Articles tagged with Mass Spectrometry
Researchers developed a mass spectrometry method to analyze tissue during brain tumor surgery, distinguishing glioma from non-tumor tissue with high confidence. The method, which takes roughly three minutes, provides actionable molecular information during surgery, potentially guiding treatment decisions and improving patient outcomes.
Researchers developed a non-invasive method to detect Meniere's disease using mass spectrometry on earwax samples, providing a rapid and cost-effective solution for diagnosis. The technology offers enhanced diagnostic accuracy and opens new avenues for monitoring disease progression and response to treatment.
SwRI's Strofio, a neutral mass spectrometer, will sample Mercury's sparse exosphere to measure surface particles. This will provide a global understanding of Mercury's surface composition and space environment, answering scientific questions about its origin story.
A new reference material for angiotensin II testing has been developed to improve comparability and standardization in laboratory results. The material, characterized using two independent approaches, has shown excellent stability and homogeneity, making it a valuable tool for method validation and quality control.
Researchers developed an AI tool, AIMe, to predict and organize small molecule structures, covering over 100 million compounds. The tool, called DeepMS2Reasoner, uses neuro-symbolic AI to simulate molecule fragmentation, providing interpretable outputs and accelerating hypothesis generation.
Researchers have developed a new method to collect and study salmon lice secretions, allowing for the examination of individual lice and reducing faecal contamination. The study found 148 secretory proteins, 64 of which were detected in each tested condition, potentially representing targets for vaccine development.
A research team has developed a reliable and economical method for studying proteins with sugar molecules attached to them in blood and tissue samples. The method uses commercially available magnetic particles and has the potential to aid in disease diagnosis and treatment.
A new international review standardizes selenosugar nomenclature and selenium metabolism, providing a harmonized operational framework for researchers. The proposed system offers concise and intuitive names, minimizing ambiguity and promoting accurate detection and identification of selenosugars.
New Purdue research improves air quality forecasting by understanding how organic aerosol molecules interact and affect evaporation rates. The team discovered that neighboring molecules in aerosol mixtures tend to
The new Wiley Registry/NIST Mass Spectral Library expands coverage to over 1.2 million spectra, enhancing the analysis of unknown chemical compounds in GC-MS workflows. This combined resource delivers high-confidence identification capabilities for leading laboratories worldwide.
University of Warwick researchers and Verdel Instruments have successfully demonstrated two-dimensional mass spectrometry on a benchtop instrument, making this powerful technique accessible for everyday laboratory use. The Q-2DMS method preserves up to tenfold more usable spectral information when analyzing closely related or near-isob...
A new approach combines AI with high-resolution mass spectrometry and toxicology databases to predict biological effects of environmental chemicals. This framework helps researchers prioritize candidates for laboratory testing and health risk assessment.
A comprehensive review in Biomedical Analysis assesses the current state and future of direct mass spectrometry for quality control, safety, and authentication of herbal medicines. The technology offers a dynamic way to ensure the safety and proper processing of potent herbal medicines by monitoring toxic compounds in real-time.
The NIST/EPA/NIH EI Mass Spectral Library 2026 and NIST MS/MS Spectral Library 2026 are now available in various formats, providing expanded GC-MS and LC-MS coverage for laboratories to analyze mass spectra with high confidence. These libraries support evolving analytical workflow needs and deliver broader coverage and flexibility.
Researchers at Texas A&M University develop a laser technique called TRIP to directly measure quantum forces shaping proteins, enabling accurate prediction of how pharmaceutical drugs interact with them. This breakthrough could lead to the design of medicines tailored to specific diseases, revolutionizing precision medicine.
Researchers at Purdue University have developed a next-generation technology platform designed to dramatically accelerate one of the slowest stages of cancer drug discovery. The platform combines chemical synthesis, biological testing, and mass spectrometry into a single integrated workflow, allowing researchers to generate, evaluate, ...
A new chemical tagging approach has been developed to accurately sequence short peptides without relying on databases, opening possibilities for food science, nutrition, and biomedical research. The method successfully identified all 132 peptides with zero errors, highlighting its accuracy and reliability.
Researchers have captured the most detailed structural images to date of a specific type of protein's DNA repair process, revealing key steps in its repair activities. The findings provide insights for drug targets that could halt the process in cancer cells empowered by mutated BRCA genes.
Researchers at Tohoku University discovered a hidden mechanism in DNA damage caused by singlet oxygen generating abasic sites. This process is common and represents one of the main forms of DNA damage, alongside guanine-related types.
Scientists developed a high-spatial-resolution mass spectrometry imaging method to study lipid metabolism heterogeneity during drug-induced cell apoptosis at the single-cell level. The method achieved a spatial resolution of approximately 800 nm, allowing researchers to profile alterations in the cell membrane microenvironment and meta...
