Articles tagged with Metabolism
Research from the University of Missouri School of Medicine found that endurance exercise alters liver cell energy production, with female rats producing more proteins and male rats modifying existing proteins. Both sexes showed improved liver health, with reduced fat and markers of fibrosis.
Researchers discovered a protein called SLC25A34 that connects the body clock, temperature, and diet to how fat cells store and spend energy. This protein, found in mitochondrial cells, acts as a switch that responds to time of day, temperature, and food intake, influencing fat burning and storage.
A new driver of resistance in HR+ breast cancer has been identified through the discovery of FAH's nuclear role in stimulating CDK9 activity. This finding suggests a possible path to target resistant cancer cells and offers a new biomarker for resistance to CDK4/6 inhibitors.
USF Health researchers have uncovered a previously unknown brain region, the dorsal posterior periventricular hypothalamic nucleus, which plays a crucial role in regulating metabolic health in response to cold temperatures. The discovery offers a potential new pathway for developing treatments to improve metabolic function and prevent ...
A UCLA study found that a dietary supplement, Ca-αKG, reduced lung tumor growth in female mice, but increased tumor growth in male mice. The supplement activated genes associated with better outcomes in women with lung cancer, but had the opposite effect in men.
Researchers found that gut bacteria-derived polyamines, including putrescine and spermidine, contribute to extended lifespan in fruit flies. The study used genetically engineered E. coli to investigate the specific contribution of polyamines to host lifespan, revealing a sex-dependent effect with males living longer than females.
A new tool, the Molecular Community Network (MCN), has been developed to identify unknown molecules in the
A study with mice found that seven days of strength training activated lipid breakdown mechanisms, reduced fat cell size, and decreased fat around the intestines. This effect occurred even before any weight loss was observed on the scale.
Researchers at the University of Basel found that a drug called fenoterol increases energy expenditure in humans without activating brown fat. This suggests that a more complex regulation of brown fat in humans may be at play, and could have implications for future obesity treatments.
A new study reveals that high levels of cysteine are toxic to cells due to its ability to unleash stored iron, overwhelming mitochondria and triggering cell death. Cells keep free cysteine levels low by converting it into the antioxidant glutathione, which is safer to maintain at higher concentrations.
Pennington Biomedical researchers propose a new understanding of how protein restriction promotes healthy aging and extends lifespan by triggering a coordinated whole-body response. The response connects cellular nutrient sensing with hormones, brain function, and changes throughout the body, influencing healthy aging and longevity.
Researchers found that energy-demanding tissues have larger macrophage crews to manage waste, with the number of macrophages tracking mitochondrial activity and waste production. This system is critical for tissue health and function, and may help preserve tissue function as we age.
Researchers created a predictive model called enzyme-gated network expansion to understand the earliest stages of enzyme evolution. The model predicts that α/β folds were predominant in early enzymes, driving metabolic reactions.
Researchers found that meal timing programs the liver's daily rhythms and can have serious metabolic and health consequences when out of sync. The liver uses food signals to activate metabolic pathways, which can conflict with the body's natural circadian clock, leading to health issues.
Dr. Emily Flanagan's five-year NIH grant will investigate how energy intake and expenditure influence infant growth and future obesity risk. The study aims to improve energy-intake standards for infants and identify critical periods for interventions promoting healthy growth.
Researchers found that impaired peroxisomal function can increase insulin secretion while promoting insulin oxidation and disrupting pancreatic beta cell maturity. Healthy peroxisomes play a role in protecting insulin from oxidative modification and degradation, and helping beta cells maintain their specialized characteristics.
The University of Louisville is launching the Nutrition and Metabolic Health Center to tackle chronic diseases, with a focus on prevention and new treatments. Researchers will investigate the impact of nutrition and environmental factors on health, with the goal of improving prevention and treatment options.
Scientists have discovered a new connection between energy-producing mitochondria and chronic inflammation in senescent cells, which promotes age-related diseases. Blocking a related gene and using a drug called CTPI-2 reduced inflammation and promoted healthier aging in mice.
A new international review standardizes selenosugar nomenclature and selenium metabolism, providing a harmonized operational framework for researchers. The proposed system offers concise and intuitive names, minimizing ambiguity and promoting accurate detection and identification of selenosugars.
A key molecule released during exercise, L-β-aminoisobutyric acid (L-BAIBA), has been discovered to strengthen muscles, improve exercise performance, and protect against muscle damage in type 2 diabetes. The study reveals L-BAIBA's role in muscle adaptation, metabolism, and contraction, offering promising insights for future therapies.
