Articles tagged with Heart
Scientists have identified a set of genes in zebrafish that reactivate after damage to the heart and patch it up like new. The researchers hope to use CRISPR tools to reactivate similar genes in humans and jump-start repair of the heart and other tissues after injury.
A new software tool called VR-Omics has the potential to further our understanding of other childhood diseases. The technology can identify previously undetected cell activities of cardiac rhabdomyoma, a type of benign heart tumour that can cause respiratory distress and irregular heartbeat.
A team of scientists has found that the ion channel PIEZO2 is crucial for coronary vessel formation and heart development. Without PIEZO2, coronary arteries may develop improperly, leading to oxygen supply issues in the heart muscle. This discovery could lead to earlier diagnosis and treatment of congenital heart defects.
Scientists at The University of Texas at Arlington identified a new enzyme, IDO1, that plays a crucial role in inflammation and cholesterol regulation. By blocking this enzyme, macrophages regain their ability to absorb cholesterol, offering a potential new way to prevent heart disease.
AIMP3 is essential to avoiding mistakes in protein synthesis, not affecting protein production, according to Brown University researchers. The discovery could lead to new treatments for heart diseases linked to homocysteine buildup and has implications beyond the heart.
PerDeCT is a device designed to monitor cardiac patients after surgery and provide early diagnosis of cardiac tamponade. The device aims to balance the benefit and risk of using devices to monitor cardiac output and detect tamponade easily, before damage is done.
The PREVENT calculator improved estimates of heart attack risk when combined with coronary calcium score. Researchers analyzed nearly 7,000 adults and found that the PREVENT score matched the level of calcium buildup according to the CAC score.
A team of researchers from the University of Arizona College of Medicine - Tucson has identified a potential drug candidate for heart failure with preserved ejection fraction (HFpEF). The study, published in Cell Metabolism, found that a key ingredient triggering HFpEF is an enzyme that converts glucose into harmful byproducts, ultimat...
Researchers created over 3,800 anatomically accurate digital hearts to investigate how age, sex, and lifestyle affect heart disease. They found that age and obesity cause changes in the heart's electrical properties, which could explain why these factors are linked to a higher risk of heart disease.
A Banksy artwork created in 2013 will be auctioned off to support the American Heart Association. The piece, featuring a red heart-shaped balloon, was originally vandalized but later enhanced by the artist before being donated to the organization.
Katrina Ascencio-Holmes, a chief nurse officer at Sutter Health, is the American Heart Association's 2025 National Woman of Impact Winner. She works to raise awareness about cardiovascular disease in women and funds lifesaving mission through the Go Red for Women movement.
Researchers at UCL and the Francis Crick Institute have identified the origin of cardiac cells using 3D images of a heart forming in real-time. They found that cardiac cells emerge rapidly during gastrulation and follow distinct paths to form the heart's pumping chambers and atria.
A study published in Molecular Motabolism found that prolonged water-fasting can increase inflammation and stress on the body, potentially exacerbating existing heart and vascular conditions. However, some benefits were observed, including a reduction in amyloid beta proteins associated with Alzheimer's disease.
A study of 273,770 individuals with cardiovascular disease found that increasing lipoprotein(a) levels significantly increases the risk of subsequent cardiovascular events. Treatment with high-impact LDL-C lowering therapies may help reduce this risk.
Researchers at University of East Anglia developed 4D flow MRI scan to diagnose aortic stenosis more accurately and reliably than current ultrasound techniques. The technology offers more accurate measurements of blood flow through heart valves, leading to better prediction of when patients need surgery.
A new MRI technique measures a person's 'functional age' of their heart, revealing how unhealthy lifestyles add years to their heart's aging process. This method has the potential to transform heart disease diagnosis and offer a lifeline to millions by catching problems early.
Researchers at the University of Mississippi have developed a new technology that can detect heart attacks in real-time, using artificial intelligence and advanced mathematics. The resulting wearable device is lightweight and energy efficient, with an accuracy rate of 92.4%, outperforming current methods.
A new study identified 56 non-clinical risk factors associated with sudden cardiac arrest (SCA), finding that improving unfavorable profiles could prevent up to 63% of SCA cases. Lifestyle habits and environmental factors were found to be the most impactful in preventing SCA cases.
Researchers at ISHLT marked the 10-year anniversary of modern DCD heart donation, significantly increasing transplant volumes worldwide. Comparable outcomes have been achieved with DCD hearts compared to traditional DBD hearts, leading to a surge in DCD programs globally.
