Researchers developed a wireless eye-pressure monitoring system to capture daily changes in eye pressure, revealing daily rhythms and circadian influences. The study suggests eye pressure follows a daily pattern linked to the body's internal clock, with nighttime increases driven by neural signals.
A new clinical practice guideline aims to standardize the identification and management of infants at increased risk for cerebral visual impairment (CVI). The guideline recommends comprehensive ophthalmologic evaluation and referral to developmental services within the first six months of life to access interventions as early as possible.
Rising rates of ocular syphilis and ocular toxoplasmosis are putting people at risk of preventable vision loss. Early diagnosis and treatment can significantly reduce the risk of permanent sight loss. Regular eye examinations and timely reporting of vision changes are crucial in protecting sight.
The new technique overcomes hardware barriers to provide highly accessible and affordable 4D imaging for diagnosing and monitoring complex eye diseases like glaucoma. It captures true 3D and 4D volumetric data, overcoming limitations of conventional 2D imaging.
Researchers aim to understand the conditions that determine the survival of transplanted retinal cells and develop more effective regenerative therapies for geographic atrophy. They also seek to uncover early mechanisms that contribute to infertility and create a more detailed blueprint for human germ cell development.
Finnish researchers have discovered that vatinoxan improves anaesthesia safety in rats by inhibiting exophthalmos and improving tissue oxygenation. This breakthrough could spare millions of animals from adverse effects, resulting in more reliable study results and reduced animal numbers.
The latest figures from the European Registry of Quality Outcomes for Cataract and Refractive Surgery show significant improvements in safety and efficacy, with complications such as posterior capsule rupture occurring at a low rate. The registry has recorded nearly five million cataract surgeries, with the most common procedure being ...
Researchers developed a low-cost smartphone attachment to capture diagnostic-quality eye images, which can be reviewed remotely by ophthalmologists. Community health workers and remote ophthalmologists agreed on 96% of cataract diagnoses, challenging the assumption that specialist presence is necessary for accurate screening.
A new vision condition, EFEMP1-associated late-onset retinal degeneration (L-ORD), has been discovered, causing slow decline in peripheral vision and night vision loss. The p.Arg140Trp variant in the EFEMP1 gene leads to abnormally thick material building up between eye cells, affecting rod photoreceptors' recovery in darkness.
A study among young women with regular eyelash extensions found most had Demodex folliculorum skin mites, causing eye irritation and blocked meibomian glands. Simple hygiene steps and proper treatment can mitigate these issues, the researchers advise.
Researchers discovered PECAM-dependent mechanism for immune cell traffic in the retina, identifying neutrophils as proresolving mediators. Targeting PECAM controlled white blood cell traffic, leading to improved clinical outcomes in uveitis model.
Researchers at Kyushu University found a new molecular pathway that explains why intraocular pressure increases at night. Norepinephrine increases RHOB in the eye's drainage system, weakening its
Uwe Wolfrum's research on Usher syndrome aims to prevent vision loss in patients with the disorder. His team uses human retinal organoids and pig models to investigate the molecular mechanisms of the disease, paving the way for gene-based therapies.
Researchers found that enhancing autophagy, a cellular recycling process, helps preserve retinal nerve cells in glaucoma models. This approach may protect against cell loss and degeneration, potentially complementing current treatments.
A study reveals systemic lipid metabolic rewiring in Bietti's crystalline dystrophy, with patients showing distinct plasma lipid signatures and compensatory metabolic network changes. The research also identifies potential blood-based biomarkers for disease monitoring and treatment safety.
Researchers developed a collagen scaffold to deliver stem cells to treat ARK, a progressive eye condition causing profound visual loss. After three months, treated eyes showed significant improvement in vision, with an average ETDRS score increase of 24 letters.
A three-year study found that posterior scleral reinforcement slowed macular fundus tessellation and preserved subfoveal choroidal thickness in children with progressive high myopia. The researchers suggest that PSR may help delay early myopic maculopathy-related changes, possibly through mechanisms beyond axial elongation.
A study found a significant decrease in postoperative endophthalmitis rates after implementing a multifaceted surgical safety culture intervention, from 0.038% to 0.013%. The rate dropped by 64.4% among patients undergoing inpatient ophthalmic surgery.
ISM9077 boasts potent inhibition across species, excellent exposure and permeability traits, and a favorable safety profile in preclinical studies. It modulates pathological inflammation, supporting broad indication expansion into therapeutic areas like aging and neurodegenerative diseases.
Researchers tested cortisone eye drops to slow ROP progression in 100 premature babies. The intervention reduced treatment-requiring ROP by 47% compared to placebo.
