A team of researchers at Ohio State University has identified a noncoding RNA that binds to ATP, which could lead to the development of new therapeutic nanomaterials. The discovery builds on previous work and follows up with an investigation into the mechanism of how this RNA binds to ATP.
Researchers at the University of Illinois Chicago have developed a new imaging method that allows scientists to see previously hidden enzyme activities in small regions across the whole cell. The technique, dubbed Fluctuation Increase Negated by Intra-Chain (FINICI), flips the optical readout of negative biosensors into positive, reada...
Researchers found that macrophages and monocytes in the gut mesentery interact to prevent salmonella from spreading. Removing macrophages allows monocytes to flood the organ, highlighting the role of these immune cells in regulating tissue damage.
Researchers identified miR-29a as a pivotal regulator of cancer development, which can act as both a tumor suppressor and an oncogene. Natural bioactive compounds such as curcumin, EGCG, and resveratrol have been shown to restore normal miR-29a expression through epigenetic remodeling and inhibition of oncogenic signaling pathways.
Researchers at the University of Zurich have identified 10 biomarkers in saliva that can detect acute sleep deprivation. The study uses machine-learning methods to analyze metabolic changes in saliva, providing a new milestone for forensic research.
Researchers at the University of Pittsburgh School of Medicine discovered an unexpected chromosome interaction between telomeres and centromeres in some aggressive cancers. This interaction creates a genetic signature that could help identify ALT-positive tumors, which are often challenging to treat due to genomic instability.
Researchers at University of Würzburg discovered that inhibiting an enzyme involved in sugar metabolism makes cells more susceptible to cell death. The 'double agent' inhibitor blocks the enzyme while attacking another protective protein, leading to a paradoxical effect.
Researchers aim to understand how chronic alcohol exposure changes the brain's stress circuitry, with potential breakthroughs in treating AUD. Advanced neuroscience approaches will be used to examine PACAP's role in excessive drinking, anxiety-like behaviors, and pain sensitivity.
This study reveals Yanghe Decoction's anti-tumor effects on osteosarcoma cells by modulating the PI3K/AKT and p38 MAPK pathways, inducing ROS-mediated mitochondrial dysfunction. YHD also inhibits tumor growth and metastasis in orthotopic OS mouse models.
Researchers developed a new method to identify intricate RNA structures that are likely to have significant biological functions. The multi-site DMS-MaP approach allows for direct measurement of RNA folding in cells, revealing key 3D structures and protein binding sites.
Researchers propose a new model explaining how cancer cells adapt to treatment resistance through a previously overlooked molecular mechanism. The model involves the family of proteins AP-1, which helps cancer cells explore different gene expression patterns until they find one that improves survival chances.
Researchers reveal lactylation as a key player in lung cancer progression and drug resistance, highlighting potential targets for overcoming treatment resistance. The study identifies self-reinforcing loops that sustain acquired resistance to EGFR-TKIs and provides a framework for developing precision therapies.
The TREM-1 receptor is a central amplifier of inflammatory responses, involved in sepsis, arthritis, and neurodegenerative diseases. Several antagonists have shown promise in preclinical models, but more research is needed to define therapeutic windows and identify responsive patient subgroups.
Gramine, a natural indole alkaloid, suppresses triple-negative breast cancer by inducing ferroptosis. It targets the CUL3–MTDH axis, reducing E3 ubiquitin ligase activity and downregulating ferroptosis inhibitors.
Wendy Thompson, a Senior Clinical Lecturer at the University of Manchester, has been awarded the IADR Distinguished Scientist Award in Pharmacology/Therapeutics/Toxicology Research. Her research focus on antimicrobial stewardship and primary dental care has made significant contributions to the field.
A recent study found that IGFBP1 levels are significantly higher in elderly IBD patients and negatively correlated with inflammation-related markers. Elevated IGFBP1 levels were associated with lower clinical, endoscopic, and histological disease activity, suggesting a promising non-invasive tool for managing elderly IBD patients.
A study using NMR, mathematical modeling and simulations reveals the role of tryptophan-rich residues in activating the human adenosine A2A receptor, a key drug target. The research provides new insights into the mechanisms of GPCR function and could lead to next-generation pharmacology.
Researchers at Baylor College of Medicine discover tubulin's role in preventing toxic protein clumps in brain cells, potentially fighting Alzheimer's and Parkinson's diseases. Tubulin steers Tau and alpha synuclein proteins towards their healthy roles, reducing toxic aggregation.
Preclinical studies reveal that MR hinders cell proliferation, triggers cell cycle arrest, and enhances standard treatments. Early-phase clinical trials report positive results on safety and tolerability, suggesting utility of MR as a complementary treatment strategy.
