Articles tagged with Pancreas
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Dresden researchers have developed a system to test multiple compounds on human pancreatic organoids, identifying 54 compounds that affect pancreas development. These compounds inhibit the GSK3A/B protein and drive progenitor cells to differentiate into functional acinar cells. The ability to generate acinar organoids is valuable for s...
Scientists created three-dimensional pancreatic models to study the development of fluid-filled cavities. They found that low pressure and high cell proliferation rates produce complex, star-shaped lumens. The discovery can help understand organ development and diagnose diseases.
Researchers developed an organ-on-a-chip platform to study the gut-islets axis and its regulation by hormones. The system successfully reproduced key features of the axis, including bile acid-induced GLP-1 release and insulin secretion enhancement.
Researchers developed a reliable dataset to determine the best AI model for pancreatic cancer detection, finding that AI outperformed clinicians in detecting and diagnosing the disease. The study suggests that AI can support radiologists in their work and potentially lead to earlier diagnosis and faster treatment.
The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.
Researchers discovered that pancreatic tumors form pseudosynapses, exploiting the body's nervous system to drive tumor growth. Calcium waves triggered by glutamate binding promote metastasis and cancer progression.
A new imaging approach allows researchers to visualize how dual-acting diabetes and obesity drugs like tirzepatide interact with cells in the pancreas and brain. The tool, called daLUXendins, provides insight into the metabolic effects triggered by these drugs, which stimulate both GLP-1R and GIPR receptors.
A recent study published in Nature Communications has found that specific cell subtypes are more prone to developing into diabetes. By tracking these subtypes over time, researchers can better understand how they drift over time or under different conditions. The findings hold promise for potential prevention and treatment strategies.
A team of international scientists successfully 3D printed functional human islets using a novel bioink, paving the way for more effective and less invasive treatment options. The bioprinted constructs maintained their structure without clumping or breaking down and showed promising results in laboratory tests.
Researchers at Nagoya University found that patients with high-risk stigmata and invasive nodules in their pancreatic cysts had a significant impact on their survival. The presence of invasive nodules led to improved survival rates after surgery, while those without invasive nodules had favorable outcomes even without surgery.
The study found an increase in pancreatic adenocarcinoma among all age groups, while a notable rise was observed in colorectal adenocarcinoma among younger patients. This trend highlights the importance of early detection and evaluation for clinicians when evaluating patients with relevant symptoms.
Researchers found significant disparities in quality of care and outcomes for patients with metastatic pancreatic cancer. Patients with higher social vulnerability indices were less likely to receive guideline-concordant systemic therapy, palliative care, or survive over 12 months.
A Rice University-led team developed an implantable 'cytokine factory' that triggers potent immune responses against hard-to-treat cancers. The IL-12 cytokine factory successfully induces the recruitment of tumor-targeting T cells, eliminating local and distal tumors in preclinical models.
Researchers discovered that normal pancreatic cells can temporarily retain 'memory' of cancer-linked epigenetic marks, even in the absence of genetic mutations. This finding suggests a key role for epigenetic memory in cancer development and may explain increasing cancer rates in young people.
Research in mice suggests that antibiotics during infancy can stunt insulin-producing cell growth and boost diabetes risk. Specific microorganisms, such as Candida dubliniensis, may help promote pancreatic cell development and improve metabolic function.
The Dexcom G7 CGM device demonstrated an accuracy of 8.0% in a study involving 130 adults with type 1 or type 2 diabetes, setting a new standard for continuous glucose monitoring devices.
The INHALE-3 extension study found that a regimen of inhaled technosphere insulin and insulin degludec reduced post-meal hyperglycemia in adults with type 1 diabetes. The treatment showed significant improvements in mean time in range, with 43% of participants expressing interest in continuing the regimen.
A team of scientists has successfully developed a novel platform for diabetes treatment utilizing bioink derived from pancreatic tissue and 3D bioprinting technology. The HICA-V platform replicates the structure and function of the human endocrine pancreas, supporting islet maturation and functional enhancement.
Researchers found that pancreatic cancer cells gain a survival edge by carrying copies of critical cancer genes on circular pieces of DNA outside chromosomes. The discovery highlights the importance of targeting extrachromosomal DNA in treating the disease.
Excessive alcohol consumption causes severe digestive problems, including liver damage, stomach disorders, and increased cancer risk. Chronic alcohol use can lead to conditions like cirrhosis, pancreatitis, and colorectal cancer.
A new study suggests that chronic stress and an unhealthy diet may work together to fuel the early development of pancreatic cancer. Researchers found that both stress-related neurotransmitters and obesity-related hormones activate a protein called CREB, which is linked to cancer cell growth.
