Articles tagged with Calcium
Researchers discovered that cancer cells with RET mutations produce higher levels of the OPG protein, which disrupts bone renewal and blocks destruction, favoring bone accumulation. Measuring OPG levels via blood tests could identify and monitor patients with aggressive disease.
Researchers at DGIST identified a novel molecular mechanism regulating the N-type voltage-gated calcium channel, which plays a critical role in neural signal transmission. This discovery provides an important clue for developing therapeutics for brain disorders such as neuropathic pain, epilepsy, and Alzheimer's disease.
Researchers have developed a biochar adsorbent that combines physical and chemical interactions to capture tetracycline molecules. The material showed high tetracycline adsorption capacity and good resistance to coexisting ions, suggesting potential for repeated operation.
A deep learning model combines knowledge from different catalyst families to identify a top-performing green hydrogen catalyst. The AI correctly predicted the activity ranking of 12 tested catalysts within a previously unexplored material family.
A systematic review of 69 trials involving over 153,000 adults found that calcium, vitamin D, or combined supplements have little to no effect on fracture prevention. The findings suggest that routine supplementation may not be necessary, and instead focus should be on interventions like balance and resistance exercise.
Researchers have developed CRAC channel inhibitory binders that can selectively interfere with STIM-ORAI communication, reducing calcium entry through CRAC channels. This may help restore thrombocyte progenitor production and improve treatment outcomes for Stormorken syndrome patients.
Researchers developed a new type of engineered biochar that can deliver oxygen in a controlled and stable way, overcoming limitations of current materials. The phosphate-modified biochar demonstrated strong environmental adaptability, making it suitable for complex natural environments.
Researchers have developed a calcium-modified biochar that more effectively captures organic phosphorus, offering a solution to reduce nutrient pollution in water systems. The study reveals how molecular structure influences phosphorus adsorption, providing a clearer roadmap for designing more effective materials.
Researchers developed a low-cost method to transform agricultural waste into high-quality biochar, increasing its ability to store carbon and combat climate change. The new method uses limewater treatment to improve biochar production, resulting in a 34% increase in carbon retention and improved soil structure and chemistry.
A large meta-analysis of over 48,000 children found that well-planned plant-based diets can support healthy growth and even offer additional health benefits for children. However, the study also highlights risks of deficiencies in key nutrients such as vitamin B12 and zinc if not obtained through fortified foods or supplements.
A Cochrane review found no significant effect of calcium supplementation on pre-eclampsia, contradicting long-held assumptions. The review excluded small and unreliable studies that previously suggested benefits of calcium supplementation.
Researchers have identified promising molecular targets for acute pancreatitis treatment, focusing on intracellular calcium overload and mitochondrial dysfunction. Experimental studies show that blocking calcium influx channels and enhancing cellular protection may transform AP therapy.
Researchers developed a dual-breakthrough method to recycle phosphorus from sewage sludge into smart fertilizers, enhancing soil health or rapid crop growth. The innovative approach utilizes modified hydrochar with calcium or magnesium salts, controlling phosphorus release and improving its bioavailability.
A recent study from Edith Cowan University found no evidence that calcium monotherapy increases the long-term risk of dementia in older women. The five-year double-blind, placebo-controlled randomised clinical trial on calcium supplements to prevent fracture provided accurate data on dosage and duration, strengthening the results.
A team of researchers has established the first comprehensive model of how calcium is transported out of the cell by the plasma membrane Ca²⁺-ATPase, explaining its high speed. The model reveals that PIP₂ stabilizes calcium binding and facilitates rapid release, making it the pump's primary acceleration factor.
Researchers at UCSF have successfully engineered a shapeshifting protein that can change shape in response to signals, potentially leading to breakthroughs in medicine, agriculture, and environmental applications. This achievement marks the first step towards creating stable yet dynamic proteins using AI-augmented protein engineering.
A systematic review of nearly 6000 runners found that lower energy and fat intakes were strongly associated with a higher risk of injury in female runners. A low-fibre diet also increased the likelihood of bone stress injuries.
Scientists have discovered a novel regulator of the mitochondrial sodium-calcium exchanger (NCLX), which helps maintain calcium balance in mitochondria. The discovery of TMEM65 could lead to new therapeutic agents to combat calcium overload associated with heart failure and Alzheimer's disease.
A new study by McGill University researchers sheds light on the disruption of calcium transport in the brain's AMPA receptors, linking it to autism and intellectual disability. The findings could pave the way for treatments targeting these receptors, offering hope for patients with related neurological disorders.
A large new study of over 40,000 patients found that a zero coronary artery calcium score continues to be an accurate indicator of low risk for coronary heart events even as people age. Patients with a zero plaque burden had a two to three times lower risk of death from any cause, including in seniors.
