Articles tagged with Eye Diseases
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A blind patient partially recovered natural vision through electrical stimulation of the visual cortex, independent of the implant. The recovery was sustained over time and remained even after the device was removed, suggesting individual factors may have contributed to this outcome.
A WVU research team is working to restore vision in people with inherited blindness due to genetic mutations in the Prominin1 gene. The team has observed encouraging early results using a mouse model and plans to investigate the therapy's effectiveness beyond initial restoration.
Researchers have identified a metabolically sensitive cell subtype in the eye's drainage system that shows early signs of dysfunction in a genetic mouse model of glaucoma. The study provides what the editors say are fundamental findings highlighting a potential therapeutic strategy for preventing or slowing the development of glaucoma.
A new study demonstrates the effectiveness of a widely-used eye injection in managing hypotony, a rare condition characterized by abnormally low eye pressure. The treatment, which involves injecting HPMC gel, has shown promising results in restoring vision and increasing eye pressure.
A large-scale field trial in Ethiopia found no significant difference between fluorometholone and placebo treatments in reducing postoperative trachomatous trichiasis recurrence. The study, which involved over 2,400 participants, suggests that anti-inflammatory therapy may not be beneficial for improving TT surgery outcomes.
Researchers identified changes in RNA molecules involved in cell's splicing machinery, causing retinitis pigmentosa in ~30-40% of patients with genetic disorder. Variants in five non-coding RNA genes were found to be responsible for the disease, offering a new diagnostic pathway for families worldwide.
A new study from UCLA Health found that a cardiovascular risk score can predict who will develop serious eye diseases years later. Higher cardiovascular risk scores were significantly more likely to develop conditions like age-related macular degeneration, diabetic retinopathy, and glaucoma.
Dry eye disease affects 5-15% of people, causing symptoms like redness and burning sensation. Researchers generated human tear gland organoids from stem cells to understand the connection between DED and autophagy. They found that disabling autophagy led to cellular disruption, reduced tear protein secretion, and increased cell death.
A new MIT study reveals that temporarily anesthetizing the retina of the amblyopic eye can restore its neural connections and improve vision in adulthood. The treatment, which has been shown to be effective in infancy and early childhood, may have promising clinical potential for adults with amblyopia.
This comprehensive volume provides detailed protocols for studying glaucoma disease mechanisms, drug formulation, and cutting-edge tools. It covers molecular biology, pharmacology, and histological approaches to support scientists in ophthalmic drug discovery and translational research.
Researchers observed significant increase in tear film lipid layer thickness and corneal temperature during VR sessions, suggesting stabilization of the tear film. The study provides early insights for VR headset design and usage considerations related to eye comfort and health.
The Leopoldina discussion paper recommends realigning German development cooperation to focus on both prevention and medical treatment for childhood blindness. The approach, called 'Global Clinical Care', aims to strengthen local care capacities and provide training for ophthalmic specialists through institutional partnerships.
Researchers at Aalto University have developed a promising new treatment approach for dry age-related macular degeneration (AMD), which can potentially stop the disease's progression. The novel method uses heat and near-infrared light to trigger healing responses at a cellular level, strengthening protective mechanisms of affected cells.
A cohort study found that GLP-1 receptor agonist use was associated with a reduced risk of developing nonexudative AMD, but not progression to exudative AMD in individuals with nonexudative AMD. This study may inform future randomized trials evaluating the ocular effects of GLP-1RAs in nondiabetic populations.
Tear-derived extracellular vesicles show promise as non-invasive biomarkers for ocular and neurodegenerative diseases. The study highlights their potential to provide valuable information about the eye's health, including processes related to neurodegenerative diseases.
Researchers found that 1% penciclovir cream is safe and well-tolerated when used to treat feline herpesvirus type 1-related eye infections. The cream maintained antiviral levels for over eight hours, suggesting twice-daily use could effectively manage the condition.
Dr. Kathryn Colby, NYU Langone Health's chair of ophthalmology, has received the prestigious Castroviejo Medal for her pioneering work on Fuchs endothelial corneal dystrophy. Her research explores a new surgical procedure to stimulate corneal regeneration.
A research team has discovered a previously unknown genetic cause of hereditary optic atrophy, a degenerative disease of the optic nerve associated with gradual loss of vision. A genetic variant in the PPIB gene was found to impair mitochondrial function, detectable in most known forms of hereditary optic atrophy.
Researchers developed AI-powered BlinkWise glasses that track blinking patterns to assess fatigue, mental workload, and eye-related health issues. The device uses radio signals to detect minute eyelid movements with unprecedented detail, preserving privacy and using minimal power.