Research in mice found that early-life gut microbes shape insulin-producing cell development and reduce long-term changes in metabolism and diabetes risk. Exposure to a fungus called Candida dubliniensis during infancy may also promote lifelong metabolic health by supporting the growth of insulin-producing cells.
Researchers at the University of Malaga have identified multiple genetic variants causing Familial Chilomicronemia Syndrome, a rare disease characterized by high triglyceride levels. This discovery enables accurate clinical diagnosis and treatment selection for patients with this condition.
Researchers at Trinity College Dublin have discovered a biomarker panel that can accurately identify patients at risk of developing pancreatic cancer, offering new hope for early detection and improved treatment. The study uses a combination of blood and fluid analysis to distinguish between low- and high-risk patients.
Amplified Sciences has received CLIA certification for its PanCystPro test, which helps risk stratify patients with pancreatic cystic lesions. The company plans to commercialize the test through an early access program and a clinical utility trial in 2025.
Researchers discovered that pancreatic β cells produce a neuroprotective agent called Fibroblast Growth Factor 23 (FGF23), which can stop amyloid-β-induced neuronal cell death. FGF23 may increase ribosomal proteins, helping to maintain homeostasis in neurons.
Researchers studied the prognostic power of micropapillary patterns in PDAC, finding that even small percentages serve as independent prognostic factors for decreased survival. The study suggests incorporating micropapillary pattern percentage into pathology reports could enhance patient management strategies.
Researchers discover immune cells regulate blood sugar levels by stimulating glucagon production in the pancreas. This complex neuroimmune-hormonal circuit reveals a new way the body maintains stable glucose levels, especially during periods of low energy.
A recent study has uncovered the crucial role of enzyme G6PC2 in regulating blood sugar levels by controlling glucagon secretion from pancreatic alpha cells. Genetic variations in G6PC2 impact its expression in alpha cells, and inhibiting this enzyme may provide a new therapeutic strategy for type 2 diabetes.
Mount Sinai researchers have made significant progress in understanding how human beta cell regenerative drugs work, potentially leading to a cure for diabetes. The study suggests that these drugs may be able to induce lineage conversion in human pancreatic islets, providing a new source of beta cells.
Scientists at UCSF have developed engineered T cells that act as immune referees to soothe overreacting immune responses and mope up inflammatory molecules. These cells could improve treatment for organ transplants, type 1 diabetes and other autoimmune conditions by reducing the need for harsh immunosuppressant drugs.
Scientists have developed a new organoid that includes all three key cell types in the pancreas, allowing for a clearer understanding of its early development. The research discovered a new stem cell type that can develop into these cells, and found differences between human and mouse pancreatic development.
Min Li will receive the 2024 Palade Prize for his contributions to pancreatology, recognizing his pioneering work on pancreatic cancer and metabolic reprogramming. He has been continuously funded by the National Cancer Institute for 15 years and has published over 200 high-impact articles.
Researchers found that lysosomal stress can disrupt normal pancreatic function, leading to impaired insulin production and glucose regulation in various diabetes types. Targeting lysosomal function may lead to new treatments for diabetes.
Researchers highlight liquid biopsy as a promising tool for detecting pancreatic incidentaloma and its potential to catch lesions early, thereby improving patient outcomes. The study also emphasizes the importance of clear guidelines for addressing incidental findings while balancing diagnostic utility with patient well-being.
Researchers document remarkable response to pembrolizumab in patient with metastatic adenosquamous pancreatic cancer (ASCP) and KRAS G12C mutation. The study highlights potential shift in treatment of ASCP, a rare form of pancreatic cancer traditionally underserved by current therapies.
A multicenter study found that specific KRAS mutations in pancreatic cancer can affect patient outcomes, with some variants associated with better overall survival. The research suggests revising clinical guidelines to recommend routine molecular testing in all patients with pancreatic cancer.
Researchers at University of Gothenburg propose inhibiting somatostatin to restore glucagon release and prevent dangerous blood sugar levels. This approach has the potential to save lives and is supported by experimental results in mice with type 1 diabetes.
Researchers found that adult mice with only beta cells have better glycaemic balance and insulin sensitivity than standard animals. Non-beta cells are not essential for maintaining blood sugar levels, contradicting the prevailing conception.
Texas A&M researchers are investigating the use of extracellular vesicles to deliver immune-suppressing proteins, potentially reducing the immune system's attack on insulin-producing beta-cells. The goal is to develop a novel treatment for type 1 diabetes, which currently has only lifelong insulin therapy as an approved option.