A new study compares prescribing recommendations based on traditional risk factors vs. coronary artery calcium scoring. The study found that patients assessed using the Pooled Cohort Equation had a higher rate of statin medication recommendations than those assessed using the coronary artery calcium score, with 50.7% vs. 22.3% respecti...
Researchers developed Cu/Zn solid-solution phase hosts to overcome electrochemical limitations in multivalent metal ion batteries. The material's layered crystal structure and abundant interlayer confined species provide favorable diffusion pathways for charge carriers.
Researchers discovered that Wingless triggers cellular reorganization and contraction of tissue to form constrictions in the fly intestine. This finding expands our understanding of Wingless signalling pathway and its role in morphogenesis and organ development.
Researchers have discovered a new way to stimulate cardiomyocyte proliferation, offering promising results in both human cardiac slices and live animals. This innovative approach targets calcium signaling pathways, potentially transforming the treatment landscape for patients suffering from heart failure.
The study found that combining coronary calcium score with a primary prevention strategy in intermediate-risk patients with a family history of coronary artery disease reduces atherogenic lipids and slows plaque progression compared to usual care. This data supports the use of CAC scores to assist intensive preventive strategies.
The Texas Tech University Health Sciences Center is conducting a randomized controlled trial to investigate the effectiveness of calcium and vasopressin in treating severely injured patients who experience significant blood loss. The study, known as CAVALIER, will enroll approximately 1,050 participants aged 18-90.
Researchers discovered that a network of subcellular structures similar to those responsible for muscle contraction are also present in brain cells. These structures, called contact sites, play a crucial role in transmitting calcium signals that regulate neuronal signaling. The study provides new insights into the molecular mechanisms ...
Researchers compiled a reference framework of isotope compositions indicating the type of diet for extant reptiles, providing a useful dataset to reconstruct the diet of fossil reptiles. The analysis showed that calcium isotope ratios are higher in insectivorous reptiles and lower in herbivores and carnivores.
Researchers at POSTECH developed an innovative injectable adhesive hydrogel that regenerates bone using harmless visible light. The hydrogel addresses limitations of existing treatments by simultaneously achieving cross-linking and mineralization without separate bone grafts or adhesives.
Researchers from UniSA have developed a simple strategy to increase seawater evaporation rates, making desalination more energy-efficient and sustainable. By introducing clay minerals into a photothermal hydrogel evaporator, they achieved a 18.8% higher evaporation rate for seawater compared to pure water.
Researchers at Radboud University Medical Center developed a super microscope that combines live imaging and electron microscopy, allowing visualization of protein complexes in real-time. This technique opens up new avenues for studying arterial calcification and its potential link to COVID-19 vaccine entry.
A study found that using an orbital atherectomy device to remove calcium from blocked coronary arteries before stenting procedures did not improve patient outcomes. The device was used on patients with moderately severe calcification, rather than extreme cases, and did not show significant benefits.
Researchers from Johns Hopkins Medicine discovered how a brain cell surface molecule shapes neuron behavior, finding that it suppresses selectivity in neurons. The study's findings may help scientists better understand causes of autism, schizophrenia, and epilepsy.
A new study found significant intake inadequacies for nearly all evaluated micronutrients, with iodine and vitamin E deficiencies being the most prevalent. The researchers estimated inadequate intakes were higher for women than men in some countries, highlighting a need for targeted dietary interventions.
A Vanderbilt University Medical Center study found that higher thiazide doses significantly lower urine calcium, leading to fewer symptomatic kidney stone events. The researchers suggest monitoring calcium excretion while on thiazide therapy to adjust dose and diet.
A new study reveals that the Sierra Nevadas are a significant source of groundwater for California's Central Valley aquifer, with some areas relying almost entirely on it. The research found that the groundwater is mixed in age, with some water being as young as 4 years old and others dating back over 40,000 years.
Research findings suggest that higher intakes of calcium and zinc before conception can lower the risk of hypertensive disorders during pregnancy. Participants with higher pre-conception intakes of these essential minerals were 24% less likely to experience hypertensive disorders compared to those with lower intakes.
Researchers discovered a step-by-step process of calcification in aortic valves, revealing two defense mechanisms: osteopontin and collagen fibers. The study provides new insights into understanding cardiovascular calcification and potential therapeutic applications.
Researchers from Tokyo Institute of Technology experimentally revealed that high-density Ca introduction enhances superconductivity in graphene-calcium compounds through confinement epitaxy, leading to increased critical temperatures. This breakthrough could enable the development of C6CaC6 superconductors with wide applicability in qu...
Desert isopods rigorously regulate their intake of macronutrients and calcium, preferring biological soil crust over plant litter. The research highlights the crucial role of ingested microorganisms in facilitating digestion and growth.
