A modified acupuncture needle enables minimally invasive sampling of lymph node-derived DNA for molecular profiling, offering a robust alternative to current clinical liquid biopsy approaches. The novel platform, His@PDA@Needle, is significantly less invasive than conventional lymph node biopsy and intended to complement histopathologi...
A new study reveals molecular features linked to more aggressive prostate cancer in patients classified as low risk, highlighting biological differences that may not be apparent from clinical measures alone. The results could lead to new therapeutic strategies and more precise risk stratification.
Researchers from Shibaura Institute of Technology used molecular simulations to investigate how an enzyme's shape affects molecular recognition and ligand retention. They found that enzyme shape influences ligand retention, with 75.6% of trajectories in the closed group retaining ligands compared to 55.1% in the open group.
A Baylor College of Medicine-led team developed an AI-powered strategy to discover small molecules called 'molecular glues' to treat disease. They found a new class of molecular glues that can potentially neutralize harmful proteins linked to blood cancers and autoimmune diseases.
Complimentary press passes are now available for the Association for Molecular Pathology 2026 Annual Meeting & Expo in Seattle, featuring over 200 exhibiting companies, 60 educational sessions, and 500 poster presentations. Reporters can register to attend in person or access press materials online.
Researchers developed molecular antennae to boost visible-light sensitivity of azobenzene photoswitches, preserving stability. The new design achieved high visible-light sensitivities, with one molecule reaching 8,100 M⁻¹ cm⁻¹.
Elke Deuerling, a renowned molecular biologist, has been awarded the Sir Hans Krebs Medal 2027 for her groundbreaking research on protein balance and proteostasis. Her work focuses on deciphering the molecular processes that maintain cellular protein levels, ensuring the health and viability of organisms.
A research team at Osaka Metropolitan University mapped molecular gas throughout Stephan's Quintet, a nearby group of interacting galaxies. They found that regions with turbulent gas formed stars less efficiently, even with abundant gas present. Turbulence prevents gas from settling and collapsing, creating fewer opportunities for star...
A comprehensive molecular study of ageing found that genetic factors and environmental influences continuously interact to shape an individual's ageing journey. Researchers identified distinct biological shifts, including correlations between environmental exposures and molecular profiles, which may indicate higher risk of disease and ...
An eight-year study of 335 women reveals individual molecular trajectories of aging diverge from population-wide patterns, influenced by genetics and environmental exposures. The study found over 5,000 genes and 181 metabolites changed over time, including those associated with age-related diseases.
Scientists at UCSF QBI mapped 1,800 protein interactions across 100 autism risk genes, revealing how diverse genetic mutations converge on shared molecular pathways. The study provides a framework for designing medicines that target multiple genetic forms of autism simultaneously, offering advantages in brain delivery and tolerability.
Advances in single-cell and spatial multi-omics are helping researchers understand brain development, disease, and therapeutic opportunities by integrating molecular layers with cellular and spatial context. This approach has revealed regulatory relationships and cell-type-specific changes in Alzheimer's disease, Parkinson's disease, a...
Researchers created a programmable DNA nanodevice that penetrates lipid membranes using mechanical motion, delivering molecular cargo into synthetic cells. The device enables active control of membrane transport in space and time.
Researchers at Dana-Farber Cancer Institute have developed a protein degrader discovery platform that identifies molecular glues that can target disease-related proteins for elimination. The team discovered the first molecular glue degrader, M12, which is metabolically activated and can degrade multiple cancer-related proteins.
Professor Röthlisberger's work has pioneered ab initio molecular dynamics and QM/MM multiscale simulation methods, providing rigorous frameworks for investigating complex molecular processes. Her research has guided scientific discovery in areas like quantum chemistry, materials science, and sustainable energy.
A collaborative study between Insilico Medicine and top research institutions uses AI to identify therapeutic targets for IP-SNSCC, a rare and aggressive subset of head and neck cancers. The study provides the first comprehensive molecular atlas of this disease, enabling future translational research.
A rare case of uterine carcinosarcoma was reported, characterized by a dual molecular signature that may refine prognosis and guide treatment decisions. The patient's tumor displayed a high-grade endometrioid homologous uterine carcinosarcoma with TP53 and MSH6 genetic alterations.
Researchers at Tohoku University developed a method to restore the mechanical strength of degraded polybutylene terephthalate by repairing molecular chains with a chain extender. The technique recovers plastic tensile strength to nearly that of virgin material, enabling high-performance plastics to be reused instead of discarded.
Researchers have identified a specific location where DNA begins opening inside living yeast cells, marking the start of DNA replication. The study revealed a molecular gate that helps prepare DNA for copying and coordinates multiple stages within a compact area of the genome.
