Articles tagged with Systems Neuroscience
Researchers developed a computer model of the human cortex linking microscopic chemistry to brain-wide patterns of activity. The model found that regional differences in receptor density improve coordination between brain regions and information flow.
Researchers found that local electric fields exert influence on neurons via ephaptic coupling, which helps explain variations in brain activity even within the same task. The study suggests that manipulating these electric fields could be a potential therapeutic approach for improving brain function in disease.
A new framework, criticome, integrates experience until age 25, reframing autism, schizophrenia, depression, and trauma as developmental disorders. The study suggests that screen-saturated childhoods may produce adult dysfunction, highlighting the importance of early experience in brain development.
Research using EEG reveals that caffeine can reduce slow-wave activity and shift brain patterns towards wakefulness, even if sleep duration appears normal. This can lead to a vicious cycle of fatigue and poorer sleep quality, highlighting the need for personalized approaches to caffeine consumption.
Genomic Press launches Brain Health, a new peer-reviewed journal dedicated to the science of lifelong brain resilience, featuring research on glial plasticity and recovery from depression. The inaugural issue explores the intersection of fields including cognitive reserve, sleep, aging biology, nutritional psychiatry, and social sciences.
Researchers subjected fruit flies to extreme gravitational forces and found they adapted and recovered, showing resilience in movement and energy use. The study suggests the brain makes energy trade-offs based on gravity levels, with moderate increases pushing for more movement and higher energy demands.
The American Association for the Advancement of Science (AAAS) has partnered with Research Networks to publish Computational and Structural Biotechnology Journal, Computational and Structural Biotechnology Reports, and Brain Organoid & Systems Neuroscience Journal as Science Partner Journals. These journals will publish high-quality re...
Researchers found that a small section of intact corpus callosum is enough to sustain full integration of the two brain halves, contrary to previous assumptions. The discovery has implications for epilepsy surgery and brain injury recovery.
The Lehigh University team created a computational model to predict the hemodynamic response of patients with AFib, helping tailor neurostimulation dosages. The model validated against clinical data and predicted accurate effects on blood pressure, heart rate, and stroke volume.
Scientists at RIKEN Center for Brain Science found that fruit flies use separate circuits to compute pleasant and unpleasant odors, challenging the idea that 'good' is the opposite of 'bad'. The discovery may contribute to a better understanding of human brain's flavor appreciation mechanisms.
Salk scientists pinpoint gracile nucleus as brain area responsible for differentiating between painful and non-painful touch, with dysfunction leading to chronic pain. Altered neuronal activity in the dorsal column nuclei drives mechanical allodynia, causing the brain to misinterpret innocuous light touch as painful.
A new study by Universidad Miguel Hernandez de Elche researchers reveals that brain slow waves are guided by neuronal excitability, not anatomy. The discovery uses advanced computational models to analyze local and global brain activity, shedding light on states like deep sleep and anesthesia.
The team will study neurons within a brain organoid, a millimeter-sized, three-dimensional structure grown in the lab from adult stem cells, to design smarter and more sustainable artificial intelligence. They aim to replicate complex computations that occur in the human brain to improve AI efficiency.
A study found that memories acquired while awake are stored in a more permanent form during REM sleep, requiring the reactivation of only three adult-born neurons involved in memory formation. This process is synchronized with theta rhythm activity and essential for proper memory function.
A new study demonstrates the potential to produce cellular spheroids from clinically relevant embryonic stem cells to generate scaffold-free chondrogenic or osteochondrogenic graft tissues. The researchers successfully cultured ES-MSC cellular spheroids, which matured into neocartilage tissues expressing cartilage-associated genes.
Researchers found measurable changes in brain signals responsible for motor control and movement after 12 dynamic cycling sessions. The study suggests long-term exercise programs could have wider restorative effects on the brain signals of Parkinson's Disease patients.
The brain segments and organizes events into experiences by placing unique bookmarks on them, allowing us to revisit and learn from our lives. The lateral entorhinal cortex creates a signal that constantly drifts in a pattern never repeating itself, marking the beginning and end of an experience.
The study identifies the brain circuit controlling associations between stimuli and allows for indirect associations. The amygdala plays a crucial role in linking olfactory and taste stimuli.
Researchers at UC Davis developed a brain-computer interface that translates neural activity into speech in real time. The technology allows individuals with ALS to communicate more naturally and inclusively, with 60% of synthesized words intelligible to listeners.
Researchers have identified a specific group of neurons in the brain responsible for suppressing binge drinking behavior. The discovery may lead to new therapeutic targets for treating alcohol dependency and related health challenges.
