A team of researchers at Texas Biomed has identified the interaction between an Ebola virus protein and a human cell protein that may be crucial to understanding the virus's life cycle. By studying this interaction in human cells using live virus, the scientists hope to develop potential drug targets to stop the disease.
A cellular protein called Hsp70 plays a critical role in Zika virus infection, facilitating attachment to cells, replication inside cells, and release of mature virus particles. This discovery validates Hsp70 as a potential target for developing new therapies to prevent or treat Zika virus infection.
Researchers studied dengue virus fusion peptide structures, revealing a hydrophobic region and polar 'collar' crucial for cell membrane fusion. This review aims to expand knowledge on the mechanism of virus infection, potentially leading to new inhibition methods.
Researchers have identified a new genus of filovirus from fruit bats in China, which shares similarities with Ebola and Marburg viruses. The Mengla virus has been found in different geographic locations than other filoviruses and poses a potential risk of interspecies transmission.
Researchers have identified a new genus of filovirus from a Rousettus bat in China, which shares genetic similarities with Ebola and Marburg viruses. The M?nglà virus poses a potential risk of interspecies transmission and has only been detected in bats so far.
Scientists have developed a new vaccine against the Zika virus, which can prevent microcephaly and other serious conditions in unborn babies. The vaccine is based on the yellow fever vaccine and offers complete protection.
Researchers developed a versatile vaccine effective in mice against Powassan virus and other tick-transmitted flaviviruses. The mRNA-based vaccine platform shows promise for rapid production of vaccines against emerging flaviviruses.
Researchers identified a new interaction between the Ebola virus protein VP30 and human host protein RBBP6, which disrupts virus growth. The study provides potential therapeutic targets for treating Ebola virus infections.
Researchers discovered a human protein, RBBP6, that interferes with the Ebola virus replication cycle. By mimicking this protein's function, a small molecule drug could potentially block Ebola virus infection in human cells.
Scientists visualized a real virus with a three-dimensional model to track its movement within a mosquito's body. The study found that the virus leaves the midgut within 32-48 hours, revealing a narrow window for prevention. Researchers aim to inhibit genes involved in virus release to prevent future transmission.
Researchers have generated six Zika virus antibodies that could be used to diagnose and potentially treat the mosquito-borne disease. The neutralizing property of these antibodies prevents the virus from infecting cells, rendering it harmless.
Researchers at German Primate Center found that MERS virus mutations make it more resistant to the human immune system. This could lead to a rise in severe cases and potentially trigger a pandemic.
A new study reveals how the poxvirus tricks cells into activating their own cell movement mechanism, allowing the virus to spread rapidly. The researchers found that a specific protein, vaccinia growth factor, plays a key role in this process, and that targeting this pathway could lead to new antiviral strategies.
Researchers have used high-resolution electron microscopy to reveal how an anti-cancer virus interacts with tumor cells, increasing its potential. The Seneca Valley Virus selectively targets a receptor found in over 60% of human cancers, offering a promising approach for cancer treatment.
Researchers have developed a new vaccine strategy that offers partial protection against the highly contagious infectious bronchitis virus. The recombinant virus vaccine approach has potential to be more cost-effective and respond to emerging new virus strains, but further research is needed to develop a more robust vaccine.
Researchers at MU have successfully produced a litter of pigs genetically resistant to a deadly porcine virus by means of gene editing. The pigs lack the enzyme ANPEP, which is necessary for an infection, and were not infected when exposed to the TGEV virus.
Researchers at the University of Minnesota Medical School have made a groundbreaking discovery about the influenza virus, finding that its replication rate differs significantly between various cell types. The study reveals that certain cells are protected from severe infection, while others remain vulnerable to viral damage.
Scientists at Scripps Research have identified rare antibodies that can bind to the Ebola virus and stop infection, potentially leading to a universal therapy. The new research reveals how these antibodies work by targeting a conserved region of the viral fusion loop.
Researchers have developed a method to separate infected and uninfected cells, revealing how Zika virus manipulates the human immune system by suppressing gene production in macrophage cells. This approach provides a more accurate account of Zika's effect on macrophages and shows that the virus uses two methods to stop their function.
Scientists at the University of Cambridge have developed a new technique to determine the structure and interactions of the Zika virus genome inside human cells. This technique, called COMRADES, can screen for host-virus RNA base-pairing and reveal interacting sequences, offering potential targets for anti-viral therapies.
