Articles tagged with Organ Cultures
A new study replicated patient- and sex-specific hallmarks of Inflammatory Bowel Disease (IBD) in a human organ chip, identifying stromal fibroblasts as key drivers of inflammation, fibrosis, and enhanced cancer risk. The model also recapitulated the impact of pregnancy hormones on IBD severity in female patients.
Researchers developed mosaic mini-brains to study focal cortical dysplasia type II, a condition causing seizures in children. The findings support the two-hit model, suggesting that complete loss of DEPDC5 is necessary and sufficient to initiate the disease, with mosaicism determining lesion extent.
Researchers at King's College London have developed a new brain organoid system that reduces variability and allows for longer-term recordings of neural activity. The approach enables the simultaneous study of multiple parallel cultures, providing a better understanding of how drugs or gene variants affect neural networks.
Researchers developed an advanced organoid model for human spinal cord injury and tested a promising regenerative therapy. The treatment triggered neurite growth and reduced scarring in injured organoids, offering validation for its potential to work in humans.
Researchers created pea-sized mini-stomachs with three main regions, replicating human stomach function and acid secretion. The study models a rare genetic disease, paving the way for personalized treatment and accelerated clinical approval.
Researchers developed a new human brain tissue platform called miBrains, integrating all major brain cell types and modeling brain structures, cellular interactions, activity, and pathological features. The models can be customized through gene editing and are derived from individual patients' genomes.
Using embryoid models made of stem cells, researchers uncovered important processes mimicking the first moments of human development. The team applied AI neural networks to thousands of images collected with confocal fluorescent microscopy to detect features and protein marker expression data.
The team will study neurons within a brain organoid, a millimeter-sized, three-dimensional structure grown in the lab from adult stem cells, to design smarter and more sustainable artificial intelligence. They aim to replicate complex computations that occur in the human brain to improve AI efficiency.
The new book explores organoid bioengineering, using pluripotent and adult stem cells to create models for various organs. It discusses breakthroughs in personalized cancer care and large-scale production protocols supported by advanced tools like 3D printing and genome editing.
Recent advances in biofabrication and biomedical electronics have led to the development of biohybrid-engineered tissue (BHET) platforms, turning passive constructs into intelligent systems. These platforms show promise in diverse applications, including brain organoids and cardiac tissues, blurring the line between biology and machine.
A new framework outlines crucial validity standards for stem cell technology to study devastating brain disorders, aiming to translate laboratory discoveries into effective treatments. The framework addresses the critical gap in translating genetic discovery to clinical application.
Researchers at Stanford Medicine successfully grew heart and liver organoids with integrated blood vessels, allowing them to overcome the current size limit. These vascularized organoids can grow larger and reach a more mature state, making them more useful as biological models for research and potential treatment of various diseases.
A new organoid model reconstructs the liver periportal region and models aspects of cholestatic liver injury and biliary fibrosis. The model combines different cells assembled together in a stepwise process, enabling the study of molecular and cellular mechanisms of liver disease.
Scientists have created a comprehensive bat organoid model to study zoonotic viruses, enabling early detection and drug testing for future outbreaks. The platform, comprising diverse bat species and organs, has led to breakthroughs in understanding virus behavior, isolation, and treatment.
The University of Texas at Arlington's 23 patents granted in 2024 helped boost the UT System's position among the nation's top innovators in patent technology. The UT System ranks No. 3 in the National Academy of Inventors' prestigious top 100 ranking.
The American Heart Association will strengthen and expand Hawaii's stroke system of care, reducing death and disability rates from stroke in rural populations. The initiative aims to enhance coordination among emergency responders, hospitals, and healthcare providers.
A professor is conducting a study to increase forest farming in Appalachia, with the goal of creating a sustainable economy for the region. The project aims to develop the workforce and formalize businesses to ensure efficient supply chains.
Researchers found that pancreatic cancer cells gain a survival edge by carrying copies of critical cancer genes on circular pieces of DNA outside chromosomes. The discovery highlights the importance of targeting extrachromosomal DNA in treating the disease.
CerTracker LLC, a digital credential management platform, aims to streamline compliance and onboarding for healthcare professionals. The company will use the $10,000 grant to reduce administrative burdens and improve workforce efficiency in healthcare settings.
