Articles tagged with Brown Adipose Tissue
Researchers at the University of Basel found that a drug called fenoterol increases energy expenditure in humans without activating brown fat. This suggests that a more complex regulation of brown fat in humans may be at play, and could have implications for future obesity treatments.
Researchers found that energy-demanding tissues have larger macrophage crews to manage waste, with the number of macrophages tracking mitochondrial activity and waste production. This system is critical for tissue health and function, and may help preserve tissue function as we age.
A study found that tirzepatide significantly increases brown adipose tissue activity and volume in premenopausal women with obesity. The medication also shows potential signs of converting white subcutaneous fat into more metabolically active 'beige' fat.
Researchers discovered brown adipose tissue protects against atherosclerosis and inflammation in humans with obesity, showing lower arterial inflammation and healthier blood profiles. Higher brown fat activity correlates with reduced vascular inflammation and improved cardiovascular health.
Researchers have identified a key protein that activates brown fat by expanding blood vessels and nerves, which can regulate body temperature and is linked to weight loss. The findings suggest a new approach to treating obesity that deviates from suppressing appetite.
A study by UNICAMP researchers found that women with a history of yo-yo dieting have increased body fat, worse metabolic indicators, and reduced brown fat activity. The 'yo-yo effect' impairs metabolism and reduces BAT activity in women.
Researchers found that the loss of beige fat increases the sensitivity of blood vessels to angiotensin II, leading to hypertension. The team identified QSOX1 as a key enzyme involved in this process, which is normally kept off by beige fat.
Long-term exposure to fine air pollutants like PM2.5 can impair metabolic health by disrupting the normal function of brown fat through complex epigenetic changes. The study identified two enzymes, HDAC9 and KDM2B, as key drivers of this process.
A new study found that adipose-derived extracellular vesicles, tiny cell messengers in obese individuals, accelerate the buildup of amyloid-β plaques in the brain, a hallmark of Alzheimer's disease. Researchers hope targeting these tiny cell messengers could reduce the risk of Alzheimer's disease in people with obesity.
Researchers at WashU Medicine discovered a novel way brown fat burns calories and improves metabolic health by exploiting cellular parts called peroxisomes. Mice with increased peroxisome activity showed improved insulin sensitivity and weight control on high-fat diets.
IRB Barcelona researchers discovered a new strategy to combat obesity by activating brown fat, boosting energy expenditure and improving metabolic health. The approach, driven by Neuritin 1 protein, increased energy burning without affecting food intake or physical activity.
A synthetic molecule called Pep19 has been shown to reduce visceral fat and improve sleep quality in overweight adults, with no side effects observed. The study involved 24 volunteers who took either a placebo or Pep19 in capsules, and found a 17% reduction in visceral fat and improved sleep quality in those who received the molecule.
Researchers uncover a critical endocrine link between brown adipocytes and pancreatic β-cells, revealing the ZNF638-RBP4-retinol-ATRA pathway's role in T1D pathogenesis. Targeting this axis may halt disease progression.
Researchers at Weizmann Institute of Science discovered that nerve cells can sense mechanical forces in fat tissue, regulating brown fat activity and influencing energy balance. Mice lacking this sensing ability were resistant to obesity and metabolic conditions.
Researchers discovered a specific gene-lacking mouse model with unusually potent brown fat tissue, expanding lifespan and increasing exercise capacity by 30%. The team is working on a drug to mimic these effects in humans. Deliberate cold exposure can also increase brown fat naturally.
A new mechanism by which brown fat is converted into heat has been identified, revealing a potential target for treating obesity and related metabolic diseases. The MCJ protein plays a crucial role in this process, protecting against health problems associated with obesity such as diabetes and increased blood lipids.
Researchers found that brown adipose tissue enhances exercise endurance and supports healthy aging by improving blood circulation and reducing cellular stress. The study suggests that treatments mimicking BAT's benefits could lead to innovative therapies for improved energy levels and heart health.
Researchers from Kumamoto University identified SerpinA1 as a key regulator in combating obesity and enhancing glucose metabolism. The study found that activating brown adipose tissue could pave the way for innovative treatments for diabetes and metabolic disorders.
Adipo Therapeutics' lead product ADPO-002NP shows promising results in increasing energy expenditure and improving insulin resistance by browning white adipose tissue. The company is now raising $8 million to move the treatment to first-in-human Phase I clinical trials.
