Articles tagged with Proteomics
The BRAIN Initiative Cell Atlas Network (BICAN) has published a 3D atlas of the human basal ganglia, a group of nerve cells controlling key functions like learning and movement. This comprehensive database could be used to create personalized therapeutics and treatments for conditions like Parkinson's disease and addiction.
A research team found that increased expression of the lipa gene in Plesiomonas shigelloides is associated with stronger bacterial attachment, greater biofilm formation, and more severe disease symptoms in southern catfish. The findings highlight a potential target for infection control and provide a foundation for investigating the in...
A study validated a proteomics workflow that quantified about 50% more proteins in cervicovaginal fluid samples collected daily from the same women. The method allows researchers to track changes in protein levels from one day to the next, opening up new ways to study fertility and biomarkers of clinical interest.
A new study has identified 17 plasma proteins associated with all-cause mortality in older adults, which also track with measures of biological ageing across multiple organ systems. These proteins, including ERBB1 and MIC-1/GDF15, show associations with mortality risk and biological age across different organ systems.
Researchers developed openDVP to make Deep Visual Proteomics easier to use, adapt and scale. The tool enables spatially mapping thousands of proteins inside cells, preserving their tissue context. This technology deepens understanding of disease development and helps design better disease interventions.
Researchers used palaeoproteomics to analyze ancient proteins in sediments from a 60,000-year-old archeological site in South Africa, revealing the presence of collagen from the common eland. The findings provide new insights into the complex technical and symbolic behaviors of early Homo sapiens.
A molecular atlas of exercise-associated changes in mice reveals distinct responses to exercise varying by tissue, cell type, sex, and circadian phases. The atlas provides a comprehensive resource for understanding systemic molecular adaptations to endurance exercise, enabling the development of personalized exercise strategies.
A new labeling tool has revealed hexokinase-1 as a G-quadruplex binding protein, which may connect metabolism and gene regulation. The method, developed by Tohoku University researchers, overcomes previous limitations and captures unexpected protein interactions.
Tortoise beetles use a yellow pigment gene to create protective spheres for symbiotic bacteria, which are essential for their survival. The spheres are made from a dense, glue-like matrix formed from the yellow protein, and are essential for the bacterium's digestion and survival.
AOCs enable ultrasensitive proteomics and targeted RNA therapy, converting antigen recognition into amplifiable nucleic acid signals. The review explores AOC design and applications in diagnostics and therapeutic delivery, highlighting key barriers to clinical adoption.
Researchers have identified candidate treatment targets for high-grade glioma in children, adolescents, and young adults, with distinct tumor biology and outcomes across patient groups. The study found that kinases, including CDK8, ATM, and ATR, may suppress oxidative phosphorylation and are potential targets for therapy.
Researchers have developed a new method to collect and study salmon lice secretions, allowing for the examination of individual lice and reducing faecal contamination. The study found 148 secretory proteins, 64 of which were detected in each tested condition, potentially representing targets for vaccine development.
A research team has developed a reliable and economical method for studying proteins with sugar molecules attached to them in blood and tissue samples. The method uses commercially available magnetic particles and has the potential to aid in disease diagnosis and treatment.
Researchers developed a method to quantify individual cell damage using molecular markers, enabling detailed analysis of disease progression in tissue samples. This method can distinguish early disease mechanisms and differentiate between patient-specific and general disease progression.
Phages orchestrate an explosion of protein modifications inside host cells to evade bacterial immune systems. The T7 kinase enzyme triggers massive phosphorylation, disabling bacterial defenses. This discovery could lead to novel bioengineering approaches for phage therapies.
Researchers have developed spatialproteomics, an open-source software package that makes it easier to analyze complex tissue images. This framework guides users from raw microscopy images through cell segmentation, annotation, and spatial analysis, standardizing workflows and enabling more efficient and reproducible results.
New study reveals how resistance exercise damages skeletal muscle and triggers a coordinated repair process. The research identifies key proteins involved in this network, providing insights into optimizing training programs for athletes and improving rehabilitation strategies.
Researchers have identified a panel of key proteins in blood that can predict the emergence of ALS symptoms months to years before they arise. This discovery could enable early intervention with preventative therapies.
A three-year project aims to create a new formulation that supports the targeted and less invasive regeneration of injuries affecting intimate tissues. The researchers focus on extracellular vesicles, tiny particles released by cells, to facilitate intercellular communication and tissue regeneration.
A study found that brain immune cells undergo substantial remodeling in midlife, leading to chronic neuroinflammation and potential dementia risk. The research used advanced single-cell analysis techniques to analyze postmortem hippocampal tissue from 40 healthy adults.