The 2026 release expands coverage of emerging novel psychoactive substances, including synthetic cannabinoids, fentanyl analogs, and pharmaceutical drugs. The database provides comprehensive and up-to-date support for forensic, toxicology, and drug surveillance workflows.
A University of Houston optometry researcher warns of the dangers of red-light laser myopia therapy for children, citing vision damage reports and the need for rigorous safety validation. The professor's quality improvement study found that two popular devices exceeded national standards for safety classifications.
Researchers found a significant decrease in lead concentrations in hair samples from Utahns, spanning over 100 years. The study demonstrates the impact of environmental regulations on public health and highlights the importance of protecting against toxic metals like lead.
Researchers at Boston Children's Hospital have developed a novel mass spectrometry tool called FLEXITau to analyze brain tissue from 203 patients with various tauopathies. The study identified 145 post-translational modifications and 195 cleavage sites across tau, providing a precise molecular roadmap for diagnostics and drug development.
A new study from Harvard found that North Atlantic pilot whales have 60% lower concentrations of per- and polyfluoroalkyl substances (PFAS) in their bodies since the phaseout of these chemicals. The researchers measured bulk organofluorine levels as a proxy for total PFAS concentrations, including newer types of PFAS.
Researchers found viable spores of mycotoxigenic fungi, DNA fragments, and traces of toxins remained after gamma irradiation, highlighting the need for stricter testing and better safeguards in the cannabis industry. This is particularly concerning for immunocompromised individuals who may be at higher risk.
Researchers at Cold Spring Harbor Laboratory have developed a new technique to improve mass spectrometry, enabling better drug target discovery and tumor analysis. The innovation increases sensitivity by breaking down scans into smaller bins, allowing for more accurate measurement of differences in concentration.
A new online tool has been developed to detect drug exposure directly from patient samples, revealing a more accurate picture of what drugs are in a person's body than what is listed on their medical record. The tool uses a publicly-available library of chemical fingerprints from thousands of drugs and their breakdown products.
The ACRF MATRIX Centre will enable researchers to study cancer cells and their surrounding environment with unprecedented molecular resolution. This will help develop combination therapies targeting both cancer cells and the microenvironment.
Wiley has expanded its spectral libraries with major updates to IR, Raman, and LC-MS collections, delivering researchers enhanced capabilities for faster and more confident compound identification. The expansion brings over 9.5 million high-quality spectra, including 1 million IR spectra and 161,000 Raman spectra.
The study reveals a temperature-dependent mechanism evolution effect on RhRu3Ox catalysts, leading to more stable oxygen evolution reactions. The researchers demonstrate that the catalyst remains stable for over 1000 hours at room temperature, paving the way for efficient and durable electrochemical devices.
A new approach allows scientists to directly correlate gene expression with metabolite abundance, enabling the elucidation of complex plant natural product biosynthetic pathways. This method can help identify specialized cell types involved in producing therapeutically relevant chemical compounds.
A research team at the University of Münster has developed a new measurement method that combines fluorescence microscopy with MALDI mass spectrometry imaging, revealing metabolic differences in tumors. This allows for faster and more precise diagnoses and targeted therapies.
Saiful Chowdhury's five-year project aims to create a blueprint of how immune proteins work, which could lead to new medical treatments for cancer and inflammatory diseases. The team will use advanced proteomics technologies to map protein interactions and modifications.
Researchers at IOCB Prague have developed a comprehensive data set called MSⁿLib, which contains millions of records on small molecules. This opens up new possibilities for faster drug discovery, environmental monitoring, and advances in artificial intelligence.
The Blavatnik Regional Awards recognize exceptional postdoctoral researchers in Life Sciences, Physical Sciences & Engineering, and Chemical Sciences. Veena Padmanaban, Valentin Crépel, and Xiao Xie are this year's winners, honored for groundbreaking discoveries in cancer cell biology, condensed matter physics, and chemical biology tools.
KnowItAll 2026 introduces Trendfinder, a tool that brings Principal Component Analysis (PCA) into the KnowItAll environment, enabling simplified chemometric analysis. The new application also enhances LC-MS and NMR capabilities, providing users with advanced analytical capabilities.
The new AEC-MS protocol provides comprehensive analysis of highly polar and ionic metabolites, improving molecular specificity and selectivity. This innovation has led to new applications in metabolomics, including studies on gut microbiome metabolism and energy substrate utilization.
Researchers developed a new microfluidic method to preserve worm anatomy, linking lipid signals with body structure using mass spectrometry imaging. They identified several lipids clustering in distinct anatomical regions, providing insight into how fat molecules are organized and function across the worm.