Scientists replace toxic additives in hydrogels with D-sorbitol, a safe sugar alternative found in chewing gum, to create bioelectronic devices that are soft, safe, and integrated with natural tissue. The new material has increased biocompatibility and improved electronic performance.
Assistant professor of electrical and computer engineering Natasa Miskov-Zivanov is receiving a $581,503 NSF CAREER Award for her project that leverages AI to design more effective lymphocytes for cancer immunotherapies. The system aims to accelerate the process of designing new therapeutic cell designs.
A recent MIT study identified a potential signature of unconsciousness that can be measured to improve anesthesiology care. Researchers found that different anesthetics affect brain wave phase in the same way, leading to misaligned local communications and functions.
Researchers developed a live brainstem imaging method to study the nucleus tractus solitarii's role in emotion regulation and body-brain interactions. The D-PSCAN technique enabled high-resolution visualization of NTS neural activity in response to vagus nerve stimulation and gut hormone cholecystokinin, shedding light on potential the...
Researchers at the University of California San Diego have made a groundbreaking discovery about how our brains learn new information. Using sophisticated imaging techniques, they found that individual neurons follow multiple rules during learning, rather than one set of uniform rules as previously thought. This new understanding has s...
The Greater Mouse-Tailed Bat uses its long tail as a dynamic sensing tool to avoid obstacles and orient itself in complex environments, especially when vision and echolocation are limited. The study found that the bats' ability to navigate decreased significantly when their tail was numbed.
A new review article identifies major themes in AI application to neurosciences, including a 5-fold increase in AI-related publications. The study also notes a surge of over 13-fold in clinical neurology AI-related publications in the past decade.
Researchers have experimentally confirmed complex synchronisation patterns in oscillatory systems, including leaf-like structures and gaps representing unsynchronised states. This breakthrough builds on previous studies using breathing-soliton lasers to explore nonlinear dynamics.
Researchers at WVU have discovered a way to fine-tune zinc activity to improve messaging in the brain, with potential applications for treating conditions such as autism, schizophrenia and Alzheimer's disease. The study identified new compounds that can selectively change synaptic connections by modulating zinc levels.
Researchers have identified three cell types in the median raphe nucleus that control decisions on perseverance, exploration, and disengagement. These findings may help understand neuropsychiatric conditions such as OCD, autism, and major depressive disorder.
Researchers at Sainsbury Wellcome Centre develop novel experimental setup called Translocator, isolating fundamental elements of locomotion and motion-source separation. The team finds that individual cells in primary visual cortex use motor and vestibular signals to determine visual flow origin.
Three UK researchers will receive a £100,000 (US$126,000) prize at the 2025 awards, honouring their work in Life Sciences, Chemical Sciences, and Physical Sciences & Engineering. The winners were selected from 94 nominees representing 45 academic institutions.
Researchers at NYU Langone Health identified a new direct feedback loop in the brain that mixes sensory information, memories, and emotions to label sights and sounds as more important. This discovery may lead to new solutions for problems like post-traumatic stress disorder and autism.
A University of Ottawa neuroscientist has led a Canadian research team to discover how neural stem cells integrate signals from different cell types and decode them. The study found that low daughter cell numbers trigger activation, while high numbers keep them in quiescence, offering new insights into cellular relationships and potent...
Neuromorphic computing is poised to emerge into full-scale commercial use, driven by the need for energy-efficient solutions. The review article proposes strategies for building large-scale neuromorphic systems that can tackle complex real-world challenges.
The Advanced Research + Invention Agency has awarded $84.2 million to Rice researchers to explore and unlock new methods for interfacing with the human brain at the circuit level. The project involves developing a distributed network of minimally invasive implants to stimulate neural circuits with cell-type precision.
Neuroscientists at WashU develop a novel method to create personalized brain models, shedding light on individual variations in brain dynamics and their impact on cognition and behavior. The study reveals new insights into the mechanisms underlying person-specific differences in brain electrophysiology.
Researchers developed a wireless power transfer system for electrophysiological recording in freely moving laboratory mice. The system provides a robust platform for real-time neuronal activity monitoring and offers significant potential for advancing neuroscience research.
A team of scientists has pinpointed a critical neural circuit for female sexual rejection, revealing how the brain integrates signals to shape behavior. The ventromedial hypothalamus, specifically progesterone-sensitive neurons in the anterior VMH, play a crucial role in determining whether a female accepts or rejects mating attempts.
