Articles tagged with Disease Intervention
A digital therapeutic intervention CT-155 has shown promising results in improving motivation and pleasure negative symptoms of schizophrenia with a small-to-moderate effect size comparable to psychosocial interventions and pharmacologic treatment. CT-155 is a scalable and accessible option for improving schizophrenia negative symptoms.
Binghamton University receives $500K grant for 'brain-on-a-chip' project to advance dementia research. The project will establish advanced imaging and electrophysiological analysis infrastructure for studying living brain tissue models.
The Open Access Journal of Italian Medical Laboratory (JDReAM) has been revived by MDPI, aiming to promote high-quality, interdisciplinary research in medicine. The journal, led by Prof. Michele Maffia and Prof. Prisco Piscitelli, publishes research addressing human health and disease from various scientific perspectives.
This randomized clinical trial found spectacle lenses with highly aspherical lenslets reduced myopia progression and axial elongation in children over 24 months. The study supports the use of these lenses as a safe and effective myopia control intervention.
A comparative study of 11,681 US cancer clinical trials reveals that industry-sponsored trials focus on single-agent drug therapies, while federally sponsored trials evaluate nontreatment interventions and rare cancer therapies. The study highlights the differences in trial design and objectives between industry and federal funding.
The study proposes a public health agenda for AI to improve delivery of proven health interventions through patient identification, outreach, and care coordination. Government leadership, cross-sector partnerships, and sustained investment are essential for realizing this potential.
A new study found that patients from wealthier European countries tend to start biologic treatments earlier but stop or switch treatment earlier, experiencing lower disease activity. The study highlights the importance of ensuring timely and equitable access to effective treatment for patients with PsA and axSpA.
A new theory proposes that critical illness arises from loss of physiological coordination, not just organ failure. The Entropic Critical Illness Theory views living organisms as open systems with a continuous need to regulate entropy.
A hybrid lifestyle program showed potential benefits for cardiometabolic health among adherent participants with obesity, but failed to achieve significant weight loss. The study suggests further investigation into the program's effects on metabolic health.
Researchers develop two virtual culturally grounded interventions to address substance use among urban American Indian and Alaska Native emerging adults. The studies show reduced substance use, including cannabis and alcohol consumption, as well as social connections with tribal communities.
Objective physical fitness assessments reveal a graded association between balance, agility, strength, and cardiorespiratory fitness with reduced all-cause mortality. This study suggests integrating fitness assessments into routine practice may improve risk stratification and guide function-oriented interventions.
A health coaching intervention combined with self-measured blood pressure monitoring increased healthcare engagement and BP control by 12 months postpartum. This strategy supports reducing long-term uncontrolled hypertension among patients with high blood pressure during pregnancy.
Researchers developed a model to optimize countermeasures while considering containment costs, identifying a clear threshold for optimal control. The study found that measures become necessary only when the disease reaches a certain severity, and that vaccination campaigns can help reduce transmission rates.
After COVID-19 pandemic restrictions relaxed, Kawasaki disease incidence rebounded in Japan, with distinct age-dependent patterns. Nonpharmaceutical interventions may have contributed to the observed greater rebound in older children, while infants showed minimal changes, suggesting different exposure pathways.
A nonrandomized trial found that aggregate neighborhood environmental interventions, including abandoned house remediation, significantly reduced fatal opioid overdoses. Community trash pickup and vacant lot cleanup were not associated with significant reductions or increases in opioid overdose rates.
A decision analytical model and microsimulation study found that expanding alcohol screening and brief interventions in primary care could reduce premature mortality from major alcohol-related causes of death in US adults. By 2030, this expanded approach is projected to decrease annual alcohol-related potential years of life lost by −5...
Direct patient or caregiver prior authorization engagement is associated with adverse outcomes, including delays and suboptimal care. This study may inform future research and intervention development to navigate PA-related administrative burden.
The study found significant progress in reducing cancer mortality disparities for breast and uterine corpus cancers, but persistence in prostate cancer remains. The findings highlight the need for targeted interventions to accelerate progress in equitable cancer prevention and control.
A blood test measuring phosphorylated tau 217 (P-tau217) can estimate an individual's risk of developing cognitive impairment over 2, 5, and 10 years. Higher P-tau217 levels are associated with increased risk of progression to cognitive impairment in cognitively unimpaired older adults.