Researchers discovered a connection between mitochondrial calcium transport and autophagy, a process where cells break down and reuse components. The study found that NCLX protein plays a crucial role in regulating this link, which has implications for understanding energy metabolism and developing disease treatments.
Menopausal hormone therapy is appropriate to treat vasomotor symptoms in early menopause without contraindications. WHI evidence does not support routine supplementation with calcium plus vitamin D or a low-fat diet for preventing fractures and breast/colorectal cancer, respectively.
Scientists have discovered a positive relationship between calcium concentrations and potato plant resistance to bacterial wilt. Calcium supplementation can significantly reduce the growth rate of the pathogen and negatively affect its ability to form biofilms and move.
Researchers identified a novel mechanism where APP-CTFs disrupt organellar communication, interfering with cellular homeostasis and leading to endolysosomal dysfunction. This finding suggests that preventing APP-CTF accumulation could be crucial for developing new AD treatments.
A review of mitochondrial energy metabolism in diabetic cardiomyopathy reveals disrupted dynamics and oxidative stress as key triggers. Targeted therapies, such as antioxidants and ketogenic diets, show promise in combating this debilitating condition.
A recent study by the University of Cambridge found that farmed salmon production leads to a loss of essential nutrients. Consuming one-third of current food-grade wild feed fish directly could maximize nutrients from the sea. This approach could help address global nutrient deficiencies and improve both diets and ocean sustainability.
A new study has identified a crucial role for plant MLKL proteins in regulating cytoplasmic calcium ion concentration, which is responsible for innate immune responses. The research found that activated plant MLKLs maintain higher calcium levels, activating downstream immune machinery and conferring disease resistance.
A 20-year analysis found that calcium and vitamin D supplements reduced cancer mortality by 7%, but increased cardiovascular disease mortality by 6% in postmenopausal women. The study suggested that cancer incidence depends on pre-supplementation status, while CVD mortality is higher among supplement users.
A new study published in Radiology found that coronary artery calcium scoring can identify patients with a low risk of heart attacks or strokes. Patients with a zero coronary artery calcium score showed very low risk of major adverse cardiovascular events, suggesting they may not require invasive coronary angiography.
Researchers capture atomic resolution images of ionotropic glutamate receptor transporting calcium, revealing a temporary pocket that traps calcium. The mechanism discovered is conserved across all species of mammals and has implications for synaptic function and learning processes.
A new method enhances electrochemical surface area in calcium-doped perovskite, La0.6Ca0.4MnO3, overcoming common bottlenecks in hydrogen fuel cell applications. The activated material demonstrates superior oxygen reduction reaction performance.
Researchers have developed a synergistic antitumor drug that activates calcium channels in tumor cells, leading to a deadly influx of calcium ions. The treatment involves using a bioactive agent to generate reactive oxygen species, which triggers the activation of calcium channels in both the outer membrane and endoplasmic reticulum.
Researchers studied how epithelial cells sense small changes in their environment using ion channels. They found that even small movements can trigger rapid intracellular calcium changes via mechanosensitive cation channels, which play a key role in touch sensation and other physiological functions.
A new study found that low-dose calcium supplementation (500mg per day) was as effective as high-dose supplementation (1,500mg per day) in preventing preeclampsia, with no significant difference in preterm birth rates. The findings provide an opportunity to revise the WHO's current recommendation for pregnant women with low-calcium diets.
Researchers discovered that microglia regulate neuronal activity in a brain region-specific manner, playing a key role in how anesthesia works. Microglia depletion delayed induction and led to early emergence of anesthesia.
Researchers identified Benidipine as a compound promoting the death of cigarette smoke-induced senescent lung cells, improving lung emphysema. The dihydropyridine family of calcium channel blockers constitutes a new class of senolytics that could improve lung diseases.
Researchers from Tokyo University of Science developed a novel, low-cost hydrogel using seaweed extract that prevents wound expansion and promotes healing. The hydrogel demonstrates significantly lower adhesion and swelling compared to conventional hydrogels, making it an excellent alternative for treating skin wounds.
Researchers have identified a small molecule that reverses four types of chronic pain in animal studies without troublesome side effects. The compound, CBD3063, binds to the inner region of a calcium channel, indirectly regulating its activity and reducing neurotransmitter release.
A new study by Intermountain Health found that high levels of coronary calcium are common among people who have a heart attack but no known risk factors. The study suggests that scans to detect plaque buildup should be part of standard care for these patients, enabling early diagnosis and treatment.
A recent study found that ocean acidification in the Mediterranean is already affecting the calcification of marine plankton, with negative consequences for marine ecosystems. The research suggests that anthropogenic carbon dioxide emissions are the main driver of this decline, while ocean warming may be mitigating this effect.