Articles tagged with Synaptic Plasticity
A new study reveals that astrocytes actively participate in motor-learning circuit rewiring by eliminating synapses in the striatum. The research identifies MEGF10 as a key molecular mediator of this process, which is regulated by dopamine signaling and neural activity.
Researchers at the University of Iowa Health Care identified acetazolamide as a potential target for preventing opioid use disorder relapse. The study found that blocking the activity of brain enzyme carbonic anhydrase 4 boosted acid-sensing ion channels, reducing drug-seeking behavior and relapse in mice.
Researchers developed a new tool to track changes in the synaptic proteome over time, correlating changes to synaptic dysregulation and synapse loss. The results suggest that toxic tau oligomers impact postsynaptic structures first, leading to a dynamic cascade of events that contribute to neurodegeneration.
Scientists at Salk Institute find protein CCN1, secreted by astrocytes, maintains stable neural circuits in adult brains. The discovery could lead to new therapeutics for brain injury and stroke.
Researchers discovered that vertebrate lonesome kinase (VLK) triggers direct extracellular interaction for phosphorylation, mediating injury-induced pain. This process attracts N-methyl-D-aspartate (NMDA) receptor proteins, strengthening synaptic connections and enhancing postsynaptic potentials.
A new review from the University of Victoria suggests that psilocybin and 5-MeO-DMT may help treat concussions and traumatic brain injuries by increasing neuroplasticity and reducing inflammation. The compounds have shown promise in treating depression, anxiety, and other conditions in clinical research.
A study by NYU Abu Dhabi researchers has found a key mechanism that shapes brain development and how it may be disrupted in autism and schizophrenia. The research reveals the role of m6A methylation in regulating protein production in growing neurons.
Researchers have discovered that the brain uses separate synaptic transmission sites to regulate spontaneous and evoked activity, a process essential for learning, memory, and mental health. This dual system enables the brain to maintain stability while adapting and learning.
Ion channels can 'remember' previous signals, leading to changes in the receiving neuron that last for hours or days. This collective memory can accumulate over time, reducing communication between neurons and contributing to lifelong learning.
Researchers at the University of California San Diego have made a groundbreaking discovery about how our brains learn new information. Using sophisticated imaging techniques, they found that individual neurons follow multiple rules during learning, rather than one set of uniform rules as previously thought. This new understanding has s...
Researchers have developed a new way to map how individual connections between neurons change across the entire brain during learning. The method, DELTA, provides a brain-wide map of how individual synaptic proteins change over time, allowing scientists to understand how synaptic connections change and pinpoint areas of the brain impor...
A new study from the University of Chicago suggests that patterns of activity in the brain continually reshape memories, even after learning has occurred. Researchers found that behavioral timescale synaptic plasticity (BTSP) is a key driver of this process, explaining the dynamic shifting of place cells in the hippocampus.
Researchers found that Copia's capsid plays a crucial role in controlling structural synaptic plasticity at the Drosophila neuromuscular junction. The study suggests that this parasitic genome element influences neuronal communication and behavior.
Researchers have uncovered a mitochondrial process that supports brain cells critical for learning, memory, and social recognition. The study reveals the critical role of the mitochondrial calcium uniporter in enabling neurons to strengthen connections through synaptic plasticity.
Researchers at the University of Arizona have made groundbreaking discoveries about levodopa-induced dyskinesia, a common complication in Parkinson's disease patients. The study found that the motor cortex becomes disconnected during dyskinetic episodes, leading to indirect causation rather than direct involvement.
Dr. Gail Cornwall is investigating the structure of the brain extracellular matrix, a network of proteins and polysaccharides found in the space between neurons and glia. Her research aims to identify novel structural elements and mechanisms that enable brain plasticity and sex-specific responses.
A new study mapped genes linked to schizophrenia and uncovered a mechanism disrupting synaptic plasticity in affected individuals. The researchers identified three proteins mediating impairments of plasticity, holding promise for new treatments.
A recent study suggests that synaptic plasticity is a collective action, where the behavior of one synapse influences others. The researchers found that strong competition among neighboring spines affects their dynamics and influences the direction and extent of plasticity. Understanding how neurons manage synaptic resources may contri...
Researchers uncover the importance of kainate receptors in enabling synaptic plasticity and transmission in the cerebellum. The study's findings have significant implications for understanding neurological disorders and developing new treatments.
