Articles tagged with Cell Growth
A Mount Sinai study reveals that loss of p53 can reorganize Wnt signaling into a radial gradient, allowing mutant cells to expand through normal tissue. The researchers found that the spatial organization of Wnt signaling, rather than its overall activity, plays a critical role in this process.
MIT researchers have found that lung cancers can use two different mechanisms to evade KRAS-inhibiting drugs, with some tumor cells developing resistance by amplifying the KRAS gene and others changing their tumor type, leading to new insights into treatment resistance and potential targets for new drugs.
A research team at KAIST has uncovered the molecular mechanism by which amino acid signals activate cell growth signaling. The findings suggest a potential basis for next-generation anticancer therapies that target abnormal growth signaling in tumor cells.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
TIGIT is a second-generation immune checkpoint that exerts immunosuppressive effects through multiple pathways, promoting a hypoxic tumor microenvironment. Combination with PD-1 inhibitors has shown remarkable promise, improving objective remission rates and progression-free survival.
Researchers identify TGF-β signaling pathway as key regulator of osteoblast quiescence, suggesting its inhibition can aid in reactivation of dormant osteoblasts. Combining TGF-β-blocking antibodies with anti-sclerostin treatment shows promising therapeutic potential for osteoporosis treatment.
Researchers at the University of British Columbia have identified genes and pathways responsible for plant recovery from environmental stress, including cold snaps and flooding. This discovery could lead to the creation of climate-resilient crops that can recover faster and more efficiently after climate events.
Researchers at Weill Cornell Medicine develop a new method to generate functional endothelial cells from adult tissue, potentially enabling vascular grafts and organ transplants. The approach involves using small molecules to trigger cell division without aging or losing function.
Researchers investigated pipetting speed's effect on yeast growth and gene expression, finding it had little to no impact within a tested range. The study provides guidelines for increasing efficiency and reproducibility in robot-based experiments.
Researchers have developed three-dimensional spheroid cultures that better replicate cell-cell interactions and nutrient gradients, leading to a greater understanding of tumour tissue behaviour and drug responses. The study highlights the importance of mimicking tumour architecture in testing cancer therapies.
Research at Max Planck Institute for Dynamics and Self-Organization explores how growth impacts cell migration. The study reveals a critical threshold of motility above which colony growth inhibits cellular movement, with implications for biology, tissue engineering, and medical research.
Researchers from the University of Cincinnati Cancer Center presented abstracts highlighting contrasting effects of a protein on head and neck, breast, and lung cancers. The study found increased levels of IL-9 in patients with head and neck cancer correlated with decreased survival, while elevated IL-9 was associated with smaller tumo...
A new study maps the daily movement of cyanobacteria in Florida's largest freshwater lake, revealing how these harmful algal blooms form and behave. The research provides critical insights into managing the risks associated with cyanobacteria blooms.
A team of researchers has identified a novel oncometabolite that accumulates in tumors and impairs immune cells' ability to fight cancer. The study highlights how the metabolic environment of tumors influences T cell function, opening new possibilities for improving cancer immunotherapy by targeting tumor metabolism.
Engineers at University of Bristol spin-out company Impulsonics have created a technology that can move cells using acoustic waves, enabling critical lab tasks to be carried out on a benchtop device. This innovation has the potential to accelerate drug discovery and unlock personalized medicine screening in clinics.
Researchers at Osaka Metropolitan University identified the CcMCA1 gene as a key player in the development of haustoria, structures that allow Cuscuta campestris to feed on host plants. Suppressing this gene expression can reduce the number of haustoria per centimeter, offering potential for controlling invasive plant species.
A new review highlights how breast cancer cells change their communication and growth patterns, helping tumors survive, spread, and resist treatment. The review explores disrupted signaling pathways, including PI3K/Akt/mTOR and RAS/RAF/MEK/ERK, which can promote tumor progression and resistance to treatment.
Researchers at MIT successfully triggered a key enzyme in starfish egg cells using different patterns of light, prompting predictable movements and contractions. The study provides a new optical tool for controlling cell shape in its earliest developmental stages.
Researchers have discovered a protein called MdfA that enables bacteria to shut down into dormant spores under extreme conditions. This process allows bacteria to survive in uninhabitable places and evade hospital cleaning, making them potentially deadly superbugs.
A new type of antibody that stimulates the immune system to target cancer cells has shown promise in reducing tumor growth in treatment-resistant breast and ovarian cancers. The study found that the antibody, IgE, uniquely stimulated otherwise inactive immune cells to directly target HER2-expressing cancer cells.