A study published in Communications Medicine found that early vitrectomy surgery can be more beneficial for patients' vision than the current antibiotic-first approach. After six months, patients who received this treatment showed a median improvement of 40 additional letters they could read compared to those receiving antibiotics.
Scientists have identified a previously unknown waste drainage system at the back of the eye, called the posterior ocular lymphatic outflow, or POLO pathway. This discovery provides a new framework for understanding leading causes of blindness and opens opportunities for harnessing this system to treat disease.
A large retrospective study found that semaglutide and other GLP-1 drugs did not increase or decrease the risk of developing a blinding eye condition in adults with type 2 diabetes. The study analyzed data from over 200,000 patients and found no significant difference in the risk of neovascular age-related macular degeneration.
A multicenter study found that patients with irregular corneas achieved significant visual acuity improvements after wearing a four-zone scleral lens for three months. The lenses showed encouraging fitting efficiency and patient comfort, with minimal adverse events reported.
Dr. Lisa Ostrin and Dr. Sayan Ghosh join SUNY Optometry to expand expertise in myopia, ocular development, and age-related macular degeneration. Their research aims to improve patient care, public health, and vision science.
A Phase 1/2a clinical study demonstrates long-term survival of transplanted human neural progenitor cells in patients with retinitis pigmentosa, maintaining a favorable safety profile. Visual acuity remained stable, and imaging showed cells remaining present in the subretinal space for at least one year.
Researchers used structured light from quantum optics to transform Boehm's brushes into brighter patterns, improving their detectability. This technique may help diagnose retinal diseases like macular degeneration.
A five-year study will focus on developing and evaluating compounds to treat best vitelliform macular dystrophy, a rare inherited retinal disease affecting the retina. The research aims to improve patients' lives by preserving sight.
Biomedical engineers at Duke University have successfully grown specialized blood vessel cells critical to retinal health from induced pluripotent stem cells. These 'retinal endothelial cells' integrated into damaged tissue to regenerate blood vessels, restore function, and form functional vascular tissue in a lab-grown environment.
A new study calls for formal recognition of toxoplasmosis as a neglected tropical disease by the World Health Organization. The disease, which can cause permanent vision loss, affects one third of the world's population and has significant impacts on global health.
A recent study published in Eye Discovery evaluated the early visual quality after KLEx surgery using the VISUMAX 800 platform. The study found excellent safety and efficacy outcomes, with most subjective visual symptoms improving over time. However, glare symptoms persisted longer than expected, highlighting the need for preoperative ...
A Norwegian University of Science and Technology study found that doctors in hospitals treating the most premature babies were more likely to diagnose eye disease requiring treatment. This contradicts expectations that these doctors would be over-diagnosing. The researchers are now investigating possible reasons for this difference, in...
A novel treatment approach for diabetic macular edema has shown promise in reducing treatment burden and cost without compromising visual outcomes. The '1 + 1 + PRN' sequential regimen involves fewer injections, which may improve patient adherence and quality of life.
A team of SUNY Optometry researchers will track children's real-world visual habits using wearable sensor technology and eye-tracking tools. The goal is to identify measurable signs of risk for myopia onset and progression.
Sebaceous adenoma is a rare, slow-growing benign tumor arising from sebaceous glands. A new case report describes the clinical, histopathological, and immunohistochemical features of this tumor, highlighting its diagnostic challenges and importance of distinguishing it from more aggressive conditions.
A recent study published in Eye Discovery identified a coordinated failure of tissue regeneration and vascular control in corneal alkali burns. The research found that limbal stem cells, transient amplifying cells, and macrophages form an amplified VEGF communication network, leading to excessive vascular growth and vision loss.
The article discusses how AI is unlocking hidden potential in multimodal ophthalmic datasets, enabling high-precision screening and early detection of eye diseases. It highlights the integration of various imaging modalities and non-imaging data types to provide a comprehensive diagnostic framework.
The study utilizes high-sensitivity LC-MS to quantify TCA cycle intermediates in mouse ocular tissues, revealing dual differences in metabolic characteristics based on spatial distribution and biological sex. Key findings include tissue-specific metabolic phenotypes and sexual dimorphism of metabolic profiles.
A new study published in Eye and Vision finds that one drop of low-dose atropine can produce daylong effects in managing myopia. The researchers found that the drop showed clear changes in pupil size and focusing ability, but no short-term structural effects on the eye.
A USC-led team is working on a medical device that uses tears to monitor health, starting with dry eye disease. The device aims to provide continuous monitoring and automated medication delivery, improving patient comfort and treatment efficacy.
Kiora Pharmaceuticals' Phase 1 ABACUS-1 study of KIO-301 demonstrates short-term ocular safety and feasibility in patients with late-stage retinitis pigmentosa. The Phase 2 trial is underway to evaluate functional visual improvements and compare them to a control group.