Researchers have uncovered clay tablets with ancient cuneiform writing, game boards, and large structural remains at the ancient Mesopotamian site of Kurd Qaburstan in Iraq. The study sheds new light on literacy, urban development, and social inequality in this Middle Bronze Age city.
Researchers created digital reconstructions of Aztec death whistles and found they produce unique air turbulence, creating a chilling sound. Listeners perceived the whistle's sound as natural and organic, similar to human voices or screams, suggesting a symbolic association with mythological entities.
Researchers developed a novel neural network model to reconstruct 3D digital images of relief-type cultural heritage objects from old photos. The model improves the accuracy of depth estimation and soft-edge detection, enhancing the preservation of cultural heritage.
Researchers develop a novel edge-highlighting visualization technique to improve the clarity of complex 3D structures, revealing sharp edges and intricate details. The technique, tested on real 3D point cloud data, offers interactive rendering speeds and enhances depth perception.
The National Endowment for the Humanities has awarded a Preservation Assistance Grant to Texas A&M University's Anthropology Research Collections. The grant will help protect and improve access to the university's anthropological and archaeological materials, while also providing new learning opportunities for graduate students.
Researchers will classify autism types, identify responsible genes, and develop precision therapy for autistic patients. The team will employ neural organoids derived from diverse brain samples to accelerate autism research.
The Centre for Research and Innovation for Black Survivors of Homicide Victims argues that the prevalence of homicide grief in Black communities is a pandemic. The researchers recommend strategies such as promoting research, enhancing early detection, and improving culturally responsive support services to address this issue.
A team of researchers led by Associate Professor Ken Natsuga found that cell-cell adhesion governs pattern formation in keratinocytes. Starvation also plays a crucial role in the formation of these patterns, which are influenced by cell proliferation and differentiation.
A team of scientists created a new method to 3D print vascular networks that mimic naturally occurring blood vessels. After perfusion, the printed biomimetic vessels displayed healthy and functional heart tissue responses, including synchronization with cardiac drugs.
Scientists have developed mini-colon tissues that can simulate the complex process of tumorigenesis outside the body with high fidelity. These miniature organs mimic the physical structure and cellular diversity of colon tissue, allowing researchers to study colorectal cancer development and test potential therapies.
A quasi-experimental study of 35 health care facilities found chlorhexidine bathing and nasal decolonization to be effective in reducing multidrug-resistant organism prevalence. The interventions also led to decreased infection-related hospitalizations, costs, and deaths among nursing home residents.
A study by Incheon National University researcher finds that job autonomy alone is not enough for public servants to engage in proactive change-oriented behavior. The study identifies factors over which public managers have control, including information, norms, incentives, and human relationships, as levers to encourage change.
A novel score, the Phoenix Sepsis Score, predicts mortality in children with suspected or confirmed infection. The new criteria outperform existing organ dysfunction scores and International Pediatric Sepsis Consensus Conference criteria
A study by Waseda University explores the effects of different vascularization strategies on brain organoids, improving cell differentiation and transcriptome profiles. Vascularized cerebral organoids exhibit a gene expression profile closer to fetal human brains than non-vascularized ones.
A novel contamination-detection method enables faster and safer T-cell therapy production, reducing the risk for patients and speeding up treatment. The method uses cutting-edge technology to identify harmful microorganisms within 24 hours.
Researchers developed a photoelectrochemical technique to precisely tune the lasing wavelength of microdisk lasers with subnanometric accuracy. The new approach facilitates the fabrication of micro- and nano-laser batches with precise emission wavelengths.
A study by Texas A&M University found that pregaming is linked to unsafe alcohol use and other risky behaviors among college students. Pregaming was associated with a two-day increase in alcohol use frequency and was found to be around 2.5 times more likely to lead to cannabis or other drug use.
Researchers at TUM have developed a method to create mini-hearts in Petri dishes using stem cells. The resulting organoids mimic the earliest stages of human heart development and can be used to investigate congenital heart defects, potentially leading to new treatment methods.
A study found that gestational iron deficiency may contribute to cognitive impairments like autism, ADHD, and learning disabilities. Researchers identified a specific embryonic neuronal progenitor cell target for GID, which disrupts interneuron development.
Researchers highlight recent progress in organotypic models, which offer a balance between the accessibility and control of in vitro context. These models have been used to study various aging-related phenotypes, including skin, gut, and skeletal muscle, providing valuable insights into the underlying mechanisms.
