Researchers at Sanford Burnham Prebys discovered that blocking an energy transfer enzyme shifts mammalian hearts into a regenerative state, promoting regeneration and improving recovery after a heart attack. By modulating heart cell metabolism, scientists can potentially awaken the heart's dormant regenerative abilities.
Researchers develop biodegradable nanobone material that activates body's own healing properties to regrow bone, reducing need for invasive procedures. The material generates 80% more new bone than a material control and activates a key bone-repair growth factor with 10 times the level achieved using conventional methods.
Researchers developed a wearable patch that uses room light to treat skin wounds, promoting wound closure and tissue regeneration. The patch, made of a stretchable silicone elastomer, emits red light that activates a photosensitizer, inducing collagen crosslinking and alleviating inflammation.
Researchers found specialized astrocytes in mouse brains that can repopulate damaged areas and rebuild cells. These 'regenerative' astrocytes send newly formed cell nuclei to the site of injury, knitting the network back together.
Scientists have uncovered a new mechanism used by heart cells to resist reprogramming and found that carbohydrate sulfotransferase 7 (CHST7) is the most potent preventer of reprogramming in mouse and human cells. By targeting CHST7, researchers may develop treatments to help the heart fix itself after injury.
Researchers mapped the human kidney's developmental axis and engineered synthetic organizer cells to recreate key signals, producing improved lab-grown organoids. These advances enable more reliable models for studying disease and evaluating potential therapies.
The Journal of Regeneration aims to explore regeneration across diverse disciplines and kingdoms of life, covering research from molecular genetics to clinical translation. The journal seeks to examine recurring principles shared between animals and plants, including cellular plasticity and epigenetic remodelling.
A USC-led team has developed a way to grow and genetically engineer progenitor cells that give rise to macrophages, a type of immune cell promising for cancer immunotherapies. The team successfully expanded these cells in the laboratory and engineered them to target specific cancer markers.
A new study reveals substantial differences in gene expression patterns between aging mouse and human skeletal muscle. Fewer than 5% of biological pathways show shared changes, emphasizing the need for cross-species targets in aging research.
A new study from Northwestern University developed a customized video game to help chronic stroke survivors regain lost arm function. After six weeks of therapy, participants showed significant improvement in arm function and daily activities, with scores improving up to 7.8 times that of the control group.
A comprehensive review of biochar-hydrogel composites reveals that their effectiveness lies in the surface chemistry of advanced composite materials. The study identifies function-specific performance and emphasizes the need for standardized durability testing to ensure long-term stability and scalability.
Researchers developed a two-step treatment using growth factors FGF2 and BMP2 to redirect fibroblast cells towards regeneration. The study suggests that regeneration may not be lost in humans but rather obscured by the healing process.
A team of researchers discovered that the way cells sense oxygen determines if regeneration can even begin in mammalian limbs. They found that regenerative-competent amphibians show reduced oxygen-sensing capacity, while mammals respond strongly to oxygen and switch off regenerative programs.
Researchers at Pohang University of Science & Technology discovered a way to prime skin cells for regeneration before injury, enabling rapid and effective healing. This approach, called mosaic partial reprogramming, reshapes surrounding cells and tissue microenvironment to accelerate wound healing.
A new model of brain wiring could shorten the path to developing medicines for multiple sclerosis and other degenerative brain diseases. The model, made of a water-filled gel, replicates the physical properties of human axons and has been successfully grown from human cells in the laboratory.
A comprehensive study of collagen supplements found benefits in skin elasticity, hydration, and osteoarthritis symptoms. However, there were no meaningful improvements in sports performance or muscle recovery, dispelling some myths surrounding its use.
Researchers focus on system-level resilience and long-term biological coordination to understand aging as a loss of coordination between biological systems. Studies show how mitochondrial signaling influences inflammation in senescence and microbiota–brain interactions shape aging trajectories.
A team of researchers at Washington State University discovered that rete ridges, a microscopic skin structure shared by humans, pigs, and grizzly bears, develop shortly after birth. This finding holds potential for new therapies to reverse or slow skin aging and improve wound and scar repair.
Researchers at Sanford Burnham Prebys found that transplanted stem cells develop neurons with unique codes to navigate and form connections in the brain. These codes guide the growth of axons and explain why most neurons of a particular subtype send axons to specific brain regions.
The Minimum Information about Organoid Research (MIOR) framework introduces a structured reporting standard for organoids, ensuring reproducibility and interoperability. The six-module framework outlines essential descriptors for reporting organoid research, supporting translational use in drug screening and precision medicine.