A new study from Rice University and Houston Methodist reveals that NREM sleep enhances neuronal and behavioral performance by fostering brain synchronization and information encoding. Researchers replicated these effects through invasive stimulation, suggesting promising possibilities for future neuromodulation therapies.
Researchers discovered brain cells that map an animal's position in behavioural coordinates, helping understand how the brain generates complex behaviors. The findings may be useful in understanding psychiatric conditions such as schizophrenia.
Researchers from the FlyWire Consortium have created a detailed wiring diagram of every neuron in the adult fly brain, revealing substantial similarities between individual brains. The map includes 50 million connections between neurons, providing insights into neural circuits and their functions.
A Princeton-led research team has built the first neuron-by-neuron and synapse-by-synapse roadmap through the brain of an adult fruit fly. The map reveals connections within the brain at every scale, enabling researchers to better understand its underlying logic and potentially develop tailored treatments for brain diseases.
Researchers have found a new brain mechanism that detects prediction errors between expected and actual sensory inputs, boosting responses to unexpected information. This discovery could offer insights into the neural circuits underlying autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs).
Researchers developed a new brain-computer interface that translates brain signals into speech with up to 97% accuracy, enabling a man with amyotrophic lateral sclerosis (ALS) to communicate with friends and family. The system was tested in real-time conversations with continuous updates, achieving high word accuracy rates.
A roundtable discussion explores the integration of positive psychology and autism, highlighting its potential to amplify strengths and improve interpersonal dynamics. The study suggests that appreciating character strengths can have a significant impact on daily life.
Researchers have uncovered new insights into how the brain regulates imitative behavior, a phenomenon that facilitates interaction and social cohesion. The study used advanced brain stimulation technique to pinpoint the causal role of different circuits in facilitating or inhibiting automatic imitation.
Studies in mice reveal that orexin plays a key role in deciding between physical activity and consuming food, particularly when both options are available. By understanding this process, scientists aim to develop strategies to overcome exercise barriers and address the global obesity epidemic.
A study published in Current Biology found that bouncing is the primary movement facilitating synchronization in dance, occurring independently of music and partner movements. Researchers identified two modes of synchrony: music-driven and partner-driven, with bouncing acting as a supramodal rhythm regulator.
Researchers genetically engineered Toxoplasma gondii to produce and release therapeutic proteins in the human brain, bypassing the blood-brain barrier. The method has potential implications for treating diseases caused by protein deficiencies or abnormal expression.
Researchers at Colorado State University used human stem cells to study synaptic connections in the brain, focusing on GABAergic synapses. They found that Gephyrin promotes autonomous assembly of these synapses, which can develop independently of neuronal communication. This understanding could lead to new treatments for neurological d...
This study reveals that thalamocortical connectivity plays a vital role in the formation of functional brain networks. The researchers used advanced neuroimaging techniques and computational models to map changes in thalamocortical connectivity across different age groups, from infancy to adulthood.
Researchers created a virtual rodent with an artificial brain that can move like a real rodent, simulating complex behaviors using biomechanical data from real rats. The model uses deep reinforcement learning and AI to predict neural activity across behaviors.
Among Medicare enrollees, researchers found that being female, white, healthier, and wealthier was associated with a higher risk of TBI. The study also found that participants who went on to be diagnosed with TBI were less likely to have lung disease or cognitive impairment at enrollment.
Researchers developed AI software to analyze animal behavior, enabling precise linking of brain circuits and neurons. The program reconciles differing results by providing transparent explanations for machine-learning predictions, facilitating cross-lab comparisons and reproducibility in behavioral research.
A groundbreaking system utilizing a flexible tactile sensor based on electrical impedance tomography (EIT) offers significant advantages in terms of flexibility and sensitivity compared to conventional methods. The system achieved high classification accuracies, with reconstructed images and measured voltage vectors.
A new study reveals that neural activity related to sound detection and movement are temporally separated but share commonalities, with neurons adapting their activity based on experience. The findings shed light on the brain's complex processing of sensory information and behavioral choices.
A new study by UNC-Chapel Hill researcher Jennifer E. Arnold examines how people use 'they/them' pronouns in a spoken storytelling context. The findings show that college-aged speakers are able to adopt and use nonbinary 'they' with ease, suggesting a natural process of language change.
Researchers discovered a class of cerebellar inputs, called climbing fibres, are essential for associative learning to occur. These
Researchers developed a custom-built, low-cost mesoscope that can adapt to different neuroimaging experiments in live mice and rats. The system offers excellent spatial and temporal resolutions, achieved through its reversible tandem lens configuration, which enables flexible experimentation.