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Mapping the hidden rules of a key immune sensor

A comprehensive map of human STING reveals how different regions regulate immune signaling and how small genetic changes can alter its behavior. The study identifies both known and previously unknown regulatory sites, providing new insight into how immune signaling is regulated.

Unknown controller of women's health, wellness discovered

Scientists have identified a unique chimeric RNA called UBA1-CDK16 that plays important roles in women's blood cell development and disease severity. The findings suggest the chimeric RNA may serve as a natural brake to protect women from excessive autoimmune activity.

SAMSUNG T9 Portable SSD 2TB

SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.

Completeness, accuracy nearly doubled for Japanese genome mapping

A team of researchers has made a significant contribution to understanding human genetics by mapping the Japanese genome, revealing new insights into genetic disease shaping in the Japanese population. The study nearly doubled the complete reconstruction rate to 91.2%, enabling better personalized medicine and treatment options.

How cells fight infection from the inside

Scientists discovered a new way cells fight infection, using a method called antibody-directed xenophagy (ADX), which can digest bacteria and viruses inside infected cells. ADX is triggered by a protein called TRIM21, which flags invading pathogens for destruction.

Tort immunity and nursing home staffing

A cohort study found that introducing immunity in US nursing homes was associated with lower overall staffing and staff-to-resident time. During the COVID-19 pandemic, many states adopted immunity from tort liability for harms to nursing home residents.

Apple iPhone 17 Pro

Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.

We can help the body fight entire viral families

Researchers at La Jolla Institute for Immunology have discovered that combining key vaccine ingredients could give the body the tools it needs to fight the entire family of arenaviruses with a single vaccine. This approach may protect against life-threatening infections from Lassa virus, Junin virus, and many other arenaviruses.

Breaking the bottleneck in in vivo and in situ monitoring: Science Bulletin reports a host-based antifouling gold nanotube sensor for the selective detection of mechanically sensitive serotonin release in intestinal mucosa

Researchers developed a flexible electrochemical sensing platform that captures dynamic small-molecule chemical signals in the gut. The platform reveals a new mechanism underlying enhanced intestinal mechanosensation under microbe-related stimulation, enabling real-time monitoring of serotonin release.

Celestron NexStar 8SE Computerized Telescope

Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.

Why feeling sick may be important for surviving infection

Researchers propose a different view on symptoms of illness, suggesting they're part of an integrated immune strategy that helps promote survival. The brain-immune axis is key to this coordinated system, influencing both brain activity and behavior in response to threats.

LRRC8A - a multifaceted regulator in human pathologies

LRRC8A plays a multifaceted role in various diseases, including cancer, where it promotes proliferation and invasion via multiple pathways. In neurology, LRRC8A is implicated in epilepsy and ischemic stroke, while also regulating metabolic processes and immune function.

Rigol DP832 Triple-Output Bench Power Supply

Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.

How bacteria outsmart the immune system: Two-pronged strategy revealed

Researchers have discovered how a disease-causing bacterium uses a single protein to interfere with the body's defenses in multiple ways, offering a clearer picture of how infections take hold at the cellular level. This discovery highlights the importance of targeting specific interactions between bacterial proteins and human cells in...

Kestrel 3000 Pocket Weather Meter

Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.

A new “molecular switch” for inborn immunity identified

Researchers discover enzyme ANKIB1 crucial for innate immune signalling, driving type I and type III interferon induction. This finding solves a long-standing puzzle in innate immunity and provides opportunities for new therapies for devastating diseases.

A universal 'instruction manual' helps immune cells protect our organs

A universal 'instruction manual' helps immune cells protect our organs by identifying MafB, a key genetic regulator that enables macrophages to reach full maturity and preserve organ health. This discovery sheds light on how the immune system sustainably protects multiple organs from chronic diseases.

Smarter tissue and organ repair thanks to made in Ottawa next-gen hydrogel

Researchers from the University of Ottawa have developed a groundbreaking biomaterial that combines strength, adaptability, and biological compatibility for soft tissue repair. The hydrogel is made from synthetic peptides and can be precisely tailored through chemical design, making it an attractive alternative to existing biomaterials.