Researchers at the University of Pittsburgh School of Medicine develop an experimental 'living eye drop' using naturally occurring eye bacteria to accelerate corneal wound healing. The engineered bacteria, Corynebacterium mastitidis, continuously secrete interleukin-10, a protein that regulates inflammation.
A University of Houston optometry researcher warns of the dangers of red-light laser myopia therapy for children, citing vision damage reports and the need for rigorous safety validation. The professor's quality improvement study found that two popular devices exceeded national standards for safety classifications.
A study published in Cornea reveals that aniridia not only alters corneal structure but also affects sensory nerve function, leading to a progressive decline in corneal sensitivity. In adulthood, patients experience difficulty distinguishing stimulus intensity and reduced tear production, compromising eye defense mechanisms.
A new study proposes that myopia is driven by how we use our eyes indoors, with prolonged close-up focus in low-light environments limiting retinal illumination. This mechanism could lead to a paradigm shift in understanding and controlling myopia progression and control.
A blind patient partially recovered natural vision through electrical stimulation of the visual cortex, independent of the implant. The recovery was sustained over time and remained even after the device was removed, suggesting individual factors may have contributed to this outcome.
A WVU research team is working to restore vision in people with inherited blindness due to genetic mutations in the Prominin1 gene. The team has observed encouraging early results using a mouse model and plans to investigate the therapy's effectiveness beyond initial restoration.
Researchers have identified a metabolically sensitive cell subtype in the eye's drainage system that shows early signs of dysfunction in a genetic mouse model of glaucoma. The study provides what the editors say are fundamental findings highlighting a potential therapeutic strategy for preventing or slowing the development of glaucoma.
A new study demonstrates the effectiveness of a widely-used eye injection in managing hypotony, a rare condition characterized by abnormally low eye pressure. The treatment, which involves injecting HPMC gel, has shown promising results in restoring vision and increasing eye pressure.
A large-scale field trial in Ethiopia found no significant difference between fluorometholone and placebo treatments in reducing postoperative trachomatous trichiasis recurrence. The study, which involved over 2,400 participants, suggests that anti-inflammatory therapy may not be beneficial for improving TT surgery outcomes.
Researchers identified changes in RNA molecules involved in cell's splicing machinery, causing retinitis pigmentosa in ~30-40% of patients with genetic disorder. Variants in five non-coding RNA genes were found to be responsible for the disease, offering a new diagnostic pathway for families worldwide.
A new study from UCLA Health found that a cardiovascular risk score can predict who will develop serious eye diseases years later. Higher cardiovascular risk scores were significantly more likely to develop conditions like age-related macular degeneration, diabetic retinopathy, and glaucoma.
Dry eye disease affects 5-15% of people, causing symptoms like redness and burning sensation. Researchers generated human tear gland organoids from stem cells to understand the connection between DED and autophagy. They found that disabling autophagy led to cellular disruption, reduced tear protein secretion, and increased cell death.
A new MIT study reveals that temporarily anesthetizing the retina of the amblyopic eye can restore its neural connections and improve vision in adulthood. The treatment, which has been shown to be effective in infancy and early childhood, may have promising clinical potential for adults with amblyopia.
This comprehensive volume provides detailed protocols for studying glaucoma disease mechanisms, drug formulation, and cutting-edge tools. It covers molecular biology, pharmacology, and histological approaches to support scientists in ophthalmic drug discovery and translational research.
Researchers observed significant increase in tear film lipid layer thickness and corneal temperature during VR sessions, suggesting stabilization of the tear film. The study provides early insights for VR headset design and usage considerations related to eye comfort and health.
The Leopoldina discussion paper recommends realigning German development cooperation to focus on both prevention and medical treatment for childhood blindness. The approach, called 'Global Clinical Care', aims to strengthen local care capacities and provide training for ophthalmic specialists through institutional partnerships.
Researchers at Aalto University have developed a promising new treatment approach for dry age-related macular degeneration (AMD), which can potentially stop the disease's progression. The novel method uses heat and near-infrared light to trigger healing responses at a cellular level, strengthening protective mechanisms of affected cells.
A cohort study found that GLP-1 receptor agonist use was associated with a reduced risk of developing nonexudative AMD, but not progression to exudative AMD in individuals with nonexudative AMD. This study may inform future randomized trials evaluating the ocular effects of GLP-1RAs in nondiabetic populations.
Tear-derived extracellular vesicles show promise as non-invasive biomarkers for ocular and neurodegenerative diseases. The study highlights their potential to provide valuable information about the eye's health, including processes related to neurodegenerative diseases.