Machine perfusion technology significantly extends the time donor hearts can be transported, enabling longer-distance transplants. This innovation has already led to more organs being accepted from regions previously unsuitable due to transportation constraints.
A noise-adapted AI model using lead I ECGs estimated heart failure risk with high accuracy, suggesting a potential strategy for early detection. The study's results highlight the promise of wearable and portable ECG devices in identifying at-risk patients.
Hunter Medical Research Institute has formed a memorandum of understanding with Novartis (Aust & NZ) to explore future research projects focused on improving cardiovascular health. The partnership aims to accelerate innovation and enhance patient care through collaborative research initiatives.
Scientists discovered sweet taste receptors on the surface of heart muscle cells, which increase the force of contraction when stimulated with artificial sweeteners. This breakthrough may lead to novel treatments for heart failure and provide insight into arrhythmogenesis.
A new study published in the European Journal of Cardio-Thoracic Surgery found that mechanical heart valve replacements have better long-term survival rates compared to biological valves. Patients who received mechanical valves had improved survival up to 13 years after surgery, with smaller valves showing greater benefits.
Sucosky's research aims to build a device replicating the bicuspid aortic valve to investigate how unusual stress leads to its hardening. The goal is to uncover molecular pathways that could be targeted with pharmaceutical treatments.
Researchers found that brief ozone exposure reduces blood oxygen saturation, triggers hypoxia-related biomarkers, and increases arterial stiffness. Ozone pollution is a worldwide health issue, linked to increased risk of cardiovascular diseases.
A new Northwestern University study reveals that achieving equity in social drivers of health, particularly education, can nearly eliminate the gap in heart health between Black and white women. The study found that educational attainment had the largest impact on maternal cardiovascular health disparities. Improving access to healthy ...
Researchers at Karolinska Institutet and Columbia University identified a mini-brain within the heart with its own nervous system that controls the heartbeat. This discovery challenges current views on how the heartbeat is controlled and may lead to new insights into heart diseases and treatments.
Researchers at Nanjing University confirm link between SLC25A1 protein and congenital heart defects caused by placental problems. The study found that loss of SLC25A1 leads to placental growth issues, which in turn cause heart defects.
Researchers identified protein kinase N as a key regulator of heart fibrosis, which threatens heart function. Deleting this enzyme reduced cardiac dysfunction, suggesting anti-PKN treatments may protect against heart failure.
A temporary heart stimulator self-assembles around the heart after injecting nanoparticles, correcting irregular heartbeats and facilitating ECG measurements. The device can operate for up to five days with low power inputs from handheld devices like mobile phones.
The AHA PREVENT equations could reduce eligibility for statin and antihypertensive therapy among 15.8 million US adults due to lower atherosclerotic cardiovascular disease risk predictions. This change may impact treatment guidelines and recommendations.
Researchers at the Lewis Katz School of Medicine will investigate how injured heart cells communicate with other cells throughout the body using microvesicles known as exosomes. The study aims to understand how specific molecules, such as microRNAs, facilitate communication pathways between cells in the heart and vasculature.
Researchers discovered a step-by-step process of calcification in aortic valves, revealing two defense mechanisms: osteopontin and collagen fibers. The study provides new insights into understanding cardiovascular calcification and potential therapeutic applications.
A study by Washington State University found ChatGPT's generative AI system provided inconsistent heart risk assessments for patients with chest pain. The AI failed to match traditional methods used by physicians and returned different results for the same patient data, highlighting its limitations in high-stakes clinical situations.
Research published in Heart Rhythm suggests that the three-month blanking period after atrial fibrillation (AF) ablation may not be necessary, as early AF recurrence is a predictor of late recurrence. The authors propose shortening the blanking period to one month, citing studies that show higher risks of long-term recurrence for patie...
A new study published in the New England Journal of Medicine found that half of patients discharged from hospital after a heart attack are treated with beta-blockers unnecessarily. The study shows that these patients have suffered a small heart attack and have retained heart function afterwards.
A study led by Michigan Medicine found that around 10% of deaths following percutaneous coronary intervention are potentially preventable. Complications during procedures contributed to 20% of the nearly 1,200 deaths reported during the study period.
A study published in JAMA found that Black candidates have lower heart offer acceptance rates compared to white candidates of the same gender, while women have higher acceptance rates than men. These disparities persist after adjusting for various factors, highlighting the need for further investigation into site-level decision-making.
A new study from Ohio State University Wexner Medical Center found that treating anxiety and depression significantly improves heart disease outcomes, with a 75% reduction in hospitalizations or emergency room visits. The study suggests a collaborative care model is essential for managing cardiovascular and mental health.