A recent study revealed that brassinosteroids are distributed unevenly between new cells formed during cell division, influencing root growth and development. The findings provide a comprehensive understanding of how these hormones regulate plant growth and development at the cellular level.
Researchers have developed ExPOSE, a method that allows for the visualization of plant cells with greater resolution, enabling studies on protein and RNA location, and cellular response. The technique uses protoplasts to overcome cell wall challenges, paving the way for a powerful new toolkit in plant biology.
A study found that soil bacterial communities show increased antimicrobial resistance due to the presence of a predatory bacterium, Myxococcus xanthus. The researchers suggest that exposure to growth-inhibitory molecules released by M. xanthus leads to the enrichment of resistant isolates.
Researchers at Tel Aviv University have developed a novel method to measure PTEN gene activity, which is associated with cancer and autism. This breakthrough may lead to personalized therapeutics and earlier disease detection.
Researchers have discovered several novel downstream p53 targets that could lead to improved cancer therapies. The study highlights the critical role of p53 in preventing cancer and identifies two new genes, ALDH3A1 and NECTIN4, as potential targets for cancer treatment.
Researchers aim to identify key mechanisms and molecular targets to prevent tumor progression in Rhabdomyosarcoma patients. The study focuses on the TAK1 protein, which plays a significant role in regulating cell growth, and its potential inhibition as a therapeutic approach.
Researchers at UCSF used CRISPR gene editing technology to transform ordinary white fat cells into 'beige' fat cells that voraciously consume calories to make heat. Implanted near tumors, these cells outcompeted cancer cells for nutrients, beating back five types of cancer in lab experiments.
Researchers developed a novel microscopy technique to study metabolic changes in individual cancer cells at the single-cell level. They found that radiation treatment caused significant metabolic shifts in head and neck squamous cell carcinoma cells, particularly through the activation of HIF-1α.
Researchers found a genetic change, pR552*, that could give the RB1 gene a new function leading to cancer growth. This challenges the common belief that both copies of the RB1 gene must be damaged for cancer to develop.
Researchers at the University of Pittsburgh have developed a new way to grow T cells that can live longer and better destroy cancer cells in mice. By adding a compound called dichloroacetate to growth media, they created T cells less reliant on glucose and more efficient at using other energy sources.
A review of cell death and aging in cancer research reveals the significance of cellular senescence in promoting cancer growth. The study highlights the potential of various types of programmed cell death, such as necroptosis and pyroptosis, as therapeutic targets against senescent cells.
The Chris Chang Lab develops a copper-detection tool to uncover how copper regulates cell growth in lung cancer. The probe identifies cells with elevated copper levels and reveals a connection between copper and the antioxidant response mediated by NRF2.
Researchers found that heart muscle cells can grow and survive in microgravity, suggesting a new approach to regenerating damaged hearts. The study uses cardiac spheroids to mimic the human heart structure and function, leading to increased survival rates and potential for improved cell therapy.
A recent NUS Medicine study found that a molecule called DUSP6 plays a major role in helping colorectal cancer grow, with higher levels linked to poorer prognosis and decreased survival. Researchers suggest blocking DUSP6 could lead to new therapies for CRC treatment.
A new strategy enhances pharmaceutical production in Chinese hamster ovary cells by knocking out a gene circuit responsible for producing lactic acid. The approach improves growth rates and significantly increases protein yield, overcoming a decades-old challenge in biomanufacturing.
Organoids, derived from stem cells, closely mimic human tissue for biomedical research and drug testing. Standardization is crucial for generating reliable results in organoid construction, requiring approved operating procedures and informed consent from donors.
Researchers found that megakaryocyte conditioned media from younger mice was more effective at promoting blood vessel growth and improving healing. The study provides a potential approach for developing new therapies to speed up fracture recovery in older individuals, reducing pain and improving mobility.
Researchers develop ultrasound-based method to control cell growth and orientation in cultured muscle cells. The technique uses ultrasonication to promote differentiation of myoblasts into myotubes, offering a promising alternative to current methods.
Researchers at Tufts University discovered that TB bacteria maintain a consistent growth rate throughout their life cycle, defying expectations. The study also reveals new growth behaviors of TB bacteria, including the ability to grow from either end after division.
Researchers at Tokyo University of Science have successfully captured viral infection process under a light microscope using the giant Mimivirus. The footage showcases the proliferation of the virus and its release from cells, highlighting its biological significance in ecosystems.
A new University of Cincinnati Cancer Center study reveals how copper helps clear cell renal cell carcinoma cells grow and advance. Copper accumulation is associated with worse outcomes for patients with ccRCC, and it boosts energy and growth in cancer cells.