A KAIST research team has developed a new molecular system that can selectively switch the pathway through which electrons are transferred during oxygen activation. The findings provide a fundamental design principle for next-generation catalysts and energy-conversion technologies.
Researchers at the Institute for Basic Science have developed a new strategy for electrically controlling molecular quantum systems, enabling precise control of individual molecular spins. This breakthrough offers a practical approach to building future molecular quantum technologies.
Elaine S. Jaffe, a distinguished investigator at the NCI Center for Cancer Research, has transformed our understanding of lymphoid malignancies through her groundbreaking research. Her work has led to significant advancements in disease classifications, diagnosis, and treatment.
The Association for Molecular Pathology recognizes Dartmouth Health medical director Laura J. Tafe for her exceptional leadership and dedication to the field of molecular diagnostics. She has been a member of the organization since 2007 and has held various positions, including president in 2023.
Dr. Elaine S. Jaffe receives AMP's highest honor for pioneering contributions to lymphoma diagnosis and treatment. Dr. Laura J. Tafe is recognized for her leadership and service to the organization, while Dr. Daniel E. Sabath receives the Meritorious Service Award for his dedication to scientific excellence and organizational service.
Daniel E. Sabath, a professor at UW Department of Laboratory Medicine and Pathology, has won the Association for Molecular Pathology's 2026 Meritorious Service Award for his dedication and effort over three decades. He is being honored for his leadership roles, scientific expertise, and collaborative spirit in advancing education and s...
Scientists have discovered that oxygenic photosynthesis is possible with only one photosystem, overturning a long-held assumption in biology. The study, published in Nature Communications, shows that the absence of one photosystem can be compensated by an alternative mechanism.
A new study reveals that CDK8 helps plants allocate sulfur for growth and defense by regulating the use of sulfur in molecular machinery. Plants can switch between high-sulfur and low-sulfur defense strategies, conserving sulfur when necessary, to maintain immunity.
A study has identified a set of plasma proteins that can be used to diagnose and monitor patients with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD). The researchers created a molecular disease trajectory, which identifies key sets of genes involved in the disease progression.
Researchers at Saitama University have developed a sequential annulation strategy to construct regioisomeric ladder-type oligothiophenes with precise control over thiophene ring orientation. This allows for the systematic synthesis of complex molecular structures, paving the way for the design of next-generation organic semiconductors.
Researchers designed a molecular cage that slows down molecular switching, allowing them to observe the sequence of events. The study reveals a conformational-selection mechanism behind guest-induced structural changes, opening doors for designing future molecular machines and smart materials.
Prof. Yehu Moran's election to EMBO recognizes his groundbreaking research on the evolution of biological defense systems, advancing our understanding of life and exemplifying the university's scientific excellence.
Researchers developed a tool to observe complex molecular choreography in real-time, shedding light on how a key protein locates the correct regions of the genome to initiate an adaptive response. The study proposes that transcription produces a 'dynamic RNA hub' that recruits the DNA mutator protein AID.
A research team has successfully designed a novel electrolyte for fluoride shuttle batteries, which boasts high electrochemical stability and reversibility. The KBF4-containing electrolyte effectively regulates the fluorination reaction, enabling reversible electrode reactions.
MD4SB integrates molecular dynamics tools into three European Research Infrastructures, enabling researchers to share and reuse data, and accelerate drug discovery. The project also involves pharmaceutical companies like Almirall and Sanofi.
A team of scientists found that periods of darkness allow molecular assemblies to reorganize and evolve towards more stable structures. This process is faster and more effective than keeping the light on continuously.
Researchers at The University of Hong Kong have developed a way to design polymers with precise molecular structures, allowing them to control material properties such as stiffness, strength, and elasticity. By introducing copper ions, the team can dynamically alter the rigidity of these materials.
Researchers found that linear alkane molecules passed through nanoscale pores faster than shorter ones, with transport rates determined by pore size and gate flexibility. The study revealed a two-step transport mechanism involving an encounter complex at the outer surface of the nanocube.
Gary Ulaner, a renowned nuclear medicine expert, has been elected president-elect of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). He aims to advance SNMMI's Mars Shot initiative, expand educational activities for professionals, and increase funding for training new radiochemistry and physics specialists.
UW researchers found that most biology education guidelines lack connections to society, with only 7% of elements discussing ethics and public health issues. This can lead to a lack of engagement and retention among students, as real-world examples support their interest in science and help develop their scientific identity.
The Society of Nuclear Medicine and Molecular Imaging recognized six new Fellows for their exceptional contributions to the field. The SNMMI Fellowship honors members who have demonstrated excellence in scientific discovery, educational efforts, or clinical practice.