Researchers at NYU Langone Health found that herpes simplex virus uses protein ICP4 to make human cell nuclei more fluid-like, allowing for faster replication. This makes the nucleus easier for the virus to copy itself and increases production rate of new viral copies
Researchers found Xijiaqi Formula reduces neuroinflammation and promotes neuroplasticity in CHF rats, improving cognitive function. The formula also enhances molecular signatures of neuroplasticity by regulating PDE4-cAMP/PKA/CREB signaling.
The CU Anschutz School of Medicine has achieved the best ranking in NIH funding in 20 years, moving to No. 21 among all medical schools. This is attributed to the growth in NIH funding from $314 million, with nine clinical departments ranked in the top 15.
Acta Pharmaceutica Sinica B Volume 16, Issue 1 publishes original articles on various pharmaceutical sciences topics. The journal covers pharmacology, pharmaceutics, medicinal chemistry, natural products, and more. Recent studies explore the use of neg-entropy as a drug target for chronic diseases and psoriasis treatment.
In a mouse study, researchers successfully used RNA micelles to shrink metastasized tumors in lungs by delivering chemotherapy drugs and an RNA molecule that blocks cancer survival. The treatment significantly reduced tumor growth and improved outcomes for mice with colorectal cancer lung metastasis.
David J. Segal has been appointed as the chair of UC Davis Department of Biochemistry and Molecular Medicine, known for his groundbreaking research in gene-editing technologies. He is developing targeted molecular tools to treat rare genetic disorders, including Angelman syndrome and neurofibromatosis type 1.
Researchers at the University of Houston have discovered that loss-of-function in epicardial proteins leads to left ventricular noncompaction, or spongy heart, causing pediatric-onset heart failure. A new therapeutic approach may prevent babies from being born with this life-threatening disease.
Review of Clinical Pharmacology and Pharmacokinetics has transitioned to an open-access model, with all published content available on the new ARPHA website. The journal benefits from ARPHA's one-stop publishing solution, high-level integrations, semantic enhancements, and advanced metrics.
Venetia Zachariou, a BU researcher, has been recognized as a Class of 2025 Fellow of the American Society for Pharmacology and Experimental Therapeutics. She is known for her work on signal transduction and epigenetic mechanisms of neurological disorders.
Researchers at the Medical University of South Carolina are developing a new therapy for Type 1 diabetes that combines stem cell biology, immunology, and transplantation science. The goal is to restore beta cell function and insulin production in people with T1D without using immunosuppressive drugs.
A new study from the Medical University of South Carolina suggests that the complement system, a part of the body's innate immune system, plays a major role in brain damage after repeated concussions. The research found that reducing complement activation can help protect the brain and reduce cognitive impairments.
Current Molecular Pharmacology has achieved a major milestone with its real-time CiteScore advancing to 7.2, indicating the journal's high-quality research and rigorous peer-review process. The journal continues to strengthen its position as a key platform for innovative pharmacological research.
A recent study published in Current Molecular Pharmacology reveals CoQ2's sedative-hypnotic properties, inducing reversible loss of righting reflex and altering electroencephalogram activity. The compound disrupts mitochondrial membrane potential by inducing excessive proton leak and inhibiting electron transport chain complexes I and IV.
Researchers found altered gene expression in the brain's stress-processing hub, and inhibiting signaling pathways reduced relapse-like behavior. However, blocking both signals simultaneously cancelled this effect, highlighting potential risks of combining treatments.
Researchers found that eradicating aging cells in mice with a combination of dasatinib and quercetin reduced senescent cells, improved memory, and decreased seizures. The study's results suggest a potential new approach to treating temporal lobe epilepsy.
Researchers suggest melatonin may play a significant role in managing SLE and its complications, including lupus nephritis. Studies have shown melatonin can reduce renal inflammation and oxidative stress, but more robust clinical trials are needed to confirm its effectiveness.
A study has uncovered a promising three-lncRNA signature that could improve early diagnosis and treatment strategies for non-metastatic hepatocellular carcinoma. The lncRNAs HEIH, MIAT, and HOTAIR were found to be significantly elevated in cancerous tissues.
Researchers at University of Cologne identify p35-mediated CDK5 hyperactivity as a central mechanism limiting nerve regeneration in diabetes. Targeted interventions using peptides restore nerve fiber growth, leading to significant motor and sensory improvements.
The Virtual Cell Pharmacology Initiative (VCPI) aims to build the first standardized framework for virtual cell modeling in drug discovery. Ginkgo Datapoints is offering free high-throughput RNA profiling via its platform, generating over 12 billion data points and aiming to test at least 100,000 compounds.
Dr. Zhavoronkov's exceptional research influence has been validated by Clarivate, with over 310 peer-reviewed papers since 2012. His work has garnered over 16,500 citations per Google Scholar, primarily on generative adversarial networks and reinforcement learning for drug discovery.
