Articles tagged with Narcotics Addiction
Researchers found that introducing new objects in a nonsocial environment reduced fentanyl intake over time and helped rats stop seeking the drug faster. Enriched environments also showed lower levels of stress hormones, linked to relapse in standard conditions.
A new study found that naloxone may not be sufficient to reverse respiratory depression caused by potent synthetic opioids like fentanyl and sufentanil. The study's findings raise concerns for patient safety, observation practices, and dosing strategies.
A team-based buprenorphine clinic incorporated a trained chaplain into patient care, providing a psychologically safe space for conversation and supporting patients in identifying recovery capital. The clinic reported successful outcomes, with eight patients achieving at least 12 months of sobriety.
Researchers analyzed Oregon Medicaid case data and found that severe burns requiring hospital-level care are a growing threat in the overdose epidemic. People who smoke drugs like fentanyl and methamphetamine account for most of these cases, with butane torches posing a significant risk due to locking mechanisms.
Researchers from Weill Cornell Medicine found that state laws prohibiting private insurance from requiring prior authorization for buprenorphine did not significantly improve treatment retention. Despite a decrease in opioid overdose deaths, nearly 55,000 people still died from opioid overdose in 2024.
Researchers found that GLP-1 medications are effective at reducing the risk of developing substance use disorders across all major addictive substances, including a 14% reduced risk for developing any substance use disorder. The study also showed significant reductions in severe harm, including overdose and death, among patients with p...
A meta-analysis of longitudinal studies found that broad spiritual practices, such as attending religious services and meditation, were associated with a 13% reduced risk of hazardous drug and alcohol use. This reduction was greater (18%) among individuals attending religious services at least once per week.
A new study published in JAMA found that emergency department-initiated buprenorphine for opioid use disorder was well-tolerated and effective, with a low risk of withdrawal. The 7-day extended-release and sublingual buprenorphine groups showed similar treatment engagement rates on day 7.
Researchers found that patients with substance use disorder received life-saving treatments only when addiction consult services were involved. Fentanyl use was associated with dramatically worse visual outcomes, highlighting the importance of addressing underlying conditions alongside acute medical problems.
Research suggests that deaths from synthetic opioids like nitazenes have been underreported, with some studies suggesting a 33% excess in drug-related deaths. The team believes that the non-detection of degraded nitazene breakdown products is to blame for the undercounting.
A new national survey found that nearly three-quarters of clinicians encounter obstacles when starting buprenorphine treatment for patients using fentanyl. Researchers emphasize the need for evidence-based guidelines to initiate buprenorphine in light of more potent drugs.
A recent national survey found that 88% of adults view opioid overdose deaths as a serious problem, but political differences over responsibility persist. The study suggests that more people are placing blame on pharmaceutical companies and individuals, rather than those who use opioids.
A new study in NC found that many residential substance-use service providers require patients to engage in unpaid labor, restricting access to evidence-based treatment. Providers with labor requirements are less likely to offer recommended treatment and more likely to operate without a state license.
A $2.67 million gift from the estate of Dr. William A. Gibson will establish the Michael Conner Gibson Endowed Professorship in Psychology and the Michael Conner Gibson Research Endowment, accelerating UH's addiction research program.
A new study found that nearly half of patients discharged with take-home methadone successfully connected to treatment within 72 hours. The likelihood of successful follow-up increased if patients were already enrolled in an OTP or received higher methadone doses.
The University of Houston is part of a statewide effort to fight the opioid epidemic by investigating opioid use disorder among people living with HIV in Harris County. Researchers aim to integrate prevention methods, including Screening, Brief Intervention, and Referral to Treatment (SBIRT), into treatment for those affected.
A new study from Tulane University found that 22 states have prohibited prior authorization for opioid use disorder medications, making it easier for people to get potentially life-saving treatment. This trend signals a positive shift in state legislative efforts to address the opioid crisis, with more states removing barriers to care.
A new study reveals that laws restricting pain clinics, or 'pill mills,' where opioids were often prescribed, reduced risky opioid use by 5 percent. Enacting such laws near the onset of the crisis in the 1990s could have reduced risky use by 30 percent over time.
The analysis explores how reduced fentanyl production costs affect the structure and conduct of the illegal opioid supply industry. It also assesses potential consequences for drug law enforcement organizations, finding modest declines in expenditures and income-generating crime.
A new clinical trial is testing an intervention to reduce staff stress and improve methadone treatment retention for opioid use disorder. The four-year study will examine the effectiveness of a multi-modal intervention in reducing work-related trauma and traumatic stress symptoms among methadone treatment staff.
