A small study found that five volunteers with late-onset Alzheimer's disease showed significant improvements in cognitive tests and decreased biomarker tau proteins after two years of receiving 40Hz light and sound stimulation. This suggests that the therapy may slow cognitive decline and have direct biological impacts on Alzheimer's p...
A UK-wide study of 5,509 people with MS found that the condition significantly affects health-related quality of life. The research used EQ-5D-5L tool to measure changes in health status, revealing varying thresholds by MS type and relapse history.
In a new Stroke article, Dr. Joseph Broderick predicts stroke care advancements by 2050, with a focus on patient-wearable diagnosis tools and AI-driven treatments for ischemic and hemorrhagic strokes. Researchers will overcome the challenge of neuroprotection and develop smaller, safer clot removal devices.
African nations are well-equipped to tackle dementia and brain health with the Africa Task Force on Brain Health. The six-year framework will accelerate preparedness and protect aging citizens.
The 15th annual Les Turner Symposium on ALS will bring together leading researchers to discuss the latest research and perspectives on the disease. Dr. Don Cleveland, a renowned expert, will deliver a keynote address on developing designer DNA drug therapy for neurodegenerative diseases.
A new study from McGill University found that increased physical activity in older adults with cardiovascular conditions is linked to greater social support and access to greenspace. Brain imaging revealed a connection between brain connectivity and exercise behavior change.
Researchers highlight the importance of designing 'human-in-the-loop' systems with expert input for AI model training and validation. Machine learning models offer more interpretable results, but generative AI requires robust safeguards to protect patient data.
Post-traumatic vasospasm (PTV) is a sudden narrowing of brain arteries that can lead to stroke and long-term neurological damage. Early diagnosis using tools like transcranial Doppler ultrasound and S100 protein blood tests is crucial to prevent secondary brain injury.
Scientists found a promising candidate, pleiotrophin, which is essential for brain development and function; restoring it may improve brain circuits in individuals with Down syndrome and other neurological diseases. The study's findings suggest using modified viruses to deliver the protein directly into cells could lead to new treatments.
Graz University of Technology and the University of Regensburg are conducting research on the interaction of cell types at the blood-brain barrier, with a particular focus on sex-specific differences in depression. The study aims to identify mechanisms contributing to depression and develop targeted therapies.
A new clinical trial is investigating the use of advanced brain monitoring to improve epilepsy diagnosis and management. The trial involves multiple sites across Europe, including Ireland, where patients will undergo long-term outpatient monitoring using a subcutaneous EEG system.
Nemours Children's Health neurologist Rodney Scott will investigate malfunctions in the brain's hippocampal region to identify shared therapies for patients with autism, epilepsy, and Alzheimer's disease. He aims to develop novel methods of brain stimulation that could restore healthy function across a range of disorders.
A University of Cincinnati study found increased neutrophil-driven inflammation after intracerebral hemorrhage (ICH) seven days post-stroke, compared to earlier time points. The researchers also identified miR-3613 and miR-3690 as key regulators of this process, suggesting potential new treatment targets.
A new study found that child neurologists often lack knowledge and education on motor difficulties in children with autism. Motor impairments are common in autistic children, affecting their development, language skills, and social interactions. The study recommends more training for medical students and residents to recognize and addr...
This study found that aged rats living in socially enriched environments retained better memory and cognitive flexibility than those housed alone. Socially housed rats showed increased activity in the hippocampus and reduced overactivity in the anterior cingulate cortex, suggesting a more balanced and efficient neural response.
A new system developed by researchers at Nagoya University can detect genetic mutations in brain tumors with high accuracy and speed. The system successfully identified key markers for diagnosis of diffuse glioma, a common type of brain tumor.
Senescent astrocytes lose their ability to support brain endothelial cells, leading to BBB dysfunction. Increased angiotensin signaling is implicated in this process.
Researchers found a significant increase in AMPA receptors across Long COVID patients' brains, correlating with cognitive impairment severity. This discovery provides a direct biological explanation for brain fog symptoms and may lead to novel treatments.
A new study published in Biomaterials has developed a tiny, bioengineered system to deliver anti-inflammatory proteins to specific targets in the brain. The AstroCapsules, which are 300 micrometers in diameter, were confirmed to function when implanted into the brain and reduced neuroinflammation by measuring inflammatory biomarkers.
A study published in Neurology found that preterm infants who received more skin-to-skin contact had stronger brain development in areas related to emotion and stress regulation. The study also linked longer skin-to-skin sessions to improved brain connectivity and lower stress markers.
