Articles tagged with Peripheral Nervous System
Researchers develop cellular model to reproduce NF1-associated tumour progression, identifying new therapeutic opportunities. The combination of olaparib and selumetinib shows promise in reducing tumour growth.
Researchers have discovered that within the first few weeks of development, some embryo cells are already selected to take on particular roles in the peripheral nervous system. This finding overturns longstanding assumptions in biology and opens up new avenues for research into developmental diseases and potential therapies.
Researchers used Caenorhabditis elegans to model chemotherapy-induced neurological dysfunction and tested two compounds for improved recovery. Both sildenafil citrate and Resveramorph-3 significantly reduced seizure-like behaviors and duration, suggesting their potential as therapeutic candidates.
A study published in PNAS reveals that peripheral neuropathy can reduce macrophage immune cells' ability to clear dead cells through efferocytosis, leading to chronic pain. Restoring this process may offer a new therapeutic strategy to prevent inflammatory signaling and improve nerve repair.
The study found that men, Black patients, and those living in low socioeconomic areas were disproportionately affected by the increased amputation rates. The authors emphasize the need for aggressive prevention, early diagnosis, and intensive risk factor management to address the growing burden of diabetes and PAD.
A study by Wake Forest University School of Medicine reveals that a stress response in immune cells contributes to chemotherapy-induced nerve damage. By blocking this pathway, researchers aim to develop new treatments to protect cancer patients from debilitating side effects.
A groundbreaking study in The American Journal of Pathology reveals a perineural pathway that enables HIV-infected immune cells to redistribute throughout the body, sustaining inflammation. The findings highlight the importance of the connection between the central nervous system and peripheral nervous system in immunity.
A study published in Neurology found that Hispanic people have a higher risk of peripheral neuropathy than white people, despite adjusting for known health and lifestyle risk factors. Social factors such as food insecurity and lack of health insurance also increased the risk of neuropathy in Hispanic individuals.
The researchers developed a new imaging technology that enables the creation of high-resolution 3D images of an entire mouse body, including its peripheral nervous system. The technology allows for the mapping of nerve routes at the subcellular level, providing insights into neural regulation and disease mechanisms.
A joint research team from POSTECH and Hanyang University developed a personalized stimulation control mechanism using evoked compound action potential feedback mechanisms to treat urinary disorders. This technology enables precise adjustment of tibial nerve stimulation in real-time, based on individual nerve responses, improving patie...
Binghamton University researchers have created a hydrogel electrode that includes conductive carbon nanotubes to monitor nerve activity in spinal cord neurons and leg muscles in mice. The technology solves the problem of rigid materials causing damage during movement, allowing for long-term functionality and single-cell signal detection.
Researchers at Johannes Gutenberg University Mainz have discovered that histone deacetylase 8 (HDCA8) inhibits the conversion of Schwann cells into their repair phenotype, slowing down peripheral nervous system recovery. Removing HDAC8 accelerates regeneration and restores sensory function.
A study on fruit fly larvae revealed the presence of neurons with mechanoreceptors in their peripheral taste organs, allowing them to sense food texture. This discovery sheds light on the complex process of tasting texture and highlights the importance of multisensory contributions in food perception.
Professor Robert Fledrich has been awarded an ERC Consolidator Grant for his research on the regeneration of peripheral nerves. His team aims to investigate the conditions required for successful nerve regeneration, focusing on glial cells' metabolic dynamics and communication pathways.
Researchers discovered a new component of the peripheral nervous system that acts by increasing energy metabolism in the body. This finding paves the way for simpler and cheaper drugs to control obesity and weight gain.
A previously unknown mechanism in the brain causes migraine attacks by carrying proteins to specific nerve cells, explaining one-sided headaches. The discovery may lead to new treatment options and help understand other headache diseases.
Researchers describe how a spreading wave of disruption and brain fluid flow triggers headaches, detailing the connection between aura symptoms and migraine pain. The study identifies potential new drug targets for migraines, including proteins that bind with sensory nerves in the trigeminal ganglion.
