Articles tagged with Endocrine System
Researchers found that an approved antifibrotic drug, finerenone, can reduce ovarian fibrosis and promote follicle growth in women with premature ovarian insufficiency. Clinical trials showed that finerenone improved follicle development and mature oocyte quality in women with POI.
The Alliance for Clinical Trials in Oncology will host a webinar highlighting recent clinical advances in breast cancer, multiple myeloma, and leukemia. Researchers will present key findings from ASH and SABCS meetings, impacting treatment outcomes.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
Exposure to single and mixtures of perfluoroalkyl substances (PFAS) was associated with higher odds of endocrine disruption (ED) among women. Certain PFAS compounds, particularly n-PFOS, were found to disrupt endocrine function and harm health.
The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.
Researchers discovered that pancreatic tumors form pseudosynapses, exploiting the body's nervous system to drive tumor growth. Calcium waves triggered by glutamate binding promote metastasis and cancer progression.
A study by the Gerald P. Murphy Cancer Foundation's Center for Exceptional Longevity Studies found that retaining gonad function can significantly impact frailty mortality risk. Male dogs with shortest testis exposure had high mortality risks, while those with longest gonad exposure showed no consequence of increasing frailty.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
The Kavli Foundation and NSF have announced new grants to explore how nervous systems respond, resist, or recover from the challenges of a changing world. This research aims to uncover fundamental principles of neurobiology and reveal how animals adapt cognitively and behaviorally to a changing world.
A study published by The Endocrine Society found that obesity and early type 2 diabetes in adolescence can interfere with bone development, potentially increasing the risk of fractures and osteoporosis later in life. Researchers followed 48 teenagers for a year, finding that teens with obesity and type 2 diabetes showed less improvemen...
Despite supply shortages and insurance coverage obstacles, patients taking GLP-1 medications achieve clinically significant weight loss when paired with intensive lifestyle interventions. The study found that consistent medication courses combined with lifestyle changes and support remain the most effective weight-loss program option.
A study of over 7,600 Brazilian women found that early menarche increases risk for metabolic and heart problems, while late menarche may protect against obesity but increase certain heart issues. Understanding age at first period can help doctors identify high-risk patients and guide personalized screening and prevention efforts.
A study found that consuming aspartame, sucralose, glycyrrhizin and added sugars may increase the risk of early puberty in children, especially those with genetic traits. This association was strongest for central precocious puberty, a condition linked to emotional distress and metabolic disorders.
An animal study found that early-life exposure to endocrine-disrupting chemicals can alter the brain's pathways controlling reward preference and eating behavior. Male rats showed a temporary preference for sugary solutions, while female rats gained weight after preferring high-fat food.
A new study presents preliminary data suggesting that grandparents' exposure to endocrine-disrupting chemicals may impact the age when girls get their first period. The research found that certain chemicals in both mothers and fathers were linked to earlier puberty, with stronger effects seen in granddaughters.
A new study found that intermittent energy restriction significantly improved fasting blood glucose and triglycerides, while also increasing insulin sensitivity. The IER group showed the greatest advantages in reducing these markers compared to time-restricted eating and continuous energy restriction groups.
Researchers found that tirzepatide reduced body weight and body fat by approximately 20% in mice, resulting in a significant reduction of tumor volume. The study suggests that this new anti-obesity drug may have a beneficial impact on breast cancer outcomes.
A real-world study of 120 postmenopausal women found that using tirzepatide and menopause hormone therapy simultaneously led to superior total body weight loss percentage compared to using tirzepatide alone. This combined treatment also resulted in a higher percentage of participants achieving at least 20% weight loss.
A long-term study of healthy men found that minimally elevated blood sugar levels can lead to declines in sperm movement and erectile function. The study suggests that lifestyle choices and medical interventions can help preserve or revive reproductive health in aging men.
Research suggests that thyroid hormone treatment can improve gut health in individuals with hypothyroidism, particularly those with autoimmune thyroiditis. The study found a higher prevalence of SIBO in people with hypothyroidism compared to controls, which was mitigated by thyroid medication.
Researchers compared CECS and EES techniques for treating giant and irregular pituitary tumors. The study found that CECS resulted in a higher gross tumor removal rate (66%) and lower postoperative bleeding rates compared to EES.
