Articles tagged with Amines
A rare genetic mutation has been discovered that can explain why some people do not respond to newer schizophrenia treatments. The mutation, known as C182F, removes a structural bond in the TAAR1 receptor, blocking its binding site and rendering drugs ineffective.
Researchers at Flinders University discover a genetic mutation that silences a brain receptor, rendering it unresponsive to both natural trace amines and clinical drug candidates. The C182F variant eliminates receptor signaling and reduces cell surface expression, with profound implications for emerging psychiatric treatments.
A recent Chinese study analyzed urine samples from 457 residents across 16 cities, revealing significant associations between primary aromatic amine (PAA) exposure and oxidative DNA damage biomarker 8-OHdG. The findings suggest that even low concentrations of PAA may contribute to long-term cancer risks in the general population.
A nationwide biomonitoring study in China detected 25 primary aromatic amines with varying levels of exposure among residents. High concentrations were observed in smokers, non-adults, and industrialized cities, with correlations to oxidative DNA damage.
Researchers developed a reliable and affordable purification technique for chromatography using calcium chloride, applying to organic compounds like amines and peptides. The technique has shown promising results in purifying APIs with high accuracy.
Researchers found that inactive amines used in herbicides could be more important nitrosamine precursors than previously thought, potentially posing serious health risks even at low concentrations. The study suggests shifting trends in herbicide formulation and use necessitate closer examination of these chemicals
Researchers at Institute of Science Tokyo developed porous organic crystals with ultrahigh-density amines, achieving fast CO2 adsorption and high thermal stability. The unique 2.5-dimensional skeleton reduces the cost for CO2 separation from flue gases.
Researchers developed a novel one-step synthesis method for unsymmetrical ureas, avoiding the use of phosgene and reducing corrosive acid generation. The new carbonylation mode is applicable to various aromatic and halogenated amines, enabling efficient production of nitrogen-containing compounds.
Researchers at UC Berkeley have developed a metal-organic framework that can capture CO2 at extreme temperatures, relevant to cement and steel manufacturing plants. The discovery has the potential to change how scientists think about carbon capture and reduces the need for costly infrastructure.
A new covalent organic framework (COF) material developed by UC Berkeley researchers can capture CO2 from ambient air without degradation, making it a promising solution for reducing atmospheric greenhouse gases. The material's high carbon dioxide capacity and selectivity make it an attractive alternative to existing carbon capture tec...
A case report describes a woman who experienced bilateral blurry vision after using hair dye with aromatic amines. The incident highlights the potential risk of retinopathy associated with certain hair dyes.
Scientists improve stability and bioavailability of mRNA nanocarriers using triphenylphosphonium, leading to increased protein production in tumor tissues. The TPP-based system also shows higher mRNA levels in blood after 30 minutes compared to amine-based micelles.
Researchers at Okayama University developed a switchable process to synthesize 3-aminoindolines and 2'-aminoaryl acetic acids from a common substrate using Grignard reagents and azide compounds. The new protocol utilizes tautomerism to control chemoselectivity and achieves efficient synthesis with good yields.
Amino acids from lysine, glutamic acid, leucine, and serine exhibit superior curing properties compared to commercial hardeners. This study demonstrates the potential of these bio-based epoxy curing agents as a renewable alternative to petrochemical-derived amines.
Researchers from Tohoku University developed a unique chemical reaction to attach two distinct functional molecules to the N-terminus of peptides with a glycine amino acid, achieving site-selective modification and stable carbon-carbon bonds. The method shows potential for labeling diverse peptides and larger proteins for purification,...
Researchers from Osaka University developed an economical catalyst for a common chemical transformation, replacing rare metals with cheaper substitutes like nickel. The novel catalyst showed high activity, reusability, and high yields.
A research team at Osaka University has found a way to synthesize alkylamines in a sustainable and cost-effective manner, using a novel catalyst system that produces only water as a byproduct.
A team at UNC-Chapel Hill has developed a new process for synthesizing amides with 100% atom efficiency, employing environmentally friendly cobalt. This approach offers an attractive alternative to traditional methods, which often generate waste and poor atom economy.
Researchers develop method to produce valuable chemicals at lower cost, using ozone and copper catalyst. This breakthrough could make cancer treatment more affordable, with prices potentially reduced from thousands to just a few dollars.
Researchers developed a new catalyst using bismuth selenide, a topological insulator, to synthesize organoureas at room temperature with almost 100% yield. The catalyst's unique properties allow for stable surface states and recyclability.
Researchers at CABBI develop photoenzymatic system to efficiently synthesize chiral amines, crucial chemical building blocks with wide applications. The team's new method addresses a longstanding challenge in synthetic chemistry and offers a promising platform for biomanufacturing.