Researchers at Texas A&M University develop a laser technique called TRIP to directly measure quantum forces shaping proteins, enabling accurate prediction of how pharmaceutical drugs interact with them. This breakthrough could lead to the design of medicines tailored to specific diseases, revolutionizing precision medicine.
Researchers discovered blood RNA biomarkers that could support earlier diagnosis of Alzheimer's disease, potentially reducing the need for invasive tests. They identified brain-specific markers in circulating blood nanoparticles, which may offer a minimally invasive approach for diagnosing the progressive neurodegenerative disease.
A cohort study found that demographic, clinical, and healthcare factors influence the uptake of metabolic bariatric surgery among US adults with obesity. The study suggests improving access to this life-changing procedure through targeted policies and interventions could have a significant impact.
Adults with prediabetes who undergo lifestyle intervention show a lower burden of multimorbidity compared to those not receiving the intervention. Lifestyle programs can persistently reduce the development of chronic conditions in this population.
Hospitalized children with acute respiratory tract infections often have underlying chronic conditions that require intensive care. The study found that these patients are at a higher risk of severe disease and death. Understanding the epidemiologic profile of this population can help optimize outcomes for pediatric patients.
Patients described GLP-1 RA therapy as a facilitator of lifestyle change, highlighting the need for standardized guidelines on patient education and clinical support. The quality of care was highly variable, leading to potential expectation management issues around adverse effects and long-term management.
Researchers found that rice-fish coculturing reduced snail populations, leading to lower disease incidence among rice farmers and their families. The intervention also increased rice yields by over 25% and improved soil nutrients.
A randomized clinical trial found that an app-facilitated palliative care intervention maintained health-related quality of life and reduced acute care use. This digital self-management approach also boosted patient self-efficacy.
A low-calorie diet and behavioral support program significantly reduced weight in older patients with overweight and persistent atrial fibrillation at 8 months. The study found no safety concerns or impact on atrial fibrillation symptoms, cardiac remodeling, or need for further rhythm control interventions.
A cluster randomized trial found comparable improvements in 6-month outcomes between intervention and control groups, indicating no independent effect of the clinical decision support system. The study suggests that other factors may be responsible for the observed benefits.
A cross-sectional study of patients with de novo metastatic breast cancer found racial and ethnic disparities in disease presentation. De novo metastatic breast cancer disproportionately contributes to breast cancer mortality in the U.S., emphasizing the need for tailored interventions to improve care delivery and outcomes.
Primary care-based discussions on reproductive goals, immunizations, and risk-reducing interventions optimize pregnancy outcomes. Prepregnancy counseling reduces maternal morbidity and mortality, while also promoting healthy fetal development.
A cluster-randomized trial found that an adaptive mobile health intervention effectively reduced the rate of gestational weight gain and total gestational weight gain among pregnant patients with overweight or obesity. The study suggests that technology-based interventions can be a valuable tool in managing excess weight during pregnancy.
A nationally representative study found nearly 1 in 10 U.S. adults with heavy drinking and obesity conditions, highlighting the need for preventive efforts in younger and middle-aged adults without insurance or Medicaid coverage to curb rising rates of alcohol-associated liver disease deaths.
The Journal of Fast-Track Health will publish original research on global health challenges, including communicable and non-communicable diseases. The journal aims to bridge the gap between urban and national health responses through rigorous science and practice-oriented approaches.
The study identified six sleep health dimensions in young adolescents: irregularity, timing, duration, social jetlag, weekend oversleep, and continuity. Greater irregularity was associated with higher concurrent transdiagnostic mental health symptoms, while shorter duration was linked to increased symptoms at follow-up.
Huntington's disease is caused by a toxic protein that builds in brain cells and spreads to other cells through tunneling nanotubes. Disrupting this pathway reduces the spread of the disease-causing protein, suggesting a new target for therapy.
A decrease in colorectal cancer incidence was observed among individuals with negative screening colonoscopy results, particularly men, suggesting risk-based follow-up strategies. Nonadherence to scheduled colonoscopies increased the risk of CRC, highlighting the need for targeted interventions to improve early detection.
A new clinical trial will investigate whether adding the oral medication vorasidenib to standard chemotherapy improves progression-free survival for people with newly-diagnosed, grade 3 IDH-mutant astrocytoma. The study aims to recruit 400 individuals with this type of brain cancer and evaluate the safety and side-effect profile of the...
A mixed-methods cohort study found daily living impairment is linked to slower recovery in older adults post-surgery. Targeted interventions, such as preoperative education and caregiver support, can optimize recovery experiences for both patients and caregivers.
