Articles tagged with Insulin Resistance
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A new study from the University of Victoria found that higher insulin levels at age 47 predicted younger onsets of hot flashes and night sweats. Insulin may be a stronger predictor of hot flashes when taking other metabolic variables into account, while body mass index (BMI) appeared more closely associated with estrogen level changes.
A new study reveals that people with an unexpectedly high metabolic BMI have up to a five times higher risk level for diseases such as diabetes and fatty liver. Metabolic BMI is based on advanced metabolomic analyses and identifies obesity-linked changes in metabolism that can be present even at normal weight.
Researchers have uncovered a microbial metabolite called trimethylamine (TMA) that can block a key immune pathway and improve blood sugar control. TMA, produced by gut bacteria from dietary choline, targets IRAK4, a protein that triggers inflammation and insulin resistance in diabetic individuals.
A study published in Environmental Endocrinology found that teens with higher blood levels of PFAS before bariatric surgery had smaller improvements in blood sugar over five years. This could lead to the metabolic benefits of the surgery fading within a decade.
A research team at Max-Planck-Gesellschaft found that pregnant mice exposed to fatty food smells developed more pronounced obesity and insulin resistance in their offspring. The brains of the offspring showed similarities to those of obese adult mice, suggesting a potential link between maternal diet and child health.
Research on leptin reveals its multifaceted roles in MAFLD, including regulation of energy balance and metabolism. Leptin therapy shows promise in rare cases of leptin deficiency but is largely ineffective in obesity-associated hyperleptinemia.
This review highlights SIRT1 as a key regulator in MASLD, orchestrating metabolic homeostasis, immune modulation, and inter-organ communication. SIRT1's therapeutic potential is supported by natural product activators and synthetic small-molecule compounds.
A recent USC study tracked 85 young adults over four years and found that increased ultra-processed food consumption was linked to elevated blood sugar and early signs of diabetes risk. The researchers also discovered that limiting UPF intake can help prevent disease.
Researchers at Northern Arizona University are developing a breakthrough tool to detect early signs of Alzheimer's disease. The new technology uses microvesicles in the blood to identify biomarkers indicating improved neuroplasticity, which can help track the disease's progression.
Researchers have identified a risk category called 'pre-prediabetes' that occurs years before standard criteria for prediabetes are met. This stage is characterized by severe insulin resistance and measurable cardiovascular disease, highlighting the need for early detection and treatment.
Researchers found genetic peptides called alpha-defensins that shape gut bacteria, producing healthier microbiomes and reducing insulin resistance. This discovery suggests personalized treatments can be tailored to individual genes, offering new hope for addressing chronic diseases like obesity and diabetes.
IRB Barcelona researchers discovered a new strategy to combat obesity by activating brown fat, boosting energy expenditure and improving metabolic health. The approach, driven by Neuritin 1 protein, increased energy burning without affecting food intake or physical activity.
A landmark clinical trial found that Transcendental Meditation significantly reduced diabetes risk factors and supported weight loss in older Black women at high risk for heart disease. Meditation improved blood sugar control, insulin resistance, cholesterol, and weight.
This review synthesizes evidence highlighting immune aging as a critical accelerator of type 2 diabetes pathogenesis. Chronic low-grade inflammation, organelle stress pathways, and the ominous octet framework contribute to metabolic-inflammatory vortex, disrupting β-cell function and insulin signaling.
A groundbreaking brain imaging study confirms intranasal insulin safely reaches key memory regions in older adults with Alzheimer's. The research reveals differences in uptake among individuals with early cognitive decline, paving the way for personalized treatment approaches.
Researchers have uncovered unique molecular fingerprints for insulin sensitivity, challenging traditional binary classification of people with type 2 diabetes. These signatures can help identify individuals at risk earlier than current methods, paving the way for personalized treatments and precision medicine.
A study found that children exposed to higher levels of air pollution experienced rapid weight gain and higher BMI by age 13, leading to increased insulin resistance in their mid-20s. The study suggests early interventions can help reduce the risk of chronic disease.
A recent study published in Diabetes Care found that persistently high blood sugar and insulin resistance significantly increased the risk of worsening functional and structural heart damage during adolescence to young adulthood. The study showed a five-fold increase in prediabetes prevalence among adolescents, with females being dispr...
A study found that exposure to traffic-related air pollution in childhood is associated with increased body mass index (BMI) and insulin resistance later in life. Higher BMI growth from early adolescence into young adulthood may partially explain this link.
A recent study found that parental metabolic traits, particularly those of the mother, can significantly affect a child's cardiometabolic health. The research showed that mothers have a greater impact on blood sugar and cholesterol levels in their children, while fathers' genes play a stronger role in insulin function over time.