Salk scientists pinpoint gracile nucleus as brain area responsible for differentiating between painful and non-painful touch, with dysfunction leading to chronic pain. Altered neuronal activity in the dorsal column nuclei drives mechanical allodynia, causing the brain to misinterpret innocuous light touch as painful.
Johns Hopkins researchers used machine learning to analyze electric activity of mini-brains grown in a lab, revealing unique firing patterns associated with schizophrenia and bipolar disorder. The study improves accuracy in distinguishing between healthy and unhealthy brain organoids, paving the way for potential diagnostic tests and p...
A team of researchers at the University of Cologne has made a groundbreaking discovery about the molecular basis of inhibitory synapse formation. They found that gephyrin filaments play a crucial role in forming post-synapses, which are essential for billions of synapses in the brain. This study has significant implications for underst...
Researchers discovered that FGF21, a muscle hormone released during exercise, is elevated in people with ALS and may play a protective role. Higher levels of FGF21 were associated with slower disease progression and longer survival in patients.
Researchers found that a high-fat diet impairs memory formation in fruit flies by reducing autophagy, a crucial cellular recycling process. This suggests that lifestyle interventions promoting autophagy, such as exercise or intermittent fasting, may improve cognitive decline associated with HFD.
A University of Houston researcher found that recording brain activity while listening to a story can help diagnose primary progressive aphasia, a rare neurodegenerative syndrome. The method was up to 75% effective in classifying the disorder's subtypes using machine-learning algorithms and electroencephalography data.
A study found that older adults with Parkinson's disease have a higher rate of brain amyloid positivity compared to younger patients, even without dementia. The researchers suggest this may indicate an accelerated transition from healthy cognition to dementia in PD patients.
Researchers developed new methods to accurately target the centromedian nucleus for deep brain stimulation in patients with drug-resistant epilepsy. Advanced imaging techniques, such as high-resolution MRI and DTI tractography, improve targeting accuracy by identifying specific brain pathways and neural firing patterns.
The VasCog-2-WSO criteria update provide operationalization and guidance on neuroimaging and fluid biomarkers for VCID diagnosis. This new standard aims to facilitate diagnostic consistency among clinicians and researchers worldwide.
A $8.6 million NIH grant has renewed funding for the Rare Disease Clinical Research Network project, focusing on cognition, communication, and neuropsychiatric symptoms in individuals with rare diseases. The initiative aims to develop biomarkers, support pilot projects, and foster skilled investigators.
Home high-intensity aerobic training outperforms home balance training in improving ataxia symptoms, fatigue, and aerobic fitness among those with cerebellar ataxias. Regular training maintained benefits at 1 year.
A new form of electric brain stimulation, HD-tDCS, has been shown to be effective and faster than traditional treatments for depression. Participants who received the therapy reported significant improvements in mood scores, which were sustained during follow-up assessments.
A study found that fine particulate matter air pollution exposure is associated with increased dementia severity and Alzheimer disease neuropathologic changes. Population-based studies are needed to better understand this relationship.
Researchers at POSTECH and Korea Brain Research Institute unveil NeuO's mechanism of selective neuron staining through PAK6 kinase phosphorylation. This breakthrough opens path for precise tracking and study of living neurons in brain.
A new AI-based model identifies four central state dimensions that better capture the progression of MS, including physical disability and brain damage. The findings could fundamentally change diagnosis and treatment for MS patients.
A team of researchers created a 3D-bioprinted model of stenotic brain blood vessels to study the effects of abnormal flow patterns on endothelial cells. The model successfully replicated physiological conditions, including upregulation of inflammatory markers.
A recent study published in JAMA Neurology suggests that using hearing aids can lower the risk of developing dementia, particularly in individuals under age 70. This finding highlights the importance of early intervention for hearing loss and its potential role in preventing age-related cognitive decline.
The University of Houston is expanding its behavioral health offerings with new ABA training programs, addressing growing need for behavior analysts. Salaries range from $63,000-$77,000 annually, with autism diagnoses on the rise due to improved screenings and assessments.
A NIH-funded study by Georgetown University researchers found that strokes can rob a person's ability to use word meanings to recognize words while reading. The study, published in the journal Brain, identified a key brain region and connections affected by this deficit.
Researchers identify key symptom categories and biomarkers for anti-NMDAR encephalitis, a rare autoimmune brain condition. Clinical manifestations suggest the presence of anti-NMDAR encephalitis through NMDA antibody checks, uric acid levels, C-reactive protein, and thyroid-related hormones.
The JAK2-STAT3 pathway contributes to inflammation and injury after ischemic stroke. Targeting this pathway shows promise for reducing brain swelling, neuronal death, and improving recovery. Several inhibitors have been found effective in preclinical models, including Tyrphostin AG490, Ruxolitinib, and natural compounds like genistein.
