Articles tagged with Senescence
A new study from the University of Minnesota Medical School has identified certain naturally occurring polyunsaturated lipids that selectively induce death in senescent cells, which are old and damaged cells that accumulate with age. These lipids trigger a process called ferroptosis, which can be used as a potential treatment for age-r...
Researchers identified a drug-and-supplement combination therapy that reduces senescent cells, inflammation, and injury in diabetic kidney disease. The treatment approach involves senolytics, which selectively target senescent cells.
Researchers focus on system-level resilience and long-term biological coordination to understand aging as a loss of coordination between biological systems. Studies show how mitochondrial signaling influences inflammation in senescence and microbiota–brain interactions shape aging trajectories.
Researchers have characterized the association between cellular senescence and human brain structure in both development and late life. The study found that senescence-related gene expression is linked to brain volume and cortical organization, with distinct roles depending on cell type and stage of life.
Researchers found a progressive shift in RNA contents of sperm with age, potentially contributing to health risks of having kids later in life. The discovery may lead to improved fertility outcomes and diagnostic tools.
Research from King's College London found that theobromine in dark chocolate is linked to lower biological age. The study tested blood-based markers of biological ageing and found a correlation between theobromine levels and reduced biological age.
Researchers developed a machine learning tool, SAMP-Score, to identify compounds that induce senescence in p16-positive cancer cells. The tool successfully identified a promising candidate, QM5928, which triggers senescence without killing cancer cells.
A study by the Gerald P. Murphy Cancer Foundation's Center for Exceptional Longevity Studies found that retaining gonad function can significantly impact frailty mortality risk. Male dogs with shortest testis exposure had high mortality risks, while those with longest gonad exposure showed no consequence of increasing frailty.
Researchers at Mayo Clinic have developed a new technique to identify senescent cells using aptamers, which can potentially lead to targeted therapies. The study found several rare aptamers that bind specifically to fibronectin on the surface of mouse cells, offering a promising approach for characterizing and treating senescent cells.
Researchers found that polyamines primarily activate glycolysis in cancer cells, upregulating eIF5A2 and five ribosomal proteins associated with cancer malignancy. In contrast, eIF5A1 promotes healthy aging by activating mitochondria via autophagy.
Researchers found that exosomes from senescent cells and circulatory exosomes carry molecular signatures associated with biological aging and cellular senescence. These signatures include proteins, lipids, and microRNAs linked to inflammation, oxidative stress, and tissue remodeling.
Researchers found that AUF1 helps prevent aging by breaking down enzymes involved in glucose metabolism. The study's findings improve our understanding of how metabolism affects the aging process.
A study at the Garvan Institute of Medical Research found that inactivation of a stress pathway makes ER+ breast cancer cells ignore stress signals, allowing them to evade treatment. The JNK pathway acts as a cellular alarm system, and its disruption leads to treatment resistance.
Cancer cells with abundant circular DNA elements (ecDNA) carrying oncogenes like MYCN are resistant to chemotherapy. Combining standard chemotherapy with a secondary therapy targeting these senescent cells leads to improved outcomes in mouse models of neuroblastoma and medulloblastoma.
The UT Health San Antonio research team, led by Blake Rasmussen, has been selected as a semifinalist in the XPRIZE Healthspan competition. They will use a low-frequency ultrasound spa to develop a non-invasive treatment that helps renew cells and tissues, potentially improving overall health and longevity.
A new study introduces a novel muscular clock, MAA, which measures how quickly an individual's muscles are aging compared to their actual age. The research found that about 25% of healthy middle-aged and older adults experience accelerated muscle aging, increasing the risk of sarcopenia.
Wild chimpanzees show reduced participation and performance in tool-use behaviours as they age, with individual differences in impact observed. The study provides evidence that old age leads to a gradual withdrawal from tool use, affecting efficiency and daily tasks.
Researchers found that telomerase inactivation in immune cells or connective tissue cells slows tumor growth, but creates conditions for aggressiveness. In contrast, endothelial cell preservation suppresses metastasis.
Some precursor plasma cells in patients with MGUS and SMM enter cellular senescence, a dormant state that prevents cancer progression. In contrast, patients who develop bone marrow cancer lack this protective mechanism. The discovery offers hope for early intervention and potential treatments that promote or inhibit senescence.
Researchers found that consuming foods high in methyl adaptogens, such as green tea and berries, can reduce markers of epigenetic aging. The study, which involved middle-aged men, suggests that targeted food choices may help slow the aging process.
