Articles tagged with Inflammatory Response
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Scientists at UCSF have developed engineered T cells that act as immune referees to soothe overreacting immune responses and mope up inflammatory molecules. These cells could improve treatment for organ transplants, type 1 diabetes and other autoimmune conditions by reducing the need for harsh immunosuppressant drugs.
A recent study by Krishna Rao Maddipati suggests that chronic inflammation has a distinct etiology, differing from acute inflammation. The study proposes increasing anti-inflammatory compounds to treat chronic inflammation, potentially leading to new advancements in cancer therapy.
Researchers found that intravenous administration of immunomodulatory nanoparticles after TBI can limit inflammatory cell infiltration and reduce behavioral decline and lesion size. The treatment was shown to be safe without noticeable toxicity in mice.
Acute-on-chronic liver failure (ACLF) is characterized by metabolic alterations that disrupt immune function, contributing to disease progression. Metabolite imbalances, such as elevated lactate levels and reduced ketone bodies, further suppress immune responses.
A new study suggests that immune system imbalances may trigger and sustain depressive symptoms, particularly in high-risk groups. The review challenges traditional neurotransmitter-focused theories and offers insights into the complex interactions between inflammation and depressive symptoms.
A new study found that the heart sends signals to the brain to increase sleep after a heart attack, promoting healing and reducing inflammation. This communication between the heart and brain is mediated through the immune system and can lead to improved recovery and reduced risk of further cardiovascular events.
A new study reveals that mild and asymptomatic SARS-CoV-2 infections can trigger immune responses in pregnant individuals, causing serious inflammatory responses in the developing fetus. The study also found that even without full infection, a pregnant individual's immunological response to infection may impact the fetus.
Researchers will showcase results of a randomized clinical trial demonstrating Biovanta's efficacy in reducing common cold symptoms by strengthening the respiratory barrier and controlling inflammation. The presentation will also include preclinical data on antiviral formulas targeting rhinovirus and influenza.
A study found that naldemedine reduces constipation in cancer patients taking opioids, improving quality of life and reducing nausea. After 14 days, 64.6% of naldemedine-treated patients showed no signs of constipation compared to 17.0% in the placebo group.
Researchers found that macrophages produce lipid mediators that promote and suppress inflammation in AKI. The study suggests that MAFB regulates the production of pro-resolving LMs, shifting from a pro-inflammatory to a pro-resolving state.
Established biomarkers such as CRP, ESR, vitamin D, and platelets continue to be vital in IBD management. Novel biomarkers like MAdCAM-1, oncostatin M, NOD2 mutations, and anti-Integrin αvβ6 offer promise for improving diagnostic accuracy and predicting treatment response.
Researchers found that inflammation in the gut affects ISCs' regenerative capacity even after resolution of inflammation. The study used cellular and animal models to show that exposure to inflammation reprograms the epigenome, leading to reduced regeneration.
Researchers at Tokyo Medical and Dental University discovered the role of A20 in suppressing chronic hepatitis by inhibiting the DCLK1-JNK pathway-dependent chemokines. In mice lacking A20 expression, hepatic stellate cells displayed spontaneous inflammation and increased chemokine levels.
Researchers explore fecal calprotectin and C-reactive protein as biomarkers for inflammatory bowel diseases (IBD), with multi-target tools showing promising results. These biomarkers hold potential for improving diagnostic accuracy and monitoring disease activity, leading to more effective IBD management.
The article discusses current endoscopic treatment approaches for IBD-related complications, highlighting the advantages and disadvantages of techniques like EBD and EMR. These methods offer minimally invasive options but require expertise and careful patient selection.
Recent research highlights gluten's role in inducing harmful immune responses in chronic inflammatory diseases, including celiac disease and other autoimmune conditions. Gluten withdrawal can alleviate symptoms, while a gluten-free Mediterranean diet may be a healthier alternative for overall nutritional adequacy.
Researchers found that COVID-19 proteins can lower cortisol levels in the brain, leading to a heightened stress response and inflammation. The study suggests that this phenomenon may contribute to the neurological symptoms of Long COVID, including fatigue, depression, and memory problems.
Researchers have discovered a new regulator affecting immune cells, which could lead to treatments reducing inflammation in diseases such as arthritis and severe COVID-19. The study found that the regulator, MICL, plays a key role in regulating inflammation in these diseases.
A team of researchers at McMaster University discovered that the epithelium plays a crucial role in directing the inflammatory response to gluten in celiac disease. They found that this inner lining of the upper intestine is not just involved in absorbing nutrients, but also activates immune cells in response to gluten.
A newly developed granzyme B PET imaging method can non-invasively detect IBD and provide a real-time picture of active inflammation. This technology could guide personalized patient management strategies and monitor treatment efficacy.