A randomized crossover trial found that a joint-AI model improved clinical diagnosis, but future trials are warranted to confirm its effectiveness. The AI model demonstrated positive human-AI interaction, suggesting its potential to facilitate accurate diagnoses.
A recent UNIGE study highlights the risks of high-protein diets, also known as Paleolithic diets, which can lead to severe neurological disorders. Excess protein increases ammonium production, overwhelming the liver and potentially causing coma in severe cases.
A study published in Science Advances reveals a special group of 'first responder' cells in the pancreas that trigger blood sugar response. These cells respond to glucose quicker than others, initiating the response and regulating the activity of other beta cells.
The study reveals a functional hierarchy of beta cells, with a small group acting as 'first responders' to initiate the glucose response. These cells produce and supply Vitamin B6 to regulate the activity of other beta cells, offering new insights into diabetes pathology and potential treatments.
A new study from the University of Oklahoma found that measuring circulating microRNAs is likely as effective as measuring blood sugar levels in determining how young people with type 2 diabetes will fare. The study also found a 20% decrease in beta cell function during the first six months of treatment.
A potential new strategy for reducing diabetes risk associated with antipsychotic medications involves co-administering drugs that block dopamine receptors in the brain alongside those that stop these same receptors in the pancreas. This approach may limit metabolic side effects and improve glucose metabolism.
Researchers developed an antioxidant gel to preserve islet function after pancreas removal, significantly improving survival and preserving normal blood sugar levels in animals. The new approach could enable patients to live pain-free without complications of diabetes.
An experimental monoclonal antibody drug called mAb43 appears to prevent and reverse the onset of clinical type 1 diabetes in mice, lengthening their lifespan. The drug targets insulin-making beta cells directly and shields them from immune system attacks, raising the possibility of a new treatment for the autoimmune condition.
Leading investigators are creating a one-stop resource for human pancreatic data, standardizing and disseminating curated information on the human pancreas to foster collaborative and reproducible diabetes research. The PanKbase program aims to provide machine-actionable data following FAIR principles.
Research reveals a significant connection between oral bacteria and accelerated pancreatic cancer development in mice. Viable Porphyromonas gingivalis was found in the pancreas of healthy mice after gum application, causing changes in the organ's microbial balance.
A recent literature review discusses the underlying mechanisms of type 2 diabetes, including insulin resistance and b-cell failure. The review also explores potential therapeutic strategies, such as replenishing and regenerating b-cells, pancreas transplants, and stem cell-derived b-cells.
Researchers discovered a potential treatment for Alzheimer's disease also prevents Type 2 diabetes by blocking the formation of toxic IAPP clusters. A synthetic peptide was shown to bind and neutralize these clusters, keeping beta cells alive.
A multicenter study found that a small pancreas size predicts a faster progression to stage 3 Type 1 diabetes. The study also suggests that using pancreas volume measurement combined with validated metabolic risk measures can more accurately predict disease development than either method alone.
A new DNA methylation-based method enables accurate assessment of pancreas cell composition, identifying specific cell types and providing insights into beta-cell dysfunction. The study offers direct clinical implications for understanding diabetes development and guiding tailored treatment strategies.
Researchers identified a significant decrease in insulin-producing beta cells with increasing age, correlating with pancreatic intraepithelial neoplasias. The study suggests that islet cell loss may be a key driver of senile diabetes, informing potential preventative treatments.
Researchers discovered that fruit bats have a genetic system controlling blood sugar levels, allowing them to consume up to twice their body weight in sugary fruit daily. The study's findings may lead to the development of better insulin- or sugar-sensing therapies for people with diabetes.
A Learning Health System model is being developed to increase organ donation and reduce disparities in access to transplantation. The project, led by Hennepin Healthcare Research Institute, will use data tools to track progress and improve equity in organ donation across the US.
Researchers found that vaccination of neonatal mice with group A Streptococcus promotes clonal expansion of innate-like B cells producing antibody against N-acetyl-D-glucosamine (GlcNAc), reducing Type 1 diabetes risk. These GlcNAc-specific B-1 B cells aid in producing tolerance, facilitating efficient clearance of apoptotic beta cells...
Researchers at Tohoku University successfully regenerated pancreatic beta-cells in mice by stimulating autonomic vagal nerves connected to the pancreas. This innovative approach improved insulin function and increased beta-cell numbers, ameliorating diabetes symptoms.
The Whipple procedure has seen significant improvements in mortality rates thanks to high-volume centers like Johns Hopkins, led by Dr. John Cameron, who reduced in-hospital mortality to less than 5%. Closed-suction drainage developed by Dr. Cameron further enhanced the procedure's safety and effectiveness.