Researchers have uncovered a new understanding of how cardiac events are interconnected with the brain and nervous/immune systems. They found that sensory neurons in the vagus nerve detect injury and transfer signals to dedicated brain structures, leading to activation of the immune system.
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Researchers at the University of Notre Dame investigated how brain networks are organized and work together to form a unified system. They found evidence for system-wide coordination in the brain that is both robust and adaptable, suggesting that intelligence reflects how brain networks are coordinated and dynamically reconfigured.
Researchers at Karolinska Institutet created the first activity-based maps of the prefrontal cortex, revealing a hierarchy of information flow rather than tissue structure. This challenges traditional definitions of brain regions and has major implications for understanding brain organisation overall.
Researchers found that early communication between three pairs of brain regions is associated with favorable six-month functional outcomes. The study identified signature patterns in resting-state functional MRI data that can strengthen standard prognostic methods for assessing outcomes after moderate-to-severe brain injury.
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A mouse study by Okinawa Institute of Science and Technology researchers has found that acetylcholine release is essential for breaking habits and enabling new choices to be made. The study's findings may help understand diseases such as Parkinson's disease, addiction, and obsessive-compulsive disorder.
Researchers at Brown University have created a bioluminescence tool that enables the measurement of activity in living brain cells without damaging them. The CaBLAM tool uses bioluminescent light production to capture single-cell and subcellular activity at high speeds, allowing for longer recordings and reducing hardware requirements.
The EBRAINS Summit 2025 will bring together experts to assess how neuroscience can drive medical progress, digital innovation, and responsible data use. Preliminary results from the EPINOV clinical trial, integrating virtual brain technology for epilepsy surgery planning, will be presented.
A new study found that individuals with a history of major depression showed higher MRI markers associated with neuroinflammation in the VTA, suggesting increased extracellular inflammatory processes. Current depressive symptom severity was associated with distinct microstructural changes indicating different underlying pathophysiologi...
Researchers developed a novel method called cytoarchitecture-based link estimation (CABLE) to infer axonal pathways from routine histology, reconstructing three-dimensional whole-brain fiber tracts at cellular scale. CABLE outperforms existing neuroimaging tools in resolving complex geometries and has potential applications in psychiat...
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A new study by Carnegie Mellon University's Wood Neuro Research Group uses advanced brain imaging and a digital visualization tool to better understand how pain is processed in the brain for people with sickle cell disease. The team found that patients had reduced connectivity across key brain networks linked to pain perception, partic...
Researchers used data from the Human Connectome Project to build computational models that linked connectivity with brain activation across various cognitive processes. The findings show a consistent correlation between connectivity and function, suggesting that specific patterns of connectivity can predict brain activity.
A new study by New York University researchers found that the brain processes multiple words at once in a hierarchical manner, similar to a subway system. The brain coordinates different levels of processing, such as sounds, words, and meanings, without interference, allowing for efficient interpretation of speech.
A study from the Norwegian University of Science and Technology found that older people tend to interpret ambiguous facial expressions as positive. The researchers discovered that this is due to adaptations in the locus coeruleus, a small organ at the bottom of the brain responsible for regulating alertness and attention.
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The Neuropixels Ultra probe overcomes technical challenges in recording individual cells across multiple brain regions. It detects twice as many brain cells and distinguishes specific subtypes, enabling scientists to decode and track brain cell performance related to visual stimuli.
Researchers developed a fiber-optic method to track Alzheimer's plaques in freely behaving mice, allowing for real-time monitoring and long-term tracking of pathological changes. The technique uses fluorescent dye to bind specifically to amyloid fibrils and provides a minimally invasive way to study disease progression.
A new study published in Biological Psychiatry found that individuals with similar levels of autistic traits are more attracted to each other and their brains synchronize in unique ways during passive and active communication. This suggests a novel approach for building social connection among people with autism by tailoring environments.
Researchers developed a new method to correct for variations in brain imaging measurements, reducing bias and increasing the accuracy of studies on ADHD. The traveling-subject method demonstrated reduced measurement bias while maintaining sampling bias, revealing decreased brain volume in critical regions for cognitive functions.
Researchers found that brain maps of the hand and lips remained consistent even after amputation, contradicting previous views of reorganization. This study has implications for treating phantom limb pain and controlling robotic replacement limbs via neural interfaces.
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A new study found that tolcapone increases activity in the prefrontal cortex during self-control tasks, associated with better behavioral control and reduced alcohol consumption. The findings suggest that medications increasing prefrontal dopamine could be a promising lead for treating alcohol use disorder.