A new study led by Arizona State University researcher Michael Lynch explores the substantial energy demands required to maintain and evolve multicellular life. Multicellular organisms require a tenfold increase in energy compared to protists, highlighting how respiration and metabolic processes are crucial for advanced life forms.
Researchers successfully immortalized lip cells, enabling the development of clinically relevant lab-based models to test treatments for lip injuries and infections. The 3D cell model was tested with Candida albicans yeast, showing promising results for wound healing and infection studies.
The Graduate Assistance in Areas of National Need program will fund eight doctoral students at WPI, increasing the department's diversity and footprint. The fellowships will help create new career paths in life sciences.
A new co-culture system uses photosynthetic microorganisms to remove waste products and enhance muscle cell growth, resulting in a 30% reduction of lactate and over 90% reduction of ammonia. This innovation provides a low-cost, sustainable alternative to animal serum for cultured meat production.
Researchers used genomic technology to study Marjolin's ulcer, a rare and highly aggressive skin cancer that grows on chronic burn wounds. The study reveals insights into how keratinocytes switch their function to become cancerous, creating a fertile environment for tumor cells to grow and spread.
Researchers at Umea University have discovered how embryonic stem cells transition into specialized cells, highlighting the importance of LSD1 protein in cancer development. The study suggests that targeting only LSD1's enzymatic activity may not be enough for cancer treatments to be effective.
Researchers discovered that dividing bacterial cells adapt to crowded environments by slowing their growth, forming a pattern of concentric circles. This process can inform strategies for controlling the spread of harmful microorganisms, such as in infections or manufacturing.
A team of researchers discovered a mechanism that determines the spiral shape of Rhodospirillum bacteria, revealing a novel link between cell shape and fitness. The study found that an outer membrane porin-lipoprotein complex modulates elongasome movement to establish cell curvature in R. rubrum.
A team of researchers led by Julia Vorholt at ETH Zurich initiated laboratory partnerships between bacteria and fungi to study the beginnings of an endosymbiotic relationship. They found that when certain bacteria are passed on to the next generation of fungi through spores, the fungus adapts and becomes more inhabited.
Researchers at UCSF used cryogenic electron microscopy to study the protein TGF-Beta, which plays a crucial role in development and cancer. They found that TGF-Beta can signal even when bound to a 'straitjacket' within the cell membrane, challenging decades-old dogma on its function.
Researchers propose a new approach to understanding cancer evolution, acknowledging the importance of environmental influences and epigenetic changes. By refining the clonal evolution model, they aim to develop more effective cancer therapies that consider the full complexity of cancer cell evolution.
Terasaki Institute scientists have created a novel bioink derived from egg whites, offering abundant proteins and excellent biocompatibility. This breakthrough technology has the potential to create more accurate tissue models for drug testing and develop functional tissue replacements for regenerative medicine applications.
A study found that space-traveling muscles have impaired regeneration and gene activities associated with sarcopenia. Drug treatment partially prevented the negative effects of microgravity on muscles, suggesting a potential therapeutic approach for astronauts and older adults.
Researchers used interferometry to study biofilm growth and found that the contact angle with the substrate plays a key role in determining fitness. The team discovered that the shape of the biofilm's edge, which resembles a spherical cap, is influenced by this geometry.
Researchers found that metformin increases levels of microRNAs miR-2110 and miR-132-3p, targeting genes PIK3R3 and STMN1 to slow down cancer cell growth and division. This study provides new insights into metformin's molecular mechanisms and its potential as a preventive agent for reducing cancer growth.
Researchers identified protein JUN as a potential therapeutic option to slow tumor growth in prostate cancer, contradicting previous findings that linked high JUN levels to increased tumor growth. The study showed that JUN slows tumor progression and improves immune response, providing a new starting point for therapy development.
Scientists discover Epstein-Barr virus alters gene regulation in nasopharyngeal cancer cells, leading to rapid tumour growth. The study offers new insights into the link between EBV and NPC, shedding light on intricate processes underlying disease progression.
New study reveals two novel mechanisms that contribute to antibiotic resistance in bacteria, accelerating the growth of resistant bacteria during treatment. These mechanisms can occur independently and are linked to increased gene copy number variation and heteroresistance, complicating treatment for patients.
Researchers have successfully grown functional human liver cells in a different species, offering a potential solution to the shortage of donor organs for liver transplants. The breakthrough uses interspecies blastocyst complementation to produce transplantable human liver cells, which can effectively mitigate chronic liver fibrosis.