Research on muscle biology and repair. Covers tissue maintenance, Parkinson's protection, repair-cell preservation, and muscle strength with age.
Researchers discovered that declining cardiolipin levels in aging muscle mitochondria trigger a defense mechanism to protect cells from ROS damage. By mimicking this decline in young mice, they found that restoring cardiolipin levels can reverse muscle wasting and prevent early deaths.
A randomized clinical trial found that supervised physical therapy after ACL surgery yielded greater improvements in pain, function, and muscle strength compared to a self-directed exercise program. Researchers concluded that supervised exercise therapy combined with education offers meaningful short-term benefits for young adults with...
Research shows ultrasound stimulation can reduce passive stiffness in the soleus, a deep calf muscle, suggesting potential for non-invasive management of deep muscle stiffness. The technique also shows promise for preventing sports-related muscle injuries.
Researchers found that energy-demanding tissues have larger macrophage crews to manage waste, with the number of macrophages tracking mitochondrial activity and waste production. This system is critical for tissue health and function, and may help preserve tissue function as we age.
Researchers found that exercise-induced molecular changes contribute to neuronal health, improving movement and quality of life in PD patients. Exercise types such as aerobic exercises, resistance training, balance training, and multimodal exercise were found to be helpful in reducing falls, disabilities, and improving brain function.
Scientists have discovered that TRF2, a protein previously known for protecting chromosome ends, plays a crucial role in preserving the identity of muscle stem cells and enabling their regenerative abilities. This new understanding may lead to the development of therapeutic strategies for muscular dystrophy and cancer research.
Researchers at Kyushu University identified a molecule that strengthens hepatocyte growth factor (HGF), a key muscle-repair signal. The compound, lipoic acid trisulfide (LASSS), enhances HGF's binding affinity for satellite cells, restoring its ability to repair muscle fibers and counteracting age-related muscle loss.
A new study published in Nature Communications finds that a protein called saxiphilin can neutralize the potent neurotoxin saxitoxin, preventing and even reversing paralytic shellfish poisoning. The discovery could have important public health implications as saxitoxin accumulates in shellfish and causes poisoning when consumed.
A new study has identified 50 previously unknown subfamilies of myosin genes that drive subtle differences in muscle function among various animal species. The findings suggest that the evolution of animals is not solely driven by external appearance, but also by factors nested beneath the surface.
A major international study led by Curtin University found diabetes risk is linked to both excess body fat and poor muscle health, with nearly 15% of people with sarcopenic obesity developing type 2 diabetes within 10 years. Maintaining muscle strength and mass may be as important as managing body weight in assessing diabetes risk.
Sarcopenia affects over 60% of individuals above age 80 and is influenced by distinct biological mechanisms in women and men. Hormones like apelin, insulin, and oxytocin play a crucial role in maintaining healthy skeletal muscle, with sex-specific differences affecting muscle aging and disease progression.
Mouse study uncovers how oxygen-sensing transcription factors regulate muscle physiology, improving glucose tolerance and producing erythropoietin. The findings suggest that selectively targeting each isoform can lead to different physiological outcomes.
Injectable peptides marketed online for enhancement purposes are raising concern due to lack of regulation and limited research. The use of these substances is blurring the line between legitimate treatment and enhancement use, complicating enforcement and creating uncertainty for clinicians, regulators, and consumers alike.
Researchers have discovered a key protein, Mylpf, essential for fast-twitch muscle fibers to form and contract. The study found that even partial reduction in Mylpf function can hinder muscle formation, leading to diseases like muscular dystrophy.
A systematic review and meta-analysis found that creatine supplementation does not significantly reduce inflammatory markers in the body. Despite its ergogenic effects on physical performance, creatine's anti-inflammatory properties are limited to specific contexts, such as intense exercise.
Researchers uncovered previously unknown features in the limb musculature of the macaroni penguin that help explain its efficient movement on land and underwater. The study found modified key wing muscles and a unique configuration of shoulder muscles giving penguins an 'underwater flying' wing stroke.
A 42-year-old theory about children's body mass index (BMI) decrease before continuous rise is refuted by new analysis. Increasing muscle mass, not fat, causes the increase in BMI seen around age 5-7 years.
Researchers found that patients with both COPD and sleep apnea had significantly lower muscle strength and functional capacity compared to those with isolated COPD. The study highlights the importance of monitoring sleep-disordered breathing in the COPD population to improve quality of life.
New research reveals that skeletal muscle retains a 'molecular memory' of repeated disuse, which differs between young and old muscles. Younger muscles show resilience, while older muscles become increasingly susceptible to atrophy. The study provides insights into how muscle responds to inactivity and its potential for recovery.