Researchers found that administering PEPITEM to older mice reduced exaggerated immune responses, indicating a potential geroprotective agent. The study also revealed an age-related decline in the PEPITEM pathway, which could be rescued by the peptide.
Researchers describe redundant innate immune pathways triggered by AAV vectors, including sensing of viral genome and cytoplasmic DNA sensors. The study highlights the need to understand complex biologic mechanisms underlying adverse reactions to AAV vectors in human gene therapy trials.
Researchers found that mice lacking the G900 region exhibit reduced inflammatory response and suppressed Th2 differentiation when exposed to allergens. This discovery highlights the importance of the G900 gene enhancer in regulating immune responses and has implications for personalized treatments and asthma care.
Researchers found that adding an anti-inflammatory drug to immune checkpoint inhibitor therapy resulted in a high response rate of 67% among patients with stage 4 non-small cell lung cancer. The study suggests that reducing chronic inflammation may improve the effectiveness of immunotherapy.
Scientists at Salk Institute discover a molecular mechanism that helps macrophages mount a coordinated response tailored to a specific immune challenge. The discovery reveals new immune system mechanisms that could be targeted with therapeutics to regulate inflammation.
Research reveals that clonal hematopoiesis of indeterminate potential (CHIP) drives inflammatory bone loss diseases like periodontitis and arthritis. Rapamycin shows promise as a potential treatment for CHIP-driven inflammation.
A new animal model has been developed to study periodontitis, allowing researchers to analyze tissue components simultaneously. The study found that the expression of the Il1rl1 gene was higher in peri-root tissue five days after ligation, highlighting its role in inflammation and osteoclast differentiation.
A large register-based study found that young adults with low stress resilience are more likely to develop psoriasis later in life. The study, based on data from over 1.6 million Swedish men, showed a significant link between stress resilience and the risk of developing severe cases of psoriasis.
Researchers found that gut bacteria-generated linoleic acid metabolite KetoC markedly reduced inflammation and immune cell expansion. gKetoC also suppressed prolonged T-cell proliferation and dendritic cell activation. The study suggests a potential molecular axis governing the immunomodulatory effects of gKetoC.
A new analysis has found evidence supporting the use of treatments to enhance mucosal healing and reduce inflammation in the gut, leading to improved outcomes for children with malnutrition. The study identified that a short course of treatment can restore mucosal integrity, reducing intestinal damage and systemic inflammation.
The study found that decreasing LSECtin levels increases specific immune cells that contribute to disease progression, suggesting restoring these levels could restore altered liver functions. Researchers restored LSECtin activity in cirrhotic animal cells using anti-inflammatory mediators, proposing a potential therapeutic strategy.
Two anti-inflammatory molecules, TGFβ1 and HpTGM, reduce the inflammatory response within the injured heart and scarring. Treatment with these proteins at the time of reperfusion reduces infarct size and mature scar size.
Researchers found that synbiotics, a combination of prebiotics and paraprobiotics, improved the gut microbiome of Magellanic penguins, reducing inflammation and enhancing overall health. The study also revealed that parasynbiotics can modulate inflammatory responses in penguins.
A study using a xenotransplantation model has revealed that human microglia respond to amyloid-β plaques with a complex immune response, influencing the disease course. The research highlights the importance of considering genetic factors in microglia-targeted therapies for Alzheimer's disease.
Researchers at Ohio State University found that eating fatty food before surgery triggers an inflammatory response in the brain, leading to impaired memory function. The study also showed that taking a DHA omega-3 fatty acid supplement can prevent these effects.
The Wim Hof method has been found to increase epinephrine levels and decrease pro-inflammatory cytokines, indicating a potential anti-inflammatory response. However, its impact on exercise performance is less clear, with some studies showing benefits and others finding no significant difference.
This study investigates Schisanhenol's potential to treat cytokine storm by inhibiting inflammatory responses and alleviating acute lung injury. Network pharmacology analysis reveals multiple mechanisms of action.
Researchers discover how S1P molecules are released from SPNS2 protein via small cavities, enabling potential treatment for inflammatory diseases. The study provides a foundation for designing future drugs targeting the protein.
A recent study published in Nature found that smoking has a lasting effect on the immune system, with certain defense mechanisms persisting for up to 10-15 years after quitting. The research used a large cohort of healthy volunteers and identified three key factors: smoking, latent cytomegalovirus infection, and body mass index.
Researchers develop nanovector nanogels that selectively target glial cells involved in spinal cord injury inflammation, reducing damage and improving recovery. The treatment demonstrates potential for modulating glial cells in neurodegenerative diseases like Alzheimer's.