Sriram Gubbi, a physician-scientist at NIDDK, won the Endocrine Society's 2025 Endocrine Images Art Competition with his image 'The Cosmic Bubble', showcasing follicular thyroid carcinoma cells. The competition celebrates the beauty of endocrine science through microscopy.
A comprehensive review article synthesizes decades of research on stress hormone systems in primate brains, revealing key differences between rodents and primates. The findings highlight the importance of considering anatomical differences when developing treatments for stress-related psychiatric disorders.
The EndoCompass project aims to guide future studies and funding programs with a research roadmap for better hormone health in Europe. Manuel Heitor will share his perspective on the future of research in Europe, emphasizing the need for greater investment and coordination.
Researchers developed tiny human ovary organoids using stem cells to understand gonad development and disease. The models replicate key aspects of ovarian follicles, offering a powerful platform for studying gene function in a controlled environment.
Research finds high levels of phthalates in mothers' urine associated with shorter anogenital distances in 3-year-old boys and girls, a marker of reproductive health and hormone disruption. The study emphasizes the need for preventive measures to protect vulnerable groups from endocrine-disrupting chemicals.
Research suggests that antibiotics taken during infancy, especially in the first three months, may lead to earlier onset of puberty in girls. The study, which analyzed data on over 322,000 children in South Korea, found a significant association between early antibiotic exposure and increased risk of central precocious puberty.
The event aims to create a positive scientific and policy legacy from the Congress in Denmark, Europe, and internationally. The conference will focus on key research presented at the Joint Congress and future priorities from the EndoCompass Research Roadmap.
The European Society of Endocrinology and the European Hormone and Metabolism Foundation launch a global campaign to raise awareness about hormone balance and its impact on chronic diseases. Small steps can make a big difference in improving hormone health.
Researchers found that the current standard monitoring time of one-and-a-half to two months following surgery is too short to accurately identify recurrence and inform treatment decisions. Monitoring PSA levels for at least three months can avoid overtreatment and mislabel patients as having recurred.
Researchers developed a hybrid bioink that maintains physiological properties of adipose tissue, promoting differentiation and regeneration. Bioprinted adipose tissues promoted wound healing in mice by inducing re-epithelialization, tissue remodeling, and blood vessel formation.
Researchers discover immune cells regulate blood sugar levels by stimulating glucagon production in the pancreas. This complex neuroimmune-hormonal circuit reveals a new way the body maintains stable glucose levels, especially during periods of low energy.
Christopher Kassotis, a Wayne State University assistant professor of pharmacology, has been recognized for his outstanding work on endocrine disruption research. His research focuses on identifying and characterizing environmental chemicals that impact human and animal health.
A new animal study published in the Journal of the Endocrine Society found that early life exposure to polychlorinated biphenyls (PCBs) may lead to behavioral problems in rats. PCBs, which have been banned for decades, can reprogram a developing neuroendocrine system and cause developmental and hormonal changes.
Scientists have developed a new organoid that includes all three key cell types in the pancreas, allowing for a clearer understanding of its early development. The research discovered a new stem cell type that can develop into these cells, and found differences between human and mouse pancreatic development.
A nationwide study found that Swedish young men with delayed puberty are more likely to use healthcare services later in life. They were also more likely to be admitted to hospital and prescribed medications, indicating potential long-term health consequences.
Dr. Reichlin's groundbreaking work on brain-hormone interactions and his influence on generations of endocrinologists are being celebrated through a Festschrift series in Brain Medicine. The series explores multiple facets of his contributions, including pioneering work on hypothalamic control of pituitary function and early recognitio...
The Endocrine Society's new statement highlights research gaps on opioids' effects on the endocrine system, which can lead to conditions like male hypogonadism and secondary adrenal insufficiency. Clinicians need to monitor patients using opioids for signs of these health consequences.
A study published in the Chinese Medical Journal projects a significant rise in global thyroid cancer burden, with 821,214 new cases and 47,507 related deaths reported worldwide in 2022. The incidence is expected to increase by 44.1% from 2019 to 2030, with women experiencing higher rates than men.
A study from Goethe University Frankfurt reveals that venomous crustaceans, specifically remipede crabs in Mexican cenote caves, contain a variety of toxins with pharmacological potential. The xibalbines peptides effectively inhibit potassium channels and activate signaling pathways involved in pain sensitization.
