Researchers developed an advanced generative model called ALADYNOULLI to uncover underlying disease processes and predict individual outcomes. The model reduced complex patient histories into 21 reproducible 'latent' disease signatures, which were highly similar across datasets and reproduced known disease processes.
Researchers used PET imaging to find significantly lower muscarinic acetylcholine M1 receptor availability in schizophrenia patients compared to healthy individuals. This study provides the first in vivo evidence of widespread M1 receptor deficits in schizophrenia, supporting the development of muscarinic-based therapies.
Astronomers have detected an atmosphere on a rocky planet, LHS 1140 b, in the habitable zone of its host star, which is consistent with conditions for liquid water and potentially life. The discovery was made using the WINERED spectrograph on the Magellan Clay telescope and reveals helium escaping from the upper atmosphere.
Researchers use AI models to design synthetic RNA-guided nucleases with novel properties, outperforming natural enzymes in multiple cell types. The study reveals new structures and interactions of AI-designed proteins, demonstrating their potential for genetic engineering applications.
A new study reveals two recurring dental designs in mammals, optimizing for either cutting or crushing performance. The tradeoff between these abilities has shaped the evolution of carnassial teeth, influencing dietary adaptability.
A study published in Science reveals that dendritic cells build and maintain structures called tertiary lymphoid structures (TLSs) within tumors, which serve as local command centers for the immune system. These hubs play a key role in antitumor immunity and may be a target for future therapies.
A team of astronomers has detected the first atmosphere on an Earth-like, rocky planet orbiting within the habitable zone of another star. The discovery provides evidence that worlds with conditions similar to Earth could exist beyond our solar system.
Scientists have successfully prepared and studied radium molecules precisely with lasers in tabletop experiments, marking a breakthrough in understanding the universe's matter-antimatter asymmetry. The new method can be applied to other atoms to create similarly chilled molecules.
Researchers will examine Protein S's role in pancreatic cancer and develop new therapeutic strategies. The study aims to improve understanding of the disease and reduce mortality rates.
A recent study found that patients perceive medical professionals as more credible when AI agrees with their diagnosis. However, disagreement can increase perceptions of medical uncertainty and doctor laziness. The researchers suggest strategies to communicate AI disagreement effectively and reduce patient mistrust.
A new Cornell study found that drinking water at meals can lead to consuming more food, rather than less. The researchers also discovered that adding spice to snacks can decrease eating volume, making it a potentially effective strategy for reducing energy intake.
A new study by University of Florida Assistant Professor Jason Dittmann reveals that the rocky exoplanet LHS 1140b may have its own atmosphere. The planet's age and atmospheric composition suggest a steady-state atmosphere with water, which could persist over time.
Researchers found that tissue-resident macrophages, responsible for clearing senescent cells, become dysfunctional with age, leading to chronic inflammation and organ damage. Blocking a specific receptor on these cells preserved youthfulness of multiple organs in mice.
Three Oak Ridge National Laboratory researchers have been elevated to IEEE senior membership for their outstanding work on energy infrastructure. Shamim Hasan, Mohammad Khalid, and Deepika Patel were recognized for their research in electromagnetic transient modeling, power system protection, and microgrid controls.
Researchers discovered the brain's brief 'dual tracking' ability to process two conversations simultaneously, potentially explaining why some individuals excel in busy social situations. This finding may help improve hearing technologies and provide insight into why certain people struggle with multitasking.
A new study reconstructs the geographic origins and early-life movements of Africans liberated from slave ships on St. Helena, providing valuable insights into the transatlantic slave trade. The research found that these individuals originated from a wide geographic area, including modern-day Angola and Zimbabwe.
The rapid drying of the Aral Sea has released over 200 teragrams of carbon into the atmosphere, shifting the region's land-use carbon balance from a net sink to a significant source. Restoration efforts could help halt continued carbon loss and generate financial incentives for reflooding the lake.
A team of researchers, led by Sergey Stavisky, has developed an AI-based speech neuroprosthesis that can translate brain signals into speech with high fidelity. The device has enabled a man with amyotrophic lateral sclerosis (ALS) to generate fluent sentences and sustain full-time employment.
A study found that virtual-physical scenario simulation improves nursing students' learning immersion in home visit training, but the effects on skills need further investigation. The integrated simulation model increased students' emotional buy-in and learning experience, making the interaction feel more realistic.
A research team identified Crocin II, a natural compound derived from saffron, as a promising therapeutic candidate for metabolic dysfunction-associated steatotic liver disease. By reducing ANGPTL8 protein levels, Crocin II alleviated liver fat accumulation and improved lipid profiles.
