Articles tagged with Perfusion
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Researchers at SwRI and Trinity University are working on a new prodrug to mitigate ischemia/reperfusion injury (IRI), which causes permanent cellular and tissue damage. The team aims to protect against IRI by targeting protein misfolding during cellular stress.
Machine perfusion technology significantly extends the time donor hearts can be transported, enabling longer-distance transplants. This innovation has already led to more organs being accepted from regions previously unsuitable due to transportation constraints.
A study on donor lungs preserved outside the body demonstrated that HOPE is a safe and effective method for lung preservation, with no rejections and similar short-term outcomes compared to direct transplantation. The study found that extending perfusion times can optimize donor lungs for future therapies.
Researchers developed collagen-based scaffolds that can integrate with a vascular and perfusion organ-on-a-chip reactor to form complete tissue engineering platforms. The team demonstrated the ability to create non-planar 3D networks in soft, organic material by printing helical vascular networks modeled after DNA structure.
The UMCG's perfusion technique has led to a record number of liver transplants in the Netherlands and is gaining international attention. With the protocol now open to every transplant center worldwide, more organs can be made suitable for transplantation, resulting in better patient outcomes.
A study published in Mayo Clinic Proceedings found that patients who can exercise during cardiac stress testing have a lower mortality rate than those who cannot. The researchers discovered that assessing a patient's ability to exercise during testing provides a stronger distinction between high- and low-risk patients.
A new laparoscopic imaging technique uses stereo depth estimation and speckle-illumination SFDI to accurately map the optical properties of biological tissue. The device provides detailed optical property maps, enabling surgeons to identify critical tumor margins and improve clinical outcomes.
Researchers found that clot-dissolving medication alteplase improved stroke patients' recovery by more than 50% when given up to 24 hours after the beginning of an ischemic stroke. This breakthrough may provide hope for stroke patients worldwide who may not have access to clot-dissolving medications within the approved time window.
Researchers at the University of Gothenburg found that hearts stored in a 'heart-in-a-box' method experienced lower rates of heart failure and severe organ failure after transplantation. This breakthrough method uses hypothermic oxygenated machine perfusion to keep the heart oxygenated and functioning better.
Researchers investigate the effects of space travel on astronauts' eye health, specifically fluid shift and its relation to Spaceflight Associated Neuro-ocular Syndrome (SANS). They examine potential countermeasures, such as lower body negative pressure, to combat microgravity-induced changes in ocular perfusion pressure.
Researchers develop method to preserve donor hearts for more than 24 hours, a major improvement over current six-hour time window. The new approach uses normothermic ex-vivo heart perfusion and has shown strong improvements in extending the shelf-life of donor hearts.
Researchers at UMCG have successfully performed liver transplants after prolonged preservation using a perfusion machine, showing similar outcomes to immediate transplants. The new method allows for safer and more efficient liver transplantation during the day, reducing complications and mortality rates.
Researchers developed a new method to detect hypertrophic cardiomyopathy (HCM) using combined cardiac diffusion tensor imaging and cardiac MRI perfusion scans. The study identified abnormal microstructure and microvascular disease in people with genetic mutations but no symptoms, allowing for early detection of the condition.
A new study published in Annals of Surgery reveals promising results for normothermic machine perfusion in liver transplantation. The randomized controlled trial found that this technology showed particular promise in marginal donors and those with higher risk factors, demonstrating a lower incidence of dysfunction and cardiovascular s...
Researchers developed a chest imaging protocol using photon-counting CT, allowing for simultaneous evaluation of lung structure, ventilation, vasculature, and perfusion. The protocol showed advantages over standard CT, providing high image quality at lower radiation doses and better spectral resolution.
A study published in The Annals of Thoracic Surgery found that lower oxygen delivery thresholds are associated with reduced risk of kidney injury. Researchers recommend reevaluating current guidelines for oxygen delivery during cardiopulmonary bypass to minimize unnecessary blood transfusions and improve patient outcomes.
Researchers have developed a non-invasive technique using laser speckle imaging to visualize microvasculature in donor hearts and detect abnormal blood flow. The method enables precise visualization of blood circulation, potentially identifying hearts suitable for transplantation.
Researchers at Aston University have discovered a new approach to process LDF light signals, allowing for more precise measurement of blood flow in specific areas of the vascular bed. This innovation has shown significant improvement in diagnostic accuracy for detecting microvascular changes in patients with type 2 diabetes and age-spe...
Researchers have developed an innovative amputated human limb model to evaluate molecularly targeted fluorescent probes for human tissues. The model allows for controlled testing of imaging agents with zero risk to patients, improving the accuracy and safety of surgical procedures.