The review explores the pathophysiological mechanisms linking obstructive sleep apnea syndrome and metabolic syndrome, highlighting recent advancements in therapeutic strategies. Treatment approaches aim to break the harmful cycle between OSA and MetS, which affects approximately 14% of the global population.
A new study published in Nutrients found that eating two cups of mango daily can help lower insulin concentration levels and improve insulin sensitivity in overweight or obese adults. The study, conducted at the Illinois Institute of Technology, showed significant reductions in insulin resistance and improved beta-cell function.
Researchers have discovered a novel approach to protecting insulin-producing beta cells from glucolipotoxicity, a condition linked to type 2 diabetes progression. The findings could lead to promising treatments targeting beta cell dysfunction, potentially slowing or preventing disease progression.
A dynamic signaling network plays a crucial role in regulating insulin action in human muscle cells. The study reveals previously unknown mechanisms that could be used to treat type 2 diabetes, including the stimulation of specific enzymes and protein kinases.
A recent study found that a brief consumption of highly processed foods can alter the brain's sensitivity to insulin in healthy individuals, potentially leading to obesity and type 2 diabetes. This effect was observed even after returning to a balanced diet for one week.
A study of over 6,000 Brazilians found that consuming polyphenols from foods like fruits, coffee, chocolate, and wine can reduce the risk of metabolic syndrome by up to 23%. The study also found that flavan-3-ols in red wine were associated with a lower risk of developing the condition.
A study published in Cell Communication and Signaling describes new molecular mechanisms underlying insulin resistance in skeletal muscle. The research reveals that PPARβ/δ regulates InsRβ protein levels by reducing lysosomal activity and EphB4 levels, offering potential drug targets for type 2 diabetes.
Researchers explore the connection between Alzheimer's and metabolic syndrome, finding links between insulin regulation, high blood pressure, and obesity. The study suggests that maintaining healthy blood fat levels may be crucial for brain health, paving way for potential therapeutic developments.
A new study published in JSCAI reveals a lower risk of cardiovascular events for people with Type 1 diabetes, compared to those with Type 2 diabetes. The research highlights the importance of distinguishing between the two types of diabetes and developing targeted treatment strategies.
Researchers at Rutgers University have discovered that a weekly injection of diabetes medication can replace painful daily hormone shots for people with a rare genetic form of lipodystrophy. The study found that the drug tirzepatide improved insulin resistance and normalized blood glucose levels in patients, reducing the burden and pai...
A study published in Nature Metabolism found that four percent of Greenland's Inuit population has a gene variant that increases their risk of type 2 diabetes by tenfold. Exercise has been shown to increase insulin sensitivity in these individuals, suggesting it may be an effective way to reduce their risk of developing the disease.
A new study identifies three molecular clusters in women who develop type 2 diabetes after gestational diabetes, pointing to potential precision-medicine approaches. The clusters are driven by pancreatic beta-cell dysfunction, insulin resistance, or a combination of both.
The novel compound HPH-15 outperforms metformin by activating AMPK at lower doses, improving glucose uptake and reducing fat accumulation in high-fat diet-induced obese mice. Additionally, it exhibits antifibrotic properties, potentially addressing liver fibrosis.
Researchers found a novel link between aortic stenosis and insulin resistance, with certain biomarkers increasing the risk of the disease. The study's findings suggest that managing metabolic health could be a new approach to reduce the risk of AS and improve cardiovascular health in aging populations.
The review explores the pathophysiological relationship between OSA and MetS, revealing a complex cycle of increased cardiovascular risks. Treatment options, including CPAP, weight management, and metabolic surgery, are discussed for improving patient outcomes.
A study published in PLOS ONE found that adults diagnosed with type 2 diabetes at a younger age are more likely to develop dementia. The researchers analyzed data from over 1,200 U.S. adults and found a graded association between age at diagnosis and dementia risk.
Metformin, a widely prescribed diabetes drug, may increase risks of obesity and diabetes in newborns when given to pregnant women. The study found that the drug accumulated in the fetal kidneys, liver, and other organs, leading to growth restriction, which has been linked to an elevated risk of obesity and insulin resistance in childhood.
A new review reveals how leptin resistance, a key feature of obesity, exacerbates metabolic syndrome by triggering pro-inflammatory pathways and mitochondrial dysfunction. The study identifies potential therapeutic targets for restoring leptin sensitivity and mitigating its metabolic effects.
Researchers suggest stress hormones may be primary driver of obesity-related diabetes, rather than impaired insulin signaling. The study found that excess food consumption stimulates the sympathetic nervous system, increasing stress hormones that counteract insulin's effects.
A new Australian study found that night shift workers who eat meals or snacks during their shift have significantly worse glucose tolerance compared to those who fast. Insulin sensitivity is also disrupted among all participants, regardless of their eating habits.
