Articles tagged with Symptomatology
Bone complications in sickle cell disease include early-onset osteoporosis, compression fractures, and avascular necrosis. Research aims to investigate how inflammation leads to bone complications and identify if bone cells drive musculoskeletal pain.
A digital therapeutic intervention CT-155 has shown promising results in improving motivation and pleasure negative symptoms of schizophrenia with a small-to-moderate effect size comparable to psychosocial interventions and pharmacologic treatment. CT-155 is a scalable and accessible option for improving schizophrenia negative symptoms.
Exposure to suicide attempts within social networks was linked to increased risk of subsequent suicide attempts and higher depressive symptoms in adolescents and young adults. Assessing recent exposure to suicide attempts may help identify high-risk youths undetected through symptom-based screening alone.
A meta-analysis of randomized clinical trials found that mindfulness-based cognitive therapy is associated with worsening symptoms of depression. The study examined individual participant data from over 13,000 participants, providing evidence for the potential negative effects of this therapy on depression.
Researchers found that ultraviolet irradiation and ozonation increased anti-androgenic activity in treated wastewater, exceeding an effect-based risk threshold. The study suggests balancing pollutant removal efficiency with assessment of transformation products' combined biological effects.
Celiac disease is a chronic autoimmune disorder caused by gluten intolerance, characterized by small intestine damage and malabsorption. Symptoms include diarrhea, abdominal pain, fatigue, and weight loss, with accurate testing and early treatment available to prevent complications.
A cohort study found associations between perinatal factors and changes in brain maturation among adolescents. The study used conditional-longitudinal models to assess individual growth trajectories and mental health symptoms.
A systematic review and meta-analysis investigated changes in mental health symptoms before and during the COVID-19 pandemic. The study found significant differences in symptom changes between sexes and genders, highlighting the need for targeted interventions.
A study identified four major symptom patterns in women with endometriosis, revealing a more complex picture of the disease. The research found that psychological and neurological symptoms are common in active disease, while some patients may experience a lower symptom burden.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
A clinical trial of Ceperognastat, a novel O-linked N-acetylglucosaminidase inhibitor, found no significant slowing of Alzheimer's disease progression in early symptomatic patients. The study published in JAMA suggests that Ceperognastat may not be effective in treating this stage of the disease.
A randomized clinical trial found that an app-facilitated palliative care intervention maintained health-related quality of life and reduced acute care use. This digital self-management approach also boosted patient self-efficacy.
A low-calorie diet and behavioral support program significantly reduced weight in older patients with overweight and persistent atrial fibrillation at 8 months. The study found no safety concerns or impact on atrial fibrillation symptoms, cardiac remodeling, or need for further rhythm control interventions.
A major new study has found that severe asthma patients are often battling other health conditions, with nearly all suffering from at least one major issue. The study identified three distinct profiles linked to how well asthma is controlled and the treatments needed, offering potential breakthroughs for improving care.
Researchers found that butyrate alleviates TMJ pain by reversing epigenetic and gene regulatory pathways in the brain. The study identified key genes and mechanisms involved in pain-related molecular pathways, providing new insights into the biological mechanisms of TMJ pain.
A single dose of psilocybin was associated with rapid antidepressant effects, persisting for more than 3 months. The study suggests that psilocybin may provide a rapid and relatively long-lasting antidepressant effect on major depressive disorder.
A new study suggests that a visual measure of illness perception can effectively convey symptom-related quality of life for patients with chronic lung illnesses. The study found that patients' visual perceptions of their lung disease were equally effective as standard questionnaires and test results in predicting quality of life.
A new study suggests that ultrasound stimulation can bring about functionally meaningful changes in pain perception and brain connectivity. The research found a delayed analgesic effect, with participants reporting reduced pain intensity after 28-55 minutes following TUS application.
In patients with symptomatic rheumatic heart disease, digoxin significantly reduced the risk of a composite of all-cause death or new-onset or worsening heart failure. The treatment had little risk of toxicity, making it a promising therapeutic option for these patients.
A randomized clinical trial found that genotype-guided prescribing of SSRIs did not improve depression symptoms at 3 months but showed higher remission rates at 6 months. Future studies should focus on the long-term impact of this approach.
Unsecure firearm storage is common among older adults with subjective cognitive decline, despite clinical guidance recommending secure storage for those with cognitive symptoms. The study highlights the need for improved household practices and access to fire safety education.