Researchers from Tokyo Medical and Dental University developed a new approach to grow human intestinal mini-organs in the lab. They used cell culture plates and bioreactors to create robust and healthy intestine-like tissues that can be transplanted into mice, demonstrating the potential for regenerative medicine applications.
A team of engineers at UC Santa Cruz has developed an automated system for growing cerebral organoids, miniature models of brain tissue grown from stem cells. The new method, called Autoculture, precisely delivers nutrients to individual organoids, optimizing growth and reducing cellular stress.
A team of researchers at Georgia Tech has developed a custom-built microscope that can reconstruct comprehensive 3D representations with a single camera image. This allows for quantitative analysis of organoids and provides insights into tissue development, drug interaction, and cellular behavior.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
Researchers at Harvard's Wyss Institute create functional lymphoid follicles on a chip, replicating human immune responses and predicting vaccine efficacy. The discovery offers a new tool to model the complex choreography of human immune responses to infection and vaccination.
Researchers developed a low-cost 3D-printed microfluidic bioreactor for real-time observation of growing organoids. The device reduced cell death and improved tissue development, enabling seven-day observations of brain organoids.
Corning Life Sciences is sharing its latest 3D cell culture technologies at SLAS2021 to support critical research in the industry. The company's new products, including Matrigel matrix-3D plates and Corning Elplasia plates, feature microcavity technology for high-volume spheroid production and enable rapid imaging of 3D cultures.
The study proposes three strategies to develop higher-level and unique human capital: identifying the right set of skills, promoting a training culture that enables employees to update competencies, and involving people in work-related decisions. This approach helps organizations adapt to change and stay ahead of competitors.
Research aims to examine impact of organisational cultural tightness on employee creativity and firm innovation in Asia. Tight cultures may hinder certain aspects but potentially foster other creative aspects.
Researchers emphasize the positive impact of culture and arts on health, citing World Health Organization benefits like social influence, children's development, and mental health support. Integrating art into healthcare services can promote more ethical care and improve trust among staff.
A new paper by Berkeley Haas Prof. Jennifer Chatman and colleagues shows narcissistic leaders 'infect' their organizations' cultures, leading to decreased collaboration and integrity. The researchers reveal how narcissists create lasting damage on employee morale and performance.
Researchers found that informal knowledge exchanges are more valuable than formal learning in healthcare settings, leading to a faster and more equal response to crises like the COVID-19 pandemic. This suggests that organizations should prioritize equality among staff and foster dialogue and participation.
A study finds that music samples evoke similar feelings in both Chinese and US participants, suggesting that specific emotions are more universal than broader evaluations. The research suggests that cultural differences may not be as significant in subjective experiences associated with music.
A global study found that satisfaction is the most popular metric for marketing decisions worldwide. The study analyzed over 4,000 marketing plans from 1,600 companies across 16 countries, revealing a significant relationship between total metric use and marketing performance.
The medical profession is plagued by bullying, harassment, and discrimination, which can negatively affect health and career pathways. Implementing measures of professionalism in review processes and creating safe reporting mechanisms are crucial steps towards addressing unprofessional behavior.
Researchers identified six factors associated with inclusion in healthcare organizations, highlighting the importance of creating a sense of belonging and recognition among employees. The study's findings have implications for reducing care disparities and improving cultural competencies.
A study of 1,916 employees found that those who integrated work into their personal life were more exhausted and had a lower sense of balance and well-being. Employees who did not separate work from free time reported fewer recovery activities and experienced greater exhaustion.
Scientists at the University of Cambridge have successfully grown miniature functional models of the womb lining in culture, providing a major step forward in understanding the changes that occur during the menstrual cycle and early pregnancy. The findings may lead to new insights into endometriosis and fertility treatments.
New research from the University of Missouri found that high attendance numbers at arts nonprofit events lead to fewer donations. This contradicts philanthropic culture's emphasis on accountability and success measures.
A study by researchers at Georgia State University found that firms perform better when CEO leadership style differs from the organization's culture. CEOs who adopt a similar style as the culture have a negative impact on performance. Instead, companies benefit from having different leadership and cultural styles.
Scientists at Osaka University successfully reproduced long-lasting effects of stress on memory by using organotypic slice cultures. Stress interferes with memory consolidation, leading to formation inhibition.