Molecular Genetics
Articles tagged with Molecular Genetics
UMass Chan scientists develop gene editing technology capable of rewriting entire chapters of the genome
BGI Genomics joins HGP2 rare disease alliance to close rare disease care gap in Asia-Pacific
New AI tool developed by Stowers Institute and Helmholtz Munich scientists predicts how cells choose their future — helping uncover hidden drivers of development
Researchers developed RegVelo, an AI framework that models cellular dynamics and gene regulation to predict cellular fate decisions. The model traces developmental trajectories and simulates regulatory interactions, providing insights into hidden drivers of development and potential therapeutic targets.
Scientists reveal how cells “back up” DNA replication to survive severe damage
The boy on the balcony who never came outside
Dr. Dilek Colak's journey began with a childhood observation of a boy with mental illness, which inspired her to pursue a career in neuroscience. Her current work focuses on understanding autism and schizophrenia through the study of human brain organoids.
UT MD Anderson shares latest research breakthroughs
Researchers at UT MD Anderson Cancer Center have made significant advancements in targeted therapy treatments for advanced lung cancer and early-stage classical Hodgkin lymphoma. The studies showcase high response rates with novel combination therapies and a new understanding of how an enzyme affects infertility and cancer progression.
Human telomerase shows selective cross-species activity, revealing limits of animal models
The study reveals that human TERT is only compatible with non-human primate cells, while other species show limited or no telomere lengthening. This highlights the importance of using suitable preclinical models for telomerase-based therapies.
Researchers find potential one-two punch against triple-negative breast cancer
A study published in Cell Reports Medicine found that inhibiting RNase H2 can cause significant damage to DNA and activate the innate immune system to produce signals that attract T cells to attack the tumor. This approach could lead to improved patient outcomes for patients with triple-negative breast cancer.
MIT researchers show how chromatin movement helps control gene expression
Researchers at MIT have found that chromatin can exist in two different categories: constrained and free, which affects its interaction with genes and DNA regulatory sequences. This study provides insight into gene regulation and DNA repair processes.
AI method tackles one of science's hardest math problems
Researchers developed a new framework, 'Mollifier Layers,' to tackle challenging inverse PDEs. This advance could benefit fields such as genetics and weather forecasting by inferring hidden forces that produce observable patterns.
Scientists discover a new way to make drug-resistant cancer treatable again
Researchers discovered a small molecule, UNI418, that destabilizes key DNA repair proteins, making drug-resistant cancer cells vulnerable to PARP inhibitor therapy. This approach restores tumor sensitivity and improves treatment outcomes.
New study finds task switching raises risk in transplant surgeries
A new study from Virginia Tech found that task switching in transplant surgeries increases one-year mortality rates by 14.8 percent, highlighting the need for efficient scheduling and workflow changes to minimize risks. The research also suggests that recovery time and surgeon experience level can mitigate these effects.
Mutations in the "translators" of the human cell alter the reading of the genetic code in cancer and ageing
Scientists discover that tRNA gene mutations can alter the reading of the genetic code, leading to increased protein synthesis errors. This phenomenon is linked to aging and cellular decline, with potential implications for neurodegenerative diseases like Alzheimer's.
Gene-sharing myth challenged as bacteria shown to police DNA exchange - New Study
A new study reveals that bacteria can actively limit the spread of antibiotic resistance genes by deploying molecular gatekeepers called YokF. This mechanism blocks the transfer of beneficial genes, giving microbes a competitive advantage in dense microbial communities.
Decoding the mitochondrial genomic reasons for poor bone healing during aging
Aging bone repair declines due to mitochondrial DNA structures disrupting stem cell function, reducing energy production and causing cellular senescence pathways. Targeting these structures may restore balance between bone and cartilage formation during healing.
AACR: Zedoresertib and lunresertib combination shows promising antitumor activity
The Phase I MYTHIC trial demonstrated a strong synergy between zedoresertib and lunresertib, showing durable regressions and consistent tumor shrinkage in patients with ovarian cancer. The combination achieved an overall disease control rate of 68.5% and a molecular response rate of 47%.