Researchers found a significant reduction in serine racemase protein levels in the medial prefrontal cortex and hippocampal subfields of aged rats compared to young rats, suggesting a role in age-associated decline of NMDA receptor function. No sex differences were observed in serine racemase expression.
A new microscopy system called mosTF enables fast and clear imaging of the living brain, improving tracking of rapid changes in neural circuit structure. The system outperforms traditional two-photon microscopy methods by eight times speed and four-fold signal clarity.
Salk scientists develop new method to quantify synaptic features, revealing high precision of plasticity and up to 10 times more storage capacity. The technique uses information theory to analyze synapse pairs from a rat hippocampus, offering a scalable approach for studying brain function.
Researchers discover a new mechanism of neural plasticity underlying learning and memory processes, highlighting the crucial role of chondroitin sulfates in brain function. The study provides insights into how these molecules contribute to synaptic modifications and spatial memory.
Researchers focused on measuring information transfer in biological neurons, simulated neurons, and electronic neuromorphic systems. The team demonstrated that it is possible to transform biological circuits into electronic circuits while maintaining the amount of information transferred.
Researchers at University of Cologne's CECAD Cluster of Excellence discovered that mitochondrial fusion boosts new neuron plasticity. The study found that as new neurons mature, their mitochondria fuse to acquire elongated shapes, sustaining synaptic plasticity and refining brain circuits.
Researchers at Kobe University identified differences in synaptic protein production between mice and marmosets during development. The study found that these differences may relate to evolutionary differences between rodent and primate brains, as well as their relevance to autism spectrum disorders.
A new study suggests that mushroom extract containing psilocybin demonstrates superior efficacy in stimulating neuroplasticity and promoting new connections between nerve cells. The research found that the extract had a more potent and prolonged impact on synaptic plasticity compared to chemically synthesized psilocybin.
The Kobe University discovery identifies a new key player for synaptic function, revealing that the poorly characterized protein FAM81A interacts with at least three major postsynaptic proteins and modulates their condensation. The absence of this protein leads to a significant decrease in activity in cultured neurons.
Researchers at Buck Institute for Research on Aging propose an alternate strategy for reversing memory problems in Alzheimer's disease by targeting the KIBRA protein. The findings suggest that KIBRA can rescue mechanisms that promote synapse resilience, potentially leading to improved memory function.
Researchers found a significant connection between anxiety disorders and the brain receptor TACR3, as well as low testosterone levels. Testing showed that inhibiting TACR3 resulted in increased receptors on the cell surface, blocking long-term synaptic strengthening.
Researchers found that combined use of alcohol and THC affects the prefrontal cortex, impairing synaptic plasticity in rats. The effects were more pronounced in females and were likely due to changes in gamma-aminobutyric acid signaling.
A small molecule called YM022 has been discovered to block aversive memory formation in mice, offering a new direction for developing anti-depressants. The study found that YM022 suppressed neuroplasticity-caused aversive memory formation and reduced depressive behaviors in mice.
Acute sleep loss in mice increases dopamine release and enhances synaptic plasticity, leading to a rapid reversal of depression for several days. The prefrontal cortex plays a crucial role in this process, with neurons forming tiny protrusions that change in response to brain activity.
Researchers have identified a gene called LHPP that interacts with stress to mediate aspects of treatment-resistant MDD in an animal model. Increased expression of LHPP aggravated depression-like behaviors by dephosphorylating two protein kinases, CaMKIIα and ERK.
Researchers developed a novel photonic processor with adaptive neural connectivity, allowing for the creation of complex artificial neural networks. The system utilizes waveguide-coupled phase-change material to create almost 8,400 optical neurons that can adapt their connections through synaptic and structural plasticity.
Researchers used a mathematical theory called the free energy principle to predict how real neural networks learn and organize themselves. The study successfully mimicked this process in rat embryo neurons grown in a culture dish, demonstrating the principle's guiding force behind biological neural network learning.
Research reveals a local mechanism in neurons that enables insulin-like growth factors to facilitate brain plasticity. IGF release is necessary for activating the IGF1-Receptor during synaptic plasticity, leading to neuron growth and strengthening.
Researchers at MPFI discovered Protein Kinase C delta's (PKCd) role in regulating cell-wide gene expression through synaptic plasticity. The study found that PKCd activates biochemical reactions that spread throughout the neuron, influencing gene transcription and memory formation.
Researchers discovered that adult and aged mice demonstrated improved performance in behavioral tasks after environmental enrichment, with MSK1 playing a vital role. The study highlights the importance of MSK1 in converting positive experiences into cognitive benefits across the lifespan.