A recent study reveals that Zika virus proteins bind to cellular proteins essential for neural development, leading to brain damage and microcephaly. The research identifies specific viral factors responsible for the condition, offering new insights into the virus's mechanism of action.
Research has shed light on the mechanism of sexual transmission of Marburg virus, identifying persistent infection in seminiferous tubules and specialized cells called Sertoli cells. The study suggests that targeting immunosuppressive regulatory T cells may help clear Marburg virus from the testes, preventing sexual transmission.
Researchers discovered that cytomegalovirus uses protein IE1 to replicate after PP71 proteins decay, offering potential therapeutic avenues for treatment
Researchers at Princeton University discovered that rabies virus uses a distinct transport process to reach neuronal cell bodies, contrasting with other neuron-invading viruses. Emetine, a protein synthesis inhibitor used to treat amoebic dysentery, efficiently blocks rabies virus transport by immobilizing endosomes carrying the virus.
Researchers found JE virus infection rates similar in rural and peri-urban pigs in Cambodia, with potential implications for vaccination strategies. The study's findings suggest that JE virus circulation is intense in both settings, highlighting the need for updated recommendations.
Researchers describe how Oropouche virus replicates in human cells by hijacking the Golgi complex, a process that could lead to novel targets for preventing infection. The study provides new insights into the replication mechanisms of emerging viruses.
A recent study led by Georgia State University identifies a gene from Ebola virus in myotis bats, which has been adapted to regulate their own immune response. The researchers found that the gene is attenuated in its ability to inhibit the immune response, but shares a similar structure with the Ebola VP35 protein.
A flare-up of an Ebola infection in a woman who had survived the disease a year earlier has highlighted the need for continued surveillance and strengthened health systems. The virus was detected in her family members, including her husband and sons, through genetic analysis.
Dr. Christopher Basler and his team will study Reston ebolavirus (Reston virus), a virus that resembles Ebola but does not cause disease in humans. They aim to better understand the virus's mechanisms of replication, animal disease severity, and potential ways to reduce its deadly effects.
Researchers found that Zika virus has a unique ability to ferry the virus throughout the body using macrophage cells, allowing it to bypass natural barriers. This discovery could lead to the development of effective countermeasures to protect people from the virus's devastating effects.
Researchers have created the highest-resolution image yet of the Zika virus, providing a detailed atomic model that enables efficient vaccine and antiviral compound design. The discovery was made possible by the stability of the Zika virus compared to its flavivirus cousins.
Purdue University researchers have created the most accurate picture of Zika virus to date, finding probable drug-binding pockets on its surface. This breakthrough has the potential to lead to the development of vaccines and therapeutics for this mosquito-borne disease.
A Penn study found that protein fragments in semen enhance Ebola virus transmission and protect the virus from environmental stress. Researchers suggest targeting amyloids could prevent sexual transmission of the Ebola virus.
Researchers developed a mouse model to investigate the potential long-term symptoms of congenital Zika virus infection, finding weight loss, cognitive deficits, and impaired motor function. Infliximab, a TNF-α inhibitor, showed promise in reducing seizures in young mice, offering new hope for public health crisis
A recent study found the Alkhurma hemorrhagic fever virus in ticks collected from migrating birds in the Mediterranean basin. The discovery suggests that birds may contribute to the spread of the virus to new geographical areas. Continuing surveillance is essential to understand the ecology of the virus and prevent its potential spread.
Scientists have identified a molecule found on human cells and some animal cells that could be a useful target for drugs against chikungunya virus infection. Mxra8, a key to the entry of chikungunya virus into host cells, was identified using CRISPR-Cas9.
Researchers have identified and studied antibodies from human survivors of Ebola Bundibugyo that neutralize and protect against infection with several different Ebola virus species. The newly discovered antibodies bond at a different site on the Ebola virus than other antibodies currently used to develop Ebola therapies.
A new study published in PLOS Pathogens estimates that nearly 80% of dengue virus infections are caused by individuals with mild to no symptoms who do not seek medical attention. This finding highlights the importance of proactive disease prevention strategies to curb the spread of dengue fever.
A novel marmoset model of human Zika virus infection offers new opportunities for understanding the virus's impact on congenital disease in humans. The researchers found that infection of marmoset dams recapitulates the human infection more faithfully than other animal models.