Researchers at Terasaki Institute have developed simvastatin-loaded nanoparticles to target adipose tissue inflammation, promoting fat tissue browning and weight loss. The treatment effectively inhibits obesity-related inflammation, controlled white fat production, and demonstrated strong anti-inflammatory effects.
Research reveals a link between menopausal hot flashes, increased brown adipose tissue activity and childhood cold exposure. Women with higher BAT activity are nearly three times more likely to experience bothersome hot flashes.
A team of scientists from Duke-NUS Medical School has identified interleukin-11 as a principal factor in ageing, linked to increased fat accumulation and muscle loss. Blocking the effects of IL11 could potentially increase healthy lifespan by up to 25%.
Researchers at UCSF have discovered a way to turn ordinary white fat cells into beige fat cells that burn calories, opening the door to developing new weight-loss drugs. The approach uses a protein called KLF-15 and may avoid side effects associated with current treatments.
Research from Stockholm University reveals that marsupials possess a not fully evolved form of brown fat, a crucial finding for understanding the origin and regulation of this heat-producing organ. The study suggests that the gene networks required to enable thermogenesis existed before the divergence of marsupials and placental mammals.
Research published in the Journal of Investigative Dermatology reveals that UV exposure increases energy expenditure by inducing the 'browning' of subcutaneous fat, thereby preventing weight gain. This breakthrough discovery opens up new possibilities for treating obesity and metabolic disorders.
Researchers from Denmark and Germany found a protein that switches off brown fat shortly after activation, limiting its effectiveness as a treatment for obesity. Blocking this protein could lead to promising strategies for safely activating brown fat and tackling weight loss.
Researchers found that MAFB inhibits the expression of inflammatory cytokine IL-6, reducing sympathetic nerve fiber density and impairing thermogenic capacity. This regulation plays a key role in maintaining body temperature in cold environments.
Brown fat cells convert energy into heat, protecting against cardiovascular diseases. Researchers discovered a new protein, EPAC1, that increases brown fat mass and activity, offering a potential target for weight loss therapies.
Researchers tested infrared thermography protocol, but found it unreliable for measuring brown adipose tissue activity. The team suggests alternative methodologies to study links between thermoregulation and social behaviors.
Researchers found that thyroid hormones of the mother during pregnancy affect the later activity of brown adipose tissue in offspring. High maternal thyroid hormone levels were associated with more active brown fat in offspring.
A UCLA-led team has discovered the nerve supply that activates brown adipose tissue, a potential key to treating obesity. The study found nerve branches in all eight cadavers dissected, which may lead to using nerves to stimulate BAT activity for weight loss.
Researchers found a significant association between brown adipose tissue activity and bothersome hot flashes during the coldest months of the year. The study suggests that declining estrogen levels may lead to changes in body core temperature, triggering sweating responses.
A new model for producing human brown fat cells in vitro has been developed, providing a potential solution for treating obesity and type 2 diabetes. The researchers identified key cellular signaling cues that lead to brown adipocyte formation and successfully reproduced this process in human pluripotent stem cells.
Researchers found that cold exposure increases the secretion of miR-378a-3p by brown adipose tissue, which stimulates hepatic gluconeogenesis. This process is essential for regulating whole-body glucose homeostasis during cold stress.
Scientists at the University of Copenhagen discovered a new type of fat cell called SWAT cells that provide structural integrity to adipose tissue. These flexible cells can differentiate into various types, including fat cells and progenitor cells, suggesting a crucial role in adapting to metabolic conditions.
Researchers found that women with higher-quality cardiovascular fat during midlife had stronger long-term memory and lower inflammation, while those with lower-quality fat had worsening working memory. The study suggests that taking care of heart health during menopause may protect brain health and reduce dementia risk.
Researchers have unlocked insights into how brown fat tissue can be harnessed to combat obesity and remove glucose from the blood. The study used a cryogenic electron microscope to view mitochondrial uncoupling protein 1 in atomic detail, revealing potential new ways to promote weight loss.
A new study reveals the molecular structure of UCP1, allowing scientists to develop therapeutics that activate it to burn excess calories. This breakthrough could combat obesity and related diseases like diabetes by activating brown fat tissue.
A new study suggests that cold exposure in the morning may be more effective at boosting metabolism and burning fat than in the evening, especially in men. In women, however, there was no significant difference in response to cold exposure times, but they were more tolerant of cold in the morning.
New research suggests a way to ward off age-related weight gain by stimulating beige fat cells. Beige fat has thermogenic properties that can reduce blood sugar and fatty acids causing heart disease. The study identifies a specific signaling pathway responsible for suppressing beige fat formation in older mice.