A randomized clinical trial found symptom-based dosing decreases discharge time compared to scheduled opioid taper approaches among infants with opioid withdrawal. This approach, using Eat, Sleep, Console, led to faster recovery and improved outcomes.
Researchers investigate whether micro- and nanoplastics contribute to liver disease through oxidative stress, fibrogenesis, and inflammation. They emphasize the need for increased research into plastic-induced liver injury and its potential impact on human health.
A cohort study found that bullying and restrictive legislation were associated with higher rates of psychotic-like experiences in gender-diverse youths. The study suggests that supportive environments and policies can help alleviate mental health concerns among this population.
A multicenter analysis of 920 patients with compensated cirrhosis found that interferon therapy was not associated with a higher risk of serious complications compared to standard treatment. Milder side effects were more common and required closer monitoring.
Extended low-dose apixaban effectively reduced symptomatic superficial vein thrombosis (SuVT) risk. Patients with enduring risk factors for SuVT benefited from this anticoagulation strategy.
A post hoc analysis of the Finerenone Trial reveals that sudden death in heart failure was often preceded by modest worsening of symptoms and declining quality of life. The study suggests limited specificity for sudden death among other modes of death, implying a complex trajectory before modes of death.
The study identified six sleep health dimensions in young adolescents: irregularity, timing, duration, social jetlag, weekend oversleep, and continuity. Greater irregularity was associated with higher concurrent transdiagnostic mental health symptoms, while shorter duration was linked to increased symptoms at follow-up.
Researchers developed an expert consensus to standardize the use of ultrasound-derived fat fraction for assessing liver steatosis. The study found that UDFF showed strong correlations with histological steatosis grades and MRI-PDFF, demonstrating excellent reliability and robust diagnostic accuracy.
A decision-support system improved depressive and anxiety symptoms, increased medication adherence, and reduced symptoms over time for patients with major depressive disorder. The system used clinical and demographic predictors to tailor treatment, resulting in better outcomes for patients compared to usual care.
A team of researchers has developed a method to decode fluctuations in spontaneous pain intensity in individuals with chronic pain using extensively sampled functional MRI data. The study found that neural patterns underlying pain differ markedly between individuals, highlighting the importance of individualized brain-based biomarkers.
A recent study found that nearly 6 in 10 long COVID patients have recovered, but many adults over 35 continue to experience lasting symptoms. The study's authors suggest greater investment in understanding biological mechanisms may provide insights into pathways of persistence and potential targets for intervention.
A cross-sectional study of former American football players found prior participation to be associated with worse later-life cognitive and neuropsychiatric function. The findings support a dose-response association with years and level of play, providing context for clinicians and researchers assessing symptom risk among former players.
Daily aspirin use offers no quick or reliable way to prevent bowel cancer in the general population, increasing risk of serious bleeding. However, it may have potential long-term benefits for people at high genetic risk of colorectal cancer.
A population-based study reveals that rotator cuff abnormalities are common after age 40 and often represent normal age-related changes. The findings challenge the clinical value of routine imaging for atraumatic shoulder pain, questioning the need for regular scans in this demographic.
Intravenous tenecteplase administered 4.5 to 24 hours after ischemic stroke non–large vessel occlusion improved functional outcomes at 90 days compared to standard care. However, it also increased the risk of symptomatic intracranial hemorrhage.
A recent survey study found a significant association between generative AI use and increased depressive symptoms in US adults. The magnitude of the effect varied by age group, suggesting that further research is needed to understand the causal relationship and underlying factors.
Salk Institute scientists found distinct disease courses and tolerance mechanisms in younger and older mice with sepsis, indicating a need for age-tailored therapies. The study suggests that future treatments may focus on controlling infection-generated damage rather than just targeting the pathogen.
This randomized clinical trial found yoga to significantly accelerate opioid withdrawal recovery and improve autonomic regulation, anxiety, sleep, and pain. The study supports the integration of yoga into withdrawal protocols as a neurobiologically informed intervention addressing core regulatory processes.
Researchers found that abstinent smokers have altered brain activity linked to increased pain sensitivity and a need for more postoperative pain relief. The study suggests that nicotine withdrawal affects specific brain regions, leading to higher requirements for pain management in surgery.
A 1-week social media detox in young adults was associated with reduced symptoms of depression, anxiety, and insomnia. The study's findings suggest a potential therapeutic benefit of reducing social media use for mental health concerns.
