Articles tagged with Stress Responses
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Chimpanzee cortisol levels increase with age, blunting natural diurnal rhythm and responding to stressors similarly to humans. Sex differences also emerge, with males exhibiting higher levels than females, particularly when exposed to attractive females.
Researchers at NCBS found that mistakes in protein synthesis increase the production of a quality control molecule, triggering an early DNA repair response and enhancing mutational resistance. This general advantage of mistranslation persists due to its occasional benefits under stress.
Researchers at Ludwig-Maximilians-Universität München identified a signaling pathway enabling mitochondria to transmit distress signals to the surrounding cytosol. This pathway involves enzymes OMA1 and DELE1, which trigger cellular responses to stress, potentially opening new therapeutic approaches for age-related diseases.
Researchers at the University of Cambridge discovered that random gene pulsing plays a key role in establishing spatial structures during biofilm development. This process allows for the distribution of cell states within a population, enabling the formation of complex patterns.
Researchers found that stress activates nerves that release norepinephrine, which causes premature depletion of pigment-producing cells. This leads to permanent damage and loss of stem cells, resulting in gray hair. The study advances understanding of stress impact on the body and paves way for new treatments.
A recent study published in Scientific Reports found that simple leaf wounding in plants can increase the production of healthier organic fruit. The research team discovered that stress responses created in the fruits and vegetables lead to an increase in antioxidant compounds prior to harvest, making them healthier for human consumption.
ATAD5 plays a crucial role in counteracting DNA replication stress by regulating PCNA unloading and promoting RAD51 recruitment. This study reveals ATAD5's fundamental mechanism of replication stress control, contributing to the development of cancer therapy.
Researchers at CNIC have identified molecules that act as an 'airbag' protecting cells from mechanical stress. The study shows how these molecules coordinate changes to protect the cell and prevent damage. Altering their activity could lead to new therapies for diseases related to mechanical stress.
Researchers at Goethe University develop a new method to measure acute cellular stress responses, enabling precise time-resolved measurements of thousands of proteins. This breakthrough opens the door for new therapeutic strategies in diseases like cancer and neurodegenerative disorders.
Researchers at Hokkaido University found that nuclear stress bodies help cells recover from stress by regulating intron retention, a process essential for gene expression. The discovery sheds light on the mysterious organelles' role in stress response and has implications for understanding various biological functions.
Researchers discovered that Crohn's disease-associated bacteria can switch between replicating and non-growing states within macrophages to tolerate antibiotics. This stress response allows a reservoir of antibiotic-tolerant bacteria to survive in the host and cause long-term inflammation and irritation.
Researchers discovered that cells with extra chromosome 21 in DS mice activated a biological circuit that detects stress and tamps down protein production, leading to cognitive impairments. By targeting this stress response, scientists were able to reverse learning and memory deficits in the mouse model.
A new study found that puberty may offer a window of opportunity to recalibrate cortisol responses in children who experienced early life deprivation, such as institutional care. As these children age, their stress hormone levels increase and become more responsive to stress, similar to those who were not affected by deprivation.
A study published by Professor Henrik Oster suggests that daily stress coupled with a disrupted internal clock increases the risk of developing metabolic disorders such as obesity and type 2 diabetes. This is because environmental stress can affect food intake, promote weight gain, and have long-lasting effects on stress responses.
A study found that puberty can reverse the effects of early institutional care on stress reactivity. Cortisol levels rose with increasing pubertal stage in postinstitutionalized participants, similar to those without institutional care.
Researchers found that stressed horses blink less and twitch their upper eyelids more, providing a simple indicator of agitation. The study used non-invasive measurements to test the significance of eyelid twitches as an indicator of stress.
Researchers discover that flawed removal of signal sequences leads to protein aggregation in mitochondria, causing them to stop working. However, cells execute a protective stress response to maintain key functions, ensuring survival.
Researchers found that the endoplasmic reticulum stress response helps reduce brain activity during seizures, potentially leading to more effective epilepsy therapies. The study's findings may also provide insights into other neurological disorders caused by seizures.
A recent study suggests that osteocalcin, a hormone released by the skeleton, is necessary for the fight or flight response to be triggered in bony vertebrates. This finding challenges the long-held assumption that adrenaline drives this response.
Research reveals that bone-derived hormone osteocalcin plays a critical role in mediating the acute stress response, which is distinct from hormones released by the adrenal glands. Osteocalcin levels rise in response to stress, triggering physiological responses such as increased energy expenditure and heart rate.
