Articles tagged with Gastroenterology
Researchers at the University of Tokyo have developed a pill-shaped device that can collect samples from the small intestine using a tiny extendable brush. The device is designed to be magnetically controlled, allowing it to move through extracted intestines and sweep useful samples from the intestinal surface. The technology has the p...
High-dose taurine supplementation aggravates alcohol-induced liver injury by disrupting lipid metabolism and gut dysbiosis, leading to increased hepatocellular injury and inflammatory responses. Low-dose taurine shows a protective profile by reducing hepatic fat accumulation and lowering liver injury markers.
A systematic review and meta-analysis found that approximately 40% of patients with chronic pancreatitis worldwide develop exocrine pancreatic insufficiency, a condition that can lead to malabsorption, weight loss, and deficiencies in fat-soluble vitamins. Smoking emerged as a significant modifiable risk factor, emphasizing the need fo...
A Chinese registry report presents real-world perioperative and survival outcomes for surgically treated pancreatic cancer patients, achieving high overall survival rates and encouraging surgical safety metrics. The study emphasizes the need for national-level benchmarks and standardized clinical protocols for pancreatic surgery in China.
A new AI tool predicts organ failure in acute pancreatitis with high accuracy, using multiphase CT imaging and outperforming standard scoring systems. The model achieves early automated prediction, with 55% of cases predicted at least 3 hours in advance.
Researchers found similar diarrhea outcomes among patients with low and normal fecal elastase levels, suggesting stool dilution is a possible cause. Fecal fat testing is recommended before enzyme therapy to confirm exocrine pancreatic insufficiency.
Researchers at MIT have created tiny, bioresorbable batteries that can power ingestible electronic devices, such as RFID tags and capsules that stimulate ghrelin production, for up to three days. The batteries, made from magnesium and molybdenum trioxide, can be fully broken down and absorbed by the body, reducing environmental impact.
Researchers developed targeted fecal qPCR models that showed moderate discrimination for colorectal and pancreatic cancer, offering a potential non-invasive approach for early detection and risk assessment. The study's findings suggest that fecal qPCR could provide complementary information without invasive sampling.
A study found that probiotic supplement use increased 287% among adults and 786% among young people, while fiber intake remained unchanged, between 2009 and 2023. Probiotic users consumed more high-microbial foods and fiber content than non-users, but these beneficial diet habits may be decreasing due to supplement use.
A Swedish registry study found that IBD patients with multiple close relatives having colorectal cancer are significantly more likely to develop the disease. The study suggests that future cancer screening guidelines should consider the number of cancer cases in a patient's family.
Scientists have identified a microbiome signaling system that controls intestinal movement, revealing a potential new direction for treating constipation-predominant irritable bowel syndrome. The discovery points to restoring combinations of microbial signals to restore normal function.
Researchers found that dietary tryptophan supplementation can prevent sepsis by enhancing macrophage bacterial defense through GPR37 activation, which increases phagocytic ability against bacteria. IPyA, a key metabolic product, directly binds to GPR37 on macrophages, activating RAC1/CDC42 and increasing phagocytosis.
The study found that Ct-HBx upregulates PAI-1 by opening chromatin and trans-activating its expression, increasing hepatocellular carcinoma risk and prognosis. PAI-1 levels and genetic polymorphisms serve as biomarkers for predicting HCC risk and postoperative prognosis.
Robotic gastrectomy reduces complications, blood loss, and hospital stay compared to laparoscopic surgery for gastric cancer patients, with benefits seen in both distal and total gastrectomy procedures. Longer procedures may be offset by improved visualization and enhanced dexterity.
Researchers found that active participation in colorectal cancer screening was associated with a 43% lower risk of dying from the disease, compared to just a 26% lower risk for those invited to screening. This study highlights the importance of taking part in colorectal cancer screening to save lives.
Non-invasive approaches are expanding options for assessing portal hypertension, with elastography techniques and biochemical markers showing high sensitivity and specificity. AI-powered predictive models combine clinical data to improve diagnosis, but should not replace invasive HVPG, which remains the gold standard.
Researchers found that patients with inflammatory bowel disease (IBD) are at a significantly higher risk of developing psychiatric disorders, particularly depression and anxiety. The study highlights the importance of early screening and integration of psychological care into routine IBD management to improve quality of life.
UC San Diego Health has been ranked as the top care facility in California and among the top 20 in the nation for eight medical specialties. The institution achieved this distinction through its patient-dedicated, collaborative spirit and commitment to delivering outstanding care.
The American Gastroenterological Association (AGA) is searching for its next CEO after Tom Serena's retirement. AGA has been recognized for its advocacy leadership, scientific excellence, and innovation under his leadership.