Adults who continued to eat pork while participating in a 6-month digital weight management program lost a clinically significant 5.3% of starting body weight and improved their overall diet quality scores by 4.3 points. This study challenges the notion that pork is automatically off-limits within a healthier eating plan.
A study identified novel autoantibodies associated with idiopathic myelopathy, specifically those related to vitamin B12 transport. Central nervous system vitamin B12 deficiency was also found in affected individuals. The findings suggest a potential diagnostic approach for myelopathy
Researchers at UT Health San Antonio have uncovered how the liver's internal clock coordinates the release of proteins that regulate metabolism. The findings suggest that understanding this internal clock could help guide future research on metabolic disease and inform optimal timing for meals and medication.
A new international study defines clinical obesity as a significant predictor of increased disease burden, operative risk, and cardiovascular risk in patients undergoing metabolic bariatric surgery. The study found that the majority of patients met criteria for clinical obesity, while a minority had preclinical obesity.
Researchers found that gut cell turnover depends on nutrient quantity, not specific nutrient quality, in fruit flies. Gut cells sense satiety based on cytoplasm viscosity, not amino acid metabolism.
A recent study published in Cancer Research found that sildenafil, the active ingredient in Viagra, can restrict cancer metastasis by limiting cancer cells' access to cholesterol. Combining sildenafil with statins may enhance this effect, potentially improving survival rates among cancer patients.
Researchers at Tohoku University discovered a paradox in REM sleep where the brain's energy molecule decreases despite an increase in fuel supply. This finding suggests that the brain dynamically adjusts its energy economy to support complex internal processing, revealing new insights into biological computation and sleep function.
A large-scale genetic study suggests that inherited taste preferences for sweet and fatty foods can influence eating behaviors and contribute to chronic disease risk. People with a higher genetic predisposition for these tastes tend to eat more of them, leading to a higher risk of obesity and type 2 diabetes.
Researchers developed a new cell-based approach to produce several sugars naturally found in human breastmilk, including complex oligosaccharides. The method involves engineering cultured mammalian cells to express essential enzymes, allowing for the production of structurally diverse HMOs with potential applications in infant nutrition.
Researchers developed a handheld breath detector that measures acetone levels with laboratory-level accuracy in 90 seconds. The device tracks changes in fat metabolism during various scenarios, including exercise and fasting, providing insights for clinicians to personalize treatments.
The Pennington-Louisiana Nutrition Obesity Research Center has received a five-year, $5.66 million renewal grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The award reaffirms Pennington Biomedical's position as a national leader in nutrition, obesity, and metabolic health research. The center su...
Researchers have identified a sensitive isotopic biomarker for early anemia detection using copper stable isotope ratios (δ⁶⁵Cu) in pediatric serum. The study also uncovered distinct serum metallomic patterns linked to body mass index (BMI), including a strong positive association between serum lead levels and increasing BMI.
Researchers discovered that senescent cells accumulate high levels of triacylglycerols and increase glycolytic activity, leading to increased lipid droplet accumulation. This finding suggests that lipid droplets may contribute to the harmful effects of senescent microglia in Alzheimer’s disease.
A new study published in Hepatobiliary Communications reveals that standard CT scans can detect stage-specific tissue patterns predicting severe liver complications in chronic hepatitis B-related cirrhosis. Visceral fat and muscle shifts carry different warning meanings based on the patient's disease stage.
Mouse study uncovers how oxygen-sensing transcription factors regulate muscle physiology, improving glucose tolerance and producing erythropoietin. The findings suggest that selectively targeting each isoform can lead to different physiological outcomes.
A Wisconsin lab advance has developed a way to remove liquid chromatography from peptide mapping, an essential test for determining a candidate drug's stability. This technique accelerates the process by 100-fold, allowing companies to analyze massive data influx instantly and reducing costs.
A new study from the University of Copenhagen shows that exercise plays a crucial role in improving cardiovascular health even after significant weight loss. Participants who exercised developed healthier blood vessels and lower inflammation compared to those who relied on medication alone.
Sofia Doello will investigate how microorganisms reactivate their metabolism after prolonged dormancy using the prestigious Emmy Noether grant. Her project aims to uncover fundamental principles of survival and cell regeneration in bacteria.
A new study from the University of Copenhagen suggests that longer sleep is linked to more stable blood sugar levels in healthy 18-year-olds, even among those with no previous health issues. The researchers tracked participants over two weeks and found a two-way relationship between sleep duration and blood sugar stability.
A new study reveals that excessive fibrin deposition drives chronic inflammation in diabetic periodontitis. A targeted peptide successfully stops this inflammation and promotes periodontal bone regeneration, offering a potential universal therapeutic strategy for various immune-mediated diabetic comorbidities.