A molecular movie captures cancer’s great escape from targeted therapy
A new study reveals that cancer cells may begin escaping therapy much earlier, triggered by a stress response that drives them into a temporary drug-tolerant state. Researchers identified an early molecular trigger: NF-κB, which acts as a regulator of cellular stress and survival.
How soil microbes adapt to life in lakes
Researchers found two strategies used by bacteria to colonize new habitats: acquiring new traits and reducing genome size. This study sheds light on the evolutionary biology of soil microbes, revealing unexpected results about their adaptation to freshwater environments.
How does mitochondrial DNA affect your health?
Salk Institute researchers have developed a new biological platform for studying mitochondrial DNA in human physiology, adaptation, and therapeutic development. The platform allows scientists to investigate mitochondrial DNA variation in health and disease, enabling therapeutic innovation for mitochondrial disorders.
Protein complex protects central RNA quality control from disruption
A research team discovered that a protein complex consisting of SMG1, SMG8, and SMG9 ensures the efficient execution of nonsense-mediated mRNA decay (NMD). The study found that this complex is essential for maintaining the stability of NMD under various conditions.
Brain mechanisms may vary depending on how long alcohol use occurs
Research in mice reveals direct gene regulation by alcohol metabolites, with varying effects on brain regions and exposure durations. Short-term exposure influences more genes and epigenetic programs compared to lengthy exposure.
Evolution in fast-forward: How thale cress adapts – or goes extinct
Researchers tracked genetic changes in Arabidopsis thaliana across 30 sites over five years, finding most populations adapted to local environmental conditions. However, some populations went extinct due to genetic drift, highlighting the importance of preserving biodiversity.
Optimus protein
Researchers at Kyoto University identified DHX29 as a central regulator of codon-dependent gene expression. They found that DHX29 preferentially interacts with ribosomes decoding non-optimal codons and recruits a protein complex to selectively repress mRNAs enriched in these codons.
Decoding intercontinental disjunction: Phylogenomic study unravels evolutionary history of hylodesmum
A comprehensive study using integrated genomic approach resolves Hylodesmum's taxonomic uncertainties and EA-ENA disjunct distribution. The study confirms Verdesmum as nested within Hylodesmum and reveals a complex bidirectional dispersal pattern likely facilitated by mammal-mediated epizoochory.
Study identifies gene expression program linked to neurotransmission in the living human brain
Researchers have identified a distinct gene expression program associated with neurotransmission in the living human brain. The study combines molecular data with real-time physiological recordings, revealing a coordinated set of genes whose activity tracks with neuronal signaling.
The writing on the genes and the tumor’s power grid
Recent discoveries have shed light on gene expression control in tumor growth, revealing the critical role of epigenetic marks and genomic imprinting. The findings have significant implications for cancer treatment, as they suggest that disrupting the tumor's access to neural signaling may halt its growth.
How do GLP-1 agonists affect gene expression?
Salk Institute researchers identified Med14, a protein connected to GLP-1 drug effects on pancreatic beta cells, leading to improved viability, insulin production, and stress resistance. The study suggests a potential molecular link between GLP-1 drugs and broader benefits, including type 2 diabetes susceptibility genes.
Preventing breast cancer resistance to CDK4/6 inhibitors using genomic findings
A new study from Memorial Sloan Kettering Cancer Center reveals that analyzing a patient's genomic profile can predict breast cancer resistance to CDK4/6 inhibitors. The researchers found that inheriting a BRCA2 mutation and other genetic alterations increase the likelihood of resistance. This discovery provides a new strategy for pred...
Flipped chromosomal segments drive natural selection
New research finds that chromosomal inversions help Atlantic silversides maintain genetic differences suited to cold and warm waters, influencing growth rates and vertebrae numbers. This discovery suggests a fundamental role for chromosomal inversions in local adaptation and may shape population responses to ocean warming.
Incurable muscle disease: First successes in the development of a gene therapy
Researchers at the University of Basel have developed a gene therapy that can potentially treat LAMA2-related muscular dystrophy, a rare and fatal muscle disease in children. The therapy has been shown to stabilize muscles and nerves and halt disease progression in animal models, with a single treatment being sufficient.
