A Korean research team has developed NUDGE, a foundational technology that redirects cell fate in a desired direction through a minimal, temporary intervention. The approach harnesses the gene regulatory dynamics already present within cells, allowing for a single temporary stimulus to guide a cell to a desired state. NUDGE's technolog...
The journal welcomes leading researchers with expertise in hematopoietic and muscle stem cell biology, advancing understanding of stem cell research in health and disease. Drs. Bonnet and Relaix bring significant breadth of expertise and commitment to rigorous science, enhancing Stem Cell Reports' impact.
Jun Takahashi, MD, PhD, has been awarded the 2026 Ogawa-Yamanaka Stem Cell Prize for pioneering the translation of induced pluripotent stem (iPS) cell biology into regenerative therapies for Parkinson's disease. He has achieved the world's first clinical approval for iPS cell-derived cell transplantation.
Researchers at Stanford Medicine have developed AI cell models, called universal cell embedding and TranscriptFormer, to compare cells among species and gain insights into diseases. These models can identify cell types, evolutionary relationships, and even distinguish between healthy and diseased cells.
In vivo immune cell engineering allows for direct genetic modification of immune cells in the body, enabling more efficient and accessible CAR-T-cell therapy. The approach overcomes the limitations of traditional ex vivo cell manufacturing, such as long manufacturing times and high costs.
A novel laser-fabricated plasmonic chip combines 185 nm Raman resolution with deep learning to identify and sort cancer cells. The developed sorter achieves precise cell sorting without labeling, using spatially resolved Raman signals.
Researchers have discovered that each signaling pathway leaves behind a unique fingerprint of gene activity, allowing them to reconstruct signaling histories across different cell types. This AI-driven approach, called IRIS, enables scientists to comprehensively map signaling histories at an unprecedented scale, accelerating stem cell ...
Dr. Lorenz Studer is known for his pioneering advances in stem cell biology, regenerative medicine, and the development of stem cell-based therapies for neurodegenerative disease.
Tumors expressing POU2F3, a tuft cell master regulator, represent a distinct molecular class of 'tuft cell-like' cancers. These tumors exhibit unique biological characteristics that may create new opportunities for diagnosis and targeted therapy.
Using artificial cells, researchers uncovered fundamental physical principles governing cell shape changes and front-rear polarity. They discovered that local interactions within the actin cytoskeleton can generate large-scale shape changes and front-rear polarity without relying on biochemical signaling.
A Mount Sinai study found that single-cell atlases, used for mapping the human body and training AI models, may not accurately represent global populations. The analysis of over 13,500 samples revealed an overrepresentation of European ancestry and underrepresentation of Asian and Latino individuals, highlighting the need for diverse a...
The STEM-PD trial demonstrated the safety and feasibility of stem cell-derived dopaminergic cell transplantation in patients with moderate to advanced Parkinson's disease. The findings mark an important step in evaluating this approach as a potential treatment strategy for neurodegenerative diseases.
The International Society for Stem Cell Research convenes its 2026 Annual Meeting in Montréal, showcasing groundbreaking discoveries and emerging clinical advances. The meeting features nearly 1,300 scientific posters and presentations spanning every area of stem cell research.
A USC-led team has developed a way to grow and genetically engineer progenitor cells that give rise to macrophages, a type of immune cell promising for cancer immunotherapies. The team successfully expanded these cells in the laboratory and engineered them to target specific cancer markers.
By identifying three distinct developmental stages of photoreceptor cells, researchers aim to determine which cell population is most capable of forming neuronal connections in the eye. This may lead to improved treatment outcomes for late-stage blinding conditions through cell-based therapies.
A team of researchers has discovered large droplets of proteins known as condensates near inactive chromosome regions within the cell nucleus that are a feature of some cancer cells. The newly found condensates store excess gene-activating protein TEAD1, regulating its activity and preventing toxicity to the cell.
UW researchers found that most biology education guidelines lack connections to society, with only 7% of elements discussing ethics and public health issues. This can lead to a lack of engagement and retention among students, as real-world examples support their interest in science and help develop their scientific identity.
A team of researchers at Kyoto University has discovered that the protein ZO-1 plays a crucial role in collective cell migration by riding ERK activation waves to podosomes on the basal cell surface. This movement enhances force generation, extracellular matrix degradation, and invasive cell migration.
Researchers at Kyoto University discovered that ATF6α plays a critical role in enabling the survival and proliferation of beta cells under sustained stress, leading to impaired beta cell mass expansion. The study highlights the potential for developing new therapeutic strategies to preserve and restore beta cell mass in diabetes.
A new study uses a human stem cell-derived model to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a promising candidate. Glycyrrhizin significantly prevents intestinal cell death in both stem cell models and mice with IBD, reducing inflammation and cell death.