A new study found that social media use, particularly exposure to muscularity-focused content and body comparisons, is strongly associated with increased intentions to use anabolic-androgenic steroids. Young men who frequently view muscular bodies or advertisements promoting muscle-building supplements also report stronger intentions.
Researchers report a significant association between muscle strength and lower mortality risk in women aged 63-99 years. Grip strength and chair stands were found to be key indicators of muscular strength, with even small improvements leading to notable reductions in death risk.
A new study published in JAMA Network Open found that muscular strength is associated with lower mortality rates in women aged 63-99. Controlling for physical activity and other factors, researchers discovered a significant link between muscle mass and reduced mortality risk.
Researchers found that exercise changes brain activity in nerve cells called SF1 neurons, which helps muscles and hearts become stronger. This brain region plays a key role in regulating energy use and body weight.
An 18-week study found that maintaining grip strength and chair-rise performance alongside weight loss was possible without a prescribed strength-training program, alongside improvements in biomarkers linked to metabolic and cognitive aging. A plant-forward diet featuring fresh lean pork supported healthy-aging markers in older adults.
Researchers developed a new type of bio-hybrid actuator using locust hind legs, achieving remarkable leaping capabilities and ultra-low power consumption. The actuators enable high maneuverability and autonomous self-righting capabilities, making them suitable for confined space exploration and precision medical delivery.
Researchers found that the tenascin-C protein promotes a thriving community of functional muscle stem cells needed for efficient muscle regeneration. Aging reduces skeletal muscle regeneration due to lower levels of TnC and impaired muscle stem cell function.
MIT engineers developed artificial tendons made from hydrogel to connect lab-grown muscles with robotic skeletons. The tendons improved the robot's motion and force output by three times, enabling faster and more efficient biohybrid robots.
Researchers discovered that woodpeckers brace their head, neck, abdomen, and tail muscles to hold their bodies rigid while pounding on wood. The birds synchronize their breathing with each impact, like ace tennis stars grunting noisily to stabilize core muscles.
Researchers at Sanford Burnham Prebys have developed a new method to generate more and potent skeletal muscle progenitor cells. The study found that blocking the activity of Janus kinase 2 (JAK2) yields a twofold increase in cell yield, while also delivering more mature and effective cells for regenerative medicine treatment.
Researchers found that a supplement containing high-molecular-weight hyaluronan preserves muscle mass and exercise capacity in aging mice. The study suggests that targeting the glycocalyx may be a viable therapeutic strategy to treat age-related physical dysfunction.
Researchers at Tohoku University discovered a way to strengthen legs through daily etiquette, known as Rei-ho, which emphasizes slow and controlled movements. The study found that those who practiced Rei-ho for five minutes daily increased their knee extension strength by an average of 25.9%, compared to only 2.5% in the control group.
A study published in PLOS Computational Biology reveals that different cell types and variation within these cells play a crucial role in muscle remodeling during Drosophila development. The findings show that sarcolytes, hemocytes, and fat body cells work together to break down larval muscles and scatter the fragments.
A UCLA team has uncovered new details about the muscle controlling blinking, offering a pathway toward developing blink-assisting prostheses. The orbicularis oculi muscle contracts in complex patterns that vary by action and move the eyelid in more than just a simple up-and-down motion.
Scientists have discovered that MYOD protein can act as a gene silencer, clearing out old 'furniture' to reset the cell's identity. This finding challenges dogma and opens up new avenues for understanding cellular reprogramming and regenerative medicine therapies.
Researchers found that Ozempic-induced weight loss decreased lean mass by 10% in mice, with most of the lost weight coming from non-skeletal tissues. While some skeletal muscles did shrink, others stayed the same size, and strength was affected for some but not all muscles.
Developed by a research team at POSTECH, the robot uses human muscle proteins as inspiration to generate strong force while navigating through tight spaces. The technology has potential applications in various fields, including medical settings, industrial environments, home cleaning, and caregiving robots.
Researchers reanalyzed the coelacanth's skull musculature and found that only 13% of previously identified evolutionary muscle novelties were accurate. The study also identified nine new evolutionary transformations related to feeding and respiration, revealing a more similar anatomy to cartilaginous fish and tetrapods.
Researchers have developed soft artificial muscles that provide the performance and mechanical properties required for building robotic musculoskeletal systems. The new muscles can be battery-powered, enabling robots to move more naturally and safely in unstructured environments.
A new study introduces a novel muscular clock, MAA, which measures how quickly an individual's muscles are aging compared to their actual age. The research found that about 25% of healthy middle-aged and older adults experience accelerated muscle aging, increasing the risk of sarcopenia.
