. Langlois and his team will support large-scale scientific research, protect vulnerable communities, and strengthen Canada's ability to face future health emergencies. The High-Throughput Facility infrastructure will rapidly detect and track new infectious disease threats while protecting people and communities.
The Gladstone Infectious Disease Institute is broadening its research scope to tackle pressing health challenges beyond viruses. Scientists are discovering new ways to combat antibiotic-resistant bacteria and explore the interconnectedness of viruses and bacteria in causing chronic diseases.
A cohort study investigated olfactory dysfunction in US adults with and without prior SARS-CoV-2 infection. The study found a significant association between prior infection and persistent olfactory dysfunction. High variability was observed among individuals, highlighting the need for individualized assessment and treatment strategies.
Researchers discovered onnamides, a family of compounds from Okinawan marine sponges, showing remarkable potential against Leishmania major. These compounds demonstrate potency and safety exceeding current treatments, offering new approaches to overcome drug resistance.
Researchers used computer modeling and large datasets to understand how COVID-19 was transmitted in one community in South Africa. The study found that population density and household size significantly affected transmission patterns during lockdowns and government restrictions.
A new study from the University of Illinois shows that severe flu infection in pregnant mice leads to a breakdown in placental and brain barriers, allowing potentially harmful molecules to accumulate in the fetal brain. Fibrinogen accumulation has also been linked to neuroinflammatory conditions, and researchers found it accumulated in...