Do certain circulating small non-coding RNAs affect longevity?
Researchers identified nine piRNAs linked to longevity, which could be detected through simple blood tests. The study suggests that these molecules may help predict survival and guide therapeutic targets for older adults.
URochester researchers awarded up to $22M to study a hidden driver of aging
The project aims to test whether reducing chronic inflammation triggered by DNA can help older adults stay healthier. The research focuses on retrotransposons, which become increasingly active with age, leading to tissue decline.
Engineers sharpen gene-editing tools to target cystic fibrosis
Engineers have refined a technology to edit individual genetic base pairs, reducing unintended edits and increasing safety for potential treatments. The new base editors could lead to better outcomes for some cystic fibrosis patients and more accurate models for drug testing.
FAU researchers discover novel bacteria in Florida’s stranded pygmy sperm whales
Researchers have identified three previously unknown genotypes of Helicobacter bacteria in pygmy sperm whales stranded along the southeastern US coast. The discovery raises new questions about microbial pathogens on ocean health and their impact on vulnerable species.
Eleven genetic variants affect gut microbiome
Researchers identified 11 genetic regions influencing gut bacteria and roles they play, including connections to gluten intolerance, haemorrhoids, and cardiovascular diseases. The study analyzed genetic data from over 28,000 individuals, providing insights into the complex relationship between genes and gut microbiome.
Rapid response launched to tackle new yellow rust strains threatening UK wheat
A new strain of yellow rust pathogen has broken down a key resistance gene, leaving over 50% of the UK's wheat acreage vulnerable. Researchers are racing against time to find new resistance genes and breed them into modern wheat varieties.
Researchers rebuild microscopic circadian clock that can control genes
University of California San Diego scientists have solved how the circadian clocks within microscopic bacteria precisely control gene expression during the 24-hour cycle. The researchers identified six proteins needed to rebuild this clock, generating a simplified cyanobacterial system with a clock that only needs.
From ancient fins to human hands
Research team led by biologist Joost Woltering discovers how ancient genes from fish midline fins were 'redeployed' to establish the dorsal-ventral axis in human limbs, allowing for complex limb differentiation and adaptation for life on land.
Study: Blocking a key protein may create novel form of stress in cancer cells and re-sensitize chemo-resistant tumors
A new study suggests blocking key protein p300 can create novel form of cellular stress in cancer cells, re-sensitizing chemo-resistant tumors. Cells produce proteins even with damaged DNA, leading to toxic buildup and stress inside the cell's internal quality-control system.
A broken DNA repair tool accelerates aging
A Goethe University-led study reveals how mutations in the SPRTN enzyme cause chronic inflammation and premature ageing. The research team found that damaged DNA in the cell nucleus leaks into the cytoplasm, activating defense mechanisms and leading to chronic inflammation.
Bird retinas function without oxygen – solving a centuries-old biological mystery
Bird retinas operate under chronic oxygen deprivation, relying on anaerobic energy production. The pecten oculi serves as a metabolic gateway, delivering sugar and removing waste products.
New study shows how light suppresses virulence in antibiotic-resistant pathogen
Researchers at the University of Chicago have discovered a light-sensitive signaling cascade in Pseudomonas aeruginosa that suppresses biofilm formation and virulence. The study, published in Nature Communications, identifies a small protein called DimA as the key trigger for this process.
UMass Chan scientists annotate largest map yet of human genome’s regulatory switches
Researchers have created a comprehensive map of the DNA sequences that control gene expression in human cells, identifying 2.37 million potential regulatory elements. This registry reveals previously unrecognized classes of elements and illuminates how noncoding genetic variation contributes to cell type-specific traits.
4D Nucleome Consortium produces detailed models of the 3D genome over time in cells
The study created a critical framework for understanding the architecture of the genome and its association with gene function in cells. The 4DN Consortium integrated data from over a dozen techniques to compile an extensive catalogue of looping interactions between genes and regulatory elements.
Study shows your genes determine how fast your DNA mutates with age
Researchers identified dozens of genes that regulate DNA repeat expansion, which accelerates as people age. The study found common genetic variants can speed up or slow this process by up to fourfold, linking it to serious diseases like kidney failure and liver disease.