Researchers from FAU and the Sensing Institute created a detailed computer model of the mouse brain's vasculature, simulating how brain blood vessels respond to hemodynamics and vasodynamics. The model shows that transitional vessels play a critical role in regulating flow and protecting the brain during increased activity.
Young adults with higher genetic risk for depression show reduced brain activity in response to rewards and punishments, while sex-dependent neural responses were also observed. This study highlights potential early indicators for depression before symptoms fully manifest.
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Researchers found that map-making brain cells in the hippocampus are activated differently even when navigating a static environment, shedding light on how the brain processes spatial memories. The study's findings could have profound implications for understanding memory, learning, and aging.
A study published in Scientific Reports found that 44% of autistic teens can mask their diagnosis in school settings, showing faster brain responses to faces and reduced emotional reactivity. Researchers hope this discovery will lead to better support for these teens.
The brain segments and organizes events into experiences by placing unique bookmarks on them, allowing us to revisit and learn from our lives. The lateral entorhinal cortex creates a signal that constantly drifts in a pattern never repeating itself, marking the beginning and end of an experience.
A novel study in Biological Psychiatry highlights the layered and complex interactions between clinical symptoms and neurobiological sources of variation in depression. The research found that multiple brain profiles may manifest as the same clinical symptoms, supporting the presence of both one-to-one and many-to-one heterogeneity.
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A new study published in Neuron has identified a brain region, the fusiform gyrus, as key to distinguishing between real and imagined experiences. The region's strength of activity can predict whether someone judges an experience as real or imagined.
Researchers at Aarhus University and University of Oxford used a novel neuroimaging method to show that the brain dynamically reconfigures its organization in response to auditory stimulation. This discovery opens new possibilities for studying brain responses to music, consciousness, and other phenomena.
A recent study found that caffeine increases brain signal complexity and enhances criticality during sleep, with effects more pronounced in young adults. This can lead to a state where the brain is neither fully awake nor relaxed, potentially interfering with restful recovery.
A study found that connections between visual and language processing regions in the brain influence object knowledge. Stroke patients' brains showed stronger connections meant better performance on color-identification tasks.
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Researchers have used AI and brain activity to study the Other-Race-Effect (ORE), a phenomenon where people recognize faces of their own race more easily than others. They found that faces from other races are processed more generally and with less detail, leading to less accurate recognition.
The DAM-Decision and Memory group at Universitat Jaume I studied the cognitive and neural computations that guide decision-making and long-term memory. They found that the hippocampal and medial prefrontal cortex regions use context boundaries to make decisions in both spatial and abstract contexts.
This study found that low-intensity multitask exercise increased delta power during sleep and activated the prefrontal cortex immediately after the session. The findings suggest that multitasking exercise may be a promising strategy for promoting better sleep in older adults.
Researchers developed DeepCeres, a software that uses AI tools to measure 27 structures of the cerebellum with improved precision. This will help in studying neurological pathologies such as ALS, schizophrenia, and Alzheimer's diseases.
Researchers discovered a common cognitive feedback loop used by Buddhist jhāna meditation and Christian speaking in tongues practices to achieve profound focus and joy. This 'Attention, Arousal and Release Spiral' offers insights into cultivating deep states of tranquility and bliss.
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Researchers from Michigan State University used brain-scanning tools to predict visitation patterns in urban environments. The study found that the brain's reward system can shape human behavior within cities, aiding in designing sustainable living spaces.
A Princeton-led research team has built the first neuron-by-neuron and synapse-by-synapse roadmap through the brain of an adult fruit fly. The map reveals connections within the brain at every scale, enabling researchers to better understand its underlying logic and potentially develop tailored treatments for brain diseases.
A new study published in Frontiers in Behavioral Neuroscience has found that fans of action films and comedies react strongly to negative emotional stimuli, while those who prefer documentaries or crime films show a weaker reaction. The research suggests that people choose film genres that optimally stimulate their brains.
A study in Current Biology mapped a brain circuit responsible for detecting threats and forming fear memories. The hippocampus and subiculum are key structures involved, with the subiculum transferring information to the hypothalamus.
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Researchers have discovered a new type of brain cell in the medial entorhinal cortex that accurately predicts future locations as an animal travels. This discovery helps explain how planned spatial navigation is possible and has important implications for understanding mechanisms of spatial navigation and episodic memory formation.
