A new approach combines AI with high-resolution mass spectrometry and toxicology databases to predict biological effects of environmental chemicals. This framework helps researchers prioritize candidates for laboratory testing and health risk assessment.
Researchers found that certain sweeteners, such as isosteviol, impaired two important gut bacteria linked to regulating blood sugar and gut health. The study suggests that artificial sweeteners can directly affect gut microbes, particularly when mixed with other substances.
Researchers found ultrafine particulate matter from cruise ships increases inflammatory signals and weakens cells' defense against viruses like COVID-19. The study suggests exposure to vanadium may facilitate viral replication, with potential implications for infection severity and spread.
A newly published paper reveals that Karenia cristata, the source of neurotoxins in a devastating South Australian algal bloom, is the most toxic species ever studied. The bloom caused mass mortality of marine animals and has taken an immense environmental toll on the region.
Researchers at the University of Zurich have identified 10 biomarkers in saliva that can detect acute sleep deprivation. The study uses machine-learning methods to analyze metabolic changes in saliva, providing a new milestone for forensic research.
A study monitored the eggs of 14 bird species over a decade to characterize their exposure to environmental pollutants. The analysis detected contaminants derived from DDT and other pesticides, which impact species reproduction and ecosystem health.
A multidisciplinary research team at Texas A&M University has developed a faster and more accurate test for determining the risks of airborne chemicals to human lungs. The study uses lab-grown lung cell models and found that common pollutants like acrolein and formic acid can damage respiratory barriers.
The University of Cincinnati has opened a zebrafish research facility to investigate the effects of environmental contaminants on human fertility. The lab will use zebrafish as a model organism to understand molecular mechanisms behind reproductive biology and infertility.
Wendy Thompson, a Senior Clinical Lecturer at the University of Manchester, has been awarded the IADR Distinguished Scientist Award in Pharmacology/Therapeutics/Toxicology Research. Her research focus on antimicrobial stewardship and primary dental care has made significant contributions to the field.
UL Research Institutes' Chemical Insights will present findings on chemical exposures and health risks, highlighting new methods for faster, more transparent science. The institute aims to protect people and communities through open science, education, and collaboration.
The 2026 release expands coverage of emerging novel psychoactive substances, including synthetic cannabinoids, fentanyl analogs, and pharmaceutical drugs. The database provides comprehensive and up-to-date support for forensic, toxicology, and drug surveillance workflows.
Preclinical studies reveal that MR hinders cell proliferation, triggers cell cycle arrest, and enhances standard treatments. Early-phase clinical trials report positive results on safety and tolerability, suggesting utility of MR as a complementary treatment strategy.
Chemical Insights scientists received awards for their research on vaping-associated exposures and health risks, as well as other papers that integrate molecular biology or systems biology to toxicology research. The institute's efforts aim to safeguard public health by advancing scientific understanding of chemical risks.
Research suggests that deaths from synthetic opioids like nitazenes have been underreported, with some studies suggesting a 33% excess in drug-related deaths. The team believes that the non-detection of degraded nitazene breakdown products is to blame for the undercounting.
A recent study published in Cell Biology and Toxicology found that high concentrations of nanoplastics can cause damage to kidney cells, leading to changes in cell shape, survival, and function. The research highlights the need for more investigations into the long-term risks of nanoplastic exposure on human health.
Researchers developed a 3D miniature human liver model to improve toxicology studies of chemicals. The mini-liver demonstrates physiological and metabolic capabilities, enabling the detailed analysis of contaminant-induced effects on cells.
Katie Paul Friedman, Ph.D., Director of the Center for Informatics and Screening at Chemical Insights, received the prestigious 2026 Achievement Award from the Society of Toxicology for her innovative research and dedication to training the next generation. The award recognizes her contributions to new approach methodologies transformi...
New bioimaging tools follow nanoscale pollutants from entry to accumulation in organs, enabling real-time tracking and early detection of subtle effects. AIE-based probes distinguish nanoplastics or metal nanoparticles' behavior in cells, tissues, and organs.
Dr. Zhavoronkov's exceptional research influence has been validated by Clarivate, with over 310 peer-reviewed papers since 2012. His work has garnered over 16,500 citations per Google Scholar, primarily on generative adversarial networks and reinforcement learning for drug discovery.
Researchers found that apalutamide and finasteride effectively suppressed AML progression in mice and patient-derived cells by inhibiting the androgen hormone pathway. The study provides a novel targetable pathway for leukemia patients, offering a promising new direction for treatment.
