A new AI tool developed by La Trobe University researchers can analyze routine pathology slides to predict stage-two bowel cancer patients at risk of relapse. The study analyzed over 1600 pathology slides and validated the findings across 1220 patients in three independent cohorts.
Dr. Elaine S. Jaffe receives AMP's highest honor for pioneering contributions to lymphoma diagnosis and treatment. Dr. Laura J. Tafe is recognized for her leadership and service to the organization, while Dr. Daniel E. Sabath receives the Meritorious Service Award for his dedication to scientific excellence and organizational service.
The Association for Molecular Pathology recognizes Dartmouth Health medical director Laura J. Tafe for her exceptional leadership and dedication to the field of molecular diagnostics. She has been a member of the organization since 2007 and has held various positions, including president in 2023.
A vaccine targeting KRAS mutations was safe and stimulated durable immune responses in high-risk individuals. After a median follow-up of 16.5 months, none of the participants developed pancreatic cancer, and some precancerous lesions shrank or stopped growing.
Daniel E. Sabath, a professor at UW Department of Laboratory Medicine and Pathology, has won the Association for Molecular Pathology's 2026 Meritorious Service Award for his dedication and effort over three decades. He is being honored for his leadership roles, scientific expertise, and collaborative spirit in advancing education and s...
Elaine S. Jaffe, a distinguished investigator at the NCI Center for Cancer Research, has transformed our understanding of lymphoid malignancies through her groundbreaking research. Her work has led to significant advancements in disease classifications, diagnosis, and treatment.
The Association for Molecular Pathology has elected new leaders for several committees, including Genetics, Hematopathology, Infectious Diseases, Informatics, and Solid Tumors. The newly elected leaders will work together to drive the organization's mission forward.
A new study reveals IL-6 plays a crucial role in regulating neuroinflammation and protecting the nigrostriatal pathway in Parkinson's disease. The research found that restoring IL-6 levels can reverse aggravated pathology and partially ameliorate motor dysfunction in mice.
A lifecycle framework helps laboratories overcome barriers to digital pathology adoption by integrating infrastructure, workflow redesign, validation, interoperability, and AI readiness. The framework addresses institutional governance, cybersecurity, education, and performance monitoring to ensure durable success.
The review discusses key AI concepts, including algorithms, models, architectures, machine learning, deep learning, and multimodal models. It highlights their clinical applications, such as detection of lymph node metastases, Nottingham grading, biomarker quantification, risk stratification, and prognostic prediction.
Researchers developed a compact, cost-effective diagnostic platform combining lensfree holography and deep learning for automated HER2 scoring. The system reached 84.9% accuracy for four-level HER2 classification and 94.8% accuracy for binary scoring, effectively lowering diagnostic risks.
A cohort study found that a dietary pattern with lower inflammatory potential was associated with lower dementia risk among individuals with Alzheimer disease pathology. Targeted dietary strategies may help prevent dementia in those already at elevated risk.
Researchers have developed a versatile uncertainty-aware AI framework called TRUECAM that provides customizable accuracy guarantees for cancer subtype classifications. TRUECAM outperforms existing approaches to digital pathology AI uncertainty quantification, detecting out-of-scope inputs and improving fairness across sex and race.
A large-scale study developed a predictive model for Lymph Node Metastasis (LNM) status in T1b gastric cancer using digital pathology and deep learning. The DL-T1 nomogram achieved an AUC of 0.910, indicating high accuracy in predicting LNM risk.
The Aileen Wee Professorship in Liver Diseases aims to catalyse partnerships between experts and address cancer and healthcare challenges. Prof Aileen Wee, a renowned authority in hepatobiliary pathology, will lead the professorship.
Airborne levels of formaldehyde regularly exceed EU limits in 70% of NHS pathology departments, with poor monitoring and control contributing to the risk. The researchers call for national regulatory intervention to protect NHS employees' health, citing increased risks of respiratory and reproductive problems, as well as cancers.
Professor Tony James has been awarded Honorary Fellow of the Chinese Chemical Society in recognition of his significant contributions to fluorescence chemical sensing, molecular identification, and diagnostic chemistry. He is a renowned expert in supramolecular chemistry and chemical sensing with broad international influence.
Researchers used tissue samples, pathology images, and clinical data from 672 patients to train AI models to classify meningioma subtypes and predict recurrence risk. The findings suggest that AI can help clinicians obtain more detailed tumor information without requiring advanced genetic testing.
A study published in Nature Medicine reveals that distinct cellular programs and immune-cell states are associated with Alzheimer's disease progression and resilience. Microglial responses were found to be critical in determining whether Alzheimer's pathology leads to dementia, suggesting new avenues for therapies to prevent neurodegen...