Research highlights the need for further study on the impact of sustained heat exposure on hormone release and action. Heat exposure is associated with decreased fertility, increased risks of pregnancy complications and menopause symptoms, as well as worsened conditions like thyroid disorders and diabetes mellitus.
Researchers have identified a novel target downstream of parathyroid hormone signaling that suppresses bone formation. Gprc5a negatively regulates osteoblast proliferation and differentiation by partially suppressing BMP signaling, potentially increasing teriparatide effectiveness in non-responding patients.
A study found that patients with thyroid eye disease who received teprotumumab infusions maintained efficacy 51 weeks after treatment. Nearly two years later, 82% of patients did not require additional treatment for their condition.
The duo won the competition with an image of an astrocyte cell expressing type 2 deiodinase, a thyroid hormone-amplifying enzyme. Their work highlights the importance of thyroid hormone in brain development and neuron function.
The Joint Guideline provides guidance on diagnosing and treating GC-AI, a condition affecting at least 1% of the global population. The guideline aims to improve patient care and outcomes worldwide.
Researchers discovered that people with hypothyroidism are more likely to have a type D personality, which is characterized by pessimism and negative emotions. Those with both conditions experienced high levels of anxiety, depression, and dissatisfaction with treatment, highlighting the need for further research to improve outcomes.
A recent study published in Hypertension reveals that aldosterone-producing adenomas are composed of multiple cell types that work together to promote tumor growth. The research identified two distinct cell fates involved in hormone production, with cells expressing genes associated with aldosterone synthesis and cortisol production.
A new study by UCL researchers found that financial stress is detrimental to biological health, disrupting the communication between immune and neuroendocrine systems. This can lead to disease, including cardiovascular disease, depression, and schizophrenia.
The American Heart Association and Neurocritical Care Society emphasize the need for improved critical care management of patients after cardiac arrest. The consensus statement highlights gaps in knowledge, particularly in areas like neurological, cardiac, and gastrointestinal care.
Researchers identified specific blood biomarkers that can accurately identify patients with long COVID, revealing distinct immune and hormone function differences. The study also found abnormal T cell activity, reactivation of latent viruses, and reduced cortisol levels in patients with long COVID.
Researchers establish a direct link between Covid-19 and Alzheimer's disease, attributing the connection to RAS overactivation caused by SARS-CoV-2 virus. This dysfunction leads to increased b-amyloid protein accumulation, impairing brain cell synaptic connections and cognitive functions.
The use of alternative thyroid hormone treatments is on the rise for hypothyroidism patients. A study found that desiccated thyroid extract (DTE) prescriptions have doubled over a decade, while T3 therapy has seen a significant increase in rural areas. Access to endocrine care may contribute to these disparities.
A new study suggests that eating more calories earlier in the day may improve metabolic health by reducing blood sugar fluctuations and inflammation. The study found that participants who followed an early time-restricted feeding pattern experienced a decrease in time above normal blood glucose levels, thereby improving metabolic health.
Researchers found that glial cells in the gastrointestinal tract respond to stress signals from the central nervous system, leading to inflammation and exacerbating IBD symptoms. Chronic stress can impair treatment efficiency for IBD patients using steroids.
High levels of cortisol during the third trimester of pregnancy have been linked to improved speech and language skills in young children. Research found that boys exposed to high cortisol had better word-saying abilities, while girls showed enhanced understanding skills.
A new computational model suggests that reducing hormone doses in contraceptives could effectively suppress ovulation. The model found that hormone doses could be lowered by up to 92% in estrogen-only contraceptives and 43% in progesterone-only contraceptives, while still preventing ovulation.
The Endocrine Society advocates for a personalized approach to telehealth visits in endocrine care. This policy perspective highlights the benefits of incorporating telehealth into care plans, including increased convenience and reduced disparities in healthcare access.
Mutations in EnhP disrupt a non-protein coding gene, causing pancreatic malformations and diabetes. The study sheds light on the hierarchical operation of enhancers in gene regulation.
The WVU program trains next generation of toxicologists to collect, analyze air samples from mining, fracking sites, using the university's Inhalation Facility. Students will work with preceptors from various fields to investigate health effects of inhaling toxicants.
A Phase 3 study found fezolinetant to significantly reduce the frequency and severity of moderate-to-severe vasomotor symptoms associated with menopause. The treatment also improved sleep disturbances, supporting its use for treating moderate-to-severe hot flashes.