A multicentre study found that biological ageing, measured by frailty index and telomere length, can predict cardiovascular disease risk more accurately than traditional tools. The study, involving over 14,000 individuals, suggests that incorporating biological age into risk assessments could improve cardiovascular health outcomes.
Researchers identified unique biological mechanisms that cause premature aging in the brains of individuals with alcohol, opioid, and stimulant use disorders. Different substances appear to hijack the brain's natural aging rhythm through distinct molecular mechanisms, though some pathways are shared across different substance types.
Researchers identified three subtypes of senescent skin cells with distinct shapes, biomarkers, and functions. The study found that one subtype, C10, becomes more prevalent with age and is harder to kill with existing drugs.
A study analyzing 17,500 individuals found that immune resilience counters factors of aging and mortality through TCF7 gene regulation, reducing mortality risk by 69% in midlife. This promotes salutogenesis, actively fostering health and well-being.
Researchers at Tulane University identified a potential new way to treat idiopathic pulmonary fibrosis (IPF) using an FDA-approved cancer drug. The treatment works by blocking the CTLA4 protein, which blocks overactive T cells, allowing the immune system to clear out damaged cells that cause lung scarring.
Participants who took the supplement showed improvements in grip strength, lower body mobility, and reductions in body weight. The supplement appeared to reduce stem cell turnover, regulate immune function, and influence gene activity related to stress response.
Aging (Aging-US) journal announces a commemorative collection honoring Dr. Mikhail Blagosklonny, a pioneer in aging biology. The special issue will explore key themes central to his scientific contributions, including mechanistic insights and translational approaches.
Researchers at UT Health San Antonio have discovered a way to delay or even block recurrence of the deadliest brain cancer after radiation by targeting senescent cells with experimental 'senolytic' drugs. This approach shows promise in preventing tumor growth and improving patient survival.
Breast cancer survivors experience accelerated aging due to detrimental effects of BC and its treatments, particularly systemic therapies. The study highlights the need for ongoing monitoring and potential strategies to slow down aging in cancer survivors.
Senescent cells can cause chronic inflammation through the secretion of inflammatory molecules, leading to age-related diseases. The study found that a cellular circuit controlling DNA repair can suppress this inflammation, offering potential ways to promote healthier aging.
A Finnish twin study investigated the relationship between long-term leisure-time physical activity and mortality, finding that moderate activity offers a 7% lower mortality risk. The study also found no additional benefit from high levels of physical activity in reducing mortality risk.
A new drug candidate has been developed to target and eliminate senescent cells in the liver, reducing fat buildup and preventing liver damage. The study demonstrates a safer and more effective approach to treating metabolic dysfunction-associated steatotic liver disease (MASLD) and potentially inhibiting liver cancer development.
A newly discovered mechanism has identified a key protein, AP2A1, that toggles between 'young' and 'old' cell states. By suppressing AP2A1 in older cells, researchers were able to reverse senescence and promote cellular rejuvenation. This breakthrough may lead to new treatment targets for diseases associated with old age.
A new study from Penn State finds that oral tissue samples significantly affect epigenetic clock accuracy, leading to older age estimates. Researchers tested five tissue types and seven epigenetic clocks, concluding that blood-based samples are more accurate in measuring biological age.
Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.
A study of twins found that a diet low in fruits and veggies and high in red meat and sugary drinks accelerates biological aging. Conversely, healthier diets slow down biological aging. The study suggests that diet plays a significant role in aging, even after accounting for other lifestyle factors.
A University of Barcelona team has identified a molecular mechanism that could lead to new strategies for eliminating senescent cells in cancer patients. By analyzing human senescent cells in a melanoma tumor model, the researchers found that BCL-2 family proteins play a key role in senescence survival.
A recent study led by University of Oxford researchers found that old male fruit flies' reproductive success declines due to seminal fluid limitation, not sperm quantity. Supplementation with young males' seminal fluid rescued aged males' fertility, highlighting the importance of seminal fluid quality in animal fertility.
Researchers reveal senescence's impact on liver health, from repair and regeneration to chronic disease progression. Emerging therapies, such as senolytic treatments, aim to selectively eliminate senescent cells while preserving healthy tissue.
Researchers developed a new tool to measure biological aging in individual cell types, providing insights into diseases like Alzheimer's and liver pathologies. The study found that certain brain cells and liver cells show signs of accelerated aging, making it a better tool for detecting diseases.