Researchers at Sanford Burnham Prebys Medical Discovery Institute found significant sex-based protein differences in lung adenocarcinoma, with 901 proteins varying between male and female patient samples. This study contributes to understanding cancer biology and may benefit physicians and patients.
A new study by Sanford Burnham Prebys found that bolstering the SORLA protein can reduce tau tangle toxicity, a common culprit in Alzheimer's disease and other neurodegenerative disorders. This suggests potential as a therapeutic strategy for treating these conditions.
A new study has identified molecular tumor characteristics that distinguish between different subtypes of diffuse large B-cell lymphoma (DLBCL). The findings suggest that tumors from high-risk patients, referred to as PG4 proteogenotype, are characterized by specific genetic mutations and protein patterns. These characteristics can hel...
A new chemical tagging approach has been developed to accurately sequence short peptides without relying on databases, opening possibilities for food science, nutrition, and biomedical research. The method successfully identified all 132 peptides with zero errors, highlighting its accuracy and reliability.
A recent study found that SNAI1 overexpression drives cellular senescence, ribosome biogenesis, and DNA damage in renal tubular cells, exacerbating kidney fibrosis. The researchers identified 233 proteins with altered expression levels and demonstrated that Snail1 amplifies the senescence-associated secretory phenotype.
Researchers have discovered a previously underappreciated mechanism that helps immune cells respond rapidly to infections by altering RNA splicing. This study provides new insights into immune-mediated diseases such as rheumatoid arthritis and lupus, and may lead to more targeted therapies.
A novel fecal proteomics method confirms orangutan mothers breastfeed their offspring continuously until 6.5 years old. This prolonged breastfeeding supports the high survival of orangutan offspring and contributes to their slow reproductive strategy.
Researchers propose integrating biochemical stabilization, high-throughput screening, AI-based prediction, synthetic biology, and spatial omics to map signaling networks. This integration could improve how researchers understand physiology across tissues and organs.
Research suggests that aging immune systems compromise the body's ability to control Mycobacterium tuberculosis during treatment with rifampicin and isoniazid. The study identified age-associated immune abnormalities linked to impaired bacterial clearance, including chronic inflammatory signaling and mitochondrial dysfunction.
A team of scientists has uncovered more than 1,700 new proteins known as peptideins, which are smaller than traditional proteins and may have unique biology. These proteins were found in the 'dark proteome', a section of DNA previously overlooked, and could have implications for human diseases like cancer.
A massive study involving 78,000 participants reveals new insights into the genetic regulation of blood proteins and their role in diseases. The findings hold potential to transform our understanding of different diseases and inform drug development.
Researchers discovered over 400 proteins with modified states affecting drug binding, including KRAS and NPC2. PTMs may influence therapy selection and combination, offering new opportunities for targeted treatments. The study could reshape cancer treatment and lead to more effective therapies.
A new study found that microbial proteins make up to 11% of the total protein content in fermented foods and comprise 60% of identified proteins. These microbes convert raw substrates into nutritious products, influencing gut physiology and potentially impacting health outcomes.
Scientists at MUSC Hollings Cancer Center mapped the architecture of healthy breast tissue to uncover early biological changes linked to cancer risk. The study found that body weight and breast density shape the underlying structure of breast tissue, offering new clues about how cancer risk may develop long before tumors form.
Advances in high-throughput proteomics and artificial intelligence are transforming biomarker discovery, disease prediction, and drug development. Proteomic technologies enable comprehensive snapshots of physiological and pathological states, driving breakthroughs in early diagnosis and personalized treatments.
A team led by Jiefu Li developed a new method to examine proteins lining the inside surface of blood vessels, revealing two proteins and pathways that play a role in opening and closing the blood-brain barrier. This discovery could help scientists understand how the barrier functions and develop better ways to deliver medicines for neu...
An international team is calling for a coordinated effort to map gene expression across every cell type and developmental stage of wheat. Spatial omics technologies can transform wheat research by revealing how individual cells respond to stress, regulate grain development, and control yield-related traits.
Researchers have discovered a new biomarker for immunoglobulin A (IgA) nephropathy, which is an autoimmune disease that can lead to kidney failure. Complement pathway proteins, including CFHR1, were found to be overexpressed in patients with IgA nephropathy, suggesting a potential treatment target and diagnostic marker.
Researchers discovered that PFK, a key sugar-processing enzyme, has a hidden function controlling cell division by unwinding RNA and promoting gene translation. The enzyme's ability to bind and unwind RNA was found to be crucial for cell cycle progression, with cells lacking PFK2 showing slowed growth and division issues.
Researchers at OIST identified 80 plasma membrane repair proteins in budding yeast, revealing a coordinated sequence of molecular events. The study provides a foundation for investigating plasma membrane repair mechanisms in higher eukaryotes, including human cells.