Researchers reveal distinct fates for individual cells under the same pyroptosis-inducing conditions, highlighting heterogeneity in cell death decisions. Extracellular protease-mediated proteolytic cleavages drive nuclear envelope disruption and genomic DNA degradation, promoting efficient phagocytic clearance of necrotic cell remnants.
The Stem Cell Report podcast has marked five years of exploration in stem cell research, capturing significant progress in human development, disease, and regenerative medicine. The anniversary episode reunites past guests to discuss the field's evolution, highlighting advances in therapies, organoid systems, and global standards.
PhytoCell, an ensemble learning framework, analyzes plant single-cell RNA sequencing data to identify marker genes and assign cell types accurately. The framework achieves precise annotation of cell subpopulations and effectively removes redundant noise.
A new study maps how rare mixed tumors evolve into hybrid cell states and immune-protected neighborhoods, pointing to new ways to detect and treat combined small-cell lung cancer. The findings reveal that these tumors do not arise from two separate cancers but rather from a single ancestral cell that evolves over time.
Dr. Hongmei Wang joins Stem Cell Reports as an Associate Editor, bringing expertise in early embryo and placental development. Her laboratory investigates mechanisms governing embryonic and placental development, with potential for improving reproductive health outcomes.
Researchers have identified GSK3α as a common checkpoint controlling stem cell differentiation, maintaining self-renewal and preserving identities in various stem cell types. Inhibiting GSK3α demonstrates its fundamental role in regulating stem cell biology across developmental stages and species.
Hal Duncan, a Professor and Consultant in Endodontics at Trinity College Dublin, received the 2026 IADR Distinguished Scientist Award for his outstanding research contributions in pulp biology. His work focuses on translational pulp biology and applied vital pulp treatment using epigenetic modifications.
Researchers developed an interpretable machine learning algorithm, scOMM, to classify cell types consistently across different single-cell methods. The integration strategies and scOMM establish a robust approach for cell atlas generation in complex tissues, leading to the discovery of previously undetected rare cell types.
A study published in Cell Chemical Biology reveals that an impaired transport protein and ceramide buildup can trigger replicative senescence, a state where cells remain alive but no longer divide. Ceramides accumulate inside the endoplasmic reticulum, triggering stress signals that lead to cellular limbo.
The International Society for Stem Cell Research has named Stem Cell Reports as the official conference journal for the Latest Advances in Stem Cell-Based Disease Modelling and Drug Screening meeting. The journal will focus on high-impact research spanning basic discovery to clinical translation in stem cell science.
Researchers have discovered that vitamin B2 protects cancer cells from ferroptosis, a type of programmed cell death. By targeting vitamin B2 metabolism, cancer cells may become more susceptible to ferroptosis, paving the way for new cancer therapies.
A new study has created a large single-cell atlas that maps the diverse cell types in head and neck tumors, showing how specific cell mixtures and interactions relate to tumor behavior. The atlas highlights candidate targets for improving immunotherapy responses and for overcoming chemotherapy resistance.
New research reveals that tumor cells in supratentorial ependymomas cluster into distinct neighborhoods, each with a specific role, such as proliferating or invading. Understanding these cell subtypes could help predict treatment response and inform targeted therapies for this aggressive childhood brain cancer.
Researchers mapped out the structure of a key player, augmin, in exhaustive detail, revealing its role in plant cell division and shape regulation. The study's findings could lead to new medical treatments and strategies for breeding higher-quality rice and cotton crops.
The ISSCR recognizes Dr. Kyle M. Loh's groundbreaking work on human pluripotent stem cells, enabling precision differentiation of various cell types and bridging stem cell biology and virology. His research has far-reaching implications for developmental biology, disease modeling, and regenerative medicine.
Stem Cell COREdinates and CorEUstem have transformed the global infrastructure of pluripotent stem cell research by uniting 79 core facilities across continents to advance collaboration, rigor, inclusivity, and innovation. Their shared standards and protocols have strengthened reproducibility and ensured excellence in accessible for in...
Dr. Alexander Meissner, Director at the Max Planck Institute for Molecular Genetics, has been named recipient of the 2026 ISSCR Momentum Award for his sustained scientific contributions to developmental and stem cell epigenetics. He will present his work at ISSCR 2026 in Montréal.
The International Society for Stem Cell Research has awarded the 2026 ISSCR Lifetime Achievement Award to Dr. Allen Eaves and late Dr. Connie Eaves, recognizing their groundbreaking work on blood stem cell biology, leukemia, and cancer stem cells. Their research and mentorship have profoundly influenced the field of stem cell science.
Researchers developed a new single-cell transcriptomic clock called Tictock to measure aging in specific immune cells. The study found that COVID-19 and HIV alter T cell composition and accelerate the biological age of naïve CD8 T cells, while long-term antiretroviral therapy stabilizes T cell proportions.
