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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Bacteria found in Alzheimer's brains

Researchers have discovered increased bacterial populations and specific bacteria differences in Alzheimer's brains compared to healthy brains. The findings suggest that bacterial infection and inflammation could play a role in the disease.

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Bacterial classification may be more elusive than previously thought

Scientists have found that random diversification and extinction of cells can organize bacteria into taxonomic units as effectively as traditional ecological forces. This discovery challenges current models of microbial classification, highlighting the need for a reevaluation of the task.

Drug design strategy boosts the odds against resistance development

A new rational drug design technique identifies molecules targeting multiple receptor sites on key cellular proteins, making it challenging for microbes to develop resistance. The technique has been validated and shows potential in battling drug resistance and even cancer cells.

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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.

Rethinking role of viruses in coral reef ecosystems

A new study by San Diego State University suggests that lysogeny, where viruses lie dormant within host cells, may be more prevalent under stressful environmental conditions. This finding has significant implications for understanding degraded coral reef ecosystems and preserving them.

The dangers of money

Researchers found that banknotes harbor a diverse range of bacteria, including pathogens like E. coli and Vibrio cholera. The banknotes also contain higher amounts of antibiotic-resistance genes than other environmental samples, highlighting the potential for currency to pose a health risk.

Biophysics: Conflict or coexistence

A team of biophysicists used experiment and mathematical theory to study the changing composition of a mixed bacterial population. They found that in some cases, a strain with a toxin can outcompete another strain, but this depends on various factors such as the environment and initial inoculum size. The results suggest a complex inter...

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Same but different

A study published in Science reveals how bacteria can exhibit different behaviors despite having the same genes. Researchers found that protein complexes play a crucial role in this phenomenon, and biased partitioning of these complexes can lead to the emergence of extreme phenotypes.

New mechanism to fight multi-resistant bacteria revealed

Researchers identified a compensatory mechanism in bacteria that can be used as a new therapeutic target against multi-drug resistant bacteria. The study found that the pace of adaptation in multi-drug resistant Escherichia coli strains is faster than for strains with single resistance mutations.

Distinct bacterial communities share nutrients for the common good

Researchers found that bacteria in two separate populations can synchronize their oscillations to coordinate nutrient sharing, promoting growth. This communication strategy is similar to engineered systems and allows each community to take turns consuming limited resources, leading to a faster average growth rate.

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Microbiome diversity is influenced by chance encounters

A new study found that chance encounters contribute to variations in human gut microbiome populations, which can influence health and disease outcomes. The researchers used genetically identical worms to model the gut's microbe communities, showing that initial colonization events can lead to dominant populations of bacteria.

Common bacterium may help control disease-bearing mosquitoes

Researchers at Yale University and Vanderbilt University have discovered a common bacterium that can be used to sterilize male insects, potentially controlling disease-bearing mosquitoes and agricultural pests. The discovery of two genes encoded by Wolbachia bacteria can completely sterilize male fruit flies.

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Bacteria sleep, then rapidly evolve, to survive antibiotic treatments

Researchers found that bacteria can quickly adapt to antibiotic treatments by evolving dormancy mechanisms. Once tolerant, they rapidly acquire resistance mutations, making it difficult for antibiotics to kill them. This discovery has important implications for the development of new antibiotics.

Change in astronaut's gut bacteria attributed to spaceflight

Researchers studying NASA astronaut Scott Kelly's gut bacteria found changes associated with spaceflight that reversed upon return to Earth. The study, part of the 'twins' research, also discovered fluctuations in bacterial populations between identical twin brothers Scott and Mark Kelly.

Bacteria communicate to ramp up collective immune response to viral threats

Researchers discovered that bacteria can gauge population density through quorum sensing and boost their CRISPR-Cas immune systems in response, providing new insight into bacterial collective immunity. This ability enables bacteria to preemptively elevate their immunity when most at risk of a virus spreading.

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Bacteria discovery offers possible new means of controlling crop pest

Scientists at Oregon State University have discovered a bacterium that can help control a plant-parasitic roundworm, potentially providing an environmentally friendly alternative to traditional pesticides. The worm, Pratylenchus penetrans, uses more than 150 species as hosts, and the newly discovered bacterium is a strain of Wolbachia.

Dependency can be an evolutionary advantage

Researchers found that bacteria that become dependent on their environment for essential nutrients outperform those that can produce them independently. The study's results suggest that this loss of autonomy may be an evolutionary advantage driving adaptation in bacterial populations.

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ICU patients lose helpful gut bacteria within days of hospital admission

A new study found that ICU patients experience a rapid depletion of health-promoting microbes and an increase in pathogenic strains, leading to worsening dysbiosis. Researchers tracked changes in bacterial makeup over time and compared data to healthy individuals, revealing the critical impact of ICU stays on gut microbiomes.

Calculating solutions to combat Zika

A NSF-funded mathematician is working on a model to track how to fight A. aegypti mosquitoes carrying the Zika virus using Wolbachia-infected mosquitoes, reducing their lifespan by a day or two. The goal is to create an endemic population that can displace the virus-carrying population in the wild.

Bacteria avoid age defects through collective behavior

Researchers discovered that bacteria divide asymmetrically when exposed to stress, accumulating defects in some individuals while others remain young and healthy. This collective behavior allows the bacterial colony to stay young, produce more offspring, and maintain overall health.

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Teamwork enables bacterial survival

Researchers found that strains of E. coli resistant to one antibiotic can protect other bacteria growing nearby, demonstrating a type of mutualism known as cross-protection. This phenomenon allows bacteria to form drug-resistant communities and survive in environments containing both antibiotics.