Researchers discovered that PMP22 duplication disrupts lipid metabolism and plasma membrane organization in developing Schwann cells, leading to myelin degradation and nerve damage. Targeting dysregulated lipid pathways may reverse some detrimental effects of CMT1A.
Researchers uncover pivotal aspect of GBS pathophysiology, revealing autoreactive T lymphocytes invade nerve tissue and target myelin. The findings provide novel insights into understanding GBS, opening avenues for targeted therapies for specific subtypes.
Researchers at Salk Institute uncover a mechanism for repairing damaged nerves during peripheral neuropathy, with protein Mitf playing a key role. The findings have the potential to inspire novel therapeutics that bolster repair function and heal peripheral neuropathy.
Researchers at Michigan State University found that glial cells in the gut can sensitize nearby neurons, causing them to send pain signals more easily during inflammation. This discovery could help develop new therapies to alleviate visceral pain by counteracting the glia's sensitizing efforts.
Researchers at Weill Cornell Medicine developed a non-opioid designer molecule to calm hyperactive pain-sensing neurons, showing promising results in preclinical studies. The novel drug effectively reversed neuropathic pain signs without cardiac side effects or sedation.
Researchers discovered stem cells in mouse dorsal root ganglia (DRG) with the potential to regenerate lost sensory neurons and glia. These cells, known as satellite glia, can become activated and generate new glia and, to a lesser extent, neurons after injury.
Researchers developed a technology that uses surviving neurons to restore connection between brain and arm via specific stimulation pulses to the spinal cord. This allowed macaque monkeys with partial arm paralysis to improve precision, force, and range of movement in their arms.
Researchers discovered that neurons carrying a mutation in the Nf1 gene are hyperexcitable and suppressing this hyperactivity with lamotrigine stops tumor growth in mice. The study provides an explanation for why some people with NF1 lack optic gliomas or neurofibromas, highlighting the critical role of neurons in tumor biology.
Researchers discovered a connection between atherosclerotic plaques and the central nervous system, involving immune cells, nerves, and cardiovascular tissues. This 'ABC' circuit can be modulated or disconnected, potentially leading to innovative therapies for treating atherosclerosis.
Researchers at the University of Illinois Chicago found a promising treatment for neurodegenerative diseases by stopping nerve cell degeneration. A peptide has been identified that inhibits mitochondrial fission and lets nerve cells grow normally.
Researchers at University of California San Diego School of Medicine identified the anterior insula's role in predicting and emotionally processing pain in HIV-DSP patients. The study suggests that reduced anterior insula activity or increased cingulate activity may improve pain outcomes for these patients.
Research reveals SARS-CoV-2 can enter the brain and affect neural function, leading to symptoms like headache, depression, and fatigue. Many people experience lingering cognitive or neurological problems months after initial recovery.
Researchers have developed a new interface technology that can provide natural sensory feedback from robotic prosthetics to amputees, reducing abnormal sensations and cognitive burden. The innovation uses ultra-small recording sites and molecular guidance cues to stimulate sensory axons selectively, improving control of robotic limbs.
A new approach to deep brain stimulation using light-sensitive proteins and harmless viruses could provide a minimally invasive treatment option for brain disorders. The technique has shown promise in reducing symptoms of Parkinson's disease by targeting non-neuronal brain cells.
Researchers successfully combined rat spinal cords with tissue-engineered muscles, creating a biohybrid system that produces electrical activity causing contraction. This innovation could lead to breakthroughs in understanding diseases like Lou Gehrig's and developing new surgical training tools.
Researchers at the University of Leeds have discovered a molecular mechanism that amplifies pain signals in the nervous system. This finding has significant implications for understanding and treating chronic pain conditions such as neuropathies, arthritic pains, and migraines.
Researchers at the University of Leeds have found a way to turbo charge molecular sensors in nerve cells, amplifying electrical signals to the brain and intensifying pain experience. This discovery could lead to targeted therapies for chronic pain conditions such as neuropathies and migraines.
Scientists propose that Parkinson's disease can be divided into two subtypes, with some cases starting in the gut and others in the brain. This hypothesis reconciles discrepant findings from neuropathological literature, suggesting a more complex understanding of the disorder's origins.
