Articles tagged with Cell Responses
The new grant enables LJI to lead the Human Immunology Project Consortium Data Coordinating Center, providing access to human immunoprofiling data from over 11,000 participants. This will fuel scientific collaboration in understanding immune responses to viruses, autoimmune diseases, and more.
Researchers at Uppsala University developed a prognostic method using a combination of immune cells to provide clearer disease prognoses and predict which patients will respond best to immunotherapy. The method was shown to be associated with patient fate in several types of cancer.
A high-fat diet allows the immune system to eliminate a parasitic worm that causes long-lasting infections in the large intestine. This discovery may lead to new treatments for millions suffering from intestinal parasitic infections worldwide.
Researchers identified a subset of mutations within tumor mutation burden that remain persistent and visible to the immune system, increasing likelihood of response to immunotherapy. This finding enables clinicians to more accurately select patients for clinical trials or predict clinical outcomes with immune checkpoint blockade.
A new study identifies how bacteria in deep-sea hydrothermal vents survive and thrive in the presence of toxic metals like copper and cadmium. Bacteria use transporter proteins to pump out these metals, but also employ more complex strategies, such as flagella formation and granule growth, to detoxify cadmium.
Researchers found that regorafenib, a dual PDGFR α/β inhibitor, modifies the cancer microenvironment and enhances the efficacy of anti-PD-1 immunotherapy in advanced gastric cancers. This combination therapy boosts tumor infiltrating immune cells and reduces tumor fibroblasts.
Researchers have characterized the tar spot pathogen on a molecular level, revealing its virulence molecules target specific plant organelles. This study advances our understanding of plant-pathogen interactions and contributes to developing disease control strategies.
A new study reveals that high-affinity B cells trigger a change in the criteria for admission to germinal centers, allowing low-affinity B cells to join, increasing the diversity of the immune response. This process is crucial for fighting off viruses like SARS-CoV-2 but may hinder efforts against HIV.
Researchers found women's immune responses to herpes simplex virus (HSV) vaccine are stronger, while those with prior exposure have different type I IFN signatures. This interaction may affect vaccine effectiveness.
Researchers found that p53 mutations in blood cells increase the risk of developing coronary heart disease and peripheral artery disease. The study provides solid evidence for the link between acquired p53 gene mutations and cardiovascular disease, suggesting a potential new risk factor.
Researchers have discovered that nutrient elements such as potassium, calcium, magnesium, and sodium can activate immune responses in tomato plants, leading to disease resistance. The study found that different defense signaling pathways are required for induction of immunity in response to different elements.
Researchers at the University of Bergen have developed a method to predict cancer patient survival within hours of chemotherapy. By analyzing protein ERK1/2 levels in blood samples, they can identify patients who are responding or not responding to treatment, enabling early intervention.
The CNIC study reveals two distinct mechanisms by which cells detect and respond to forces of varying strength, one mediated by caveolae and the other by newly discovered dolines. This finding has significant implications for understanding pathological processes such as atherosclerosis and neurodegenerative diseases.
Researchers developed a cell-based method to predict breast cancer treatment responses, showing promising results and potential for personalized medicine. The method uses tumour cells and supporting cells from patients, allowing for efficient drug profiling and accurate treatment prediction.
Researchers describe results using cladribine-based combination epigenetic and immunotherapy in MCL, achieving an increased overall survival greater than 40 months with durable remissions without relapse for longer than 5 years. The approach is promising in the treatment of MCL and potentially other previously treatment-refractory canc...
Researchers investigated neuronal response to excessive iron accumulation associated with age-related neurodegenerative diseases. They identified two genes, CLU and HERPUD1, that responded to aging-related iron accumulation, highlighting potential preventative strategies.
Neutrophils can generate LTB4 through cooperative transcellular biosynthesis, rescuing defective swarming behavior in genetically deficient cells. This breakthrough enables therapeutic control of infection response and potentially auto-inflammatory processes.
Researchers found that excessive iron accumulation accelerates tumor growth in F. nucleatum-positive colorectal cancer by enhancing inflammatory responses in immune cells, promoting interpatient prognostic variability. Iron levels also modulate macrophage expression profiles, transforming them into pro-tumor cells expressing CCL8.
Researchers created an atlas of the malaria infection by Plasmodium parasites in the liver, revealing differences in infected cell localization and immune response. The study's findings hold promise for developing treatments targeting the asymptomatic liver stage of the disease.
Researchers have found therapies that can help patients with relapsed multiple myeloma who tried CAR-T therapy, including bispecific antibodies and other types of CAR-T cell therapy. The study analyzed 79 patients and found that stem cell transplants and other drug combinations showed some efficacy in these patients.