A study published in JAMA Neurology found that oseltamivir treatment during flu episodes was associated with a reduced risk of serious neuropsychiatric events. The researchers debunked the long-standing theory that flu treatment causes these events, and instead found that the infection itself is more likely to be the culprit.
A study led by Dr. Jessica Bernard at Texas A&M University investigates the role of the cerebellum in cognitive functions such as memory and language, with the aim of developing a non-invasive therapeutic approach using Theta burst simulation (TBS) to improve outcomes for older adults.
University Hospitals has received American Heart Association quality achievement awards for ensuring stroke patients receive best practices and life-saving care. The institution prioritizes early detection and treatment to improve survival, minimize disability, and accelerate recovery times.
A study published in Neurology found that women with multiple sclerosis are less likely to receive disease-modifying drugs than men, even when accounting for pregnancy and postpartum periods. The study suggests that women's reluctance to use these treatments may be a factor in the disparity.
The Mount Sinai Hospital has been listed among the nation's top 20 hospitals for care excellence by U.S. News & World Report for 2025-26, with top-10 rankings in five specialties and top-20 rankings in nine. The hospital was also rated High Performing in all 22 procedures and conditions assessed by U.S. News.
Researchers develop computer program that mimics human and animal cell behavior in various parts of the body. The new 'virtual cell lab' can simulate drug responses, gene environment interactions, and other dynamic cellular molecular processes, enabling scientists to test hypotheses before conducting costly live-cell experiments.
A systematic review identified 112 studies on implantable brain-computer interfaces, which decode brain signals to control devices. The analysis found that iBCI technologies are being used to control robotic prosthetic limbs and digital technologies, but clinical outcomes were highly mixed.
Scientists successfully edited DNA directly in the brain to correct ultra-rare genetic mutations causing alternating hemiplegia of childhood. The technique improved symptoms and survival rates in mice, with implications for treating other rare genetic diseases.
A new study from UC San Francisco challenges the traditional view of how the brain strings sounds together to form words and orchestrates the movements to pronounce them. The brain relies on a wider network of neurons across many brain areas, centered in the middle precentral gyrus, to coordinate speech-motor sequencing.
Scientists have discovered that microglia play a crucial role in regulating blood flow to the brain, and targeting them may improve blood flow deficits. The study suggests that restoring microglia function could prevent or reverse memory-stealing diseases caused by lack of adequate blood flow.
A new study found significant reductions in medication use, symptoms, and procedural interventions with GLP-1 receptor agonist therapy for idiopathic intracranial hypertension. Further prospective studies are needed to confirm these findings.
Researchers developed a blood-based indicator of organ age and found that individuals with young brains have a lower risk of developing diseases associated with their brain. The study also showed that organs' biological ages can predict health outcomes, such as increased risk of Alzheimer's disease for those with an old brain.
This special collection aims to bring together cutting-edge research on cognitive aging, exploring its cellular and molecular underpinnings, as well as psychosocial and environmental factors. The collection seeks to foster a holistic understanding of how cognitive function changes with age.
Scientists developed mouse models that survive premature death, enabling pre-clinical testing of alternating hemiplegia of childhood (AHC), a devastating neurological disorder. The research reveals how different mutations can lead to distinct outcomes in AHC and sets the stage for developing gene editing therapies.
A novel model reveals that local Ang II regulation plays a crucial role in maintaining kidney function balance. The study found that damaged kidneys compensate for the loss of function by increasing blood pressure and reducing glomerular atrophy.
A comprehensive study protocol has been developed to investigate pregnancy-related stroke risk factors and long-term implications for mothers and their children. The nationwide multicenter study aims to identify key risk factors associated with ASPP and assess its impact on offspring.
A new research paper introduces DoliClock, a biological aging clock based on lipid profiles in the human brain, showing accelerated brain aging in individuals with autism, schizophrenia, and Down syndrome. The study found that dolichol levels serve as reliable biomarkers of aging.
Researchers at the University of Illinois Urbana-Champaign have developed a new non-invasive MRI approach that visualizes brain metabolism and detects metabolic alterations associated with brain diseases. The technique uses magnetic resonance spectroscopic imaging to provide insights into brain function and disease processes.
Researchers at UCLA Health have made a groundbreaking discovery about the mechanisms underlying vascular dementia. They found that targeting inflammation in brain blood vessels can promote brain repair and functional recovery in mice. This breakthrough highlights a potential new treatment approach for this understudied form of dementia.