Dual-energy CT (DECT) metrics provide insight into physiologic changes after lung cancer surgery, beyond PFTs and conventional CT. Lung perfusion ratio increases were greater after lobectomy than limited resection.
A novel algorithm uses near-infrared spectroscopy to estimate intracranial pressure (ICP) based on hemoglobin levels. The research validates the accuracy of this method using invasive ICP data.
Researchers develop new method to preserve organs by freezing them partially, allowing for longer storage duration and improved organ matching. This breakthrough could lead to more successful transplants and increased organ availability.
Researchers used CT and MRI perfusion techniques to analyze 19 patients with successful free flap reconstruction and five with wound failure. The study found that both methods showed significant differences between the two patient groups. Early postoperative scans could help surgeons intervene earlier, potentially reducing hospital stays.
A team of researchers at University of Zurich successfully transplanted a human liver that was treated in a machine, paving the way for a potential solution to the global organ shortage. The liver was preserved for three days outside the body using a custom-made perfusion machine.
A randomized controlled trial found that consuming cranberries for 12 weeks improved participants' memory of everyday events and neural functioning. The study also showed a significant decrease in LDL or 'bad' cholesterol levels, contributing to improved vascular health and brain perfusion.
The study compared lung perfusion scans during COVID-19 (April 2020 to July 2021) to pre-COVID V/Q scans (December 2018 to March 2020) in a large tertiary care teaching hospital. The results showed a 30% decline in overall lung scans performed during the pandemic.
A small study found statistically significant improvements in various symptoms, including fatigue and chest discomfort, after EECP therapy in long COVID patients. Researchers believe this is the most plausible explanation for the benefits derived from EECP and its link to long COVID.
Researchers found that tumors with few micro-blood vessels are associated with defective perfusion, impacting the efficiency of systemic chemotherapy. This study highlights the importance of improving diagnostic imaging equipment to better detect lymph node metastasis and curb cancer-related mortality.
Researchers developed a therapy to improve liver function during external perfusion, making previously unusable donor livers transplantable. The study found that being perfused outside the body triggers self-repair mechanisms in livers.
A new isolated lymphatic vessel lumen perfusion system was developed to evaluate the interaction between nanoparticles and lymphatic vessels. The system enables detailed examinations of nanomaterial movements and biological safety, paving the way for safe clinical applications.
A rare case of mediastinal tuberculoma mimicking a malignant cardiac tumor was diagnosed after postoperative pathological examination. Multimodality imaging, including echocardiography and contrast-enhanced ultrasonography, played a crucial role in distinguishing the benign condition from a malignant tumor.
Researchers demonstrate 24-hour rat liver viability in a normothermic machine perfusion system, enabling longer-term studies of liver physiology and pharmacologic effects. The study identifies predictive markers for perfusion success, including liver oxygen consumption and intra-hepatic resistance.
A multidisciplinary team from Columbia Engineering and Vanderbilt University has successfully recovered severely injured donor lungs using a cross-circulation platform. This method provides intrinsic biological repair mechanisms over long periods, enabling the recovery of lungs that cannot be saved by standard clinical EVLP.
A major study published in Nature Communications reveals that normothermic machine perfusion assessment can recover enough livers from discarded donors to allow successful transplantation. This breakthrough technique has significant implications for the liver transplant waiting list and demand for transplants far outstrips supply.
A multicenter study found that both simple and advanced computed tomography (CT) can accurately predict which stroke patients will benefit from endovascular thrombectomy. Patients with favorable imaging profiles on both CT and CT perfusion had higher odds of receiving endovascular therapy and improved functional independence rates.
Leslie Gonzalez, a Texas Heart Institute perfusion student, has been awarded the prestigious Perfusion Without Borders scholarship. She will travel with The Novick Cardiac Alliance to Medellin, Colombia in February 2020, gaining experience on global perfusion practices and preparing for lifelong involvement in mission work.
Transplant patients who received high-risk donor lungs through ex vivo lung perfusion showed improved long-term outcomes, including reduced mortality and morbidity rates. The study suggests that this technique may be a viable alternative for high-risk patients, providing access to more organs.
A new machine-learning tool developed by UTHealth can analyze CT angiogram images to identify blockages in cerebral blood vessels, defining the area of brain that has died. This allows neurologists outside major treatment centers to assess whether a patient would benefit from an endovascular procedure.
A multicenter study found that deep learning analysis of single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) improved the diagnosis of obstructive coronary artery disease. The new method showed increased sensitivity and accuracy compared to traditional methods, leading to better patient outcomes.