Scientists at St. Jude Children's Research Hospital have identified DDX3X as a crucial molecule in determining the fate of stressed cells. The molecule plays a pivotal role in regulating the innate immune response and helps cells interpret and respond to various stressors with measures meant to ensure cell survival or death. This findi...
Research from the Alkema lab reveals that the 'fight-or-flight' response triggers tyramine release, which stimulates insulin pathways to satisfy energy demands but down-regulates cellular protection against environmental stress. This dynamic regulation negatively impacts health and aging in nematode worms.
Coffman's research will investigate the role of Klf9 in regulating stress response system using zebrafish as a model, with implications for understanding chronic disease and developing novel therapies. The grant aims to elucidate pathways governing stress response and create tools for future research.
A new analysis of data on over 900 Baltimore adults has linked stressful life experiences among middle-aged women to greater memory decline in later life. The researchers found that women who experienced more stressful life events recalled fewer words and recognized less words during memory tests.
Researchers discover that moderate chromatin stress triggers a response that promotes longevity in various organisms, including yeast and C. elegans. The study suggests that this process may be conserved in other organisms, opening new possibilities for intervening in human aging.
A long-running study on premature infants found that stress from birth can lead to cognitive limitations, social struggles, and increased risk of health issues. Researchers will continue the 30-year study to understand how to limit NICU stress and mitigate its impact throughout life.
Researchers propose a model that explains why some women develop PTSD after childhood trauma, highlighting the role of hormone regulation in resilience. The study suggests that when cortisol and oxytocin levels function properly, they serve as barriers against PTSD.
Cara Boutte's research aims to better understand how mycobacteria respond to stress and develop effective treatments. The project will characterize two systems by which mycobacteria regulate cell growth and division in response to stress, leading to new mechanisms of cell wall regulation.
Researchers have identified a long non-coding RNA, LDAIR, that regulates seasonal changes in stress response in medaka fish. This lncRNA affects corticotropin-releasing hormone receptor 2 and modulates self-protective behaviors during breeding seasons.
Researchers at Lobachevsky University discovered that the electrophoretic mobility of red blood cells and buccal epithelium cell analysis can effectively assess stress response severity. These indicators reflect engagement of stress-implementing systems and immune system effectiveness.
New research confirms that drastic changes in ocean salinity can cause 'freshwater bleaching' of coral reefs, leading to cell function collapse. The study found corals sensitive to slight changes, with nearshore reefs exposed to half normal ocean salinity causing a shock response preventing normal cell function.
Researchers at the University of Helsinki have uncovered a novel cellular stress response to toxic mitochondrial proteins, which causes complex neurological syndromes. A clinically approved drug has been found to block the production of toxic proteins and trigger a stress response in animal models.
Mice exposed to ultrafine particles in utero show reduced immune responses and increased inflammation, indicating a possible link between prenatal pollution and respiratory health issues.
Researchers found that students trained in a relaxed environment acquired microsurgical suturing and cutting skills rapidly, with performance levels comparable to seasoned surgeons. The study's results challenge traditional training doctrines, suggesting that stress-free conditions can improve skill acquisition and retention.
A new study finds that stress increases rapid-eye-movement (REM) sleep, associated with genes involved in cell death and survival. The research suggests that changes in REM sleep may contribute to mood disorders like depression by activating signaling pathways in the brain.
Biological imaging experts at Colorado State University have used a custom fluorescence microscope to capture individual RNA molecules interacting with stress granules. The results show that RNA translation is completely silenced before the RNAs enter the stress granules, providing unprecedented details of the cellular stress response.
Researchers have identified a key trigger for toxic protein production in ALS and frontotemporal dementia. Targeting the integrated stress response with an approved antidepressant drug shows promise in reducing toxic protein production in laboratory tests.
Researchers found that plants prioritize protection against physical stresses over biological ones depending on leaf age, with older leaves more sensitive to pathogen attacks and younger leaves protected under abiotic stress.
Researchers discovered a mechanism involving protein alteration that controls cell response to stress, boosting immunity and extending lifespan. The discovery highlights the importance of unfolded protein response (UPR) and its regulation by ULP-4 enzyme in mitigating mitochondrial stress.