A new method for polyurethane synthesis without isocyanates was developed by Kobe University and AGC Inc. using fluorinated compounds, enabling the creation of highly elastic, wear-resistant, and durable polyurethanes with improved environmental sustainability.
Researchers from Tokyo Institute of Technology have developed a novel synthesis method for imine-based COFs, eliminating the need for long reaction times, high temperatures, and Lewis acid catalysts. The method uses an electrogenerated acid as a catalyst, enabling direct fixation of COF films onto electrodes.
Researchers at Pusan National University have created a portable molecular sensor that detects biogenic amines released from spoiled food using polydiacetylene-based beads. The sensor, which changes color to red upon binding with BAs, can be used for rapid visual detection of spoiled food during storage and distribution.
Researchers developed an algorithm using quantum computing to study amine reactions and find new compounds for carbon capture. The algorithm can quickly screen thousands of molecules and structures, vital for practical applications in fields like carbon capture.
Researchers have developed a new lithium-air battery that uses a solid electrolyte, boosting energy density four times above lithium-ion batteries. The battery can potentially power cars for over a thousand miles on a single charge and is also suitable for domestic airplanes and long-haul trucks.
Researchers at Boston College have developed a new catalytic approach that enables concurrent control of multiple convergences and selectivities in intermolecular amination of allylic carbon-hydrogen bonds in alkenes. The cobalt-based system exploits unique features of homolytic radical reaction to form desired amine products in a high...
Researchers developed a new photo-oxidation method to efficiently synthesize pharmaceutical intermediates and polyurethane from perchloroethylene, a common dry cleaning solvent. The method yields high-quality compounds with minimal environmental impact, offering a promising alternative for sustainable chemical recycling.
Researchers recreated interstellar cloud and asteroid conditions to understand how carbonaceous chondrites acquired amino acids, finding that interstellar cloud conditions are resilient to asteroid processing but influence the amount of amino acids present.
Scientists at UC Riverside have discovered that volatile repellents containing ammonia and amines can be used to combat insect-borne diseases by disrupting their sense of smell and taste. The research found that these compounds can silence olfactory neurons in mosquitoes, preventing them from detecting human skin odor.
A group of scientists developed a machine learning approach to predict amine emissions from a carbon capture plant. They analyzed data from a stress test at a German power plant and found that two amines respond in opposite ways, increasing or decreasing emissions. This new method has the potential to change the way chemical plants ope...
A study from Washington University in St. Louis found that amines used in herbicide formulations volatilize, releasing toxic particles into the atmosphere and affecting climate chemistry. The research highlights the importance of understanding amines' role in atmospheric pollution.
Researchers at Kobe University have developed a new method to synthesize fluoroalkyl carbonates, which are environmentally friendly alternatives to toxic precursors. These carbonates exhibit high reactivity and can be used to create pharmaceutical intermediates and other substances.
Researchers have created a cheap and energy-efficient way to capture carbon dioxide from smokestacks using porous melamine material. The process is simple to make and requires primarily off-the-shelf melamine powder, making it a promising solution for scaling down carbon emissions from vehicle exhaust or other movable sources.
Researchers from Tokyo Metropolitan University have developed an innovative carbon capture system that removes CO2 directly from the atmosphere with unprecedented performance. The isophorone diamine-based system achieves 99% efficiency and can process low concentrations of CO2 in air at a rate twice as fast as existing systems.
North Carolina State University researchers have developed a faster and less expensive technique for producing hindered amines, a class of chemicals used in various products. The new method uses continuous flow reactor technologies to produce hindered amines within 30 minutes, with minimal byproducts.
Researchers at UIUC discover a new method for making tertiary amines, a crucial component in many medicines, using a simple and fast process. The reaction has the potential to lead to the discovery of new medicines for currently untreatable diseases.
A new study found that dogs and cats are exposed to potentially toxic aromatic amines in their homes, which have been linked to cancer. The chemicals were detected in over 38% of urine samples from pets, with cats showing higher concentrations than dogs.
Researchers at Argonne National Laboratory have discovered a key reason for the performance decline of sodium-ion batteries, which are promising candidates for replacing lithium-ion materials. By adjusting synthesis conditions, they can fabricate far superior cathodes that will maintain performance with long-term cycling.
Researchers have created a range of permanent hair dyes that avoid the allergenic properties of traditional formulations, producing a range of hues from rosy pinks to deep blacks. The new dyes were found to be less reactive toward proteins and generated a reduced inflammatory response in cells compared to PPD.
