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Gene expression in labor; and more — press release from PLoS Medicine
A Research Article, Perspective and e-Letter all published today discuss the use of microarrays to discover genes involved in childbirth. The three papers highlight the complexity of such gene expression analyses but also how crucial it is to make original data available for reanalysis.   view more (2006-06-13)

Core needle biopsy gives an accurate picture of gene expression in whole tumor
The gene expression profile detected in the core needle biopsy of a breast tumour is representative of gene expression in the whole tumour.   view more (2006-08-21)

Gene Test Could Reduce Unnecessary Treatment For Women With Breast Cancer (pp 340, 362)
In this week's issue of THE LANCET, US researchers describe how gene expression profiles could determine whether or not women with breast cancer would respond to docetaxel treatment. Women who are likely to be resistant to the drug could be given alternative treatment. Chemotherapy or hormonal... view more (2003-07-30)

Different but equal: Settling the dosage compensation debate
Independent research papers from Dr. Peter Becker (Munich, Germany) and Dr. Mitzi Kuroda (Boston, MA) in the October 1 issue of Genes & Development delineate the mechanism of X-chromosome dosage compensation in Drosophila.   view more (2005-10-03)

Gene-expression profiling of the effects of liver toxins
Gene-expression data from liver tissue or whole blood can be used to classify histopathologic differences in the effects of hepatotoxins. It is hoped that these findings, published in BioMed Central's open access journal, Genome Biology, will lead to a more precise way of defining the potential... view more (2008-06-20)

"Sloppy Genes" Behave Like Their Neighbours: New Findings Reveal That The Regulation Of Gene Expression Is Much Less Strictly Controlled Than Was Previously Thought
The inaugural issue of Journal of Biology features groundbreaking research that challenges the traditional view of how genes are controlled. Our current understanding of gene expression, the fundamental process by which proteins are made from the instructions encoded in DNA, is that the process is... view more (2002-06-13)

New study shows that therapeutic gene expression can be sustainable for 1 year
Researchers at the Board of Governors Gene Therapeutics Research Institute at Cedars-Sinai Medical Center have shown for the first time that it is possible to sustain therapeutic gene expression in the central nervous system for up to a year, even in the presence of an anti-viral immune response... view more (2007-10-26)

Food cue-related brain activity linked to obesity?
A unique pattern of gene expression observed in rats may be linked to a conditioned desire for food and excessive food intake, an article published today in BMC Biology suggests.   view more (2007-04-27)

Researchers find an evolutionarily preserved signature in the primate brain
Researchers have determined that there are hundreds of biological differences between the sexes when it comes to gene expression in the cerebral cortex of humans and other primates.   view more (2008-06-20)

Turn-ons and turn-offs for neurons
Our brain consists of billions of nerve cells enabling to learn, remember and reason. Every time we think and experience, touch, smell or fear, millions of neurons in our brain becomes active.   view more (2007-06-20)

CDX2 — A protein that promotes leukemia
Researchers from Harvard Medical School, Boston, have found that most individuals with acute myeloid leukemia (AML) inappropriately express a protein known as CDX2 in their leukemic cells.   view more (2007-03-08)

Schizophrenia and bipolar disorder could have similar genetic causes (pp 758, 798)
Issue 6 September 2003 Embargoed 0001 h (London time) 5 September 2003. Authors of a study in this week's issue of THE LANCET provide strong evidence that schizophrenia and bipolar disorder have a similar genetic cause arising from reduced expression of genes responsible for myelin development of... view more (2003-09-03)

A molecular map for aging in mice
Researchers at the National Institute of Aging and Stanford University have used gene arrays to identify genes whose activity changes with age in 16 different mouse tissues.   view more (2007-11-29)

Fly with brain tumor may shed light on cancer causing genes
A study showing how the expression of genes changes when the brain tissue of fruit flies becomes cancerous is published this week in BMC Genomics. As the function of many of these genes is conserved across evolution, the researchers expect their results will help us to understand why human brain... view more (2004-04-14)

For some young fish, early gene expression is a clear harbinger of fated lifestyle
As juveniles, individuals of many fish species face a developmental choice that will profoundly affect their future: whether to adopt a sedentary or migratory lifestyle.   view more (2006-04-18)

Cancer signatures uncovered
A new systematic analysis of the relationship between the neoplastic and developmental transcriptome provides an outline of trends in cancer gene expression.   view more (2008-08-18)

Isolation of a new gene family essential for early development
Researchers at BRIC, University of Copenhagen, have identified a new gene family (UTX-JMJD3) essential for embryonic development. The family controls the expression of genes crucial for stem cell maintenance and differentiation, and the results may contribute sig-nificantly to the understanding of... view more (2007-08-23)

Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis
While there have been significant advances in the use of gene expression profiling to assess a cancer prognosis, a Mayo Clinic review and analysis of existing lung cancer studies shows that this technology has not yet surpassed the accuracy of conventional methods used to assess survival in lung... view more (2006-11-17)

Early predictor of breast cancer aggressiveness
Physicians may be able to make early decisions on the best treatment for breast cancer, thanks to research published in Breast Cancer Research today. A gene involved in the adhesion of cells is less active in breast tumors with a poor prognosis than those that are less aggressive, researchers... view more (2004-06-24)

Newly Identified Gene Activated In 80% Of Breast Cancer Patients
New research, published this week in Breast Cancer Research, could provide a genetic explanation for breast cancer. A George Washington University Medical Center team, led by Patricia Berg, has discovered that the gene BP1 is activated in 80% of breast cancer patients. The researchers believe that... view more (2003-04-25)

Research elucidates mechanism by which gene expression may be altered in drug addiction
Dr. Judith A. Potashkin, Ph.D. and her colleagues at Rosalind Franklin University of Medicine and Science recently completed a study investigating one of the changes in gene expression that occurs when individuals take addictive drugs.   view more (2007-09-05)

Cracking the genetic code for control of gene expression
Molecular biologists, developmental biologists and computer scientists at the Universtity of Helsinki, Finland, came together to advance towards cracking the code for how gene expression is controlled.   view more (2006-01-13)

Location, location, location: Transcriptional activity and nuclear position
Dr. Mark Groudine (FHCRC) and colleagues report on their surprising characterization of changes in intranuclear organization during murine erythropoiesis.   view more (2006-05-18)

Jefferson scientists show gene reverts cancer genes to normal, predicts breast cancer prognosis
Scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have shown that the activity of a gene that commandeers other cancer-causing genes, returning them to normal, can predict the prognosis of an individual with breast cancer.   view more (2006-11-01)

Chronic fatigue: clues in the blood
Researchers at UNSW believe that blood may hold vital insights into what is happening in the brain of patients with chronic fatigue syndrome (CFS).   view more (2007-07-09)
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