The article provides practical strategies for managing symptoms in patients receiving GLP-1 RAs, focusing on diet and physical activity interventions to support muscle and nutrient preservation. Lifestyle factors remain crucial in GLP-1 RA treatment for effective weight management.
A small study found that consuming more protein may help prevent muscle loss in adults with obesity taking semaglutide, an anti-obesity medication. The researchers noted that older adults and women may be at higher risk for muscle loss, emphasizing the importance of preserving muscle during weight loss with this medication.
Researchers explore the biological mechanisms of myopenia in RA, finding it affects individuals of all ages, with notable muscle mass loss without concurrent fat loss. The review highlights the diagnostic and therapeutic relevance of myopenia in RA, emphasizing the importance of early detection and tailored management strategies.
Research reveals that high temperatures and exposure to heavy metals reduce the frequency and pitch of non-flight wing vibrations in bees. This affects their communication, defense, and buzz-pollination abilities, which are crucial for plant reproduction and biodiversity.
New research identifies 'general motor skills' as crucial for world-class performance across various athletic disciplines. World-class experts show fewer inefficiencies in elastic tissue motions compared to regional-level and novice competitors.
A new University of Toronto study reveals that over one-third of boys and men know someone who uses steroids, increasing their own intention to use them. The research highlights the importance of targeted prevention efforts considering social environments and identity factors.
A study by researchers at the University of São Paulo found that women with low muscle mass have a significantly lower survival rate than those with normal muscle mass. Muscle mass is crucial for patients undergoing cancer treatment, and low levels can predict adverse outcomes, including mortality.
A new study reveals a strong association between viewing muscularity-oriented social media content and muscle dysmorphia among boys and men. Exposure to images of muscular bodies, posts promoting muscle-building supplements, and content featuring steroids increased the risk of muscle dysmorphia.
Research found that boys born to mothers with polycystic ovary syndrome (PCOS) or higher testosterone levels during pregnancy are less physically active at age 7. Girls exposed to similar levels of testosterone had lower muscle strength, highlighting the role of maternal testosterone and PCOS in future development.
Dr. Pasiakos joins Pennington Biomedical to lead research on muscle physiology, nutrition, neuroscience, and technology to optimize human performance in extreme conditions. His expertise strengthens capabilities for U.S. Military resilience, spaceflight bioenergetics, and elite athlete development.
Researchers at State University of Campinas found that physical exercise prevents the transition from acute to chronic muscle pain by activating an anti-inflammatory signaling pathway in immune cells. This can lead to the development of new treatments for muscle pain, potentially reducing opioid consumption.
A study found that genetic predisposition to higher muscle strength is associated with lower all-cause and cardiovascular mortality in aging men. The association remained significant even after adjusting for lifestyle factors such as smoking and body mass index.
A new study has found that combining signals from electromyography and force myography can improve the accuracy of prosthetic control. The researchers used a combination of these two techniques to classify hand gestures with high accuracy, outperforming both methods alone.
A team of researchers from Goethe University and Kiel University has discovered a way to prevent the formation of harmful protein aggregates in cultured cells. The study found that linking TDP-43 with SUMO prevents its aggregation, suggesting a potential new approach for treating ALS and other neurodegenerative diseases.
Participants who took the supplement showed improvements in grip strength, lower body mobility, and reductions in body weight. The supplement appeared to reduce stem cell turnover, regulate immune function, and influence gene activity related to stress response.
A new study by University of Illinois researchers found that a balanced vegan diet has no effect on muscle protein synthesis or muscle gain compared to an omnivorous diet. Protein distribution throughout the day also made no difference in muscle building, contrary to previous assumptions.
A study by the University of Jyväskylä found that muscles retain a memory trace of previous resistance training at the protein level for up to two and a half months. This persistence can make it easier to start training again after a break.
The study found that patients with coaxial silicone drains had lower analgesic consumption and better-preserved respiratory muscle strength during the first 2 postoperative days. This suggests that coaxial SIL drains can reduce postoperative pain and improve patient comfort and recovery following VATS lobectomy.
A study using cryo-electron microscopy revealed that autoantibodies in myasthenia gravis disrupt acetylcholine receptor function by blocking or activating the immune system's complement pathway. This knowledge helps explain treatment variability and offers a foundation for personalized therapies targeting specific antibody interactions.
Researchers calculated two indicators from body composition data to examine the relationship between muscle quality and long-term care need. People with low phase angles and extracellular to intracellular water resistance ratios were found to be at high risk of becoming dependent, especially when values fell below median thresholds.
The study reveals that muscle fibers shorten as forces increase during fast hopping, allowing for faster motion. This counterintuitive behavior enhances leg stiffness, which could impact sports training, rehabilitation, and robotics.