Researchers found significantly higher levels of IL-18 expression in osteoarthritis patients and cells compared to healthy controls. IL-17 promoted IL-18 production through the MEK/ERK/miR-4492 axis, indicating potential therapeutic targets for OA treatment.
A team of researchers from Texas Heart Institute and Baylor College of Medicine have made a significant discovery about the underlying molecular cell states within transplanted pediatric hearts. They found that donor-derived tissue-resident macrophages are crucial for graft acceptance, but their loss leads to allograft failure.
Scientists discovered a novel mechanism for removing mtDNA from mitochondria, which can initiate an immune response promoting inflammation. The discovery reveals new targets for therapeutics to disrupt the inflammatory pathway and mitigate inflammation during aging and diseases.
A new type of cell therapy has shown promising results in improving survival rates and reducing pneumonia among critically ill ARDS patients recovering from severe Covid-19. The invariant natural killer T (iNKT) cell therapy, known as agenT-797, triggered an anti-inflammatory response and activated anti-viral immunity.
Researchers found that low-dose X-ray irradiation reduced lesion size and reversed motor deficits in TBI and ischemic stroke mice, demonstrating its potential as a therapeutic strategy. The treatment also accelerated substantial motor function recovery and promoted brain rewiring after stroke.
Researchers from Osaka University have discovered a novel treatment strategy for cytokine storm, a serious inflammatory syndrome triggered by an infection or severe burn. The new approach involves blocking IL-6 receptor signaling with a short-term antibody, minimizing treatment side effects and preventing vascular damage.
A new study by University of California Riverside researchers found that high-fat diets affect not only obesity and colon cancer but also the immune system, brain function, and potentially COVID-19 risk. The study, which analyzed genetic changes in mice fed different types of fat, showed that polyunsaturated fatty acids in soybean oil ...
A recent study by the Hebrew University proposes a new etiology for early stages of type 1 diabetes, attributing it to disrupted RNA editing within pancreatic beta cells. This perspective challenges long-held beliefs about viral involvement, suggesting potential implications for treatments and cures.
Researchers at MMRI have developed a novel approach to minimize cardiac damage after a heart attack by targeting the spleen with histone deacetylase inhibitors. This targeting strategy results in a significant decrease in cardiac scar size and preservation of heart function, even after just one dose.
A major study found that patients with inflammatory conditions can boost their antibody response to a COVID-19 booster vaccination by interrupting their treatment for two weeks. The improved protection lasts for six months, and patients who interrupted treatment reported more flare-ups but most were self-managed.
A new UCLA Health study found that hormonal contraceptive pill users processed stress differently at the molecular and psychological level. They also reported a more negative emotional response to stress compared to non-users.
Researchers have found that zinc can block the production of an inflammatory molecule in Candida albicans, preventing inflammation and burning symptoms associated with thrush. Studies in mice and women with recurrent yeast infections suggest that zinc treatments may be effective in preventing reinfection.
A new study found that the gut microbiota plays a significant role in prostate inflammation in aging men, particularly those with metabolic syndrome. The researchers discovered a strong relationship between IL-6 and IL-18 expression and lipid parameters in the prostate tissue of men with BPH + MetS.
The Cusack group at EMBL Grenoble has provided insights into the interactions of XIAP and RIPK2 molecules involved in gut signalling pathways. This research sheds light on how these molecules interact, revealing a promising drug target for treating inflammatory bowel diseases.
A recent study found a compelling link between vitamin B12 deficiency and chronic inflammation, which can lead to various health problems. The research revealed an inverse relationship between vitamin B12 levels and inflammatory markers in humans and mice, suggesting that higher vitamin B12 levels may lower inflammatory markers.
Researchers found that administering precursors of Elovanoids improved neurological deficit in an experimental model of ischemic stroke. The study identified a cascade of gene responses and sheds light on potential new therapeutic avenues for treating ischemic strokes.
Researchers found that a genetic variation in the MLKL gene is carried by up to 3% of the global population, increasing the risk of inflammation and related diseases. This discovery may lead to personalized treatments for conditions like inflammatory bowel disease.
Researchers identified two SARS-CoV-2 protein mutations linked to severe COVID-19 symptoms and increased inflammation. The mutations, known as KR, were found in patients with higher viral loads and more severe symptoms.
An international team has decoded the TSPO protein to visualize neuroinflammation, revealing its relationship with microglial cells. The study's findings pave the way for optimizing observation of neuroinflammatory processes and re-reading previous studies.
A cancer drug, idronoxil, has been shown to reduce inflammation caused by COVID-19, according to research published in Nature Communications. The study found that idronoxil can target specific inflammatory pathways, limiting the damage without increasing viral replication.