A new leishmaniasis vaccine, developed using CRISPR gene-editing technology, is set to begin testing in healthy people for its safety and immune response. The vaccine has shown strong results in mice and has cleared a key FDA hurdle, paving the way for Phase 2 trials aiming to understand its effectiveness.
A European research team is developing bacteria that can produce important chemical base materials from sustainable methanol, aiming to replace fossil resources in the chemical industry. The goal is to make chemical production more sustainable without jeopardizing food security.
Researchers highlight latest developments in pathology, diagnosis, and treatment of MASLD and IPFD, revealing correlations with chronic diseases like liver cancer and pancreatic cancer. Innovative treatments, such as AI-driven approaches and organ-targeted therapies, show promise for precision prevention and therapy.
A new brain imaging test can detect Alzheimer's disease pathology in twice as many people before symptoms appear. The test uses a new tau PET tracer that identifies more tau-positive cases than the current standard, leading to better decisions about who is on an Alzheimer's trajectory.
Benjamin L. Wolozin and his team will examine RNA binding proteins, RNA metabolism, and membraneless organelles in Parkinson's disease pathology and co-pathologies. They will also test a novel compound AQV-3 to break up toxic protein aggregates.
A large multisite study found that Black and Hispanic people with cognitive impairment are less likely to show Alzheimer's pathology on brain scans compared to other racial and ethnic groups. The study highlights ethnoracial differences in dementia and underscores the need for further research into underlying causes of dementia symptoms.
A study published in Acta Neuropathologica found that APOE ε4 is associated with widespread TDP-43 pathological subtype in sporadic ALS. This discovery suggests a new perspective on why ALS pathology spreads differently among patients.
A new AI system, SPARK, enables autonomous scientific discovery in cancer pathology by generating biological hypotheses and translating them into analytical tools. The system identifies clinically relevant tissue markers linked to disease course, treatment response, and tumour progression.
Researchers at Mass General Brigham developed an ultrasensitive test to detect abnormal clumps of TDP-43 protein in cerebrospinal fluid, a biomarker for specific form of dementia called FTLD-TDP. The test shows promise in diagnosing patients with the correct pathology and tracking disease progression.
A new study combines dynamic full-field optical coherence tomography with deep learning to generate real-time virtual pathology images of fresh lymph nodes during surgery. The approach achieved high accuracy and sensitivity, reducing tissue consumption and manual workload.
The research team developed a novel AI pathology analysis system named PRET that can accurately recognize multiple types of cancer using only a minimal number of samples. PRET outperformed existing methods in 20 tasks, achieving high diagnostic accuracy rates and stable generalizability across different populations and regions.
A new AI framework combines digital pathology and structured clinical data to predict PIK3CA mutation status in breast cancer. The Multimodal PIK3CA Model outperformed single-modality models, achieving an AUC of 0.745, with strong performance across multiple clinical datasets.
Researchers developed a pathomics framework using a deep learning survival prediction model that analyzes pathology slide images and study patterns to predict patient outcomes. The model correctly stratified patients into high- and low-risk groups with significantly different outcomes.
Researchers at WashU Medicine discovered that mRNA vaccines can trigger strong anti-tumor responses even without certain immune cell subtypes, suggesting a novel pathway for cancer treatment. The study found that both cDC1 and cDC2 dendritic cells play a role in stimulating T-cell responses.
Blake Warner, a renowned expert in salivary disorders, has been awarded the 2026 AADOCR National Student Research Group Mentor Award. He leads an integrated clinic and research laboratory focused on deep characterization of disorders affecting the salivary glands. The award recognizes his outstanding mentorship in dental research.
Several open-source AI models consistently produced summaries that were more comprehensive than physician-written versions, particularly in capturing molecular and genetic findings. The study found that Llama 3.1 and DeepSeek performed best among the six evaluated models.
Researchers have developed an integrated reiterative pipeline that uses machine learning and structural biology to identify promising vaccine targets across multiple related viruses simultaneously. The system evaluates viral proteins to identify short fragments called epitopes that can trigger a strong immune response.
Alexander Kerr, NYU Clinical Professor, recognized for outstanding research on oral cavity squamous cell carcinoma and oral potentially malignant disorders. The IADR Distinguished Scientist Award is one of the highest honors bestowed by IADR, recognizing contributions to understanding oral health and disease mechanisms.
The BiliSeq test detected approximately 82% of bile duct cancers, compared to 44% with pathology alone, and increased cancer detection to nearly 90% when combined with pathology. This improved accuracy enables physicians to provide more personalized medicine and treatment options for patients.
Researchers developed an AI model that analyzes routine pathology slides to predict breast cancer recurrence and chemotherapy benefit. The model was validated in a large clinical trial and demonstrates fast, accessible, and globally scalable diagnostic capabilities.