A new study led by St. Michael's Hospital maps the potential risk of yellow fever virus spread to cities around the world, analyzing travel patterns and environmental conditions. The research highlights the need for countries to reexamine their policies to prevent yellow fever virus importation, protect travelers, and prevent exportation.
Scientists have created a detailed image of BKV, a virus affecting kidney and bone marrow transplant patients, which may aid in developing antiviral therapies. The new structures allow researchers to visualize potential targets for blocking the virus's entry into cells or preventing its assembly.
A study published in Cancer Research reveals that the Zika virus selectively kills aggressive human embryonal CNS tumor cells in vitro and in vivo. The virus was effective at concentrations as low as one viral particle per ten cells, with no impact on differentiated neurons.
Researchers developed a genetic screening tool that identified two key genes, SLC35A1 and CIC, that enable the influenza virus to infect human lung cells. The study found that modifying these genes can make cells resistant to the flu, which could lead to new antiviral drug targets.
Researchers at Yale University developed a novel RNA-based therapy to target West Nile virus, delivered through the nose. The therapy reduced the virus in the brain and allowed the immune system to destroy it, resulting in a 90% survival rate among treated mice. The treatment also provided long-term protection against future exposure.
Researchers at Georgia State University identified a chemical compound that effectively inhibits the replication of the Ebola virus and several other viruses. The study found benzoquinoline to be a potent antiviral agent with activity against multiple viruses, including Marburg virus and Zika virus.
Researchers have identified two genes, PIAS1 and IRF8, that play a crucial role in regulating the replication of Epstein-Barr virus. By understanding how these genes interact with the virus, scientists may develop new treatments for cancer types associated with EBV infection.
The study found that the CTCF protein helps herpes simplex virus regulate its own sleep-wake cycle, enabling it to establish latent infections in sensory neurons. By preventing CTCF from binding to viral DNA, the virus's ability to reactivated was weakened.
Researchers at MSU have discovered a new way viruses assemble themselves and eject DNA into host cells, with potential applications in medicine and biotechnology. The study focused on the Acidianus tailed spindle virus, which can change shape to interact with its host cells.
A study found that Ebola virus infects reproductive organs of macaques, suggesting similar infection in humans. The virus can persist in female reproductive tissues and may reach seminal fluid in men.
New virus-cracking molecules can disrupt viral capsid assembly, preventing replication and killing new copies of the virus. This breakthrough could lead to better treatments against multiple viruses, including polio and herpes.
Researchers at Hokkaido University identified a key process enabling Ebola virus entry, targeting antiviral drug development.
Researchers found that relatives of Zika virus can damage developing fetuses in mice and replicate in human tissues, raising concerns about other emerging viruses causing birth defects. The study suggests that flavivirus infections might cause pregnancy complications more frequently than previously appreciated.
A new study at WashU Medicine identified specific features of the influenza virus genome that could improve surveillance for pandemic flu. The researchers found that certain strains of the virus require similar genetic material to recombine and create a new hybrid virus.
Researchers used a plant virus to study how plants defend themselves against invading pathogens, revealing key receptor proteins that regulate RNA interference. The findings also identified a suppressor protein named C4 used by the virus to disarm the plant's defence mechanism.
Researchers successfully created a synthetic horsepox vaccine that offers protection against the vaccinia virus, which is associated with serious side effects. Mice immunized with the chimeric HPXV developed similar levels of protective antibodies as those inoculated with VACV, but had less severe reactions.
UAlberta researchers created a synthetic horsepox virus that can provide vaccine protection against smallpox. The discovery demonstrates the potential of synthetic DNA technology in advancing public health measures.
The study provides the first atomic description of the herpes virus associated with Kaposi's sarcoma, allowing scientists to identify specific targets for antiviral therapies. This breakthrough could lead to the development of new treatments for both KSHV and Epstein-Barr viruses.
Researchers at The Scripps Research Institute have discovered the workings of a promising treatment for Marburg virus, which has a mortality rate of up to 88 percent. The treatment, MR191, targets a conserved site on the virus and neutralizes it by mimicking the host receptor.
Scientists have found that a naturally occurring virus called reovirus can act as an effective immunotherapy in patients with brain cancer or other cancers that have spread to the brain. The virus replicates and kills cancer cells, while also stimulating the body's own immune system.
Researchers have discovered a way to prevent the Ebola virus from spreading by inhibiting a specific enzyme that allows it to copy itself. By blocking this enzyme, the virus's ability to produce more infection is reduced, suggesting potential breakthrough in treatment.