Researchers at Tohoku University developed a method to restore the mechanical strength of degraded polybutylene terephthalate by repairing molecular chains with a chain extender. The technique recovers plastic tensile strength to nearly that of virgin material, enabling high-performance plastics to be reused instead of discarded.
Researchers have identified a specific location where DNA begins opening inside living yeast cells, marking the start of DNA replication. The study revealed a molecular gate that helps prepare DNA for copying and coordinates multiple stages within a compact area of the genome.
A KAIST research team has developed a new molecular system that can selectively switch the pathway through which electrons are transferred during oxygen activation. The findings provide a fundamental design principle for next-generation catalysts and energy-conversion technologies.
Dr. Elaine S. Jaffe receives AMP's highest honor for pioneering contributions to lymphoma diagnosis and treatment. Dr. Laura J. Tafe is recognized for her leadership and service to the organization, while Dr. Daniel E. Sabath receives the Meritorious Service Award for his dedication to scientific excellence and organizational service.
Researchers at the Institute for Basic Science have developed a new strategy for electrically controlling molecular quantum systems, enabling precise control of individual molecular spins. This breakthrough offers a practical approach to building future molecular quantum technologies.
Daniel E. Sabath, a professor at UW Department of Laboratory Medicine and Pathology, has won the Association for Molecular Pathology's 2026 Meritorious Service Award for his dedication and effort over three decades. He is being honored for his leadership roles, scientific expertise, and collaborative spirit in advancing education and s...
Elaine S. Jaffe, a distinguished investigator at the NCI Center for Cancer Research, has transformed our understanding of lymphoid malignancies through her groundbreaking research. Her work has led to significant advancements in disease classifications, diagnosis, and treatment.
The Association for Molecular Pathology recognizes Dartmouth Health medical director Laura J. Tafe for her exceptional leadership and dedication to the field of molecular diagnostics. She has been a member of the organization since 2007 and has held various positions, including president in 2023.
A new study reveals that CDK8 helps plants allocate sulfur for growth and defense by regulating the use of sulfur in molecular machinery. Plants can switch between high-sulfur and low-sulfur defense strategies, conserving sulfur when necessary, to maintain immunity.
Scientists have discovered that oxygenic photosynthesis is possible with only one photosystem, overturning a long-held assumption in biology. The study, published in Nature Communications, shows that the absence of one photosystem can be compensated by an alternative mechanism.
A study has identified a set of plasma proteins that can be used to diagnose and monitor patients with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD). The researchers created a molecular disease trajectory, which identifies key sets of genes involved in the disease progression.
Researchers at Saitama University have developed a sequential annulation strategy to construct regioisomeric ladder-type oligothiophenes with precise control over thiophene ring orientation. This allows for the systematic synthesis of complex molecular structures, paving the way for the design of next-generation organic semiconductors.
Prof. Yehu Moran's election to EMBO recognizes his groundbreaking research on the evolution of biological defense systems, advancing our understanding of life and exemplifying the university's scientific excellence.
Researchers developed a tool to observe complex molecular choreography in real-time, shedding light on how a key protein locates the correct regions of the genome to initiate an adaptive response. The study proposes that transcription produces a 'dynamic RNA hub' that recruits the DNA mutator protein AID.
A research team has successfully designed a novel electrolyte for fluoride shuttle batteries, which boasts high electrochemical stability and reversibility. The KBF4-containing electrolyte effectively regulates the fluorination reaction, enabling reversible electrode reactions.
Researchers at The University of Hong Kong have developed a way to design polymers with precise molecular structures, allowing them to control material properties such as stiffness, strength, and elasticity. By introducing copper ions, the team can dynamically alter the rigidity of these materials.
Researchers found that linear alkane molecules passed through nanoscale pores faster than shorter ones, with transport rates determined by pore size and gate flexibility. The study revealed a two-step transport mechanism involving an encounter complex at the outer surface of the nanocube.
Gary Ulaner, a renowned nuclear medicine expert, has been elected president-elect of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). He aims to advance SNMMI's Mars Shot initiative, expand educational activities for professionals, and increase funding for training new radiochemistry and physics specialists.
UW researchers found that most biology education guidelines lack connections to society, with only 7% of elements discussing ethics and public health issues. This can lead to a lack of engagement and retention among students, as real-world examples support their interest in science and help develop their scientific identity.
The Society of Nuclear Medicine and Molecular Imaging recognized six new Fellows for their exceptional contributions to the field. The SNMMI Fellowship honors members who have demonstrated excellence in scientific discovery, educational efforts, or clinical practice.
Researchers at Cornell University have refined a CRISPR-based genetic technique in fruit flies to study gene function and development with greater precision. By replacing harsh DNA cuts with gentler 'nicks,' scientists can reduce unintended cellular damage and increase control over experiments.
