Articles tagged with Inflammatory Response
Researchers present a roadmap for developing Tregs as adaptable therapies to restore immune balance and support tissue repair. This approach holds promise for treating conditions such as metabolic and cardiovascular disease, as well as neurodegeneration.
A cohort study found that a dietary pattern with lower inflammatory potential was associated with lower dementia risk among individuals with Alzheimer disease pathology. Targeted dietary strategies may help prevent dementia in those already at elevated risk.
New therapies using regulatory T cells, known as Tregs, could target diseases with inflammation, such as cancer and autoimmune conditions. Early evaluations show good tolerance and safety profiles, but precision is key to tailoring treatments for specific patients.
Researchers identified five immunomodulatory proteins in Borrelia recurrentis that prevent activation of the human complement system, allowing the pathogen to survive in the human body. These Chi proteins also convert plasminogen into active plasmin, giving Borrelia recurrentis a significant advantage in spreading after infection.
Researchers have found a widely available drug combination to be an effective treatment for patients with systemically active Sjögren's disease. The combination of leflunomide and hydroxychloroquine reduced disease activity while maintaining a favorable safety profile.
A study using a mouse model demonstrates that microplastics can exacerbate respiratory tract inflammation and alter immune responses associated with allergies. The researchers found that the particles remained detectable in the lungs for at least 14 days, leading to an increased migration of lymphocytes and eosinophils.
Researchers found that obesity alters the biological changes in breast cancer cells, enabling them to survive and thrive. The study's findings could improve prediction and treatment of invasive breast cancer, reducing overtreatment and unnecessary treatments.
Researchers at UT MD Anderson Cancer Center have uncovered genetic and cell-state adaptive mechanisms that drive resistance to KRAS inhibitors in patients with KRAS-mutant colorectal cancer. Targeting early inflammatory responses by adding TBK1 blockade may be a promising combination strategy to overcome treatment resistance.
Researchers have used fungal light-producing enzymes to track processes like tumor progression and inflammatory responses. The study reveals the role of caffeylpyruvate hydrolase (CPH) in breaking down oxyluciferin, allowing for sustainable bioluminescence.
A study finds microplastics in the human brain associated with increased risk of stroke and dementia. Apheresis, a medical treatment, is proposed as a potential removal method for microplastics from the body.
Researchers at Garvan Institute of Medical Research discovered key immune cells malfunction in mevalonate kinase deficiency (MKD), a rare but devastating autoinflammatory disorder. Current treatments targeting inflammatory signals produced by macrophages fail in half of patients, but JAK inhibitors may provide relief.
A new freeze-dried blood product called Thrombosomes has shown promise in treating traumatic brain injuries by reducing swelling and bleeding. The product, derived from platelets with trehalose preservation, has been tested on mice and found to be effective in stabilizing damaged blood vessels.
Researchers found that antibiotics disrupt gut microbiota, suppressing protective immune system pathways and increasing severity of A. baumannii pneumonia. The study highlights the gut-lung connection as a potential therapeutic target for hospital-acquired lung infections.
Researchers identified a targetable driver of brain metastases in inflammatory breast cancer, promoting tumor invasion and triggering brain inflammation via the CXCR2 signaling pathway. Targeting sEcad or the CXCR2 pathway may treat or prevent brain metastasis.
Researchers at University College London have uncovered a key mechanism that helps the body switch off inflammation. Tiny fat-derived molecules called epoxy-oxylipins act as natural brakes on the immune system, preventing chronic inflammation linked to arthritis, heart disease, and diabetes.
Boston College researchers used piezoelectric nanoparticles to trigger macrophages, a key part of the body's immune response. The study suggests that this method could be used to activate immune cells specifically at an infection or tumor site, avoiding side effects associated with systemic administration of drugs.
Salk Institute scientists found distinct disease courses and tolerance mechanisms in younger and older mice with sepsis, indicating a need for age-tailored therapies. The study suggests that future treatments may focus on controlling infection-generated damage rather than just targeting the pathogen.
Research found that prolonged heavy drinking induces neuroinflammation, promoting negative emotional states lasting for weeks into abstinence. Inhibiting proinflammatory microglia activation during alcohol exposure blocks the development of anxiety and fear memory.
A study by the Medical University of Vienna found that plastic particles can increase intestinal inflammation and disrupt the gut microbiome, leading to ulcerative colitis. The research shows that MNP exposure triggers a pro-inflammatory immune response and alters the balance of beneficial and harmful bacteria in the gut.
Researchers found that pain-sensing neurons activate tuft cells, which release parasite-fighting immune molecules, initiating an immune response. Silencing or removing these neurons reduces tuft cell numbers, indicating their crucial role in fighting parasites and potentially driving allergic diseases.