A new study from UC Irvine researchers explores a potential therapy for addressing aging in the eye and preventing diseases like age-related macular degeneration. Injecting polyunsaturated fatty acids into aged mice improved visual function, suggesting a possible way to reverse age-related vision decline.
Researchers are conducting a national study to test the effectiveness of daily atropine drops in delaying and reducing nearsightedness in young children. The study aims to enroll over 600 children aged 6-11 who will receive either atropine or a placebo, with results comparing the timing of onset and progression of myopia.
A study found that more than half of the general population in the USA and Europe experience dry eyes, with only 20% of European patients and 17% of US patients receiving a diagnosis. The delay in seeking treatment is concerning, as early intervention can prevent inflammation and worsening symptoms.
Researchers used AI to assess images of patients' eyes and predict those who needed prompt treatment, successfully sorting up to 90% of patients. The study's findings could lead to earlier treatment and reduced unnecessary monitoring for patients with keratoconus.
Two new studies show that cataract surgery on both eyes can be safe and effective for most patients to perform immediately after surgery, with high rates of independence and minimal need for assistance. Patients receiving multifocal lenses achieved the best visual outcomes, with over 85% achieving 20/20 vision or better.
A new imaging approach has simplified retina exams by eliminating the need for mechanical focusing, making fundus cameras more accessible. The system uses a diffuser to capture 3D light information and digitally refocus images after they are taken, producing consistent resolution of about 7-10 line pairs per millimeter.
A team of researchers has received funding to study the PRPH2 gene, crucial for normal vision, but when mutated causes a range of retinal diseases leading to blindness. They aim to uncover the underlying mechanisms of PRPH2-associated pathology to develop effective therapies.
Scientists at the University of Alabama at Birmingham created novel mouse models with mutations in the DHDDS gene to study retinitis pigmentosa (RP) 59, a genetic cause of blindness. The studies revealed that both T206A/K42E and K42E/K42E mouse models exhibited changes in retinal structure and function similar to human RP59 disease.
Researchers at Wayne State University are developing novel therapies to treat ocular chemical injuries using host-derived metabolites. The project aims to reduce inflammation, promote corneal nerve regeneration, and enhance wound healing, with potential for clinically translatable treatments that can preserve vision.
A new study sponsored by Neurotech Pharmaceuticals and led by Scripps Research confirms that a neuroprotective surgical implant can slow vision loss in people with macular telangiectasia type 2 (MacTel). The implant, ENCELTO, delivers a therapeutic protein to preserve vision.
Researchers have established apple snails as a system to study eye regeneration, which may hold the key for restoring vision due to damage and disease. The team discovered that the snail eye is anatomically similar to humans and can regrow itself, with genes such as pax6 playing a crucial role in development.
Researchers have developed a groundbreaking gene therapy approach for treating neovascular age-related macular degeneration, targeting VEGF-A and ANG-2 to suppress abnormal blood vessel growth. The treatment has shown significant clinical benefits in animal models and patients with minimal side effects.
In a breakthrough study, researchers at the University of Rochester Medical Center found that microglia cells respond differently than neutrophils to photoreceptor damage in the retina. This discovery has high implications for treating vision loss caused by photoreceptor cell damage.
A new route of delivering gene therapy is being explored, potentially reducing invasiveness and increasing accessibility. Researchers will test a novel approach on non-human primates, aiming to expand access to office-based treatments.
A new study found that older people with diabetes who do not control their blood sugar levels are three times more likely to develop eye disease than those with controlled blood sugar levels. High glucose levels were also linked to an increased risk of glaucoma and macular degeneration.
A novel self-supervised learning-based domain-specific model, OSPM, was developed to detect malignant and premalignant ocular surface tumors. The model demonstrated robust performance on a large dataset of images from multiple clinical centers.
Researchers have identified a previously unknown organelle called the hemifusome that plays a crucial role in cellular sorting and recycling. This discovery could lead to targeted treatments for complex genetic disorders like Hermansky-Pudlak syndrome, which affects multiple systems in the body.
A new study found that increasing apolipoprotein M levels can slow or block progression of age-related macular degeneration, a leading cause of blindness in people over 50. The researchers also found that ApoM triggers a signaling pathway that breaks down cholesterol deposits.
Dry eye disease affects one-third of adults and one-in-five children, causing discomfort and blurred vision. A new app, MyDryEye, has been developed with optimized blinking exercises that have been shown to decrease symptom severity and frequency, with participants experiencing improved symptoms within two weeks.
The FDA has approved ENCELTO, an eye implant that delivers ciliary neurotrophic factor to slow vision loss in people with macular telangiectasia type 2. This device preserves sight in patients with this condition, which affects the central part of the retina.