A German-Swiss research team found that spatial data can remarkably predict biodiversity changes over time, identifying areas under pressure. The study used unique data from 150 meadows and shows that land use intensification leads to declining biodiversity.
Researchers at University of Cologne identify p35-mediated CDK5 hyperactivity as a central mechanism limiting nerve regeneration in diabetes. Targeted interventions using peptides restore nerve fiber growth, leading to significant motor and sensory improvements.
Researchers develop ex vivo treatment of blood stem cells with Rhosin, a RhoA inhibitor, to rejuvenate them and improve the production of healthy blood cells. This strategy targets the core of the ageing process, making blood stem cells more capable of regenerating and producing new healthy blood cells.
Muscle stem cells secrete c1qtnf3, which redirects macrophages from immune to regenerative functions, promoting tadpole tail regeneration. This discovery offers insights into the regenerative capabilities of certain animals and paves the way for further research into potential applications in mammals.
Plant biologists developed a method to grow transgenic plants in weeks instead of months by hijacking a plant's natural regeneration abilities. The technique uses bacteria carrying genetic instructions for wound healing and regeneration to trigger plant growth.
Researchers at University of California San Diego School of Medicine have harnessed bioinformatics to identify Thiorphan as a promising new drug for spinal cord injury, showing effectiveness in adult human brain cells and improving hand function in rats with SCI.
Researchers at Harvard University have discovered that salamanders rely on the sympathetic nervous system to activate stem cells throughout the body, enabling them to regrow entire limbs. This finding may provide insights into developing regenerative treatments for humans, particularly in limb regeneration and organ repair.
Lehigh University researchers used machine learning to compare bone marrow extracted from the hip and shoulder, finding six proteins that distinguish between the two extraction sites. This study may lead to standardized BMAC extraction protocols and personalized treatments based on protein concentrations.
New research from the Stowers Institute for Medical Research reveals planarian stem cells ignore their nearest neighbors and respond to signals further away in the body. This discovery may help explain the flatworm's extraordinary ability to regenerate and offer clues for developing new ways to replace or repair tissues in humans.
A new clinical trial found that feeding blueberries to infants as their first solid food can reduce allergy symptoms and support long-term health. The study suggests early introduction of blueberries may improve infants' immune systems and gut health.
Researchers have created 'skin in a syringe' by mixing cells with gelatine beads, allowing for 3D printing of functional dermis. This technology could lead to new ways to heal burns and severe wounds with minimal scarring.
Researchers have established apple snails as a system to study eye regeneration, which may hold the key for restoring vision due to damage and disease. The team discovered that the snail eye is anatomically similar to humans and can regrow itself, with genes such as pax6 playing a crucial role in development.
Researchers have made significant breakthroughs in understanding the regeneration of a freshwater snail's eyes, which share anatomical and genetic features with human eyes. The study shows that snails can regrow their eyes after amputation, with all eye structures present within a month.
Researchers at Carnegie Mellon University developed a low-cost, long-lasting indoor formaldehyde sensor with a unique polymer coating. The coating extends the sensor's half-life by 200% and enables it to regenerate when performance degrades.
Scientists at the Stowers Institute for Medical Research identified two distinct genes that regulate regeneration of sensory cells in zebrafish. The discovery may guide future studies on hearing loss and regenerative medicine in mammals, including humans.
Researchers discover vitamin C promotes epidermal thickening by reactivating genes essential for skin cell growth, suggesting a promising treatment for thinning skin in older adults. Vitamin C supports active DNA demethylation by sustaining TET enzyme activity.
A recent study has identified a gene, Zelda, that plays a crucial role in regulating the end of regrowth in fruit fly larvae. The researchers found that Zelda helps control the activity of genes involved in tissue development, revealing a new understanding of the regenerative process.
Researchers discover Hand2 gene plays key role in providing positional information for limb regeneration in axolotls. The discovery provides new insights into how cells 'remember' their position and switch on signals to regenerate structures correctly.
Researchers at the Marine Biological Laboratory found that activating specific neurons in the axolotl brain is essential for tail regeneration. The study suggests a comparable group of neurons may impact regenerative responses in mammals.
Researchers have developed a technique for in vivo 3D printing of polymers using sound localization, which can be used for drug delivery, tissue repair, and internal wound sealing. The new method, called deep tissue in vivo sound printing (DISP), has been successfully tested in mice and shows promising results.