A study published in Brain Behavior and Immunity found autoantibodies against a synaptic adhesion protein, neurexin 1α, in patients with schizophrenia. In mice, these autoantibodies caused schizophrenia-related changes, including reduced social behavior and cognitive function.
Researchers uncover a pathophysiological mechanism that initiates and sustains neuropathic pain in mice, identifying Tiam1 as a potential therapeutic target. Targeting spinal Tiam1 with antisense oligonucleotides alleviates neuropathic pain hypersensitivity, offering promise for treating chronic pain.
Researchers found that enhancing NMDAR function via increased serine racemase expression improved attention and cognitive flexibility in middle-aged rats. Upregulating serine racemase in the medial prefrontal cortex also increased glutamatergic synaptic transmission, including NMDAR activity.
Researchers from Doshisha University found that the hypothalamus's supramammillary nucleus can induce long-term potentiation in hippocampal dentate gyrus synapses through glutamatergic transmission. This type of synaptic plasticity, known as associative LTP, strengthens connections between neurons and is crucial for learning and memory.
Researchers have uncovered the underlying mechanism driving depressive systems in chronic pain, identifying a potential therapeutic target for treatment. Tiam1 protein modulates neural connections, leading to hypersensitivity and depression; ketamine blocks this effect, alleviating symptoms.
Researchers at MIT's Picower Institute found that the brain stores information in working memory by making short-lived changes in neural connections, contradicting the traditional idea of sustained neuronal activity. This new insight sheds light on the sophisticated flexibility of thought and its dynamic nature.
Research suggests exercise-induced activation of peripheral systems, such as muscle, gut, and liver, may affect neural plasticity and cognitive health. Circulating cathepsin B (CTSB) and brain-derived neurotrophic factor (BNDF) have been found to possess robust neuroprotective effects.
Researchers at UCalgary have shown that the antibiotic D-Cycloserine (DCS) increases the effectiveness of transcranial magnetic stimulation (TMS) for people with major depressive disorder. The combination treatment showed significant benefits, including improved depressive symptoms and anxiety levels.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers identified critical period plasticity in the amygdala that can be treated with therapeutic intervention at key developmental time points. Early pharmacological intervention was shown effective in reducing fear-learning in the mouse model.
Research finds that a single dose of alcohol permanently changes brain structure and function, leading to increased risk of addiction. The study used fruit flies and mice models to show that ethanol-induced changes in mitochondrial dynamics and synapse balance contribute to long-lasting behavioral changes.
A new study has partly restored the function of retina's cone receptors in two completely colorblind children using gene therapy. The treatment has been shown to activate previously dormant communication pathways between the retina and brain, drawing on the plastic nature of the developing adolescent brain.
A study from Japan's University of Tokyo reveals that users can form a strong sense of ownership with virtual robotic arms, expanding their perceived personal space. The research aims to inform the design of real-life supernumerary robotic limb systems that people can use naturally.
Researchers found that lab zebrafish have lost physiological plasticity, a characteristic that allows organisms to adjust to different environments, over time. This loss affects their ability to perform consistently across a wide range of temperatures, highlighting the costs of domestication.
A team from the University of Wisconsin-Madison found no significant differences in structural brain changes between participants who received short-term mindfulness training and those who did not. Despite this, participants reported increased mindfulness, suggesting that benefits may be related to wellness interventions more broadly.
A new neuromorphic memory device simulates both neurons and synapses in a single unit cell, enabling the development of brain-like artificial intelligence. This breakthrough achieves synergistic interactions between neurons and synapses, overcoming current limitations in neuromorphic computing.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Scientists at the University of Oxford have developed an 'optomemristor' device that facilitates three-factor learning and emulation of biological computations, making it possible to perform complex machine learning tasks. The device uses both light and electrical signals to interact and consume very little energy.
Researchers found high levels of an enzyme called HDAC9 in healthy neurons, which decline with age and more drastically with Alzheimer's. The study suggests adjusting the enzyme's level may be a potential treatment for both conditions.
Researchers found that NYX-783, a newly discovered drug, modulates NMDA receptor activity in neurons to suppress traumatic memories and spontaneous recovery of PTSD. The drug was effective in reducing fear responses and improving treatment outcomes, particularly in female mice.
Research at Clemson University reveals that flowers use UV-absorbing chemicals to create a 'bulls-eye' effect for pollinating insects, aiding survival. Plants adapt to different environments by producing varying amounts of UV-blocking or absorbing chemicals.