Researchers at Boston Children's Hospital have developed a novel mass spectrometry tool called FLEXITau to analyze brain tissue from 203 patients with various tauopathies. The study identified 145 post-translational modifications and 195 cleavage sites across tau, providing a precise molecular roadmap for diagnostics and drug development.
Researchers developed a new tool to track changes in the synaptic proteome over time, correlating changes to synaptic dysregulation and synapse loss. The results suggest that toxic tau oligomers impact postsynaptic structures first, leading to a dynamic cascade of events that contribute to neurodegeneration.
A new study has created a comprehensive atlas of lysosomal proteins in the brain, shedding light on the functions and dysfunctions of these cellular components. The data, which includes 790 proteins associated with lysosomes, could help scientists better understand neurodegenerative diseases such as Alzheimer's and Parkinson's.
A new blood test has identified a protein signature linked to cancer in patients with non-specific symptoms. The test distinguishes cancer from other conditions with high precision and can help prioritize patients for further diagnostics.
Researchers at Cold Spring Harbor Laboratory have developed a new technique to improve mass spectrometry, enabling better drug target discovery and tumor analysis. The innovation increases sensitivity by breaking down scans into smaller bins, allowing for more accurate measurement of differences in concentration.
A recent study from Medical University of South Carolina research team challenges the notion that hypermobile Ehlers-Danlos Syndrome is an isolated connective tissue disorder. The studies reveal a genetic variant associated with the disease and disruption of the immune system, which may be the underlying cause. This new understanding a...
The C-COMPASS tool uses neural networks to predict protein localizations and incorporates proteome data for reproducible analyses. It enables the exploration of spatial lipidomics by combining proteome and lipidome data, revealing changes in lipid distribution associated with metabolic perturbations.
The Spatial Touchstone project has developed a standardized framework for spatial transcriptomics analysis, providing critical metrics and quality control measures. The repository includes curated datasets from six tissue types, paired with an open-source software tool to compare samples across institutions.
Researchers identified 251 genetic variants that significantly affect circulating protein levels in Greenlanders, showing stronger genetic control over certain proteins in the Inuit population. The study uncovered 70 previously unreported associations and found links between Arctic-adapted genes and disease development.
Researchers have made breakthroughs in overcoming immune reactions behind human rejection of transplanted pig kidneys, paving the way for more successful clinical trials. The study reveals three major immune responses against the pig kidney and identifies potential biomarkers as early-warning systems for rejection.
EMBL scientists introduce HT-PELSA, a high-throughput adaptation of an earlier tool that detects protein-ligand interactions. This breakthrough enables researchers to analyze hundreds of samples in parallel while maintaining sensitivity and reproducibility.
Researchers mapped dynamic glycosylation patterns in rat serum proteins, revealing distinct cell-type-specific profiles. Female rats exhibited pronounced daily fluctuations in sugar structures, suggesting regulation by hormonal and circadian cycles.
Researchers developed innovative blood-based biomarkers to predict long-term blood pressure improvements after bariatric surgery. The study analyzed pre-surgery blood tests and identified top 10 molecules linked to improved blood pressure outcomes.
New research papers from Mount Sinai present unprecedented evidence that brain tissue from living individuals has a unique molecular character, differing significantly from postmortem samples. These findings challenge the conventional practice of using postmortem brain tissue for studying the human brain and its diseases.
A new study from the University of Copenhagen enables researchers to investigate the cause of heart diseases by analyzing thousands of proteins in heart tissue. This groundbreaking method reveals molecular patterns characteristic of heart diseases.
Researchers at KTH Royal Institute of Technology and Stanford University have identified hundreds of proteins in primary cilia, which can lead to disorders affecting the brain, eyes, kidneys, and bones. The study's findings may contribute to improved diagnosis and treatment of rare diseases, including ciliopathies.
Researchers identified 33 plasma proteins that differ significantly in patients with ALS, suggesting the disease could be detected up to 10 years before symptoms appear. Machine learning models showed strong performance in separating ALS cases from non-ALS cases, with an accuracy of over 98.3%.
Saiful Chowdhury's five-year project aims to create a blueprint of how immune proteins work, which could lead to new medical treatments for cancer and inflammatory diseases. The team will use advanced proteomics technologies to map protein interactions and modifications.
Researchers used AI to identify shared biological features between aging and fibrosis, finding new potential targets for therapy. The study found that IPF is not simply accelerated aging, but a unique biological condition shaped by age-related dysfunction.
Researchers found that children with stable gut microbiomes tend to have better growth outcomes. The study created the first-ever pediatric undernutrition microbial genome catalog, which can predict and prevent malnutrition. This discovery opens the door to new diagnostics and therapeutics for addressing global child stunting issues.