Researchers developed a flexible electrode to monitor adrenal gland activity in real-time, providing potential continuous tracking of acute and chronic stress responses. This method could aid in diagnosis and treatment of stress disorders.
Natural killer T cells use a stress-related pathway to produce cytokines, which play a crucial role in protecting against diseases. This unique mechanism highlights the selectivity of this response to this particular cell type.
Researchers at The Ohio State University found that eliminating microglia can reverse some aspects of stress sensitization, but not increased anxiety. Microglia hold unique signatures of chronic stress and play a critical role in the recurrence of anxiety after chronic stress.
Frogs from quiet ponds exhibit increased stress hormone levels and impaired immune function when exposed to traffic noise. In contrast, frogs from noisy ponds display a dampened stress response and altered immune profile, which reduces the negative effects of traffic noise.
Researchers identified a small molecule that activates the antioxidant response, a key mechanism to protect cells from oxidative stress. The discovery targets the glycolysis pathway, opening new strategies for treating diseases involving oxidative stress.
Researchers identified NGA1, a transcription factor in Arabidopsis thaliana, as a key player in early drought stress response by activating the NCED3 gene and promoting abscisic acid (ABA) biosynthesis. This finding suggests that ABA accumulation is essential for plant protection against dehydration.
Research highlights long-lasting effects of early life stress on the genome, gut, and brain, increasing the risk of anxiety, depression, and autism spectrum disorder. Novel strategies, such as inhibiting stress hormone production or resetting immune cells, may help combat these effects.
A recent Illinois study provides a global view of plant cold stress by examining the entire collection of genes, metabolites, pathways, and reactions. This approach identifies significant metabolites associated with important traits and offers a step forward in metabolic profiling techniques.
A global online survey found that heat-related work productivity loss varies significantly between developed and developing countries. The study estimated average WPL losses of 3.5 days for developed countries and 6.6 days for developing countries under different warming scenarios.
Researchers found no significant differences between synthetic and live tissue models in terms of stress levels during training. This study suggests that synthetic models can be used without sacrificing educational quality, reducing the need for live animal use.
Researchers found that spontaneous self-distancing predicts whether awe has a positive or negative effect on people. Awe can lead to a sense of smallness, making obstacles seem insignificant, but also a perception of capabilities as insignificant, making stressors unmanageable.
Researchers at the Max Planck Institute discovered that individuals with depression have a larger left hypothalamus than those without the disorder. The study found a correlation between the severity of depression and the size of the brain region, but no effect from medication.
Researchers found that nasal cells have a stronger antiviral response, while lung cells have a stronger defense against oxidative stress. This trade-off can make individuals more susceptible to rhinovirus infection when exposed to another stressor like cigarette smoke.
A recent study found that tree swallow females who absorbed a stress hormone through their skin had lower survival rates and smaller offspring. Another study showed that birds with stronger stress responses were more susceptible to lingering effects of stress.
Researchers at the University of California San Diego School of Medicine have identified a signaling pathway that activates the NLRP3 inflammasome implicated in several severe chronic inflammatory disorders. Blocking the CMPK2 enzyme may result in new treatments for osteoarthritis, Alzheimer's disease, and lung cancer.
Researchers found that neural inflammation caused by innate immune system triggers depressive behavior through activation of microglia and expression of inflammation-related cytokines. This discovery could lead to the development of new antidepressants targeting innate immune molecules.
A team of researchers from UAlberta has identified a new pathway in the brain that could lead to the development of a new treatment for anxiety disorders. By targeting the peptide NPY, they found that it can reduce anxiety and increase stress resilience. This breakthrough provides hope for finding new avenues for treatment.
Researchers identified Klf9 as a key factor mediating the detrimental effects of chronic stress on neuronal connectivity and fear responses. Silencing Klf9 expression protected mice from stress-induced changes in dendritic spines and behavior.
Researchers from the University of Würzburg have discovered a new role for stress granules in the formation and elimination of these structures. The study found that ZFAND1 protein is necessary for normal clearance of stress granules, which can lead to neurodegenerative diseases like ALS and FTD if not properly eliminated.
Researchers identify best irrigation methods for cotton in water-limited situations, challenging common assumption that producers should irrigate early and often. By reducing watering after plant emergence, yields and fiber quality can be maintained or even improved.
Researchers discovered that elevated stress response protein levels are associated with reduced kidney damage after heart surgery. High MIF levels before surgery may help identify patients at risk for acute kidney injury.