A new study by the Endovascular Therapy Following Imaging Evaluation for the Ischemic Stroke (DEFUSE 3) trial demonstrated that brain-scan guided emergency stroke treatment can be effective up to 16 hours after symptom onset. The treatment led to improved outcomes, including increased functional independence and survival rates.
Researchers developed a new MRI technique to detect placental perfusion abnormalities in pregnancies with fetal congenital heart disease. Global placental perfusion decreased and regional variation increased as pregnancies progressed, indicating early warning signs of placental dysfunction.
A new study found that normothermic machine perfusion can evaluate kidney quality and suitability for transplantation. Four out of five kidneys assessed by the technique functioned immediately after transplantation.
Researchers at the University of Pittsburgh have developed a novel stent to maintain blood flow to organs during transplant surgeries, potentially doubling successful organ donations. The stent, made of smart material, will direct selective blood flow to visceral arteries without disturbing the heart.
Researchers have developed an alginate hydrogel that can deliver angiogenic growth factors like VEGF and IGF to promote vascularization in ischemic tissues. The system increases blood flow and perfusion, improving muscle strength and tissue regeneration, with promising results in both young mice and aged rabbits.
Researchers developed a computational model to estimate blood flow conditions in the human placenta, leveraging villous tree structures and active contractions. The results showed that displacement caused by contraction can help maintain robust blood circulation even under changed mechanical properties.
Researchers found that noninvasive CT angiography and stress tests can predict future adverse cardiovascular events, including heart attacks, with similar accuracy to invasive procedures. The study suggests that the noninvasive approach is a safer and more cost-effective option for patients, and its findings have important implications...
Italian researchers identified a biomarker bio-Adrenomedullin that correlates with good microcirculation and longevity in centenarians. The study found that low levels of this peptide hormone are associated with efficient blood perfusion, similar to that in younger individuals.
A study found that cardiovascular magnetic resonance-guided care reduces unnecessary angiography in patients with suspected coronary heart disease, but was not significantly different from myocardial perfusion scintigraphy-guided care. The strategy did not affect major adverse cardiovascular event rates or disease detection rates.
Babies born with transposition of the great arteries have a surgical procedure, called the arterial switch operation, to correct the defect. Research found that adolescents whose coronary arteries were reimplanted in the 12 o'clock position are more prone to perfusion defects and potential complications.
Researchers found that brain imaging can accurately predict patient outcomes and identify those who may benefit from clot removal up to 18 hours after symptom onset. This approach could improve treatment eligibility and outcomes for ischemic stroke patients.
Researchers from Universidad Politécnica de Madrid and the National Institutes of Health provide a wealth of patient imaging data to build tools for diagnosing coronary heart disease. The publication includes a virtual machine with software and data, enabling direct experimentation and annotation.
Research found that physical exercise improves brain perfusion and visual memory in younger adults, but this effect decreases with age. The study used magnetic resonance imaging to examine the brains of 40 healthy volunteers aged 60-77, with half receiving treadmill exercise for 3 months.
A new MRI technique called arterial spin labeling (ASL) can detect signs of cognitive decline in the brain even before symptoms appear. The technique measures brain perfusion and has the potential to serve as a biomarker for very early diagnosis of preclinical dementia.
Researchers developed new methods to reduce imaging time in myocardial perfusion imaging (MPI) by up to 50%, making scans easier for patients. The methods also correct errors caused by patient movement, resulting in error-free MPI images.
A Massachusetts General Hospital-developed protocol successfully preserved rat livers for up to four days using supercooling and machine perfusion. The method could enable the use of organs currently deemed unsuitable for transplant, alleviating the worldwide organ shortage.
A new machine perfusion system has been developed to increase the supply and quality of donor organs for liver transplantation. The system preserves metabolic function, preconditioning the liver before transplantation. Key findings include improved organ viability and reduced tissue damage.
A study found a substantial decrease in the use of nuclear myocardial perfusion imaging from 2006 to 2011, with a 51% relative decline. The study suggests changing physician behavior and declines in incident coronary disease contributed to the reduction.
Scientists from the University of Pennsylvania define a novel mechanism of tumor hypoxia induced by the longitudinal gradient of residual oxygen along tumor vessels as they transverse the tumor. The researchers found large regions of moderate hypoxia that were not easily explained by existing concepts, suggesting a new scale for unders...
A new stress test protocol investigating reduced perfusion imaging in low-risk patients undergoing SPECT myocardial perfusion imaging has been found to be diagnostically safe. The study predicted that using exercise ECG stress testing alone would have no adverse effects on prognosis at five years.
A portable normothermic perfusion device has been tested on a group of twelve transplant patients, showing safe and effective preservation of donor lungs. The device has the potential to greatly improve transplant success and expand the pool of adequately-functioning donor lungs.