Researchers have developed a coherent Raman spectroscopy method that directly detects ångström-scale molecular films at interfaces without plasmonic enhancement or electronic resonance. This approach suppresses strong substrate background signals, allowing for highly sensitive interfacial Raman spectroscopy.
Researchers developed biocompatible molecular quantum nanosensors that operate inside living cells, enabling absolute temperature measurements with subcellular spatial resolution. The sensors also detect radical-related spin signals in the cytoplasm and nucleus of cancer cells.,
A study identifies subtype-specific programs in pediatric ependymoma, linking metabolic patterns to clinical aggressiveness. The research reveals distinct metabolic profiles for each molecular subtype, providing a resource for understanding the biology of pediatric ependymoma and potential therapeutic vulnerabilities.
Researchers at LMU Munich develop a surface treatment method to optimize the molecular contact in perovskite solar cells, resulting in improved efficiency, reproducibility, and stability. The approach provides a scalable solution for industry-compatible fabrication workflows.
A team of researchers from KAIST has developed a DNA-based molecular computer that can operate at a much smaller scale than conventional semiconductor devices. The system enables both computation and memory within the same device, opening up new possibilities for future computing technologies in bio and medical applications.
An international team of researchers used AI to create tiny 'smart' proteins that detect chosen targets, opening the way to low-cost biosensors. The protein switches can work inside living cells and generate electrical signals, making them suitable for various sensing technologies.
Researchers have created a high-resolution molecular map of specific sensory neurons that trigger pain, revealing two subtypes of nociceptors with distinct functional components. The study provides insights into the molecular mechanisms of chronic inflammatory pain and identifies potential new drug targets using Deep Visual Proteomics.
Hal Duncan, a Professor and Consultant in Endodontics at Trinity College Dublin, received the 2026 IADR Distinguished Scientist Award for his outstanding research contributions in pulp biology. His work focuses on translational pulp biology and applied vital pulp treatment using epigenetic modifications.
Chinese researchers develop novel post-dual OPA technique to amplify weak SFG signals, enabling detection of molecular signals at surfaces. The breakthrough opens possibilities for studying transient species in chemical reactions and other systems where surface molecular structure determines function.
Scientists have successfully constructed a phthalocyanine pentamer, a novel nanoarchitecture that integrates electronic and magnetic properties into a single molecule. The hybrid strategy combines solution chemistry and on-surface reactions on metal substrates, enabling the creation of complex molecular structures.
Preclinical studies reveal that MR hinders cell proliferation, triggers cell cycle arrest, and enhances standard treatments. Early-phase clinical trials report positive results on safety and tolerability, suggesting utility of MR as a complementary treatment strategy.
This study reclassified patients according to modern WHO Classification criteria, revealing molecular subtyping limitations, pathway co-activation patterns, and strong anatomical-molecular correlations. IDH1/2 mutations and TERT promoter mutations played key roles in determining prognosis.
Researchers develop novel method to manipulate cell structures using weak magnetic fields and isotopes, bridging structural biology, biophysics, and quantum biology. This work offers a potential new strategy for stabilizing damaged brain proteins, typical of neurodegenerative diseases.
Chemical Insights scientists received awards for their research on vaping-associated exposures and health risks, as well as other papers that integrate molecular biology or systems biology to toxicology research. The institute's efforts aim to safeguard public health by advancing scientific understanding of chemical risks.
Researchers developed a new method to discover molecular glues through large-scale chemistry and cell-based screening. They identified compounds that selectively degrade ENL in leukemia cells, demonstrating the potential of this approach for targeting previously undruggable proteins.
A research team led by Universitat Autonoma de Barcelona has discovered the molecular mechanism regulating bacterial cell division. The MraZ protein binds to the dcw gene cluster, enabling coordinated action of proteins necessary for cell division and bacterial wall formation.
Advanced Cancer Research defines a platform for integrating molecular biology, genomics, immunology, engineering, and computational science to understand cancer as a complex disease. The journal prioritizes studies that provide mechanistic depth and bridge disciplinary boundaries.
Researchers propose a new design principle for QM/MM simulations, enabling the objective and automatic determination of the quantum-mechanical region based on electronic-state changes. This approach addresses long-standing challenges in multiscale molecular simulations, demonstrating consistent applicability across different systems.
This review analyzes molecular mechanisms of DDR pathways in mediating chemotherapy resistance, elucidating correlations with BRCA1/2 deficiency and ATM/ATR signaling pathway dysregulation. The study presents a novel molecular synergy model between DDR regulation and Immune Checkpoint Blockade to enhance immunotherapy responses.