A subset of depressed individuals with chronic, low-grade inflammation may benefit from anti-inflammatory treatment, according to a systematic review and meta-analysis. The study found that anti-inflammatory medications significantly reduced depressive symptom severity and anhedonia in these patients.
A new study identifies fatty acid elongase ELOVL5 as a key promoter of inflammation resolution in the lungs. The research reveals that ELOVL5 works through a dual mechanism to dampen inflammatory pathways and generate pro-resolving lipid signals.
This study examines the association between genetic variants (GWAS loci) and environmental factors (reproductive history) in uterine fibroid development. Genetic variants like rs66998222 and rs11031731 are found to have context-specific effects, with some exhibiting protective or deleterious effects depending on abortion history.
Researchers identified a genetic inflammatory signature that defines specific depression subtypes and influences antidepressant outcomes. Higher CRP polygenic scores were associated with reduced weight and appetite loss, earlier age of onset, and lower employment status after treatment.
Researchers at UCLA Health have identified a sex-chromosome linked gene that drives inflammation in the female brain, making women more susceptible to conditions like Alzheimer's disease and multiple sclerosis. Deactivating this gene and using diabetes medication metformin showed promising results in reducing symptoms in female mice.
A new human lung alveolus chip model enables investigation of viral replication, inflammatory responses, and genetic off-target effects of a novel pan-influenza CRISPR therapy. The study achieved significant reductions in virus load and host inflammatory response after a single administration.
Research found that defense cells of trained older adults are more effective against inflammation and metabolically efficient. Regular exercise modulates inflammatory response over time, reducing markers of inflammation and increasing anti-inflammatory markers.
A new technology allows for clear observation of living retina and microglia's behavior, revealing their increased activity before tissue damage in diabetic mice. The study found that the diabetes drug liraglutide reduced microglia's activity in healthy mice too, suggesting a direct modulation mechanism.
Congenital diaphragmatic hernia is a deadly malformation of the lungs and diaphragm that causes underdeveloped lungs, leading to high mortality rates. Researchers discovered increased numbers of inflammatory cells in human lung tissue, both before and after birth, which may influence lung structure development.
A new preclinical study from Weill Cornell Medicine suggests that inflammation during pregnancy may prime offspring for anxiety. The researchers discovered that adversity in the womb configured a small percentage of brain cells to be overly active when faced with a threatening situation, creating a vulnerability to anxiety.
Scientists at Trinity College Dublin discovered that electrically stimulating macrophages can shift them into an anti-inflammatory state, promoting faster tissue repair. This breakthrough offers a potentially powerful new therapeutic option for treating inflammation-driven diseases and injuries.
Researchers have identified a new class of compounds derived from psychedelics that could open the door to safe, targeted therapies for widespread use in clinical settings. These PIPI drugs may modulate the immune system to control inflammation, potentially treating conditions such as Alzheimer's and Parkinson's disease.
Researchers found that immature neutrophils migrate into inflamed tissues upon stimulation by interferon-γ, suppressing inflammation and reducing tissue damage. In humans, these cells also produce interleukin-10, which increases in the blood of COVID-19 patients.
Researchers have discovered two solutions to alleviate inflammation caused by lipid nanoparticles, making RNA therapies safer for patients with conditions like ARDS, heart attack, and stroke. A new biodegradable lipid and a common drug called thiodigalactoside (TG) can reduce inflammation while keeping RNA delivery effective.
Research found that chronic exposure to PM10 and PM2.5 air pollutants activates harmful allergic-like immune responses in the lungs, leading to inflammation and scarring. The study suggests targeting oxidative stress or modulating NRF2 activity could be a new strategy to treat pollution-induced allergic inflammation.
Researchers developed a chemical probe that binds to damaged mitochondrial DNA, blocking enzymatic processes that lead to its degradation. This approach lessens mtDNA loss, preserving energy production in vulnerable tissues. The new molecule successfully reduced inflammation and maintained functional DNA despite chemical tagging.
A study reveals that a combination of dysbiosis, OTUD3 gene mutations, and STING signaling aggravate ulcerative colitis. The intestinal flora plays a vital role in UC, but an unbalanced microbiome with fewer beneficial microbes and more harmful ones contributes to the disease.
Researchers at the University of Pennsylvania designed a new recipe for mRNA vaccines by adding phenol groups, which reduce inflammation and improve vaccine effectiveness. The modified lipids improved vaccine performance in various diseases, including COVID-19, cancer, and genetic diseases, with enhanced efficacy and reduced side effects.
Researchers discovered a key molecular sensor detecting changes in intracellular pH that regulates immune defense against bacterial infections and influences inflammatory diseases and cancer. The findings may lead to innovative strategies for disease prevention and treatment by altering how the internal environment shapes immune function.