This cohort study found a high risk of developing functional somatic disorder (FSD) in individuals with a history of sexual assault. The pooled analysis underscores the biopsychosocial consequences of sexual assault and highlights the importance of further research and targeted interventions to address this critical issue.
A new study identifies fatty acid elongase ELOVL5 as a key promoter of inflammation resolution in the lungs. The research reveals that ELOVL5 works through a dual mechanism to dampen inflammatory pathways and generate pro-resolving lipid signals.
A randomized clinical trial found that self-administered hypnosis significantly reduced hot flash scores and daily interference compared to sham hypnosis. The study suggests that hypnosis delivered through audio files is a clinically significant method for reducing hot flashes in postmenopausal women.
Researchers discovered a connection between sugar metabolism and alcohol addiction, identifying ketohexokinase (KHK) as a key enzyme involved in the process. Blocking KHK showed reduced alcohol consumption and liver damage in mice, suggesting a potential new treatment for both conditions.
A recent study published in Chinese Medical Journal reveals that dihydroartemisinin upregulates CHAC1 through H3K9 acetylation modification, inducing ferroptosis in hepatic stellate cells and suppressing liver fibrosis progression. This discovery identifies molecular targets for developing new anti-fibrotic drugs.
Researchers explored the therapeutic potential of cannabidiol for Alzheimer's disease by assessing its effects on immune responses and neuroinflammation. CBD treatment reduced expression of key regulators for neuroinflammation in Alzheimer's mice, associated with less proinflammatory molecules.
Double negative T cells (DNT cells) play an indispensable role in suppressing intestinal inflammation, acting as antigen-presenting cells. Their impaired function may contribute to the pathogenesis of Crohn’s disease, suggesting they could be a potential therapeutic target.
Researchers identified mucins that defend against Salmonella and other bacteria causing diarrhea. Synthetic versions of these mucins could help prevent or treat illness in soldiers or travelers. The study suggests a low-cost solution to a major global health challenge.
A new study found that 80% of participants who reported a change in their smelling ability after COVID-19 scored low on a clinical scent-detection test two years later. Those with a history of COVID-19 may be especially at risk for hyposmia, an issue underrecognized among the general population.
The new journal aims to publish high-quality research on immunity and inflammation, covering all areas of immunology and focusing on the role of inflammation. It seeks to foster a deeper understanding of inflammation's role in immunity and promote innovative approaches to prevent and treat inflammation-related diseases.
This cohort study found that receiving encounters with behavioral health clinicians and psychotropic prescriptions was associated with reduced psychosocial symptoms. The results suggest that expanding integrated pediatric behavioral health care could improve outcomes among vulnerable child populations.
A cross-sectional study found that prenatal depression diagnosis and moderate to severe depression symptoms differ by maternal nativity and racial/ethnic background. Non-U.S.-born mothers tend to have better neonatal outcomes, but this association may not hold true for prenatal mental health conditions.
Home high-intensity aerobic training outperforms home balance training in improving ataxia symptoms, fatigue, and aerobic fitness among those with cerebellar ataxias. Regular training maintained benefits at 1 year.
Researchers found that an astrocytic 'brake' mechanism, fueled by the neurotransmitter GABA, blocks spinal cord repair after injury. Inhibiting this pathway with the MAOB inhibitor KDS2010 enables recovery of spinal cord function in animal models.
High consumption of ultra-processed foods is associated with higher levels of systemic inflammation and a greater risk of cardiovascular disease. The study found that individuals who consumed the most ultra-processed foods had significantly higher levels of high-sensitivity C-reactive protein, a key marker of inflammation.
A cross-sectional study found that greater lean mass and fitness are associated with fewer anxiety and depression symptoms in preadolescent children. Higher visceral adipose tissue, on the other hand, is linked to increased symptoms of both anxiety and depression.
A study found that disaster-induced displacement from home was associated with increased depression and anxiety symptoms, especially among those who never returned home. This highlights the urgent need for mental health care for displaced populations, particularly socially vulnerable groups.
A cohort study found a higher prevalence of eating disorders among adolescents from lower socioeconomic backgrounds. The study suggests that reducing population-level socioeconomic inequalities may aid in preventing eating disorders.
Researchers developed a dynamic nomogram to predict long-term survival in patients with brain abscess, identifying key predictors such as age, Karnofsky performance status, and hemoculture results. The model offers an interactive tool for individualized risk assessment, facilitating better treatment decisions and improving outcomes.