Researchers found that breast cancer cells trigger the lung's natural repair system, leading to chronic inflammation and promoting tumor growth. A repurposed drug, roflumilast, may slow this process by preventing the lung environment from aiding tumor growth.
UL Research Institutes' Chemical Insights will present findings on chemical exposures and health risks, highlighting new methods for faster, more transparent science. The institute aims to protect people and communities through open science, education, and collaboration.
LazySlide enables systematic whole-slide image analysis using AI models and links visual patterns to text concepts. The study demonstrates its potential in analyzing tissue samples, identifying biological pathways, and reducing the barrier for applying advanced image analysis methods.
Researchers from the University of Amsterdam developed a novel computational framework, Measurable Feature Prediction, to quantify the gaps in nontargeted chemical analysis. The study shows that environmental screening methods leave massive blind spots in the data, with only 0.01% of the chemical space being measurable.
Researchers at Boston University School of Medicine have discovered protein and sugar level changes that occur with aging and Alzheimer's disease brains. The study uses a unique mass spectrometry technique to capture detailed molecular information, providing new avenues for biomarker discovery and potential treatments.
New research warns that popular AI systems for predicting cancer biology may rely on visual shortcuts, raising concerns about their reliability for real-world patient care. Despite achieving high accuracy, these models often fail when conditions change or confounding factors are controlled.
This systematic review found that both chemical and non-chemical denture cleansers effectively reduce Candida species, with chemical agents demonstrating more consistent antifungal action. Non-chemical agents preserve material integrity and are preferred by patients for their taste and ease of use.
A University of Barcelona study using animal models found that early and sustained cognitive stimulation preserves brain connectivity and memory in Alzheimer's disease. Males respond better to cognitive intervention than females, which can delay the onset of the disease.
Researchers at Jeonbuk National University have developed a new dual-chemical looping process that improves the efficiency of ammonia synthesis by 8.4% and reduces global warming potential by up to 15.85 kg CO2-equivalent per kilogram of ammonia produced.
Katie Paul Friedman, Ph.D., Director of the Center for Informatics and Screening at Chemical Insights, received the prestigious 2026 Achievement Award from the Society of Toxicology for her innovative research and dedication to training the next generation. The award recognizes her contributions to new approach methodologies transformi...
Researchers found that diverse plant communities emit more complex chemical signals, which can affect individual plants and the entire ecosystem. The study highlights the importance of biodiversity in maintaining natural signaling systems and supports sustainable agriculture practices to promote plant diversity.
Researchers highlight advancements in fluidized bed design, oxygen carrier materials, and performance of chemical looping systems. They emphasize the importance of controlling fluidization regime and developing physical standards for oxygen carriers.
A Johns Hopkins-led team has created the first map of nerve circuitry in bone, revealing how sensory neurons communicate with bone-building cells to promote healing. The study identifies key protein signals necessary for bone formation and repair.
A new study led by Harvard Medical School researchers found that AI models analyzing pathology samples can infer demographic information, leading to biased diagnoses. The team developed a framework called FAIR-Path to reduce bias in these models, which showed improved performance across demographics.
Researchers summarize advances in multi-target therapies addressing Alzheimer's disease pathology, including Amyloid-beta, tau, neurodegeneration, and cerebrovascular injury. Despite promising preclinical evidence, single-target strategies have shown limited efficacy in clinical trials.
A new study using advanced computer simulations has shed light on the mysterious chemical history of the Milky Way. Researchers found that galaxies like the Milky Way can develop two distinct chemical sequences through various mechanisms, challenging previous assumptions about the role of cosmic gas flows and galaxy mergers.
A specific protein, RASH3D19, activates the RAS signaling pathway involved in aggressive tumor growth and resistance to KRAS inhibitors. Blocking RASH3D19 improves outcomes in preclinical models, suggesting a potential therapeutic strategy.
Researchers are presenting groundbreaking findings at the Association for Molecular Pathology's annual meeting, including a novel technique to study ancient DNA and rapid detection of serious fungal pathogens. The Association for Molecular Pathology is providing press materials and resources for media coverage.
Scientists have developed a targeted genetic test to improve diagnosis for X-linked dystonia-parkinsonism, a rare and disabling movement disorder that affects primarily men of Filipino ancestry. The test correctly identified cases that routine sequencing methods have missed, leading to proper diagnoses and end diagnostic odysseys.
Artificial intelligence is being used to improve diagnostic accuracy in molecular pathology, with studies showing 93% accuracy for cancer diagnosis. Researchers are also using AI to analyze chromosomal changes in blood cancer patients and provide personalized treatment plans.
Recent research in pathological foundation models has demonstrated robust representation learning capabilities and generalization performance. These models enable multi-task transfer with minimal data, significantly enhancing clinical utility and generalizability.