Researchers at UC Riverside discovered that two toxic chemicals can form when propylene glycol is heated, harming human lung cells. The chemicals, methylglyoxal and acetaldehyde, disrupt cell functions and cause damage even at low levels.
Nanoparticle-mediated cancer therapeutics offer improved targeting and reduced toxicity through passive and active mechanisms. This enhances therapeutic results while tackling drug resistance and boosting specificity.
A new study found that new psychoactive substances (NPS) are a significant concern in roadway crashes in California. NPS, also known as ‘designer drugs’, were detected in the blood of 17 patients, with most frequent being designer benzodiazepines and fentanyl analogs.
The updated Maurer, Meyer, Helfer, Weber: LC-HR-MS/MS Library contains over 5,500 mass spectra for parent drugs and poisons, along with their metabolites. This comprehensive dataset enables scientists to confidently identify unknown compounds and assess toxic substance risks.
The University of Arizona has approved a new Bachelor of Science in Medical Pharmacology and Toxicology degree to support the AZ Healthy Tomorrow initiative. The program explores the effects of chemicals on human health and prepares students for jobs in fields like poison control, medical courier, and sanitization compliance.
Cadmium induces hyaluronan synthase 3 expression via the c-Jun N-terminal kinase–c-Jun pathway, leading to increased hyaluronan synthesis. This process accelerates atherosclerosis progression in vascular endothelial cells.
Dr Tewes Tralau is a renowned biologist with extensive experience in scientific management and risk communication, succeeding Professor Dr Tanja Schwerdtle as Vice-President of the BfR. He aims to contribute significantly to ensuring the BfR remains an internationally recognized reference for consumer protection.
Researchers at Boston University School of Medicine found significant inconsistencies in hospital toxicology screening practices following serious motor vehicle collisions. The study highlights the need for standardized, equitable reporting protocols to ensure every patient receives consistent care.
The study proposes a novel approach for simultaneous extraction of metabolites and lipids from zebrafish embryos to shed light on PFOS-induced neurotoxicity. The researchers found that sphingolipids are a reliable biomarker of PFOS-induced neurotoxicity, and the method can be expanded to various biomolecules.
The BfR is seeking experts from biochemistry, medicine, toxicology, pharmacology, statistics, and sociology to advise on risk assessment issues. The selected scientists will contribute their expertise to the commissions for a four-year term.
Frogs have been found to rapidly develop tolerance to pesticides through sublethal exposures, allowing them to survive in ecosystems where pesticides are commonly used. This rapid adaptation helps protect populations over generations.
A new metabolomics method has been proven to be a reliable approach for grouping chemicals, potentially reducing the use of lab rats. The study's results show that the method can accurately group chemicals into categories, making it a viable alternative to traditional methods.
Researchers have identified a sequence within therapeutic mRNAs that causes unintended immune responses and found a way to correct these errors. By designing 'slip-resistant' mRNAs, the team aims to produce future mRNA vaccines with improved safety and efficacy.
A recent study found that people with lower education levels in Appalachian Kentucky have higher colorectal and lung cancer incidence rates. An intervention program increasing educational attainment was shown to effectively increase knowledge of cancer among middle and high school students.
Two papers advance understanding of PFOS effects on aquatic life, particularly fish, by testing multiple concentrations and confirming its presence in water. The results indicate that earlier findings were non-repeatable and likely due to biological variation rather than PFOS toxicity.
Researchers create a new, multi-chamber organoid model of the human heart, enabling them to advance screening platforms for drug development, toxicology studies, and understanding heart development. The model reveals intricate communication between chambers and provides insight into early heart development.
A new study reveals that illicit drug use is involved in nearly one in three sudden cardiac deaths (SCDs) among young adults in Victoria, Australia. The analysis of data from a statewide registry found higher levels of illicit drugs and multiple substance use among SCD patients.
Researchers analyzed PFAS levels in fish food and organisms used in aquatic laboratory experiments. They found significant contamination across different types of food and aquaculture practices, recommending pre-testing for all feeds and organisms.
A special issue of Frontiers in Toxicology highlights diverse approaches to assess chemical toxicity without animal use. Non-animal tests have been used to replace animal tests for respiratory and skin effects, but remaining challenges remain.
Researchers developed a 3D organoid model that mimics human heart development, revealing how low levels of cadmium can block cardiomyocyte formation and induce heart abnormalities. The study supports decades of toxicology research on environmental exposures contributing to human diseases.
A research team led by Ivano Amelio found that the protein p53 acts as a key to maintaining genomic stability, preventing cancer-promoting mutations. Without p53, cells become more aggressive and prone to acquire genomic instability.