Scientists at the University of Bath have developed a new method for synthesizing primary amines, used in over half of all pharmaceuticals, significantly reducing energy usage and chemical waste. This breakthrough aims to speed up drug discovery by making it easier to synthesize new chemical structures for testing.
Researchers developed Ru1/NC SAC, showcasing improved catalytic activity and selectivity in reductive amination reactions. The single-atom dispersion and coordination environment play crucial roles in determining the catalytic performance.
Researchers at USTC developed a mild and general nickel-catalysed asymmetric reductive hydroalkylation to synthesise chiral aliphatic amines. They achieved this by replacing equivalent metal reagents with olefins, facilitating carbon-carbon coupling under mild conditions.
Researchers have developed a pen-like sensor that changes color in response to harmful gases, offering a potential solution for detecting toxic vapors. The device can identify nerve agents and volatile amine vapors, with applications in food safety, environmental monitoring, and public safety.
Researchers at KAIST develop novel biosynthetic pathways for short-chain primary amines through retrobiosynthesis, expanding the strategy for bio-based production of chemicals. The team successfully produced multiple short-chain primary amines using Escherichia coli strains and renewable resources.
Scientists at University of Münster have successfully synthesized the least accessible form of vicinal aminoalcohols using a photo-initiated reaction method. This breakthrough enables the efficient production of high-quality organic compounds found in everyday products, with potential applications in pharmaceuticals and natural products.
Researchers have developed nanodiamond-embedded membrane filters that can effectively treat hot wastewater by increasing filtration rates and removing impurities. These membranes achieve this through the synergistic effects of amine links and ethyl acetate treatment, resulting in thicker, more temperature-stable membranes.
Researchers at University of Toronto have developed an electrochemical method to convert captured carbon into commercially valuable products, such as fuels and plastics. The new process significantly lowers the overall energy cost of combined capture and upgrade, making it more economically attractive.
Washington University researchers found that hydrogen bonding functional groups on amines play a key role in controlling dicamba volatility. The team's study suggests that amines with more hydrogen bonding sites decrease dicamba's ability to become airborne, potentially leading to improved formulations and reduced crop damage.
A new device uses biogenic amines to detect seafood spoilage, offering a quick and simple method for testing amine vapors from fish. The technology has the potential to revolutionize food safety by enabling real-time monitoring of spoilage levels in seafood.
Tokyo Tech researchers have developed a heterogeneous ruthenium-based catalyst capable of driving direct amination of alcohols to produce primary amines without hydrogen gas. The system achieved higher yields and showed potential for reuse, making it a cost-effective and environmentally friendly method.
Scientists have made a groundbreaking discovery about the function of actin, a crucial protein in cells, by uncovering its atomic-scale structure as it is modified. The research reveals that actin's modification plays a key role in regulating its ability to form filaments and interact with other proteins.
Researchers at Osaka University have developed a palladium-based alloy nanocatalyst that promotes the selective production of deuterium isotope compounds from formic acid. The catalyst enables a cost-effective and scalable process for producing these gases, which are useful in fine chemical production and research applications.
Scientists at Argonne National Laboratory have developed a new cathode coating that provides extra layer of protection for battery cathodes while maintaining electrical and ionical conductivity. The coating also prevents oxygen release and promotes structural stability, leading to potential energy output increases and longer lifetimes.
Chong Qiu, Assistant Professor of Chemistry at the University of New Haven, has been awarded a five-year, $700,000 National Science Foundation Early Career Award for his research on aerosols and their impact on climate change, weather forecasting, and human health. The award recognizes his work on chemicals such as amines that were pre...
Scientists from the University of Tsukuba have isolated bacteria that break down cyclic imines, a key component in medicines for hypertension. The discovery highlights copper amine oxidase as the enzyme responsible for this process.
Researchers have developed a new efficient catalyst to synthesise aromatic amines, which are central building blocks in many drugs and pesticides. The system is more active than conventional catalysts, enabling faster and more efficient production of these compounds.
Osaka University researchers have developed a practical and environmentally innocuous method for functionalizing multiply substituted amines. Their reductive alkylation approach uses hydrogen directly, generating only water as a byproduct and efficiently synthesizing a wide variety of amines, including amino acids.
A new method has been developed for synthesizing alkyl amines using photocatalysis alongside copper catalysis, overcoming the challenge of alkyl group synthesis. The approach allows for high selectivity and compatibility with functional groups, and can be carried out at ambient temperatures.
Researchers at Tokyo Tech have developed a highly selective Ru/Nb2O5 catalyst that produces primary amines from carbonyl compounds with ammonia, achieving yields of up to 99% and outperforming other catalysts.