Researchers design a novel molecular machine that controls both rotational and shuttle motions in a single molecule. The system, composed of a sterically hindered olefin motor, H-type benzimidazole, and crown ether, demonstrates the tuning effect of two motion modes within a single machine.
Researchers overcome spatial resolution limit of sum-frequency generation (SFG) spectroscopy by utilizing plasmonic near-field confinement. This breakthrough enables direct visualization of nanoscale orientation heterogeneity in interfacial molecular domains.
Researchers summarize current understanding of water-molecular sieve interactions affecting catalytic reaction processes. Water-induced reversible and irreversible structural changes impact aluminosilicate and SAPO frameworks.
Bacteria move through liquids using propellerlike tails called flagella, which alternate between clockwise and counterclockwise rotation. Researchers propose a tug-of-war mechanism instead of the traditional equilibrium 'domino effect' model, where proteins lining the tail exert pressure on their neighbors.
A new 'pocket microscope' technology enables direct molecular imaging with femtogram precision, transforming pathology workflows and opening new frontiers in space biology. The deep-ultraviolet ptychographic pocket-scope (DART) provides label-free spectroscopic contrast without external labels.
Researchers developed MolUNet++ to explicitly learn molecular representations at multiple scales, extracting substructures while preserving global context. The model achieved significant performance gains across various tasks, including drug target interaction prediction, by providing clearer structural explanations.
Current Molecular Pharmacology has achieved a major milestone with its real-time CiteScore advancing to 7.2, indicating the journal's high-quality research and rigorous peer-review process. The journal continues to strengthen its position as a key platform for innovative pharmacological research.
A hybrid material combining vanadium cluster and carbon nanotubes acts as a molecular switch toggling between oxygen and hydrogen production. The 'switch' is controlled by the arrangement of organic cations, which modulate the local electrochemical microenvironment.
Dr. Yunsun Nam's groundbreaking research on RNA-protein interactions reveals key insights for gene regulation, cancer biology, and RNA-based therapeutics. Her work uncovers molecular rules governing specificity between proteins and RNAs, shedding light on novel mechanisms linking dysregulated RNA methylation to cancer.
Dr. Eric J. Nestler's research has fundamentally reshaped global understanding of addiction and depression by focusing on resilience rather than pathology. His laboratory identified distinct molecular, cellular, and circuit changes in resilient brains that maintain normal behavioral function despite exposure to drugs or stress.
Gerald M. Wilson, PhD, joins UMSOM as Chair of Biochemistry and Molecular Biology, bringing expertise in RNA biochemistry and cancer mechanisms. He aims to strengthen departmental capabilities and foster collaboration to advance research, education, and service.
The Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research will support 18 junior investigators studying age-related diseases and healthspan. The awards, worth $375,000 each, are designed to advance research projects in basic biology of aging and geroscience.
Researchers have developed silver-based atomic switches that create stable electrical connections between individual molecules and electrodes, enabling the scalable integration of molecular components. This breakthrough paves the way for ultra-compact and energy-efficient circuits built from single molecules.
Rockefeller researchers found a molecular switch in breast cancer cells that reprograms gene expression towards tumor growth and stress resistance. This switch is mediated by the MED1 subunit of RNA polymerase II and can be activated under stressful conditions, leading to faster-growing and more stress-resistant tumors.
The ISSCR, SDB, and the Allen Institute are hosting a three-day scientific symposium featuring early-career scientists, focusing on cross-disciplinary exchange and amplifying emerging leaders in developmental biology and stem cell science. Confirmed topics include data analysis, model systems, spatial awareness, and cell fates.
A study reveals how thermophilic bacterial communities remodel their molecular machinery to withstand temperatures up to 87 °C. Heat shock proteins orchestrate a coordinated defense system to stabilize essential enzymes, providing a molecular-level explanation for microbial heat tolerance.
The American Society for Biochemistry and Molecular Biology (ASBMB) introduces a new journal, Insights in Biochemistry and Molecular Biology, broadening its scope to cover molecular life science discoveries. The journal joins ASBMB's family of journals with swift publication and constructive review.
Researchers at Institute of Science Tokyo developed a rapid cell-free method to capture detailed 3D structures of flexible sugar molecules, including the first atomic-resolution image of melezitose. The study offers a powerful tool for accelerating research in drug discovery and molecular biology.
New research papers from Mount Sinai present unprecedented evidence that brain tissue from living individuals has a unique molecular character, differing significantly from postmortem samples. These findings challenge the conventional practice of using postmortem brain tissue for studying the human brain and its diseases.
A new project aims to enhance workforce readiness in molecular bioscience by creating open-access resources and modules tailored to student needs. The Molecular Data Education Hub will host instructional materials and case studies for instructors to implement into their courses.