Researchers at the University of Gothenburg found that semaglutide reduced both cocaine use and relapse in rats, with motivation to keep taking cocaine decreasing by 52%. The study suggests that semaglutide may blunt cocaine's ability to raise dopamine levels in the brain.
Researchers found that state Medicaid policies drive population-level treatment rates for opioid-use disorder. States with expanded Medicaid coverage saw substantial increases in buprenorphine prescribing rates, while those without expansion experienced declining treatment rates after 2022.
A new study from the University of Colorado Anschutz Medical Campus introduces a more individualized approach to restarting methadone treatment for people with opioid use disorder. The findings suggest that tailoring methadone doses to each patient's unique circumstances can improve care without compromising safety.
Dr. Harriet de Wit's groundbreaking research bridges animal and human drug studies, demonstrating that MDMA enhances feelings of social connectedness and challenging addiction treatment strategies. Her discoveries have profound implications for treating trauma-related disorders globally.
Among youth aged 15-24, polysubstance-involved opioid overdose deaths rose steadily with age, driven by fentanyl and synthetic opioids. By age 21, polysubstance involvement surpassed opioid-only fatalities, primarily due to stimulants like methamphetamine and cocaine.
Adults with moderate or severe substance-use symptoms have a higher chance of initiating and staying on OUD medication treatment. The study found that most primary care patients with opioid use disorder symptoms did not receive evidence-based treatment, but those who initiated treatment remained engaged.
A first-in-human study found that naloxone reduces opioid receptor availability by 40-50 percent in brain regions, but shows a greater reduction in women compared to men. This suggests sex-based differences in how men and women respond to opioid overdose treatments.
The Be Well Texas initiative, led by the University of Texas Health Science Center at San Antonio, will expand access to opioid use disorder treatment services and recovery support across rural and urban communities. This major statewide expansion aims to reduce overdose deaths and build a lasting recovery infrastructure.
A new study by Carnegie Mellon University researchers found that opioid consumption intensity varies enormously across different populations and contexts. The study suggests that tracking average intensities of use could improve our understanding of consumption patterns and inform drug policy and treatment strategies.
A JAMA Psychiatry study recommends increasing contingency management incentives to improve opioid addiction recovery outcomes. The research team suggests using evidence-based incentive amounts, such as $128 per week for vouchers or $55 per week for prizes over 12 weeks, to effectively reduce stimulant and/or opioid use.
A Rutgers analysis of medical records reveals that Medicaid and Medicare patients with opioid addiction tend to receive behavioral health care services less often than those with other types of funding. Patients with public insurance alone were less likely to utilize treatment services compared to those with multiple funding sources.
Researchers identified reelin as a marker for cocaine-activated medium spiny neurons in the nucleus accumbens, which controls drug-related behavior. Knocking down reelin expression impaired excitability of these neurons and abolished cocaine-induced behavioral changes.
A WVU microbiology student has discovered a new species of fungus, Periglandula clandestina, that produces effects similar to the semisynthetic drug LSD. The fungus is highly efficient at making ergot alkaloids, which can be used therapeutically to treat conditions like depression and addiction.
A new study led by Boston University School of Public Health reveals that US excess deaths have been increasing for decades, with working-age adults disproportionately affected. The study found that over 1.5 million 'missing Americans' would have been averted if the US had mortality rates similar to other high-income countries.
A portable device can instantly detect dangerous street drugs at extremely low concentrations, highlighting their dangers. The device, being trialled by drug-checking services in the UK, Norway, and New Zealand, allows for cheap and on-the-spot analysis of substances.
A pilot program was conducted in South Africa to provide harm reduction and medications for opioid use disorder among people living with HIV and illicit opioid use. The study found low uptake of medication-assisted treatment after release, citing perceived ineffectiveness and delays in initiation.
A new University of Michigan study suggests that Medicaid unwinding may have disrupted the care of people receiving treatment for opioid addiction. Patients were less likely to continue filling buprenorphine prescriptions and more likely to pay with cash or private insurance in states with large versus small Medicaid enrollment drops.
A new study published in the Journal of Child Psychology and Psychiatry reveals that childhood trauma significantly increases the likelihood of engaging in risky behaviors, including harmful alcohol consumption, smoking, and illicit drug use. The research also found an unexpected connection between trauma and cardiovascular health, wit...
A new study provides the first nationwide picture of who knows about, carries, and uses naloxone to reverse deadly opioid overdoses. The survey found that people's perception of overdose risk correlates with their decision to carry naloxone, and those with high-risk profiles are more likely to carry the drug.
A recent study by UCLA researchers has discovered high amounts of bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate (BTMPS) in illicitly sold fentanyl. BTMPS is not approved for human consumption and has been linked to serious health effects such as cardiotoxicity and ocular damage.