Chemotherapy-induced pyroptosis in bladder cancer can actually make the disease more resistant to treatment by fueling cancer stem cells. Blocking this inflammatory process with belnacasan may overcome chemoresistance in preclinical models.
A large prospective study found that a healthy plant-based diet is associated with an 8% lower risk of ulcerative colitis and a 14% lower risk of Crohn’s disease. Fruits and vegetables were identified as key protective factors against inflammatory bowel disease.
A study found that exposure to β-glucan reprograms immune cells in the lungs, causing them to overreact and worsen lung damage. The research suggests that trained immunity in the lungs may have negative consequences in certain contexts.
Researchers discover a novel metabolic pathway, glyoxalase system, that regulates excessive immune responses by targeting a previously underexplored metabolic pathway. The GLO2-SLG-D-lactylation pathway suppresses inflammatory signaling, reducing inflammation in acute and autoimmune disease settings.
A new study suggests that a drug used to prevent alcohol abuse can also interrupt runaway cell death and inflammation triggered by severe trauma, particularly in female mice. The findings may lead to therapies that could shorten hospital stays and improve survival rates if administered promptly after traumatic injuries.
A recent study by Iowa State University researchers found that fruit flies missing a crucial developmental hormone, PTTH, live up to 30% longer due to reduced inflammaging. The connection between developmental timing and lifespan in fruit flies could be a useful model for studying human longevity.
A study by Korea University researchers has identified the association between viral infections and neurodegenerative diseases, such as Alzheimer's. They developed a therapeutic candidate ALT001 that improves mitophagy, reduces neuroinflammation, and suppresses viral replication.
Researchers found that inflammation in the female reproductive tract can hinder fertility, but replenishing progesterone levels can help. This discovery could improve women's chances of becoming pregnant and save more pregnancies.
Researchers found persistent inflammation in heart and lungs of patients with long COVID, even after standard tests return normal results. This study uses advanced PET/MRI imaging to detect abnormal patterns that could serve as early warning signs of future cardiac and pulmonary conditions.
A new study from Murdoch University confirms that COVID-19 vaccinations do not cause significant metabolic changes. The research monitored 167 metabolic markers in 33 participants over 480 days post-vaccination, showing no significant impact on key health indicators.
Researchers found that high-grade pre-cancer lesions triggered stronger immune responses and showed higher levels of immune-related markers PD-L1 and FOXP3. These findings suggest that HPV may begin avoiding the immune system early in infection, allowing infected cells to grow and potentially leading to cancer.
A new review from Marshall University researchers highlights emerging connections between gut health and sleep apnea, pointing to potential new therapeutic approaches for managing this common disorder. Alterations in gut microbiota composition have been consistently observed in individuals with sleep apnea, inducing systemic inflammati...
Researchers found that cortisol levels were lower in survivors, while heart rate and blood pressure responses were altered. Interleukin 1B was significantly higher, suggesting potential long-term health problems despite healthy symptoms.
Patients with acute type-A aortic dissection (ATAAD) show higher preoperative white blood cell count, IL6, IL8, TNFα, DAO, iFABP, and PGN levels, but lower PaO2/FiO2 ratio compared to controls. Postoperative levels of these markers increase, leading to worsened hypoxemia.
Researchers at the University of Maryland discovered a way to predict treatment success for cutaneous leishmaniasis, a devastating skin infection. By analyzing a patient's immune system, they identified a distinctive pattern that distinguishes responders from non-responders, with 90% accuracy.
Researchers at Aarhus University have developed a new understanding of how brain blood vessels react after a stroke. By mapping the molecular changes, they hope to find targeted therapies to improve patient outcomes.
A Mount Sinai-led team has discovered a link between gamma delta intraepithelial lymphocytes and the development of Crohn's disease. By analyzing a mouse model, they found that impaired communication between these cells led to inflammation in the lower small intestine.
Research reveals that dry air caused by climate change dehydrates airways, triggering inflammation and associated conditions like asthma and chronic cough. Higher temperatures and drier air may lead to widespread airway inflammation in the US by mid-century.
Virginia Tech researchers Pamela VandeVord and Gunnar Brolinson received a $2.17 million grant to investigate cranial osteopathic manual manipulation as a potential treatment for traumatic brain injury symptoms, particularly headaches. The noninvasive technique aims to enhance brain fluid motion and balance the autonomic nervous system.
A study by Charité - Universitätsmedizin Berlin and the German Rheumatology Research Center identified the Epstein-Barr virus as the trigger for Multisystem Inflammatory Syndrome in Children (MIS-C). The virus reactivates due to a weakened immune system, leading to an excessive inflammatory response.
Researchers found that high-fat diets caused significant changes in the brains of aged rats, including inflammatory markers and impaired memory functions, even after only three days. The study suggests that aging and diet-related inflammation may be key factors contributing to age-related memory decline.