Researchers discovered more than 200 genes with different epigenetic marks in Parkinson's disease brain neurons, but the affected genes were almost entirely different in men and women. The study opens up new avenues for investigation into how these genes contribute to the disease.
New research published in Environmental Toxicology and Chemistry found that green household consumer products (HCPs) can be either less toxic or more toxic than their conventional counterparts. The study involved testing various HCPs on grass shrimp and Daphnia Magna, a type of freshwater crustacean.
A recent study has highlighted the need for regulation of flavor chemicals and synthetic coolants in Puff electronic cigarettes due to their high levels of toxicity. The researchers found that the chemicals in disposable Puff ECs are at high levels and cytotoxic, posing a risk to public health.
A systematic literature review found that existing chemical risk assessments are inadequate and contradictory. The review of 74 toxicology studies and 74 epidemiological studies revealed an underestimation of the levels of flame retardants needed to cause harmful health effects.
The WVU program trains next generation of toxicologists to collect, analyze air samples from mining, fracking sites, using the university's Inhalation Facility. Students will work with preceptors from various fields to investigate health effects of inhaling toxicants.
A study published in Environmental Toxicology and Chemistry found that pesticide levels are low in nectar and pollen collected by honey bees in urban and suburban areas across the US. Chemical analyses detected 17 pesticides in nectar and 60 in pollen samples, with 73% of all samples containing no detectable pesticide residues.
A recent study published in Applied In Vitro Toxicology found that tobacco-free nicotine pouches exhibit reduced levels of toxicants and biological activity compared to combustible cigarette smoke. The products, manufactured by Imperial Brands, showed substantially reduced genotoxicity and cytotoxicity in three toxicological assays.
A recent study found that prenatal exposure to phthalates in maternal and cord blood may affect birth outcomes in infants, with potential estrogenic effects in females and anti-androgenic effects in males. Higher levels of phthalates were also associated with smaller head circumference in all infants.
Researchers analyzed existing studies on PFAS in breast milk, finding that levels of PFOA and PFOS exceeded children's drinking water screening values by up to two orders of magnitude. The study emphasizes the need for a national breastmilk monitoring program to provide credible advice to pregnant or breastfeeding women.
A recent study published in Frontiers in Toxicology found that heated tobacco and vape next generation products display reduced cardiotoxicity potential relative to combustible cigarette smoke. Heated tobacco aerosol showed some cardiotoxic potential, while vape aerosol exhibited no cardiotoxic effects even at high concentrations.
Researchers analyzed primary sludge from a Connecticut wastewater treatment plant, revealing trends in pandemic-related chemicals like hydroxychloroquine. The study found increases in drugs of abuse and antidepressants, as well as seasonal changes in sunscreen chemicals.
A study published in Reproductive Toxicology found that rhesus macaques exposed to wildfire smoke early in pregnancy had an increased rate of miscarriage. The researchers discovered that high levels of small particles (PM2.5) and phthalates, known endocrine disruptors, were present in the smoke.
Robyn Tanguay, a renowned toxicologist, has received an $8 million grant from the National Institute of Environmental Health Sciences. She plans to use this funding to conduct large-scale studies on zebrafish embryos exposed to 10,000 common chemicals, which could lead to significant breakthroughs in predictive toxicology.
Martin Thornhill, a renowned professor at the University of Sheffield, has received the 2021 IADR Distinguished Scientist Award in Pharmacology/Therapeutics/Toxicology Research. He is recognized for his sustained contributions to dental and medical research, covering topics such as oral mucosa conditions.
A four-fold increase in unintentional poisonings in children under 12 and a three-fold increase in ICU admissions for severe cannabis poisoning were seen after legalization. Edible cannabis products, highly concentrated and visually attractive to young children, are the primary cause of these increases.
The University of Louisville Hepatobiology and Toxicology Center has received $11.3 million in NIH funding to support its research into liver-related illness. The center aims to reduce the impact of liver illnesses through prevention and therapy development.
A recent study published in Drug and Chemical Toxicology found that BAT's modern oral nicotine pouches have a comparable toxicant profile to NRTs, with significantly lower levels of toxicants than traditional oral snus. The study suggests that MO products should be placed close to NRTs on the reduced-risk product continuum.
A study published in Environmental Toxicology and Chemistry reveals high levels of contaminants in killer whales near Norway, affecting their tissues and offspring. The findings also highlight the persistence and mobility of chemicals in marine ecosystems.