Researchers have discovered a hidden network of specialized mesenchymal support cells in the intestine that work together to maintain its inner lining. The study found four distinct populations of cells with unique genetic programs, each occupying specific locations and influencing stem cell activity and immune responses.
A clinical trial showed semaglutide improved liver scarring in patients with advanced fatty liver disease and early-stage cirrhosis. Non-invasive blood tests reflected treatment-related improvements more clearly than liver biopsies, which could reduce reliance on invasive procedures.
Nigel provides clinicians with fast, evidence-based answers, helping them make faster, more confident decisions. The platform reduces cognitive burden by enabling quick access to current evidence and reducing time spent on literature searches.
The partnership aims to streamline prior authorizations, appeals, and financial assistance, addressing delays or denials in accessing prescribed therapies. By combining AGA's clinical leadership with Forus's medication access platform, the collaboration seeks to enhance patient advocacy and access to effective treatments.
Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago identified a subtype of eosinophilic esophagitis associated with hypermobile joints and autonomic symptoms, including chronic light-headedness. Simple treatments for these symptoms can significantly improve quality of life in affected children.
A new study found that hypoxic liver injury is a common complication affecting over one in five patients with severe ARDS, strongly associated with increased mortality. The study suggests that HLI may serve as a valuable prognostic marker and reflection of systemic disease severity in critically ill patients.
The American Gastroenterological Association has launched a new professional development initiative for gastroenterology and hepatology advanced practice providers (APPs). The AGA APP GI Readiness and Credentialing program includes two pathways: the AGA Foundations Certificate for new APPs and the AGA GI Advanced Practice Certification...
Researchers found that bariatric surgery can lead to a significantly higher risk of developing alcohol problems. The altered anatomy affects how the body processes and absorbs alcohol, leading to faster intoxication and prolonged recovery times.
Researchers found a strong association between gut microbiome composition and bone health in patients with primary hyperparathyroidism. Bifidobacterium longum was identified as a key microbial driver of bone loss through immune-mediated mechanisms.
Researchers discover recurrent COPA mutations driving intestinal tumorigenesis through an independent route. These mutations activate the Wnt pathway in a way that bypasses essential amplifiers, leading to cancer progression.
Researchers discovered that enterobactin, produced by certain gut bacteria, can reduce intestinal inflammation by temporarily slowing down cellular energy production. This finding connects to the emerging concept of mitohormesis and has promising implications for treating inflammatory bowel disease.
Research published in Frontiers in Endocrinology reveals gestational diabetes influences fetal metabolic programming, shaping future risk of obesity and diabetes. Biomarkers such as leptin and adiponectin may identify children at increased risk, enabling personalized preventive strategies.
The AGA GI Opportunity Fund invests in Amplified Sciences to advance PanCystPro, a next-generation diagnostic assay for improving pancreatic cyst risk assessment. The funding supports completion of a pivotal real-world observational study and expansion of commercial partnerships.
The latest publication from Wroclaw Medical University reveals that gastrointestinal health is influenced by culture, social relationships, economic status, and individual functioning within society. Chronic stress disrupts communication between the brain and gut, leading to increased symptom severity and reduced quality of life.
Researchers explore contrast-enhanced ultrasonography as a safer alternative to invasive hepatic venous pressure gradient for assessing portal hypertension. CEUS uses microbubble-based ultrasound contrast agents to track blood flow through the liver and surrounding vessels.
Dr. Byron L. Cryer brings extensive experience to the AGA presidency, with expertise in gastroprotection and upper gastrointestinal pharmacology. He has authored over 150 peer-reviewed publications and served on various academic leadership roles.
A comparative study found that endoscopic sleeve gastroplasty (ESG) is associated with significantly greater short-term weight loss than oral semaglutide. Patients undergoing ESG achieved a mean total body weight loss of 12.7%, compared to 8.7% in those receiving semaglutide.
Researchers found that Rhein reduces pancreatic and intestinal damage, restores intestinal barrier integrity, and promotes repair macrophage responses. PPARγ is identified as the central mediator of Rhein's effects.
A study found that PEG tube aspirate and vomitus display distinct color patterns, with the aspirate being yellow-green and the vomitus dark brown. This contrast can serve as a diagnostic clue for gastric outlet obstruction in resource-limited settings.
Researchers have developed a new class of biodegradable, all-metal microrobots that can penetrate tissue and deliver medications without causing damage. These microrobots demonstrate both strength and safety in testing on mice, paving the way for potential applications in drug delivery and biopsy procedures.
The American Gastroenterological Association recommends increasing dietary fiber and reducing time on the toilet as effective initial treatments for hemorrhoids. However, common remedies like sitz baths and over-the-counter creams have limited evidence supporting their effectiveness.