Dr. Volkow emphasizes the importance of prevention strategies and research on stress, trauma, and social determinants in substance use disorders. She also highlights promising new directions in treatment, including GLP1 medications, to address the treatment gap in addiction.
A new study found that completing a six-month substance use disorder treatment program instead of arrest and prosecution reduces the risk of arrest, incarceration, or fatal overdose. Participants who completed the program had a more favorable crime and overdose profile compared to those who did not engage or complete the program.
A North Carolina State University study found that only 12% of organizations providing residential opioid substance use services are licensed by the state. Only a quarter allow patients to access proven opioid agonist treatment (OAT), which has better outcomes and cuts overdose deaths in half.
Researchers found that women with opioid use disorder face structural barriers and stigma that may keep them from engaging with traditional harm reduction practices. Increasing accessibility of harm reduction tools and expanding education are key recommendations to reduce overdose risk for women.
Researchers at UCSF find that smoking fentanyl poses increased risks of fatal overdose, especially among those with opioid tolerance. The study highlights the need for harm reduction-based education campaigns to address this emerging risk.
University of Texas at Dallas researchers have developed a first-of-its-kind, handheld electrochemical sensor that can accurately detect fentanyl in urine within seconds. The device detects even trace amounts of fentanyl with 98% accuracy and could be used to test for the drug in saliva, helping first responders make treatment decisions.
The University of Pittsburgh School of Pharmacy's PERU has received a $7.8 million grant to develop and implement measurement-based care into community opioid treatment programs across Pennsylvania. This project aims to improve treatment access, promote recovery, and reduce fatal overdoses by addressing patient needs through personaliz...
Researchers found that buprenorphine was associated with a slightly lower risk of malformations overall compared to methadone, with an 18% reduction in relative risk. Both therapies are strongly recommended over untreated opioid use disorder during pregnancy.
Mobile methadone units show significant impact in expanding opioid treatment access in rural areas, with a 13-point increase in Medication for Opioid Use Disorder (MOUD) treatment rates. Adding units exclusively to rural Louisiana provides nearly 20% of beneficiaries within 24 miles of a provider.
A UCLA study found that substance abuse treatment can lead to reduced methamphetamine usage and longer periods of abstinence. The study, which analyzed responses from nearly 300 men in Los Angeles, suggests that even limited treatment options can be effective in reducing methamphetamine use.
A new study found that law enforcement's role in post-overdose outreach programs may undermine their effectiveness. The research highlights the importance of law enforcement data and contact information to reach overdose survivors, but also notes challenges posed by police involvement due to lack of training and negative past experiences.
A new study published in JAMA Network Open shows that methadone use following surgery in infants can increase hospital stay and delay recovery. Babies who required methadone needed to stay in the hospital an average of 21 days longer after surgery, as well as more days on ventilators and IV nutrition.
A new study shows that earlier transfer to specialized care is associated with better outcomes for infants with NOWS, including shorter hospital stays and less exposure to medication. The study found that nonpharmacologic interventions, such as swaddling and pacifier use, are critical to clinical outcomes.
A new study by Harvard T.H. Chan School of Public Health found significant racial inequalities in treatment for opioid use disorder, with White patients receiving medication up to 80% more frequently than Black and Hispanic patients. Despite similar numbers of healthcare visits, disparities persist.
A new Northwestern Medicine study found that only 7% of Medicaid enrollees with opioid use disorder (OUD) received residential treatment, highlighting a significant gap in care. Residential treatment centers provide structured support and are considered one of the best treatments for severe substance use.
A novel community-focused strategy implemented in Pennsylvania counties led to a 30% reduction in opioid overdose death rates. The approach, developed by University of Pittsburgh researchers, prevented 1,818 opioid-related deaths over two years.
Researchers investigate how COVID-19 pandemic policies impacted access to life-saving treatment for opioid use disorder in minority groups. They aim to understand structural mechanisms of disparities and encourage the healthcare system to review and change social policies.
Researchers at UC San Diego found a steep rise in HIV incidence among people who inject drugs in Tijuana, driven by undiminished drug tourism. The rate of infection is 11 times higher than in San Diego residents who do not cross the border.
Researchers found that exposure to addiction medicine consult teams led to a significantly reduced risk of death within three months of discharge. Medication played a key role in reducing mortality for patients with opioid use disorders, while other components may be crucial for those with alcohol use disorder.
Researchers pinpointed nerve cells in the nucleus accumbens shell that respond to environmental stimuli associated with prior drug use. This finding may aid in developing targeted treatments for relapse prevention.