McCullough's research advances the field of cardiovascular science, with a primary focus on sex differences in stroke. Her work has led to significant discoveries about cell death pathways during ischemic insults.
A new study in Cell Systems explores the benefits of using multiple data types in drug discovery. Gene expression and cell morphology provide complementary information for drug prioritization, advancing drug discovery, functional genomics, and precision medicine.
Researchers developed a new machine-learning approach to classify macrophages, which are key immune cells involved in pro- or anti-inflammatory responses. This technology could be used as a diagnosis tool or to highlight the role of specific cell types in disease environments.
Conscious perception of sound generates specific neuronal assemblies in the brain, differing from spontaneous brain activity. Under anesthesia, similar assemblies are present but lack sound-specificity, highlighting the importance of cortical creativity in sensory processing.
Scientists at Massachusetts General Hospital have developed a technology that enables cells to produce oxygen on demand, opening up new avenues for research and potential clinical applications. This breakthrough could improve therapies for conditions like cancer, which often have low oxygen levels.
Researchers have developed a new approach to test the efficacy of multiple anticancer drug combinations simultaneously, rapidly, and accurately. Combi-seq overcomes limitations of conventional technologies by using microfluidics to carry out large-scale experiments with small sample volumes.
Researchers in Cell Reports study neuronal responses to bright and dark surfaces, finding that large bright surfaces activate both light-ON and light-OFF neurons, increasing the combined response with surface brightness and size. This challenges the long-standing assumption that only surface edges drive strong cortical responses.
A team from UNIGE and HUG identified a protein regulation mechanism that reduces melanoma cells' capacity to adapt and resist treatment. They found that targeting this mechanism with an enzyme inhibitor reduces therapeutic resistance in all melanoma cells.
A new study provides valuable insights into the roles of B cells and plasma cells in early-stage lung cancer biology, highlighting their influence on tumor development and treatment outcomes. The research also reveals environmental factors and molecular features that contribute to the landscape of infiltrating immune cells.
Researchers at La Jolla Institute for Immunology discovered how Zika virus forces dendritic cells to churn out lipid molecules, allowing the virus to build copies of itself. This study provides a major step forward in developing antiviral therapies against multiple flavivirus infections.
Researchers have identified two effective antibodies that neutralize all known strains of COVID-19, including Delta and Omicron variants. These breakthrough antibodies could eliminate the need for repeated booster vaccinations and strengthen immune systems, especially in at-risk populations.
Researchers at Rice University have created a new optical tool called homo-FRET that allows them to observe the real-time activity of two-component systems in bacteria. This breakthrough enables scientists to study the behavior of deadly pathogens and antibiotic-resistant bacteria, shedding light on their mechanisms and potential targe...
Researchers identified differences in PTK activity between normal and cancer kidney tissue, with Src family kinases and PI3K pathways exhibiting high activity. Ex vivo treatment of clear cell RCC with TKIs revealed that tivozanib and cabozantinib were more potent inhibitors than sunitinib or pazopanib.
Researchers successfully developed artificial replicas of GPCRs, allowing for controlled activation and replication of original functionality. The method enables precise modulation of immune cells' responses, holding promise for treating diseases targeted by GPCRs.
A novel subset of CD8+ regulatory-like T cells (CD8+TRLs) has been identified as 'first responders' to stroke, providing fast-acting and lasting protection. These cells reach the brain within 24 hours after stroke onset, releasing molecules that provide direct neuroprotective effects.
Researchers at Moffitt Cancer Center used mathematical modeling to study the impact of tumor size, immune cell populations, and interactions on cancer treatment outcomes. The models predicted optimal therapeutic approaches for different types of therapies, including cytotoxic chemotherapy and immunotherapies.
A study published in Nature Physics reveals that specialized cell movement may explain the progression of cancer and cystic fibrosis. Cells with ruffled edges sense viscosity and adapt to increase their speed, moving faster through mucus than blood. This discovery sheds light on disease mechanisms and potential treatments.
Researchers at Weill Cornell Medicine discovered that chemokines can form DNA-bound nanoparticles that induce chronic, dysfunctional immune responses. This new mechanism may play a central role in autoimmune diseases such as scleroderma and lupus, where inflammation goes awry.
A KAUST-developed nanotechnology platform uses tiny iron wires that bend in response to magnetic fields to accelerate bone cell formation. Bone-forming stem cells grown on the moving substrate transform into mature bone much faster than usual, potentially paving the way for more efficient regeneration of bone.