A new monkey species, Likweli, has been discovered in the Democratic Republic of Congo's Lomami National Park. The species, a rare and cryptic Colobus monkey, was identified through physical traits, genetics, and vocalizations.
A study found that cancer care providers are more likely to be aware of the risks of cannabis use, but less comfortable discussing it with patients. In contrast, survivors feel more comfortable discussing cannabis with their care team and hold more positive attitudes towards its use.
The European Law Institute has approved its first comprehensive framework for dealing with digital assets and personal digital content after death. The rules provide a dual legal framework recognizing the need for protection, privacy, and dignity in digital inheritance.
A new analysis from the University of Illinois and the Illinois Soybean Association finds that Illinois corn and soybean farmers could lose up to $609 million per year if the state bans the weedkiller glyphosate. This would represent a 3.6% revenue loss, mainly due to the need for more expensive herbicide products.
A comprehensive review finds that climate change affects waterborne diseases differently across bacteria, viruses, and parasites, highlighting the need for tailored public health approaches. The study recommends 'no-regrets' investments to reduce risk and promote community resilience.
A new editorial highlights the need for public health leadership to build trustworthy AI in health. The authors argue that public health expertise is essential to ensure AI systems are equitable, transparent and effective across diverse populations.
Ester Sztein, GSA's Director of International Programs, receives the AGI Award for her work in expanding access to geoscience education and fostering international collaboration. The award recognizes Sztein's commitment to increasing public awareness of the critical role geoscientists play in addressing societal challenges.
Researchers identified a distinct biological subtype of obesity that responds well to GLP-1-based medications like tirzepatide. Patients in this group lost an average of 21.5% of their body weight after six months of treatment.
Researchers successfully demonstrated the Talbot effect in diatom-inspired three-dimensional structures in the terahertz range. The fabricated structures replicate the native architecture of diatom frustules and reveal distinct optical roles for each layer.
Lehigh University has joined an international research consortium to advance commercial space research and innovation, with a focus on low-Earth orbit technology and microgravity science applications. The partnership aims to develop foundational technologies for future commercial platforms, including the Starlab space station.
A new study reveals that freshwater exported from the Black Sea into the Aegean Sea during the Early Holocene triggered major environmental changes across the Eastern Mediterranean. The findings challenge previous views on the formation of Sapropel 1, a widespread organic-rich sediment layer deposited during this period.
Researchers at the German Cancer Research Center found that overweight individuals are associated with more than 10% of all cancer cases, nearly twice the previous estimate. The analysis considered accurate measures of body fat and methodological biases to reach this conclusion.
Research led by the University of Surrey found that hospitals with high EU nurse reliance before Brexit experienced the greatest decline in patient outcomes afterwards. This was due to lower hiring standards when skilled workers became harder to attract.
A new carborane-based material has been developed to improve the efficiency of perovskite solar cells. The material offers several advantages, including lower energy requirements for deposition and reduced losses at the interface between the C60 layer and the perovskite absorber.
The COSPAR 2026 press tour offers a unique opportunity for accredited media to explore the historic Villa Galileo and INAF Arcetri Astrophysical Observatory. The event is free of charge but has limited participation, with full details and schedules sent to registered participants.
Researchers have discovered that TSPAN7, linked to intellectual disability and cancer progression, senses membrane curvature and polymerizes into a helical assembly. This 'transmembrane skeleton' resists mechanical deformation and provides structural reinforcement to tubular membranes, distinct from the classical cytoskeleton.
A structure-guided peptide vaccine targeting PCSK9 induced durable anti-PCSK9 antibody responses in mice, guinea pigs, and rhesus macaques. The vaccine reduced hypercholesterolemia and atherosclerosis in animal models. Further optimization is required for potential human application.
A study by the University of Konstanz found that politicians' views on climate change are more polarized than those of their constituents, particularly on the political fringes. This disparity makes it challenging for elected representatives to accurately represent the interests of their constituents and implement effective climate pol...
Researchers measured high-energy gamma-ray emissions from unstable curium nuclei produced in fission, providing insights into pygmy resonances and the fission process. The study's results enable reliable comparisons of gamma-ray emissions across isotopes, aiding nuclear theorists in improving models describing fission dynamics.
A vaccine targeting KRAS mutations was safe and stimulated durable immune responses in high-risk individuals. After a median follow-up of 16.5 months, none of the participants developed pancreatic cancer, and some precancerous lesions shrank or stopped growing.