A low-cost digital intervention increased expectation to adopt health behaviors among adults using GLP-1RAs, with effects persisting for 2 weeks. The written microsteps intervention plus short video boosters may play a role in promoting sustained behavior change.
A nationwide cohort study found a significantly elevated incidence of out-of-hospital cardiac arrests on post-holiday weekdays, particularly among vulnerable populations after consecutive rest days. The study supports enhanced emergency preparedness and targeted public health messaging during holiday periods.
A cohort study found that adolescent cannabis use is associated with an increased risk of developing psychiatric disorders, particularly psychotic and bipolar conditions. The study's results inform the development of interventions and policies to prevent or delay adolescent cannabis use.
Cohort study finds prenatal depression and gestational diabetes independently increase childhood obesity risk, while children exposed to both face the greatest risk, highlighting need for universal screening and targeted interventions.
A cohort study found a disproportionate increase in postpartum depression among women and adolescents in low-socioeconomic status communities following state abortion bans. The legislation disproportionately affects vulnerable populations, highlighting the need for targeted mental health support and policy interventions.
A study published in JAMA found that salpingectomy significantly lowers the risk of developing tubo-ovarian carcinoma. The procedure, typically performed during unrelated pelvic or abdominal surgery, is now recommended as a preventive measure for eligible women.
The study analyzed US state-level adult obesity prevalence from 1990 to 2022, showing a significant increase to 42.5% by 2022 and forecasted to 46.9% by 2035. Disparities in obesity rates vary substantially by race and ethnicity.
Adverse experiences throughout life increase dementia and stroke risks, with depression as a mediating factor. Implementing life-course interventions addressing psychological trauma and mental health can reduce neurovascular disease burden.
A cohort study found that Medicaid expansion under the Affordable Care Act was associated with lower overall mortality among women with breast cancer aged 40-64. The benefits of expanded coverage were uneven, highlighting persistent disparities in healthcare access for certain populations.
A randomized clinical trial found that a smart speaker-based intervention significantly improved mental distress, quality of life, and diabetes self-care among older adults with type 2 diabetes. This easily implemented self-management strategy may enhance health outcomes in this population.
Researchers are studying microchimeric cells that can play complex roles in a person's body, including healing wounds and regulating the immune system. However, more research is needed to understand their role in health outcomes, particularly pregnancy complications and autoimmune diseases.
A large cohort study found no association between community water fluoridation and adverse birth outcomes, providing reassurance about its safety during pregnancy. The study highlights the importance of rigorous causal designs in evaluating public health interventions.
Financial settlements from opioid epidemic lawsuits are being redirected to fund potentially lifesaving interventions. These efforts aim to curb overdose deaths and improve public health outcomes.
Both bariatric surgery and semaglutide treatment were associated with significant fat mass loss, moderate fat-free mass loss, and an improved FFM to fat mass ratio. These findings support interventions aimed at preserving muscle mass while promoting weight loss.
A new rapid test for hepatitis C could identify more patients who can be cured if insurers increase reimbursement to cover the test's high cost. The test's point-of-care feature makes it ideal for early screening and treatment in clinics and emergency rooms.
A national longitudinal cohort study found consistently worse mental health outcomes among middle-aged and older adults at high risk of obstructive sleep apnea. Integrated screening and intervention strategies are needed to address this association.
Using GLP-1 receptor agonists may lower the risk of vertebral compression fractures and related surgical interventions in people with type 2 diabetes. The study suggests that these medications have a bone-protective effect, offering benefits for patients.
A randomized clinical trial shows that semaglutide improves glycemic control and weight outcomes in individuals with schizophrenia. The study suggests using glucagon-like peptide-1 receptor agonists as an early intervention strategy to reduce cardiometabolic risk in this population.
A substantial prevalence of avoidant/restrictive food intake was found in the general pediatric population, with affected children at risk of developmental difficulties across multiple domains. The study suggests a need for broad support interventions and advances understanding of the genetic underpinnings of this condition.
Adults with higher levels of physical activity during midlife and late life have a lower risk of all-cause and Alzheimer's disease dementia. This cohort study, part of the Framingham Heart Study Offspring cohort, found similar reductions in risk across different age groups.
A state-level incentive program aimed at improving diet in SNAP participants showed no significant increase in fruit and vegetable intake. However, the study found benefits among existing high-fruit-and-vegetable consumers. Enhanced implementation strategies may be needed to maximize public health outcomes.