The UNLV study found that brain activity patterns change with the number of experiences, not time, and that increasing speed affects perception. The research suggests that our brains register a 'vibe' about time, making it faster when we're having fun or doing tasks efficiently.
Researchers used advanced brain imaging techniques to identify key regions and networks involved in creative thinking. The Default Mode Network (DMN) was found to play a crucial role, with activity originating from the DMN before being evaluated by other brain regions.
The study reveals a unique, ring-shaped organization of the antennal lobe, with specific glomerular clusters encoding different odors. This coding mechanism differs from other insects and vertebrates, with the representation of odor valence encoded in higher brain centers.
Researchers have developed a highly sensitive diamond quantum magnetometer that can achieve practical ambient condition magnetoencephalography. The novel magnetometer uses a single crystalline diamond to detect magnetic fields, achieving record sensitivities of up to 9.4 pT Hz-1/2 in the frequency range of 5 to 100 Hz.
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A new study shows that psilocybin initiates a pattern of hyperconnectivity in the brain linked to the ego-modifying effects and feelings of oceanic boundlessness. The findings provide insights into how the brain works on psychedelic drugs and their potential use to treat psychiatric disorders.
Researchers from Kobe University developed an AI image recognition algorithm that can predict mouse behavior based on brain functional imaging data, achieving 95% accuracy. The model identified critical cortical regions for behavioral classification and demonstrated near real-time speeds.
A team of researchers created the first brain-wide map of prairie voles during mating and pair bonding, discovering 68 distinct brain regions active across seven circuits. The study found that male ejaculation elicits a profound emotional state in both males and females, coordinating the formation of a bond.
The ultra-high resolution NexGen 7T scanner allows neuroscientists to see functional MRI features 0.4 millimeters across, enabling the study of brain circuitry underlying different diseases with higher spatial resolution. This will help track signals propagating through the brain and reveal underlying causes of developmental disorders.
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A team of neuroscientists and physicists at Princeton University studied the brain of Caenorhabditis elegans to understand how information flows through a network of interacting neurons. They used optogenetics to activate individual neurons and observe how other neurons responded, shedding light on the complex neural connections.
A research team has developed a new method for mapping brain activity to understand behavior changes in patients with neurological disease. The technique uses CaMPARI images to track brain activity and can be used to study the effects of Alzheimer's disease on brain function.
The Digital Twin Brain platform combines intricate brain atlases and dynamic neural models to simulate human brain functions. This innovative approach holds promise for advancing artificial general intelligence and precision mental healthcare.
Researchers aim to create detailed maps of neuronal connections in sections of mouse and macaque brains, with the goal of creating full wiring diagrams. The projects use innovative techniques such as transmission electron microscopy and barcoded connectomics to visualize brain cell shape and cell-to-cell connection networks.
A team of scientists has developed a rigorous accounting of the neurons in the tiny brain of a humble C. elegans worm, mapping out how its brain cells encode essential behaviors such as movement and feeding. The atlas reveals the underlying logic of how the worm's brain produces a sophisticated repertoire of behaviors, even as environm...
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Research from UTHealth Houston reveals that different brain regions are engaged when processing simple versus complex melodies and sentences. The study used intracranial electrodes to map brain activity during music and language tasks, finding shared temporal lobe activity but distinct sensitivities to melodic and syntactic complexity.
A new study by investigators from the Brigham and Women’s Hospital found that lesions associated with epilepsy are connected to a common brain network, suggesting the brain connections disrupted by the lesions are key. This discovery may have clinical implications for predicting epilepsy risk and targeting treatments.
Researchers analyzed 557 subjects to link genetic variations, brain structure, and behavior to intelligence test performance. They found specific brain areas where gene variations influence brain characteristics, which in turn affect intelligence.
Researchers identified structural changes in the thalamus and strengthened connections with the temporal cortex, enabling visual cortex activation through non-visual stimuli.
A team from McGill University has created a database called neuromaps, which combines over 40 existing brain maps to help scientists find correlations between patterns across different brain regions. The tool provides standardized space to view and compare each map, improving reproducibility of results.
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The CMU Array, a new microelectrode array, offers customized treatments for neurological disorders by allowing for three-dimensional sampling and ultra-high-density configurations. This technology has the potential to transform how doctors treat conditions like epilepsy and limb function loss.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers at the University of Rochester Medical Center used fMRI to study how the brain processes complex audiovisual speech. The study found that watching a narrator tell a story activates an extensive network of brain regions involved in sensory processing and cognitive functions associated with comprehension. This finding has pot...