Researchers have identified a family of proteins called PIN-FORMED as essential for auxin transport, guiding plant growth and development. The discovery provides the first structural basis of auxin transport by PIN proteins and sheds light on how herbicides can be recognized by these proteins.
Researchers developed a new method using magneto-active polymers to study cellular behavior and replicate complex biological processes. The system allows for real-time control of mechanical forces on cells, enabling the analysis of mechanisms behind traumatic injuries and tissue damage.
A detailed understanding of interleukin 2's role in the immune system has been gained through a new mouse model, enabling scientists to identify potential new uses as an immune-modulating biologic drug. This breakthrough may lead to optimized autoimmune and cancer treatment while avoiding unwanted side effects.
Researchers discovered two novel categories of cells in the BLA that respond to ethological stimuli, including event-specific neurons responding to one type of stimulus and panresponsive neurons responding equally well to multiple stimuli. These findings suggest a larger role for the BLA in memory and behavior.
A randomized, placebo-controlled pilot study found that NB-UVB phototherapy decreased mortality in hospitalized COVID-19 patients with no adverse events reported. The treatment was effective in both vaccinated and unvaccinated patients, with reduced pathologic inflammation and improved intracellular killing of pathogens.
Researchers found that severe asthma patients produce growth factors that block corticosteroids from working, leading to frequent breathing problems. This discovery may lead to new treatments targeting these growth factors to improve outcomes for patients with severe asthma.
A gene associated with Nascimento Syndrome triggers cells' defenses against environmental attacks by modifying proteins under stress. Rad6, a master regulator of this process, helps cells adapt to stressful conditions, shedding light on the disease's progression.
Researchers at UNIGE discovered that temperature changes trigger organ-specific effects in all tissues, leading to distinct gene expression profiles. The study's web-based application provides access to thousands of gene expression profiles, enabling further research and potential therapeutic applications.
Researchers at MedUni Vienna identified five distinct subtypes of small cell lung cancer, each responding differently to therapies. High ASCL1 expression is linked to poor survival, while high POU2F3 expression correlates with better outcomes and sensitivity to standard chemotherapeutics.
Researchers discovered that memory B cells produce non-specific antibodies to combat virus mutants, working alongside phagocytes to screen for variants. This mechanism may offer protection against SARS-CoV2 and HIV variants, and could influence vaccine development.
A molecular switch, p57, enables stomach stem cells to change allegiance from normal digestion to injury response, potentially leading to new treatments for gastric pathologies. The study's findings suggest that p57 is a key regulator of reserve stem cell state in gastric chief cells.
A new study found that naming legislation after a victim increases support for the law and its associated punishment, with notable benefits for laws named after African American women. The study used distracted driving as an example and surveyed a national sample of 1,000 U.S. adults.
Researchers at NC State University have created a stem cell-derived model that sheds light on the effect of dopamine on gene activity in neurons, revealing gene desensitization in human cells. The study provides a blueprint for future research into the relationship between dopamine and addiction.
Assistant professor David Knowles at Columbia University wins a $500,000 NSF CAREER Award to develop a new framework and tools for analyzing alternative splicing in diseases such as ALS and cancer. The project aims to create more accurate algorithms for single-cell and long-read RNA-seq analysis.
Researchers found a 1000-fold increase in skin microbiota and larger lesions after smallpox vaccination, but all groups had equal protection from re-infection. The study suggests that manipulating commensal skin microbiota might enhance the efficacy of intradermal vaccines.
A new study found that microglia regulate neuronal subtypes differently in response to bacteria, affecting intrinsic excitability. Pyramidal cells exhibited lower excitability, while Purkinje cells showed higher excitability when modulated by microglia.
A study by Tokyo University of Science researchers has demonstrated that a computationally-light model can simulate complex brain cell responses, including periodic and quasi-periodic responses. The Izhikevich neuron model was found to be capable of reproducing both types of responses at lower computational cost.
Researchers developed a new treatment option for relapsed or refractory CD30+ lymphoma using natural killer cells complexed with a CD30/CD16A bispecific antibody. The treatment showed an overall response rate of 89% in patients with advanced lymphoma.
Scientists at Johannes Gutenberg University discovered that fruit fly eyes can distinguish six types of global motion patterns generated by self-motion. The T4/T5 cell subtypes directly represent complex motion cues rather than uniform directions, matching the fly's actual behavior closely.
New research suggests the brain uses multiple strategies to process smells, employing both snapshot-like and evolving ensemble approaches. The study provides new tools for scientists to quantify and interpret brain activity patterns.
Dendritic cells, or 'sentinel' immune cells, are vital to maintaining the body's immune balance. Researchers have discovered their essential role in treating cancer and severe viral infections by preventing immunopathology.