A recent study published in Cell reveals that ethnicity and geography significantly influence human molecular diversity, including metabolism, immunity, and gut microbiota. The research found distinct molecular signatures associated with each ethnic group, highlighting the complex interplay between genetics and environment.
Researchers have developed a coherent Raman spectroscopy method that directly detects ångström-scale molecular films at interfaces without plasmonic enhancement or electronic resonance. This approach suppresses strong substrate background signals, allowing for highly sensitive interfacial Raman spectroscopy.
Researchers developed biocompatible molecular quantum nanosensors that operate inside living cells, enabling absolute temperature measurements with subcellular spatial resolution. The sensors also detect radical-related spin signals in the cytoplasm and nucleus of cancer cells.,
Researchers at LMU Munich develop a surface treatment method to optimize the molecular contact in perovskite solar cells, resulting in improved efficiency, reproducibility, and stability. The approach provides a scalable solution for industry-compatible fabrication workflows.
A study identifies subtype-specific programs in pediatric ependymoma, linking metabolic patterns to clinical aggressiveness. The research reveals distinct metabolic profiles for each molecular subtype, providing a resource for understanding the biology of pediatric ependymoma and potential therapeutic vulnerabilities.
A team of researchers from KAIST has developed a DNA-based molecular computer that can operate at a much smaller scale than conventional semiconductor devices. The system enables both computation and memory within the same device, opening up new possibilities for future computing technologies in bio and medical applications.
An international team of researchers used AI to create tiny 'smart' proteins that detect chosen targets, opening the way to low-cost biosensors. The protein switches can work inside living cells and generate electrical signals, making them suitable for various sensing technologies.
Researchers have created a high-resolution molecular map of specific sensory neurons that trigger pain, revealing two subtypes of nociceptors with distinct functional components. The study provides insights into the molecular mechanisms of chronic inflammatory pain and identifies potential new drug targets using Deep Visual Proteomics.
Hal Duncan, a Professor and Consultant in Endodontics at Trinity College Dublin, received the 2026 IADR Distinguished Scientist Award for his outstanding research contributions in pulp biology. His work focuses on translational pulp biology and applied vital pulp treatment using epigenetic modifications.
Chinese researchers develop novel post-dual OPA technique to amplify weak SFG signals, enabling detection of molecular signals at surfaces. The breakthrough opens possibilities for studying transient species in chemical reactions and other systems where surface molecular structure determines function.
Scientists have successfully constructed a phthalocyanine pentamer, a novel nanoarchitecture that integrates electronic and magnetic properties into a single molecule. The hybrid strategy combines solution chemistry and on-surface reactions on metal substrates, enabling the creation of complex molecular structures.
Preclinical studies reveal that MR hinders cell proliferation, triggers cell cycle arrest, and enhances standard treatments. Early-phase clinical trials report positive results on safety and tolerability, suggesting utility of MR as a complementary treatment strategy.
This study reclassified patients according to modern WHO Classification criteria, revealing molecular subtyping limitations, pathway co-activation patterns, and strong anatomical-molecular correlations. IDH1/2 mutations and TERT promoter mutations played key roles in determining prognosis.
Researchers develop novel method to manipulate cell structures using weak magnetic fields and isotopes, bridging structural biology, biophysics, and quantum biology. This work offers a potential new strategy for stabilizing damaged brain proteins, typical of neurodegenerative diseases.
Chemical Insights scientists received awards for their research on vaping-associated exposures and health risks, as well as other papers that integrate molecular biology or systems biology to toxicology research. The institute's efforts aim to safeguard public health by advancing scientific understanding of chemical risks.
Researchers developed a new method to discover molecular glues through large-scale chemistry and cell-based screening. They identified compounds that selectively degrade ENL in leukemia cells, demonstrating the potential of this approach for targeting previously undruggable proteins.
A research team led by Universitat Autonoma de Barcelona has discovered the molecular mechanism regulating bacterial cell division. The MraZ protein binds to the dcw gene cluster, enabling coordinated action of proteins necessary for cell division and bacterial wall formation.
Advanced Cancer Research defines a platform for integrating molecular biology, genomics, immunology, engineering, and computational science to understand cancer as a complex disease. The journal prioritizes studies that provide mechanistic depth and bridge disciplinary boundaries.
Researchers propose a new design principle for QM/MM simulations, enabling the objective and automatic determination of the quantum-mechanical region based on electronic-state changes. This approach addresses long-standing challenges in multiscale molecular simulations, demonstrating consistent applicability across different systems.
This review analyzes molecular mechanisms of DDR pathways in mediating chemotherapy resistance, elucidating correlations with BRCA1/2 deficiency and ATM/ATR signaling pathway dysregulation. The study presents a novel molecular synergy model between DDR regulation and Immune Checkpoint Blockade to enhance immunotherapy responses.