Researchers at KAIST have successfully developed a treatment method that restores vision by inducing retinal regeneration and vision recovery in disease-model mice. The approach involves blocking the PROX1 protein, which suppresses retinal regeneration, using an antibody developed by Celliaz Inc.
A USC Stem Cell mouse study has identified shared genes involved in regenerating cells in the ear and eye, which could lead to new treatments for hearing and vision loss. The researchers discovered that inhibiting a specific protein, p27Kip1, can encourage regeneration in both organs.
Scientists developed a new technology to produce Cre-loxP organisms in a single step, reducing the need for crossbreeding and decreasing production time. The method involves introducing a TAx9 sequence to prevent Cre gene expression in E. coli bacteria, allowing for precise control and modification of gene expression.
A groundbreaking study from Okayama University reveals that keratinocytes, not fibroblasts, are responsible for dermal collagen formation in humans and other vertebrates. Keratinocytes produce collagen fibers in a structured arrangement before fibroblasts modify them.
Researchers developed a hybrid bioink that maintains physiological properties of adipose tissue, promoting differentiation and regeneration. Bioprinted adipose tissues promoted wound healing in mice by inducing re-epithelialization, tissue remodeling, and blood vessel formation.
A study found that bacterial cellulose patches induce plant tissue regeneration by triggering cytokine signaling. The mechanism involves the production of oxidative stress and activation of defense pathways, leading to wound closure.
Researchers explore the role of efferocytosis in reducing inflammation and containing injury spread after an ischemic stroke. Efferocytosis may offer a promising therapeutic strategy to promote neural regeneration and minimize brain damage.
Mount Sinai researchers have made significant progress in understanding how human beta cell regenerative drugs work, potentially leading to a cure for diabetes. The study suggests that these drugs may be able to induce lineage conversion in human pancreatic islets, providing a new source of beta cells.
A new gene therapy has reversed the effects of heart failure in a large animal model by increasing blood pumping efficiency and dramatically improving survival rates. The therapy restored critical functions of heart cells and improved heart function on the microscopic level.
A USC Stem Cell study has identified key gene regulators that enable some deafened animals, including fish and lizards, to naturally regenerate their hearing. The researchers found a class of DNA control elements known as 'enhancers' that amplify the production of a protein called ATOH1, which induces sensory cells in the inner ear.
A new review highlights the differences in brain aging and Alzheimer's disease between humans and non-human primates, revealing that primate brains are more resistant to aging-related damage. The study suggests that tau tangles play a critical role in Alzheimer's progression, challenging the amyloid cascade hypothesis.
Researchers from the Hubrecht Institute found that tuft cells can proliferate and generate new epithelial cell types, restoring damaged gut tissue. This discovery may have important implications for regenerative medicine.
A recent study published in iScience found that the length of time cells spend engaged in the repair process is also key to regulating regeneration in African killifish. The researchers discovered that skin cells launch a genetic program that primes the whole animal to prepare for a repair response, guiding repair cells to get to work.
Researchers at the Plasticity and Remodeling of Neural Circuits laboratory aim to stimulate myelin plasticity to regenerate affected nerve fibers in MS patients. The team will explore gene therapy, pharmacological approaches, and rehabilitation strategies to enhance myelin repair.
Researchers found that inflammation in the gut affects ISCs' regenerative capacity even after resolution of inflammation. The study used cellular and animal models to show that exposure to inflammation reprograms the epigenome, leading to reduced regeneration.
A new study reveals that fasting helps regenerate and heal intestinal injuries, but also increases the risk of developing early-stage intestinal tumors in mice. The researchers identified a pathway enabling this enhanced regeneration, which is activated during refeeding after fasting.
A $1.9 million NIH grant will support research on closing cellular gaps, with implications for wound healing and cellular regeneration therapies. The goal is to develop a theoretical understanding of the process, enabling control over individual factors and potential applications in regenerating heart cells.
Researchers found that removing the choroid plexus leads to a reduction of newly born immature neurons and fewer repairing damage caused by a stroke. The study suggests that the choroid plexus keeps regenerative cells ready to deploy to injured areas in animal models.
In planarian flatworms, biogenic monoamines play a critical role in regulating female and male germ cells. Researchers discovered that these molecules form a novel signaling pathway controlling planarian germ cells, producing the 'BATT Signal' to regulate reproductive development. The study highlights the importance of monoamine conjug...
Researchers at Dartmouth College found that fruit fly oocytes can renew chromosome-linking proteins, potentially helping older women reduce pregnancy complications. The discovery could lead to new therapeutic strategies for enhancing protein rejuvenation in human eggs.