An international team of researchers established standardized guidelines for analyzing oxylipins, bioactive lipids related to inflammation and disease. The guidelines aim to improve reproducibility in laboratories and facilitate the transfer of scientific discoveries to clinical practice.
Researchers at UC San Diego developed a computational method to determine omega positions of lipids in complex biological samples. This breakthrough makes omega position information accessible even for lipids in low concentrations, significantly advancing lipid research.
Researchers have identified a previously undocumented class of PFAS in the blubber of killer whales, accumulating in fat-rich blubber. This discovery challenges the long-held assumption that PFAS primarily bind to proteins and accumulate in liver or blood.
Researchers at the University of Graz and the University of California, San Diego have developed a novel method to determine omega positions of lipids in complex biological samples. This breakthrough enables the study of biological mechanisms in unprecedented detail, particularly for inflammation-related diseases.
The Wiley Registry has received a significant update with the addition of over 17,500 new spectra. The collection now boasts a total of 913,000 high-quality mass spectral data points. These updates enhance the database's comprehensive coverage and reliability, benefiting researchers in various fields.
Researchers have made a breakthrough in understanding the molecular determinants of drug response in cystic fibrosis patients who are resistant to current treatments. By analyzing CFTR mutations, they found that some proteins can be 'corrected' and respond to FDA-approved corrector drugs.
Researchers at University of California San Diego discover itaconate stimulates seedling development, enhancing crop growth and potentially offering a sustainable solution for increasing food production. The study provides new insights into the molecule's role in plant physiology and its connections to animal biology.
A new technology using microscopic beads marked with stable isotopes enables the simultaneous detection of dozens of different antibodies in hundreds of samples. This expands the capacity of serological analysis for biomedical research, vaccine development, and epidemiological studies.
Researchers developed a technique to separate and quantify ions, nanoparticles, and aggregates in nanomedicines, improving quality control for advanced pharmaceutical products. This method ensures the safe use of metal-based nanomedicines by distinguishing between their different forms.
Researchers developed a machine learning model called DreaMS to analyze previously unknown molecules. The model significantly accelerates the analysis and uncovers unexpected chemical similarities between substances.
New research finds megalodon preyed upon a variety of species, including fish, sharks, and even crustaceans, contrary to the long-held belief that it targeted large marine mammals. The discovery was made by analyzing zinc isotopes in fossilized teeth, providing insights into the prehistoric shark's ecological versatility.
Researchers identified the earliest known use of Peganum harmala, a medicinal and psychoactive plant, in fumigation practices and inhalation nearly 2,700 years ago. The study reveals ancient Arabian therapeutic and sensorial practices using native plants for bioactive and psychoactive properties.
Researchers have developed a new method that uses expansion microscopy to overcome the spatial resolution problem in mass spectrometry imaging. This allows scientists to detect hundreds of biomolecules at the single cell level in their native locations, enabling better understanding of their functions and interactions.
Researchers use a new pipeline to make genetically engineered plants with improved oil production, reducing labor and time in the process. The FAST-PB platform integrates automation and single-cell lipidomics to accelerate plant transformation.
Researchers found a high-velocity star ejected from a globular cluster at an extreme velocity of nearly 550 km/s, suggesting the presence of an intermediate-mass black hole. The star's similarities with the cluster's chemical composition and age provide strong evidence for the IMBH's existence.
Scientists successfully identified fossil filaments of sulfur-oxidizing bacteria in gypsum samples from Algeria, providing a methodological framework for detecting biosignatures in Martian sulfate minerals. This technology could be integrated into future Mars rovers or landers.
A new method called periodic cooking optimally cooks both the yolk and white of a boiled egg, resulting in an evenly-cooked egg with higher nutritional content. The approach involves alternating the egg between boiling water and a cooler temperature, yielding soft yolks similar to sous vide eggs.
A recent study published by researchers at the University of Liverpool has confirmed that Mesozoic fossils, including dinosaur bones and teeth, still preserve their original organic materials. The team used advanced mass spectrometry techniques to identify preserved collagen remnants in a well-preserved Edmontosaurus fossil.
Researchers utilized muon spin rotation spectroscopy to investigate the regioselective muoniation of peri-trifluoromethylated 12-phosphatetraphene 1, revealing a highly reactive muoniated radical at the phosphorus site. The study provided detailed insights into the structure and dynamics of the radical.
Researchers discovered higher levels of microplastics and nanoplastics in preterm placenta compared to term births. The findings suggest that plastic accumulation may contribute to the risk of preterm birth.
The study identified 105 compounds in Shenqi Fuzheng extract, with organic acids and amino acids showing higher concentrations in the bloodstream. Compounds such as Astragalosides promptly enter the bloodstream within 5 minutes after administration.