Bacteria are individualists

A recent study reveals that bacteria can differ significantly in their response to a lack of nutrients, allowing the group to continue growing even when some cells suffer. This phenomenon promotes flexibility and diversity within bacterial populations.

Probiotics protect mice from estrogen deficiency-related bone loss

A new study links gut bacteria to post-menopausal bone loss, showing probiotics can prevent this condition by attenuating inflammation. Treatment with probiotics also reduced bone loss in normal mice, highlighting therapeutic potential for probiotics in osteoporosis prevention.

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Genetic diversity helps to limit infectious disease

Research by University of Exeter academics reveals that genetic diversity in bacterial populations can help control the spread of diseases. By generating a diverse CRISPR-Cas immune system, host diversity limits parasite evolution, leading to rapid extinction of viruses on mixed-population hosts.

Spelling mutations and evolutionary advantages

Researchers discovered that synonymous mutations in genes can significantly impact an organism's fitness and survival. In a study on the bacterium Methylobacterium extorquens, scientists found that highly beneficial synonymous mutations enabled bacteria to quickly evolve and adapt to their environment under strong selection conditions.

Oral bacteria linked to risk of stroke

Researchers have found a significant association between certain oral bacteria and the risk of hemorrhagic stroke. The study suggests that oral health is important for brain health and may play a role in the development of other diseases such as dementia and rheumatoid arthritis.

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Gut environment could reduce severity of malaria

Researchers discovered that gut microbiomes play a role in reducing the severity of malaria. Mice fed yogurt with specific bacteria showed decreased malaria pathology. The study provides a potential new approach to developing treatments for malaria.

Where wood is chopped, splinters must fall

Bacterial restriction-modification systems can overreact, leading to autoimmunity issues, according to a new study published in Current Biology. The researchers discovered that more efficient systems are prone to making mistakes, which can contribute to genetic variation and adaptive evolution.

Once thought unstoppable, bacterial superweapon falters with too many targets

Researchers found that if groups of targeted cells are large enough, the bacterial superweapon T6S can be thwarted. This allows protected interior cells to multiply quickly and replenish the group's numbers, making it impossible for the bacteria to take over. The study provides insight into how cells withstand powerful aggressors.

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Researchers develop antibiotic alternative for wound infections

Researchers at Washington State University have developed an antibiotic-free alternative to treat bacterial infections, using electrical stimulation that kills 99.99 percent of bacteria in 24 hours. The method involves passing an electric current over a film of bacteria, producing hydrogen peroxide as an effective disinfectant.

Viruses flourish in guts of healthy babies

A new study found that viruses flourish in the guts of healthy infants, with diverse viral strains and a dynamic ecosystem of interacting organisms. The researchers discovered viral strains that exclusively kill bacteria, which declines as the babies grow older.

Genetic factors drive roles of gut bacteria in diabetes and obesity

Researchers at Joslin Diabetes Center found that certain gut bacteria strains are associated with insulin resistance and metabolic syndrome in mice models. The team identified three common mouse strains with different microbiota populations, which were affected by diet and genetic background.

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Modified bacteria become a multicellular circuit

Rice University scientists have created a multicellular bacterial circuit that allows bacteria to cooperate and control protein expression. This breakthrough enables the development of biological computers that can be programmed through diet, with potential applications in treating diseases and manipulating the gut microbiome.

Study finds that high fat diet changes gut microbe populations

A high-fat diet changes the populations of bacteria residing in the gut, altering signaling to the brain and leading to overeating. The study found that this shift can cause inflammation in brain regions responsible for feeding behavior, resulting in gut-brain miscommunication and obesity.

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Does Agion silver technology work as an antimicrobial?

Researchers found that Agion silver zeolite technology significantly reduced bacterial populations on door handles, particularly gram-negative bacteria. The study suggests that the technology may be more effective than previously thought, but further research is needed to address concerns about standardization and potential side effects.

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Bacteria cooperate to repair damaged siblings

Researchers discovered that myxobacteria cells can use social behavior to repair damaged siblings by exchanging outer membrane content. This cooperative behavior improves the fitness of the entire bacterial population.

Tortoise approach works best -- even for evolution

A team of researchers found that limiting migrations among populations of bacteria produced better adaptations and allowed for a wider variety of peaks, enabling the organisms to adapt to their environment more effectively. This 'tortoise-hare' pattern highlights the importance of slow and steady evolution in achieving long-term success.

Sony Alpha a7 IV (Body Only)

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The Achilles' heel of antibiotic-resistant bacteria

Researchers identify a time window when moderately resistant bacteria are sensitive to antibiotics, allowing for optimal treatment design. A new approach may help reintroduce antibiotics that were previously disregarded due to treatment failure concerns.

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Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.

New mechanisms of 'social networking' in bacteria

Scientists deciphered bacterial communication mechanisms, revealing new ways bacteria regulate gene expression. Quorum sensing controls a variety of biologically relevant processes, and the study expands our understanding of regulation in Bacillus subtilis.

Unraveling cystic fibrosis puzzle, taking it personally matters

A recent study found that sudden growth of Burkholderia multivorans preceded periods of acute illness in a CF patient. The team used an extensive collection of lung sputum samples to analyze the bacterial community, providing critical context for their research.

Sewage provides insight into human microbiome

Researchers from Marine Biological Laboratory and University of Wisconsin-Milwaukee used sewage samples to compare human gut bacteria with high accuracy, revealing a core set of bacteria linked to obesity levels in cities. The approach provides a non-intrusive way to monitor public health without compromising individual privacy.