A new treatment strategy combining ReCET and semaglutide has been shown to eliminate insulin therapy in 86% of type 2 diabetes patients, improving sensitivity to endogenous insulin. The novel procedure, which employs electroporation, is compliance-free and disease-modifying, addressing ongoing patient adherence issues.
Research found that babies born to pregnant women consuming high-fat, high-energy diets are more likely to develop heart problems and diabetes as adults due to fetal damage. Consuming a high-fat diet during pregnancy also increases the likelihood of insulin resistance in adulthood.
A study of 500,000 UK participants found insulin resistance associated with higher risk of 26 conditions, such as sleep disorders and pancreatitis, and lower risk of five diseases, including anaemia and Parkinson's disease. Insulin resistance also linked to increased mortality risk in women.
Researchers used genetic method Mendelian randomization to show high levels of fasting insulin cause reduction in Lp(a), rather than the other way around. Low Lp(a) is unlikely to be a risk factor for type 2 diabetes, independent of pre-existing hyperinsulinaemia and insulin resistance.
A clinical trial found that consuming Mankai after meals can significantly lower blood sugar levels in patients with type 2 diabetes. The study showed a 20% reduction in post-meal blood sugar levels and faster return to baseline levels in about two-thirds of participants.
A recent study published in JAMA Psychiatry found that children with persistently raised inflammation are at a higher risk of experiencing serious mental health disorders, including psychosis and depression, in early adulthood. The research also discovered that those who experienced inflammation at a young age were more likely to devel...
Research from the University of Eastern Finland found that obesity-induced inflammation increases the secretion of extracellular vesicles from human adipocytes, which may contribute to the detrimental health effects of obesity. Visceral adipose tissue secretes more extracellular vesicles than subcutaneous adipose tissue.
Dr. Elks' research focuses on the communication loop between fat cells and immune cells, which promotes inflammation and insulin resistance when disrupted. The grant aims to uncover patterns in cell communication that can be used to treat obesity and other metabolic diseases.
Researchers discovered a unique protective mechanism in pancreatic β-cells, relying on elevated levels of pro-survival proteins like cFLIP. This discovery challenges the dominant paradigm and offers new insights into diabetes research, potentially leading to novel strategies for preserving β-cell function.
Researchers found that older female mice receiving daily whole-body heat treatment gained less weight and showed improved insulin sensitivity. The therapy also mitigated weight gain induced by a high fat diet and reduced fat accumulation in key areas.
A new pilot study provides clues about the potential benefits of both intermittent fasting and standard healthy diets on brain health. Both diets showed benefits in decreasing insulin resistance, improving cognition, and reducing glucose concentration in the brain.
A new study from the University of Oklahoma found that measuring circulating microRNAs is likely as effective as measuring blood sugar levels in determining how young people with type 2 diabetes will fare. The study also found a 20% decrease in beta cell function during the first six months of treatment.
Researchers from the University of Granada found that accumulating moderate-to-vigorous physical activity in the evening improves glucose regulation in overweight and obese adults. The study's results have significant implications for individuals at risk of developing insulin resistance or type 2 diabetes, highlighting the importance o...
A potential new strategy for reducing diabetes risk associated with antipsychotic medications involves co-administering drugs that block dopamine receptors in the brain alongside those that stop these same receptors in the pancreas. This approach may limit metabolic side effects and improve glucose metabolism.
The CCR4-NOT complex plays a crucial role in regulating RNA metabolism and stress response in C. elegans, compromising stress resistance and decreasing lifespan when depleted of subunits. This study highlights an important new role for the CCR4-NOT complex in normal aging and longevity.
Aging human pancreatic beta cells display features of senescence but maintain elevated levels of genes crucial for function and exhibit an ability to release insulin in response to glucose. This sheds light on the potential role of aging beta cells in immune regulation and their relevance to autoimmune reactions in type 1 diabetes.
A new study reveals how accumulation of IMAT drives diseases such as muscle loss, type 2 diabetes, and cardiovascular disease. Regular exercise and healthy diet can prevent and reverse IMAT accumulation.
Researchers at the University of Rochester Medical Center found that ketones can rescue impaired neuronal function in the hippocampal network. This study suggests a potential therapeutic approach for preventing or delaying neurodegenerative diseases like Alzheimer's.
A new study reveals that a cancer drug can improve insulin sensitivity and lower blood glucose levels, but eliminating a specific gene related to fat metabolism worsens insulin resistance. The research highlights the interconnectedness of fat metabolism in organs and the need for simultaneous treatment of obesity and insulin sensitivity.
Researchers at the State University of Campinas found that daily consumption of jaboticaba peel improved glucose metabolism even after meals. The study showed lower post-prandial glycemia and less inflammation in volunteers with obesity and metabolic syndrome.