Researchers develop novel method to manipulate cell structures using weak magnetic fields and isotopes, bridging structural biology, biophysics, and quantum biology. This work offers a potential new strategy for stabilizing damaged brain proteins, typical of neurodegenerative diseases.
The journal welcomes Bo Shen, Ph.D., and Luca Peruzzotti-Jametti, M.D., Ph.D. as Early Career Editors, bringing complementary strengths in stem cell niche biology and metabolism to the editorial board. Their perspectives will help ensure rigorous peer review, relevance, and global engagement.
Researchers identify a protein, PAF15, as a natural brake that prevents DNA replication from becoming overloaded and protects cells from the replication catastrophe. In cancer cells, high levels of PAF15 may create a vulnerability for targeting rapidly dividing tumor cells.
Glycosylated RNAs on the cell surface form clusters with RNA binding proteins, regulating interactions with surrounding growth factors and controlling angiogenesis. The study found that altering the amount of RNA on the cell surface can modify intracellular signaling cascades through selective interaction with growth factors.
Researchers have discovered the ExHOS nanomachine, which controls constitutive exocytosis by delivering spherical molecular packages to the cell surface. This process is essential for preserving cell fitness and vital functions such as communication and growth.
The International Society for Stem Cell Research published its most downloaded papers of 2025, reflecting the field's scientific range from pluripotency to regenerative medicine. The journal's mission is to publish rigorous, transparent, and consequential science advancing discovery while informing clinical translation.
Researchers at Johns Hopkins Kimmel Cancer Center developed a new treatment that selectively targets TRBC2-positive T-cell cancers, preserving approximately 40%–60% of normal T cells. The therapy, an antibody-drug conjugate, provides a long-sought therapeutic option for half of T-cell lymphomas and leukemias.
Researchers found autophagy plays a major role in ensuring T stem cells undergo normal cell division. Boosting autophagy could enhance memory T cell generation and improve long-term immunity.
Researchers have compiled a comprehensive list of 166 human pluripotent stem cell lines available for clinical applications, guiding researchers and developers in selecting optimal cell lines. The study aims to drive hPSC-derived products towards the clinic, addressing a knowledge gap in off-the-shelf product development.
Researchers at The Hospital for Sick Children have identified a non-coding gene called CISTR-ACT that regulates cell size. By exploring its molecular mechanism, the team found that CISTR-ACT guides a protein called FOSL2 to bind to other genes, controlling cell growth and development.
Biologists have discovered that the talin protein is crucial for successful cell adhesion in animals, a mechanism likely developed from single-celled organisms. The study reveals the evolutionary conservation of this ancient adhesion mechanism, providing new insights into the origins of animal tissues and organs.
A new dataset, TripletDGC, reveals the association between disease genes and diseases by characterizing specific cell types. The study highlights critical cell types linked to disease mechanisms, providing deeper insights into molecular basis of diseases.
The Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research will support 18 junior investigators studying age-related diseases and healthspan. The awards, worth $375,000 each, are designed to advance research projects in basic biology of aging and geroscience.
The ISSCR, SDB, and the Allen Institute are hosting a three-day scientific symposium featuring early-career scientists, focusing on cross-disciplinary exchange and amplifying emerging leaders in developmental biology and stem cell science. Confirmed topics include data analysis, model systems, spatial awareness, and cell fates.
The Biohub initiative combines world-class compute capacity, frontier AI research and engineering, and state-of-the-art experimental and imaging technologies to accelerate science. The combined team will develop datasets, laboratory technologies, and modeling innovations needed to build next-generation AI systems for biological discovery.
Researchers found that manipulating P bodies, cellular storage units, can efficiently create hard-to-develop cell types in the lab. This discovery could lead to advances in fertility treatments, regenerating organs, and testing new drugs. The study also sheds light on how embryos form and disease originates.
A new study found that selective RNA sequestration in P-bodies directs cell fate transitions by preventing translation of key cell fate-related proteins. This mechanism allows for the generation of clinically relevant cell types, such as primordial germ cells and totipotent-like cells.
The acquisition unifies genetics and stem cell research expertise to accelerate discovery and translate science into therapies. Researchers will gain access to advanced platforms, including the NYSCF Global Stem Cell Array, to study disease mechanisms and test treatments.
A study published in Communications Biology reveals that DYRK kinases are essential for maintaining primary cilia length, stability, and morphology. Malfunctioning of these enzymes can lead to cellular communication disruptions, potentially contributing to various health conditions.
Researchers from A*STAR Institute of Molecular and Cell Biology have identified two critical stem cell populations that drive colorectal cancer formation in different colon regions. The study reveals how NOX1 and NPY1R proteins mark distinct stem cell populations, providing new targets and models for developing region-specific cancer t...
Researchers at ETH Zurich discovered how protein condensates contribute to cellular information exchange. The study found that P-body and Whi3 condensates work together to stop cell division when a cell becomes old, as well as control the cell's decision to abandon mating attempts in old age.