Researchers at the University of Arizona Comprehensive Cancer Center are investigating novel immune-based approaches to prevent keratinocytic skin cancers. They aim to identify early immune signals that can activate the body's own immune defenses to prevent cancer before it starts.
This comprehensive volume provides detailed protocols for studying glaucoma disease mechanisms, drug formulation, and cutting-edge tools. It covers molecular biology, pharmacology, and histological approaches to support scientists in ophthalmic drug discovery and translational research.
A new study by Yale Ancient Pharmacology Program reveals evidence of opium use in ancient Egyptian society, suggesting it was part of daily life. The discovery also raises the possibility that alabaster jars found in King Tut's tomb contained opium as part of an ancient tradition.
Arctigenin, a monomer of Fructus Arctii, exhibits anti-inflammatory activity and prevents MASH progression through modulating the NLRP3/GSDMD-N axis in macrophages. ATG administration also reduces hepatic macrophage infiltration, serum enzyme levels, and lipid peroxidation while enhancing antioxidant enzyme activity.
Stuart S. Martin, PhD, has been appointed Chair of the Department of Pharmacology & Physiology at UMSOM, bringing over 20 years of success in advancing basic science research efforts and developing new drug therapies. His groundbreaking discovery of microtentacles on cancer cells promises to lead to new life-extending therapies.
Researchers at Weill Cornell Medicine have developed a powerful new gene-switch tool called Cyclone, which allows scientists to turn on or off target genes with precision. The tool uses a non-toxic molecule acyclovir to suppress gene activity, and has the potential to be adopted throughout biomedical research and gene therapies.
A new study from Johns Hopkins Medicine reveals that biliverdin reductase A plays a direct protective role against oxidative stress in neurons, independent of its role producing bilirubin. The enzyme modulates another key protein, NRF2, which regulates the levels of protective proteins and antioxidants in cells.
The POINT platform integrates multiple biological networks, advanced algorithms, and a comprehensive biomedical knowledge graph to analyze drug-disease interactions. It combines node degree with deep learning methods to improve target prediction accuracy.
A new study suggests that supplementing with BCAAs alongside an exercise program may help reduce fatigue, improve strength, and ease symptoms of depression for older adults. The research found notable improvements in participants who combined a BCAA supplement with an eight-week exercise program.
The National Institutes of Health has awarded a five-year, $10.8 million grant to create the New York Regional Diabetes Research Center (NYR-DRC), a multi-institutional center that aims to discover scientific knowledge and translate it into improved care for people with diabetes and related metabolic diseases. The center will bring tog...
Researchers at UIC discovered that platelet factor 4 helps regulate hematopoietic stem cell division and proliferation. Adding the protein to old blood cells reversed signs of aging in mice and human stem cells, suggesting a promising therapeutic target for preventing or improving age-related disorders.
Researchers discover that genetic glitches in the blood system, caused by aging, can spark obesity, diabetes, and fatty liver disease. Simple blood tests may help identify at-risk individuals to prevent chronic illnesses.
Nanoparticle-mediated cancer therapeutics offer improved targeting and reduced toxicity through passive and active mechanisms. This enhances therapeutic results while tackling drug resistance and boosting specificity.
Phenolic acids have been identified as a promising therapeutic frontier for vascular cognitive impairment, exhibiting potent antioxidant, anti-inflammatory, and neuroprotective effects.
Current Molecular Pharmacology is a prominent journal covering mechanisms of new drugs, innovative technologies, and omics applications. It has an impact factor of 2.9 and CiteScore of 5.5, ranking Q2 in pharmacology.
BU researchers Hui Feng and Venetia Zachariou have received a $2.1 million NIH grant to fund a five-year training program in biomolecular pharmacology. The program aims to prepare the next generation of independent investigators through individualized and multidisciplinary research training.
This book delves into the scientific foundations of mucosal vaccine platforms, discussing immunological mechanisms, novel adjuvants, and real-world development challenges. It serves as a valuable resource for professionals and students in life sciences, immunology, and pharmacology.
The new handbook provides a practical approach to harnessing zebrafish as a model organism for biomedical research, covering drug efficacy evaluation and disease mechanisms. It offers step-by-step experimental protocols and theoretical grounding for researchers of all levels.
Researchers at the University of Graz and the University of California, San Diego have developed a novel method to determine omega positions of lipids in complex biological samples. This breakthrough enables the study of biological mechanisms in unprecedented detail, particularly for inflammation-related diseases.
The book examines antibiotic-induced reproductive toxicity, microbiome alterations, and emerging concerns around antibiotic resistance. It provides critical insights for clinicians, pharmacists, researchers, and students in reproductive medicine and pharmacology.