Genomic test helps flag early aggressive prostate cancer in African American patients
A new study found that a widely used genomic test can accurately identify African American men with early prostate cancer at high risk of recurrence. The Decipher classifier linked to faster recurrence rates and supports more personalized treatment choices. Genomic testing may help better match patients with the right treatment intensi...
Scientists identify small RNA molecule that regulates cholesterol and heart disease
Researchers have discovered a small RNA molecule that plays a key role in controlling cholesterol production and the development of heart disease. The molecule, tsRNA-Glu-CTC, was found to boost SREBP2 activity, leading to higher cholesterol levels and increased risk of atherosclerosis.
Pitt and UPMC study finds epigenetic signature of pediatric traumatic brain injury, paves way for precision recovery tools
Researchers at Pitt and UPMC Children's Hospital discovered a biomarker of complicated pediatric traumatic brain injury, which may serve as dynamic indicators of post-injury recovery. The study found that children with TBI had a different epigenetic profile compared to those with orthopaedic injuries.
CDT1 overexpression suppresses DNA replication and induces DNA damage, suggesting a mechanism for cancer development
Researchers discover that CDT1 overexpression suppresses DNA replication and induces DNA damage, potentially leading to genetic mutations and cancer. The study provides molecular insights into the role of CDT1 in cancer development.
Uncovering the principle by which DNA replication initiation sites are determined in the human genome
Researchers develop a high-precision method to detect replication initiation sites in the human genome, discovering that cells can initiate DNA replication from almost anywhere. They also identify a protein complex called TRESLIN-MTBP that governs initiation zones and replication timing.
Counting salmon is a breeze with airborne eDNA
Researchers at the University of Washington successfully tracked salmon populations using airborne eDNA, finding that the airborne DNA concentration fluctuated with visual counts reported by the hatchery. The technique links air, water, and fish, providing a valuable tool for population health monitoring and management.
New mutation hotspot discovered in human genome
Researchers have identified regions of the human genome particularly prone to mutations, which can be inherited by future generations. The mutated stretches of DNA are located at the start point of genes and are more susceptible to errors during cell division.
New clues to why some animals live longer
A study by University of California, Riverside scientists found that alternative RNA processing, or
DNA shape and rigidity regulate key players of gene expression
Researchers at the University of Texas M. D. Anderson Cancer Center discovered that inflexible DNA within nucleosomes regulates the positioning of INO80, a chromatin remodeling complex. This unique mechanism allows INO80 to position itself on the surface of nucleosomes at the right location.
Epigenetic changes regulate gene expression, but what regulates epigenetics?
Scientists at the Salk Institute have discovered a new mode of epigenetic targeting in plant cells, where specific DNA sequences guide DNA methylation patterns. This finding has major implications for understanding epigenetic regulation and could inform future strategies for epigenetic engineering.
Cabernet sauvignon’s long memory revealed
Researchers at UC Davis have discovered that Cabernet Sauvignon retains molecular marks from its ancestors after 400 years of clonal propagation. The study used advanced genome sequencing to assess the stability of epigenetic modifications, which can influence traits like fruit quality and stress tolerance.
Molecule that could cause COVID clotting key to new treatments
Researchers discovered a 'sticky' molecule, P-selectin, that can cause blood clots and organ failure during COVID-19. A new mRNA therapy that drives P-selectin expression provides broad protection against coronavirus infection.
Targeted drug could benefit young patients with invasive sarcoma
Researchers identified a targeted drug that blocks a specific genetic pathway to reverse tumor-driving cellular interactions, potentially restoring DNA function and benefiting patients with synovial sarcoma. The study's findings endorse a promising strategy to improve outcomes for this rare but deadly cancer.
Aquaporin gene duplication followed by mutation in European eels restores broad solute permeability
Researchers at Institute of Science Tokyo found that European eels have restored aquaporin proteins with broad solute permeability through a recent gene duplication event. The study revealed that the genes Aqp10.2b2 and b3 acquired functional diversification, enabling them to transport urea and boric acid similar to Aqp10.1.