A new study by University of Notre Dame scientists reveals microglia can cross from the central nervous system (CNS) into the peripheral nervous system (PNS) in response to injury. This finding has broad implications for nervous system diseases and opens up new questions about the function and capabilities of these cells.
A new study from the University of Virginia identifies a compound that can recruit oligodendrocytes, a type of glial cell, to repair damage in the peripheral nervous system. This finding has implications for treating debilitating neurological disorders such as muscular dystrophy and Charcot-Marie-Tooth disease.
Researchers create StimDust, the smallest deep-tissue stimulator capable of stimulating major therapeutic targets in the peripheral nervous system. The device is powered wirelessly by ultrasound, with an efficiency of 82 percent, and can be implanted in minimally invasive procedures to monitor and treat diseases.
Researchers at the University of Basel have created a treatment approach using customized synthetic glycopolymers that act as molecular sponges to neutralize disease-causing antibodies. This innovative method has potential applications for treating other antibody-mediated autoimmune diseases.
Scientists discovered that nerve cells in ganglia can exchange information and modify sensory input to the central nervous system. This finding has potential implications for developing non-addictive painkillers targeting the peripheral nervous system.
Researchers at University of Leeds and Hebei Medical University found that Substance P reduces sensations of pain in peripheral nervous system but triggers pain in central nervous system. This discovery could lead to new methods for pain control with limited side effects.
A UCLA-led collaboration has identified a specific gene network and pattern of expression that promotes repair in the peripheral nervous system. This network does not exist in the central nervous system, but researchers have found a drug that can enhance nerve regeneration there.
A Columbia University team led by Elisa Konofagou will develop a new method for using focused ultrasound to stimulate peripheral nerves, potentially treating chronic pain and neuropathy. The four-year grant aims to advance the field of electrical prescriptions for targeted neural and bio-interface technologies.
Scientists at Johns Hopkins University have uncovered the molecular cause of peripheral nervous system dysfunction in Down syndrome. A gene called RCAN1 appears to be overactive, hindering nerve growth and development, which may contribute to heart disease, diabetes, and immune disorders associated with the condition.
Researchers at Mayo Clinic and Aarhus University have discovered a receptor system critical for correct wiring of the dopaminergic brain area during embryonic development. The study found that a cut in the SorCS2 receptor can induce cell death after peripheral nervous system damage, leading to hyperactivity and attention deficits in mice.
Researchers have identified new mutations in the SPTLC2 gene that play a crucial role in Hereditary Sensory and Autonomous Neuropathy Type 1 (HSAN 1). These findings will lead to more accurate diagnoses, improved genetic counseling, and prenatal testing for affected couples.
Researchers at Stanford University School of Medicine have discovered that antibodies are critical to the repair of nerve damage in the peripheral nervous system. In a new study, scientists show that certain antibodies can facilitate myelin clearance and nerve regeneration, while others do not.
A team of scientists found that the p75 receptor molecule has a neuroprotective effect on the sympathetic nervous system in mice with Alzheimer's disease, challenging the prevailing view of its harmful role. The study suggests that p75 could be a target for new protocols to manage dementia and memory loss.
Researchers at Peninsula Medical School have identified a protein called c-Jun that plays a vital role in the regeneration of damage in the peripheral nervous system. This discovery could lead to understanding and treating diseases such as Charcot-Marie-Tooth disease and Guillain-Barre disease.
Scientists have identified genetic mutations in heat shock proteins linked to Charcot-Marie-Tooth disease, a debilitating disorder affecting peripheral nerves. The study's findings hold promise for developing new therapies and improving diagnosis.
Researchers discovered that a special protein called importin beta is produced at the site of damage in axons, facilitating the entry of molecules into the nucleus. Blocking this process inhibits nerve regeneration, highlighting the need to identify proteins containing the "healing message"
A study found significant differences in spinal cord area between patients with diabetic neuropathy and healthy controls. The research suggests potential new therapies for detecting neuropathic process at an earlier stage.