Researchers from UH, Baylor College of Medicine and MD Anderson Cancer Center propose a new treatment approach for Crohn's disease by targeting the stress signal that fuels inflammation. They found that repurposing two existing cancer medications can promote natural repair and regeneration of the intestinal lining.
A study finds that rectal cancer mortality is increasing rapidly among adults under 45, with Hispanic and Western US populations experiencing the steepest rises. The study calls for earlier screening and increased awareness to combat this growing trend.
Researchers found that restoring a young microbiome can reverse features of aging in the liver, including inflammation and DNA damage. The study suggests that a healthy gut microbiome plays a key role in preventing liver cancer.
A new study suggests that eating late at night can disrupt bowel function and lead to constipation and diarrhea. Individuals who experienced high levels of chronic stress and ate more than 25% of daily calories after 9pm were more likely to report bowel problems, highlighting the impact of meal timing on gut health.
Researchers found distinct gut microbiome characteristics that predicted treatment response to the low FODMAP diet and rifaximin. Patients who responded to these treatments had different microbial signatures, with increases in diversity for those on the low FODMAP diet and resilience against antibiotics for those on rifaximin.
The AGA Research Foundation has awarded $2.9 million in research funding to 84 recipients, accelerating breakthroughs in digestive health. The selected researchers will focus on various aspects of digestive diseases, including gastric cancer and inflammatory bowel disease.
A new study uses a human stem cell-derived model to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a promising candidate. Glycyrrhizin significantly prevents intestinal cell death in both stem cell models and mice with IBD, reducing inflammation and cell death.
The American Gastroenterological Association has announced its 2026 recognition prize recipients, including Hashem El-Serag for the Julius Friedenwald Medal for his exceptional service to the field and AGA. Dr. El-Serag is an internationally recognized physician-scientist known for pioneering epidemiologic research on hepatocellular ca...
A national survey found significant disparities in IBS diagnosis across sex and racial groups in the US. Men and Black patients are less likely to receive a formal diagnosis compared to women and white patients, despite similar reported healthcare-seeking behavior and symptom severity.
Researchers studied 10 couples, finding that the risk of gluten transfer through an open-mouth kiss is low and can be reduced to safe levels by waiting or drinking water after consuming gluten. This study aims to alleviate anxiety and social avoidance among those with celiac disease.
A nationwide Japanese trial found that catheter ablation did not reduce the risk of recurrent stroke or major cardiovascular events in patients with atrial fibrillation who had recently experienced a stroke. The study, which enrolled 251 patients and followed them for over three years, suggests that routine addition of catheter ablatio...
The BiliSeq test detected approximately 82% of bile duct cancers, compared to 44% with pathology alone, and increased cancer detection to nearly 90% when combined with pathology. This improved accuracy enables physicians to provide more personalized medicine and treatment options for patients.
A study by researchers at Institute of Science Tokyo has identified a key gene, DOCK10, involved in abnormal insulin secretion in insulinomas. The findings pave the way for novel diagnostic biomarkers and treatment options.
A new study suggests that early life stress during pregnancy and early childhood can lead to long-term digestive issues, including gut pain and motility challenges. The research found that early life stress can shape the development of gut-brain communication, contributing to gastrointestinal symptoms in both mice and humans.
A $3.4 million NIH grant will fund a semi-automated feedback system to support people tracking diet, exercise, and weight in weight-management programs. The system aims to provide personalized feedback to increase tracking and weight loss success.
A study published in American Journal of Physiology-Endocrinology and Metabolism found that low testosterone and high fructose intake synergistically contribute to liver damage in mice. The researchers discovered that changes in gut microbiota led to increased levels of pyruvate, which promotes fat accumulation in the liver.
Aging gut affects memory formation, new study reveals gut microbiome plays a critical role in cognitive decline, but altering gut-brain communication can reverse effects in mice
The Alliance for Clinical Trials in Oncology is spotlighting new trials for colorectal cancer in March, focusing on early detection methods and treatments for treatment delays and loss of appetite. The trials aim to improve patient outcomes, with several enrolling patients with newly diagnosed colon or rectal cancer.
Semaglutide and tirzepatide prescriptions increased dramatically between 2018 and 2025, while MBS use rates declined substantially starting in 2023. Recent shifts in MBS use may be more pronounced in certain patient subgroups, such as those seeking sleeve gastrectomy or with lower BMIs.
The ORIGIN study uses advanced molecular tools to identify risk factors and early warning signals in stored blood samples from up to 13,000 service members. By analyzing these data, researchers aim to predict and prevent diseases such as cancer, heart disease, and autoimmune disorders years before symptoms appear.