Researchers discovered that Prostaglandin E2 drives skin cells to age and enables some of these cells to become pre-cancerous, leading to increased cancer risk. The study found that blocking PGE2 reduced the chances of aged cells becoming precancerous.
A University of Minnesota Medical School research team found that social stress causes DNA damage and senescence in preclinical models, accelerating aging. The study highlights a potential way to understand how life stress impacts the aging process.
Researchers developed an in vitro model of murine peritoneal macrophage aging to study molecular mechanisms and develop innovative strategies. Chronic treatment with CB3 completely prevented the increase of p21CIP1 and maintained proliferative activity in day 14 macrophages.
Researchers found that ACLY activity activates the senescence-associated secretory phenotype (SASP), a pro-inflammatory environment associated with chronic inflammation and aging. Blocking ACLY activity reduces inflammation-related genes in aged cells, suggesting a potential strategy for managing aging and age-related diseases.
A new epigenetic clock based on cheek cells accurately predicts mortality risk, outperforming previous clocks trained on blood data. The study found that specific methylation sites are linked to human mortality, and future research is needed to identify associations with age-related diseases.
A new study found that 2-bromopalmitate treatment reverses cell senescence in human vascular smooth muscle cells, reducing DNA damage markers and promoting cell proliferation. The research suggests a critical role for protein palmitoylation in regulating the senescent phenotype.
A new study reveals a link between senescent cells and the protein HIRA, which helps pack and unpack DNA. The research team discovered that HIRA is necessary for the cells to begin emitting inflammatory molecules, leading to chronic inflammation in the body.
Parents who struggle with alcohol use disorders can pass along symptoms of early aging to their children, affecting them well into adulthood. These accelerated aging effects include high cholesterol, heart problems, arthritis, and early onset dementia.
A study found that ABA, JA, and ethylene play crucial roles in the fruit's senescence, impacting biochemical metabolisms, anti-stress responses and softening processes. Optimal fruit quality is achieved at 2-4 days of storage.
A new study published in Aging explores the potential of three large DNA methylation datasets to identify biological age signals in dogs. The researchers found that biological age methylation clocks are affected by population stratification and require heavy parameterization to achieve effective predictions.
A recent Mayo Clinic study published in Nature Medicine found that senolytic drugs can have beneficial effects on bone formation in older women with a high number of senescent cells. However, these drugs may not be effective for everyone and more research is needed to better identify potential beneficiaries.
Researchers describe a new concept for an immune response against cancer and aging using senescent cell-derived vaccines. The vaccines aim to stimulate the immune system against cancer cells and slow down or reverse aging-related diseases.
A research team from Osaka University identified a key osteoporosis-related gene, Men1, and developed a new animal model of the disease. The study found that inactivation of Men1 led to cellular senescence in osteoblasts, reducing bone formation activity and increasing bone resorption.
Researchers found associations between childhood cognition, adolescent crystalized intelligence, and midlife fluid intelligence with DNA methylation age acceleration. A 1-unit increase in adolescent PPVT was associated with a 0.048-year decrease in aging.
Senescent cells, 'zombie-like' cells that resist death, accumulate in the brain with age, contributing to cognitive declines and frailty. Researchers identified a specific pathway linked to senescence in fruit fly brains, potentially paving the way for therapies to delay age-associated pathologies.
A recent study published in PLOS Biology found that post-mitotic brain neurons re-entering the cell cycle rapidly succumb to senescence. This process is more common in Alzheimer's disease and may provide valuable information about neurodegeneration, while the technique used can be applied to other inquiries.
Researchers found that people on caloric restriction lost telomeres more rapidly at first and then more slowly after their weight stabilized. The two-year timeline was not sufficient to show benefits, but those may still be revealed in longer-term data collection.
Small extracellular vesicles from young blood have been shown to dramatically extend lifespan, rejuvenate whole-body physiology, and reverse age-related degenerative changes in mice. The study demonstrates that these vesicles stimulate the expression of PGC-1 through their miRNA cargoes, ultimately improving mitochondrial functions.
A new study finds that women who have been pregnant look biologically older than those who haven't, with the number of pregnancies accelerating biological aging in young adults. The study used 'epigenetic clocks' to measure cellular aging and found a significant association between pregnancy history and biological age.
This study investigates the role of ethylene in carnation postharvest life, revealing varietal sensitivity differences. Genetic manipulation targeting key genes accelerates or delays senescence based on ethylene levels.