The Almodóvar lab is studying the link between HIV and pulmonary hypertension, a condition that increases pressure in lung arteries. By examining the interactions between different cell types and using a humanized mouse model, researchers hope to propose novel therapies to prevent lung diseases in people with HIV.
A new study published in JAMA Cardiology found that taking 3,600 steps per day is associated with a 26% lower risk of developing heart failure. The study also found that accumulating more light and moderate intensity daily activities can help prevent heart failure.
A new UofL study shows that nicotine salts in pod-based e-cigarettes can increase the risk of irregular heartbeat and cardiac arrhythmias. The research found that these aerosols stimulate the same receptor that is inhibited by beta blockers, leading to increased sympathetic nervous system activity.
A study of 620,000 children found that maternal type 1 diabetes was associated with increased risk for most types of congenital heart defects in offspring. Obesity and overweight were linked to increased risk for complex defects, such as outflow tract obstruction, while decreasing the risk for ventricular septal defects.
Black patients in integrated communities experience greatest benefits from PCI-CF openings, including a five times greater likelihood of receiving same-day PCI. Segregation is associated with poorer outcomes for racial minority groups.
A team of scientists has identified the molecular switches involved in halting heart malformations, which could lead to new treatments for tetralogy of Fallot. By targeting the BBLN protein, they aim to prevent defects in four critical areas of the heart.
The Center for Advancing Point of Care Technologies (CAPCaT) has received a five-year, $8.9 million award from the NIH to develop innovative point-of-care health technologies. The program aims to address heart, lung, blood and sleep disorders in underserved populations.
The Million Hearts Model significantly reduced first-time heart attacks and strokes, supporting guidelines for CVD primary prevention. The study's findings also suggest that the model can have a positive impact on Medicare spending.
Heart cells in developing zebrafish transition from silence to beating in a simultaneous, coordinated manner. Each cell can beat independently, and the heartbeat starts from different locations in different zebrafish.
A large Kaiser Permanente study found that moderate aortic stenosis patients have similar outcomes to those with mild stenosis. Fine-tuning physician assessment could help identify patients who may benefit from surgery, improving treatment strategies.
Researchers at West Virginia University are tracing the cause of diabetic heart disease using diabetic animal models to examine mitochondrial function. They hope to understand how faulty protein import affects the mitochondria and explore potential treatments to improve energy production and reduce cardiovascular risk.
In a groundbreaking procedure, Adriana Rodriguez received a dual-organ transplant, with her healthy liver transplanted into another patient to mitigate rejection risk. This innovative approach, known as HALT-D, demonstrates the potential for immunoprotection and has implications for highly sensitized patients requiring multiple organs.
A new study found that elevated Lipoprotein(a) levels are a significant predictor of recurrent coronary heart disease (CHD) in people over 60. The study suggests current cholesterol-lowering medications may not be effective in reducing the risk of recurrent CHD, highlighting the need for novel therapeutics to target elevated Lp(a).
Researchers found that a mutation in RPL3L, expressed only in heart and skeletal muscle, leads to impaired cardiac contractility by causing ribosomal collisions and protein folding abnormalities. The study aims to develop new treatments for cardiomyopathy and atrial fibrillation.
A study of 1,300 participants found that increased physical activity 6 months after stroke was associated with better functional outcomes. Interventions targeting individuals with decreasing physical activity in the subacute phase may play a role in improved functional recovery.
A Boston University-led study found that Black women who reported experiencing interpersonal racism in employment, housing, and police interactions had a 26% higher risk of coronary heart disease. Racism has a real impact on the heart health of Black women, increasing blood pressure and inflammation.
Researchers at The Hospital for Sick Children have discovered that dysregulation of energy production is an early sign of heart failure. They found that lysine demethylase 8 (Kdm8) helps maintain balanced energy use, but its suppression leads to changes in metabolism.
Researchers at the University of Missouri have designed a soft and breathable material that can be worn on the skin without causing discomfort. The material, made from liquid-metal elastomer composite, has integrated antibacterial and antiviral properties to prevent the formation of harmful pathogens.
Excessive trabeculation of the left ventricle does not coalesce into a compact myocardial wall, making 'LV non-compaction' an inaccurate term that should be discouraged. The review recommends using 'excessive trabeculation', which can be observed across various health and disease states.
Researchers at RIKEN Center for Integrative Medical Sciences discover genes and individual variations associated with atrial fibrillation, predicting stroke and mortality risk. They also uncover a potential treatment target, ERRg, involved in the pathogenesis of atrial fibrillation.