Researchers developed stable MXene-coated contact lenses providing enhanced protection against electromagnetic radiation. The lenses exhibited a rapid temperature rise when exposed to microwave heating, indicating strong EMR absorption and dissipation.
Researchers found that an inexpensive HIV drug can improve vision in patients with diabetic macular edema (DME) more effectively and at a lower cost than existing treatments. The drug, lamivudine, is taken orally and may represent a game-changing option for millions of patients worldwide.
A new study by Anglia Ruskin University found that global refractive correction rates are at 65.8%, six percentage points lower than in 2010, and urge urgent action to meet the WHO's target of a 40% increase by 2030.
Researchers have developed a novel surgical technique to implant multiple tissue grafts in the eye's retina, expanding treatment options for dry AMD. The new method, which maintains eye pressure during graft insertion, promotes photoreceptor survival and regeneration of the choriocapillaris.
Researchers at Wayne State University are developing a new treatment to prevent diabetic corneal complications, which can lead to vision loss and poor healing. The project combines two naturally occurring peptides to target inflammation, delayed healing, and nerve degeneration.
Researchers found that supplements of B vitamins B6, B9, and B12, as well as choline, slowed down damage to the optic nerve in glaucoma. This was observed in experiments on mice and rats with glaucoma, where eye pressure was left untreated.
Researchers found that 90% of participants had at least one sign of dry eye disease, with significant progression after one year. The study highlights the need for early detection and advice on managing the condition through simple methods such as taking screen breaks and maintaining a healthy lifestyle.
A study found that patients who experienced vision impairment due to microbial keratitis had poorer treatment outcomes if they delayed seeking medical attention or had more extensive eye damage. In contrast, patients in the US who wore contact lenses had better outcomes, possibly due to earlier treatment by their physicians.
Researchers at UC Berkeley created a platform called Oz that controls up to 1,000 photoreceptors in the eye at once, enabling the perception of a blue-green color named 'olo'. This breakthrough could provide new insights into human sight and vision loss, as well as answer basic questions about color vision.
A new study from the University of Oklahoma is targeting cell communication in the hunt for therapies to slow macular degeneration. The research team is studying how cells in the retina communicate and whether the messages they send could be programmed to treat or slow AMD.
Researchers found that a thicker preoperative macular layer in the right eye was associated with an increased risk of postoperative delirium. The study suggests that retinal imaging may serve as a non-invasive biomarker to identify individuals at risk, particularly after anesthesia and surgery.
A novel cannula delivery system allows repeated, nondisruptive delivery of imaging agents to the mouse brain during long-term multiphoton microscopy. This innovation enhances longitudinal studies on brain function, disease progression, and potential treatments.
Researchers discovered that aging causes inflammation, oxidative stress, and gene disruption in the retinal pigment epithelium, a vital layer of cells in the eye. This study provides a clearer understanding of why aging leads to eye disease and introduces a reliable laboratory model for testing new therapies.
Researchers have gained detailed insights into RBP3's structure and mechanism of action, shedding light on its role in protecting the retina from diseases. The study suggests potential therapies to slow or stop retinal degeneration, including RP and myopia.
Researchers at KAIST have successfully developed a treatment method that restores vision by inducing retinal regeneration and vision recovery in disease-model mice. The approach involves blocking the PROX1 protein, which suppresses retinal regeneration, using an antibody developed by Celliaz Inc.
The University of Texas at Arlington expert discusses the state's largest outbreak in 30 years, with fewer people getting vaccinated contributing to its spread. The MMR vaccine is 97% effective against measles and has been proven safe despite misconceptions about its safety.
A new study found that treating aged mice with montelukast improved retinal health by reducing inflammation and boosting proteasome activity. This approach may offer a promising new way to slow age-related vision loss and protect eye health in older adults.
Researchers at the NIH developed eye drops containing a short peptide derived from PEDF, which slowed photoreceptor degeneration and vision loss in animal models of retinitis pigmentosa and dry age-related macular degeneration. The treatment preserved up to 75% of photoreceptors and showed no negative side effects.
A Northwestern University study found significant disparities in glaucoma monitoring, with rural and economically distressed communities facing barriers to care. The study identified strategies to improve access, including expanding tele-ophthalmology services, home monitoring technology, and financial support.
Researchers have successfully developed lab-grown pig retinal organoids, which shared similarities with human retinal organoids. The study offers a promising approach to combatting retinal disease by testing 'human-equivalent' photoreceptors in pigs.
Researchers emphasize the importance of regular screenings and treatment to prevent vision loss in patients with diabetes. Current guidelines recommend eye exams for adults with type 1 and type 2 diabetes, while adolescents and young adults are at higher risk due to difficulty controlling their condition.