Researchers at UC San Diego discovered a previously unknown mechanism that contributes to high blood cholesterol by depleting LDL receptors. A CTSA inhibitor has already shown safety in humans and may be effective in treating high cholesterol, offering a new treatment option for patients.
Scientists discovered a natural microbial compound that protects the gut and supports future treatments for inflammatory bowel disease. UroA activates a protective pathway in intestinal epithelial cells, triggering the release of molecules associated with maintaining normal intestinal function and repairing the gut lining.
A new study published in Cell Metabolism found that a low-protein, amino acid-supplemented 'longevity diet' improved cardiometabolic markers and reduced frailty and fat mass in mice. The diet was associated with longer healthy lifespan and better metabolic health in both mice and humans.
A recent study published in Metabolism found that our internal clock independently affects the energy we burn after eating, peaking in the morning and decreasing at night. This discovery sheds light on why late eating may contribute to weight gain or struggles with weight loss.
Research explores role of short-chain fatty acids in regulating dendritic cell development and differentiation via epigenetic regulation. Study reveals butyrate increases expression of surface molecules, influencing immune-cell trafficking and localization.
Researchers from Kyushu University discovered that the circadian clock protein BMAL1 drives macrophages towards a pro-inflammatory M1 state by activating inflammatory signaling pathways. This mechanism links the body clock to intracellular metabolism and immune function, offering new insights into treating inflammatory diseases.
A new study reveals that a change in diet may have paved the way for the evolution of spectacular displays in manakins. The research found that genetic fingerprints of strong sexual selection and changes in taste and digestion linked to a fruit-based diet drove the emergence of elaborate mating behaviors.
A new paper by over 20 protein experts examines widely held propositions about dietary protein, concluding that some science is insufficient or not robust enough to support certain claims. Key findings include the importance of protein quality, individual essential amino acids, and nuance in high-protein intake during weight loss.
Researchers discovered that supergiant deep-sea isopods have a dual survival strategy to cope with nutrient-poor conditions: an enlarged stomach for storing food and extremely low basal metabolic rate. This allows them to thrive in extreme environments.
Researchers at Nagoya University identified the neural circuit responsible for timing torpor in mammals, which reduces body temperature and metabolism. The discovery provides new insights into how animals regulate energy use.
Researchers investigated the interplay between host and gut microbiota in selenium metabolism, finding that gut microbiota transform selenium into metabolites influencing utilization, detoxification, and excretion. The study also revealed that Se intake affects bacterial diversity and that gut microbes produce unique selenometabolites.
Researchers found that the gut responds to protein deficiency by activating a fast neural circuit and a slower hormonal signal, which selectively changes dietary priorities. The study reveals a previously unknown gut-brain signaling system that rapidly alters feeding behavior in animals.
Researchers identified a vitamin K-dependent GAS6 pathway that controls osteoclast maturation and bone resorption in mice. Osteoblasts use Vitamin K signals to regulate osteoclast fusion via the GAS6 pathway.
Researchers developed an AI framework, MouseMapper, to map disease-related changes in the entire mouse body. They found widespread inflammation and previously unrecognized damage to facial sensory nerves caused by obesity, which was also observed in human tissue.
A new Northwestern University study finds metformin primarily targets the gut, driving glucose utilization inside cells lining the intestine to prevent blood sugar levels from rising. The drug slows mitochondrial energy production in gut cells, allowing the intestine to metabolize extra sugar and regulate blood sugar levels.
A study reveals that S-1-propenyl-L-cysteine, a bioactive compound found in aged garlic extract, promotes inter-organ communication between fat tissue and the brain, enhancing muscle strength. Long-term administration of S1PC reduced frailty scores and increased skeletal muscle force in aged mice.
A new study from the University of Virginia finds that next-generation GLP-1 drugs can alter brain circuits controlling motivation and reward. The research shows that these drugs not only suppress appetite but also influence how the brain values food, helping explain their effectiveness and side effects.
A review from Florida Atlantic University links obesity to Alzheimer's disease through disruptions in metabolism, highlighting the importance of mitochondrial function and gut-brain axis balance. Early detection and whole-body prevention may become possible through monitoring metabolic health.
A long-term MRI study finds that lower accumulation of visceral fat is associated with preservation of key brain structures, better cognitive performance, and slower brain atrophy. The study suggests that glucose control and insulin sensitivity mediate the relationship between abdominal fat and brain aging.
A new study found that fur seals' heart rate peaks six to eight hours after returning to land, indicating a delayed recovery from the physiological costs of foraging at sea. This suggests that seals use their time onshore to actively recover and replenish oxygen stores.