Apple Watch Series 11 (GPS, 46mm)

Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.

How age, sex and genetics shape our antibodies

A study found that age, biological sex, and human genetic factors determine the quantity and specificity of antibodies produced in response to viral infections. The research has significant implications for vaccine and therapeutic design, as it shows that individual profiles can be tailored to improve treatment effectiveness.

CalDigit TS4 Thunderbolt 4 Dock

CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.

Ribosomal engineering creates “super-probiotic” bacteria

Researchers from Shinshu University used ribosome engineering to modify probiotic Lacticaseibacillus rhamnosus GG, resulting in increased colonization and enhanced immune stimulation. The engineered bacteria exhibit altered surface protein expression and induce higher activation of immune cells.

Meta Quest 3 512GB

Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.

LJI scientists discover how T cells transform to defend our organs

Researchers at LJI have discovered a cellular driver that leads to the development of tissue-resident memory T cells, which specialize in defending specific organs. The study found that GPR25 sustains TGF-\u00b2 signaling, promoting differentiation and transformation into these specialized immune cells.

A fast, lasting defense against a deadly virus

Scientists have developed a fast-acting and long-lasting vaccine against Crimean-Congo hemorrhagic fever (CCHF), which is one of the world's most dangerous infectious diseases. The vaccine, made from a virus-like replicon particle, provides durable humoral immunity for up to 18 months.

Aranet4 Home CO2 Monitor

Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.

Measles vaccination coverage after a post-elimination outbreak

A large-scale study in Ohio found measles vaccination coverage to be below the 93% herd immunity threshold, highlighting the need for sustained public health strategies to maintain elimination. The persistent immunity gaps suggest a need for equity-focused approaches.

How an immune cell receptor dampens the fight against fungal infection

Researchers have identified a key immunoregulatory mechanism in aspergillosis, where the dendritic cell receptor limits the host's response to fungal infections. Neutrophils play a crucial role in clearing fungal hyphae, and Dcir regulates their degranulation activity, which is essential for killing pathogens.

GoPro HERO13 Black

GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.

Vaccines trigger rapid lymph node responses

Researchers discovered that vaccines induce changes in stromal cells of draining lymph nodes within hours, priming the landscape for immune responses. Different vaccines activate lymph node stromal cells differently, with some inducing specific effects on lymphatic endothelial cells.

Apple iPad Pro 11-inch (M4)

Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.

RNA immunity: An overlooked antiviral defense in mammals

Emerging evidence highlights the involvement of extracellular RNAs in the antiviral defense process, with microRNAs binding viral genomes via base-pairing interactions to inhibit expression. RNA immunity represents a complementary arm of the mammalian immune system, functionally independent of traditional protein-based defenses.

Pitt study uncovers how the immune system fends off gut parasites

Researchers discovered a new pathway to boost immunity against parasitic infections, suggesting that NSAIDs like ibuprofen could be repurposed as anti-parasitic treatments. Gasdermin C plays a crucial role in this process, targeting and penetrating Rab7-positive vesicles to reduce prostaglandin d2 levels.

Garmin GPSMAP 67i with inReach

Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.

Tiny antibody has big impact on deadly viruses

Researchers at University of Queensland have discovered a nanobody to combat two highly lethal viruses with no approved vaccine or cure. The DS90 nanobody can access hard-to-reach areas of the virus to block infection.

Sony Alpha a7 IV (Body Only)

Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.

Large-scale immunity profiling grants insights into flu virus evolution

A high-throughput neutralisation assay reveals how individual immunity gaps shape flu strain success, highlighting personalised immunity and its impact on virus evolution. The study used large-scale sequencing to quantify antibody responses against circulating H3N2 flu strains in children and adults.

Apple MacBook Pro 14-inch (M4 Pro)

Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.

T cell-based cancer immunotherapy: Opportunities and challenges

Recent advances and challenges in T cell immunotherapy highlight the need for deeper understanding of T cell fate determination mechanisms to overcome immunotherapy resistance. Key regulatory factors, transcription factors, and metabolic pathways govern T cell differentiation and function.