Researchers found that Sirtuin 7 regulates brown adipose tissue functions, leading to suppressed energy expenditure and thermogenesis. The study reveals a molecular pathway involving protein deacylation and mRNA binding, which will have implications for treating hypermetabolic conditions like cancer and obesity.
Researchers aim to develop a drug that enhances brown adipose tissue response to cold exposure, potentially treating hypothermia and arctic exploration challenges. The new screening method could also optimize drug development for diseases and infections, reducing costs and time.
A randomized controlled trial found that daily almond supplementation increased the beneficial fat molecule 12,13-DiHOME in blood plasma after intense exercise. This increase was associated with reduced muscle damage and fatigue, as well as improved recovery from exercise. The researchers suggest that polyphenols in almond skin may be ...
Researchers at Salk Institute discover thousands of previously unknown microproteins in brown and white fat tissue, finding that one, Gm8773, increases feeding activity in mice. This discovery could lead to the development of a therapeutic to promote weight gain in certain disease situations.
Researchers at Karolinska Institutet discovered that SARS-CoV-2 infection triggers blood vessel formation in fat tissues, leading to thermogenic metabolism and significant weight loss. Blocking this process with an antiangiogenic drug restored weight loss in mice and hamsters infected with the virus.
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
The study demonstrates that Wilms'tumor 1-associating protein (WTAP) plays an essential role in the postnatal development and maturation of brown adipose tissue. WTAP expression is significantly increased in BAT after birth, and its deletion impairs postnatal development and leads to cold intolerance and reduced energy expenditure.
A team of scientists at Scripps Research and Calibr discovered a naturally occurring metabolite called myristoylglycine that can convert white fat cells into brown fat cells, potentially treating obesity and related diseases. The breakthrough uses a novel drug discovery method to identify endogenous metabolites with therapeutic potential.
A new study at the Turku PET Centre discovered that shorter daylight hours increase opioid receptor levels in brown fat of rats. This complements previous findings on day length modulating opioid receptor levels in brain emotional circuits.
A scientific review found that cold water swimming can reduce 'bad' body fat and improve insulin sensitivity. However, the health benefits are uncertain due to limited study quality and variability in participant profiles.
Researchers at IRB Barcelona have discovered a key mechanism behind the formation of brown adipose tissue, which is essential for preventing obesity. The study found that the NCOR1 protein is degraded through autophagy to ensure correct development of brown adipose tissue cells.
Researchers found that endothelial cells in blood vessels drive the body's metabolism and produce nitrous oxide to regulate brown fat production. This discovery reverses long-held ideas about the relationship between diabetes, fat and cardiovascular disease.
A study found that cold temperatures activate brown adipose tissue that competes with tumors for glucose, inhibiting tumor growth and prolonging survival. Researchers suggest that cold therapy could be a promising approach to cancer therapy.
A new molecule, inosine, has been identified as a key booster of fat burning through activation of brown fat cells. Studies have shown that inosine can increase energy consumption and protect against diabetes in mice fed high-energy diets.
Researchers at Joslin Diabetes Center and Brigham and Women's Hospital found that cold exposure can resolve obesity-induced inflammation while improving insulin sensitivity and glucose tolerance in diet-induced obese mice. Brown adipose tissue is activated to produce anti-inflammatory molecules, including Maresin 2.
Scientists at CNIC discovered a complex network between liver tissue connections that allows the liver to regulate body temperature. The secretion of IL-12 by liver-infiltrating macrophages blocks FGF21 production, reducing heat generation by brown fat in mice.
A study found that higher levels of active brown adipose tissue are associated with early metabolic dysfunction and pre-cooling glucose, insulin, thyroid stimulating hormone, and triglyceride levels. Activated brown fat was recruited to counteract 'pre-prediabetic' states, potentially serving as a first-line protective mechanism.
A novel therapy using sustained release of nitric oxide has been shown to ameliorate obesity and Type 2 diabetes in mice fed a high-fat diet. The therapy was found to decrease body weight, improve glucose tolerance, and stimulate the browning of adipose tissue.
A study at McMaster University found that brown adipose tissue (BAT) is less active in boys with obesity compared to their normal-weight peers. The research team used MRI scans to measure BAT activity in response to a cold stimulus, revealing reduced activity in obese boys.
Researchers found that dietary intake of flavan-3-ols activates brown adipose tissue, leading to increased heat production and fat burning. Long-term consumption of flavanol-rich foods may also lead to the development of a healthier metabolism.