Researchers found that sea anemones can selectively distinguish between beneficial and harmful bacteria thanks to 'nematosomes'. This ability is crucial for maintaining a stable microbiome. The study suggests that invertebrates may have sophisticated mechanisms for supporting beneficial microorganisms.
Northwestern University engineers created a drone called Phantom Twist that harnesses motion blur to blend into its surroundings. The drone spins up to 25 times per second, making it difficult for humans to see clearly, and can potentially monitor wildlife or inspect infrastructure with less disruption.
Researchers analyzed genetic data from almost 100,000 people across eleven world regions, identifying regional differences in gene variants GBA1 and LRRK2. This study is crucial for globally equitable diagnostics and therapies as it highlights the need to consider ancestry when diagnosing Parkinson's disease.
A recent study analyzed 42 pediatric ependymomas, defining metabolic patterns associated with each molecular subtype. The research found that fatty acid oxidation and polyamine metabolism vary across subtypes, with potential implications for therapeutic vulnerability.
Scientists have developed a simple, surfactant-free hydrothermal synthesis strategy to create spherical CeO₂ abrasives with controllable particle sizes. The resulting abrasives achieved superior surface finishes and material removal rates in chemical mechanical polishing (CMP) tests, outperforming commercial products.
New study reveals that antiferroelectric materials can exhibit unique properties beyond simple up-down arrangement of electric dipoles. Researchers identified a compound with hybrid ferroelectric-antiferroelectric domain walls, opening new opportunities for energy storage and electronic technologies.
The study introduces an integrated full-chip EUV curvilinear MO framework that merges deep-learning-enabled forward modeling and gradient-based inverse optimization. It reduces model complexity and memory usage through tunable U-Net surrogate models and slice-based approximated gradient calculation schemes.
Researchers propose a multi-objective optimization framework that identifies and corrects promising infeasible solutions, significantly improving optimization efficiency for complex distillation processes. The framework achieved optimization time reductions of 35.3% and 20.8% compared to conventional methods.
FAIR² Data Management, powered by Senscience, has been named a 2026 CODiE Award Winner in the category Best AI Data and Analytics Solution. The platform enables researchers to turn data into trusted resources that can be discovered, built upon, and used responsibly with AI.
Researchers developed a KRAS-targeted vaccine and found it generated significant immune responses in participants with a hereditary predisposition to pancreatic cancer. The vaccine was safe and produced memory T cells that persisted over time.
Researchers at University of Münster and National and Kapodistrian University of Athens used cryo-electron microscopy to elucidate the structure of UapA transporter, a key fungal transporter. The study reveals a specialized 'elevator-type' transport mechanism that could lead to new antifungal drug strategies.
A study reveals that gut bacteria can process chemically modified amino acids from heated foods, such as CML. This enzyme, SpeC, is a 'Swiss pocket knife' that breaks down these compounds, which are not absorbed in the small intestine and pass to the large intestine.
Researchers discovered that certain bacteria produce an enzyme to break down antibiotics, enabling their survival. This 'altruistic cell death' mechanism allows the bacteria population to thrive, making existing and future antibiotics less effective.
A novel salvage surgical approach combining internal neurolysis and targeted glycerol injection has provided durable pain relief for a patient with severe, treatment-resistant MS-TN. The procedure was successful in preserving sensation and reducing medication use.
Researchers found that most temperature-sensitive nerve cells are activated by cooling, and their activity reduces with warming. This finding challenges the long-standing view of temperature sensing and could guide future research into pain and sensory disorders.
A study by the University of Eastern Finland found that golf players spend approximately €330 million on golf annually, generating an estimated benefit to society almost twice as high. Golf promotes physical activity and generates €80 million in savings for society, with a Social Return on Investment (SROI) ratio of 1.9.
A nationwide study by researchers at the University of Minnesota found that adhering to posted speed limits could save an average of $22 million and 6.7 million gallons of fuel daily. This could lead to significant reductions in greenhouse gas emissions and energy consumption.
A recent study discovered that Hes6, a transcriptional cofactor, drives gastric cancer progression through the regulation of EMT and PI3K/AKT signaling. Overexpression of Hes6 was associated with increased cell proliferation, migration, and invasion in gastric cancer cells.
A cross-sectional study reveals substantial commercial price variation for common cardiovascular services, influenced by payer contracting strategies and market dynamics. The findings underscore the need for greater transparency and regulatory oversight to promote efficient healthcare spending.
Theoretical physicists develop new method to order Feynman integrals based on their geometric structure, reducing computation time by a factor of 1,000. This allows for precision predictions in high-energy physics measurements, such as those made at the Large Hadron Collider.