A pilot study found that daily blueberry consumption reduced depressive symptoms in older adults, with minor changes in gut microbiome markers. Fiber and anthocyanins in blueberries have potential to modify the gut microbiome and metabolites relevant to depression.
Researchers discovered that moderate-intensity exercise significantly improved cartilage health and tissue resilience in aging-related osteoarthritis. The molecular cargo of extracellular vesicles was found to be enriched with microRNA-29, which restored youthful characteristics in cartilage cells and reduced joint degeneration features.
Research finds accelerated brain aging in uninjured areas after stroke can predict language severity and treatment response. Brain aging patterns measured before treatment predicted improvements in language 6 months after therapy ended in patients who completed speech therapy and brain stimulation.
A study by Penn State researchers found that people who aged faster during midlife were more likely to experience memory lapses a decade later. The study, which analyzed data from 232 individuals, found that those who were aging rapidly were 18% more likely to experience a prospective memory lapse on any given day.
Participants with mild disabilities experienced a $1,177 annual reduction in care costs, compared to non-participants. Community gathering places promote social participation, exercise, and mutual support, contributing to healthy aging and mitigating long-term care costs.
A comprehensive review of the evidence links ultraprocessed foods to poorer cognitive outcomes and increased risk of dementia. The study highlights the need for further research to determine the causal relationship between these foods and brain health.
The Neighborhoods Study, a nationwide NIH-funded research initiative, investigates the relationship between social and environmental factors and Alzheimer's disease risk. Emory Goizueta Brain Health Institute is part of the study, which aims to understand how environmental exposures influence brain health and dementia risk.
A Tulane University study found that loneliness and social isolation can cost people nearly six years of life free from mental disorders like depression and anxiety. The study, published in Nature Communications, also found a smaller but still significant toll on physical health.
A vaccine that could lower the risk of dementia by half for those at high risk has sparked interest among older adults, with nearly 3 in 4 expressing interest in receiving such a vaccine. The survey results highlight a growing interest in vaccines that may prevent or delay dementia, a major concern for aging populations.
The new NCCN Guidelines for Patients with Cancer explain the importance of assessments to tailor cancer care to every person, regardless of age. The guidelines stress the need for support and validation for older adults, who face unique issues such as memory function and treatment interactions with other medications and conditions.
Research challenges traditional views of cognitive decline in aging, highlighting the brain's natural shift towards prioritizing wisdom and understanding over details. This adaptation enables older adults to effectively share accumulated knowledge and social relationships with younger generations.
A new UCLA study has found a connection between brain aging and gut biology, suggesting that people's brains may be aging decades before symptoms appear. The study, published in eBioMedicine, analyzed brain scans and stool samples to identify a link between brain communication patterns, gut bacteria, and brain aging.
A new framework proposes 'movement span' as a third dimension of aging beyond life span and health span. Movement span is defined as the duration of life during which an individual can move with confidence, responsiveness, and adaptive control.
Pennington Biomedical researchers propose a new understanding of how protein restriction promotes healthy aging and extends lifespan by triggering a coordinated whole-body response. The response connects cellular nutrient sensing with hormones, brain function, and changes throughout the body, influencing healthy aging and longevity.
Cedars-Sinai investigators found that blocking PD-L2 protein reduces aging cells and levels of inflammatory substances, improving health in laboratory mice. Human aging cells produce more PD-L2, and levels increase with age, suggesting a potential target for therapies to remove harmful cells and prevent age-related health problems.
Researchers evaluated biological age using six internationally recognized proteomic aging clocks, finding a reduction in predicted biological age among patients treated with rentosertib. The drug also showed promising dose-dependent reversal of Forced Vital Capacity (FVC), a measure of lung function declining with age.
Researchers developed a computational model to study aging in 40 types of human tissue, identifying three major aging patterns and underlying molecular changes. Tissues show bimodal structural aging, with accelerated aging from 35-40 and 55-60, coinciding with fertility decline and menopause.
A recent study from the Dog Aging Project found that dogs with five or more chronic diseases were more than twice as likely to die as dogs living with only one diagnosed condition. Chronic diseases can dramatically shorten a dog's lifespan, highlighting the importance of managing multiple diseases together rather than individually.
A study led by Albert Einstein College of Medicine found that children of centenarians live longer and have lower risks of cardiovascular disease and hypertension. The research, analyzing data from three geographically diverse studies, suggests that inherited biological factors beyond lifestyle contribute to exceptional healthy aging.
Research reveals that increased tau protein levels during aging may contribute to the rise of depressive symptoms. The study, published in JNeurosci, suggests that monitoring depressive trajectories in aging populations could complement other measures to help assess risk for neurodegenerative disease.
Dr. Mina Sedrak has received a $3.6 million NIH grant to develop strategies for improving physical recovery and reducing frailty in older adults after hematopoietic cell transplantation. The grant will support a multisite randomized clinical trial testing the effectiveness of combining exercise with a senolytic therapy in improving phy...
The partnership program combines an MS in Nutrition with a geriatric care-focused dietetic internship, offering a streamlined 21-month path to advanced clinical nutrition training. Students gain supervised practice experience in various care environments, including subacute clinical care, outpatient nutrition, and long-term care.
A new study reveals how memories change with age, with older adults struggling to recall specific details and general knowledge becoming more prominent. The research highlights the importance of understanding how memory evolves over a lifetime, shedding light on how to support healthy cognitive ageing.
Scientists have discovered a new connection between energy-producing mitochondria and chronic inflammation in senescent cells, which promotes age-related diseases. Blocking a related gene and using a drug called CTPI-2 reduced inflammation and promoted healthier aging in mice.
A study published in PLOS Medicine found that socioeconomic inequalities are associated with reduced mobility and function in older adults, with poorer individuals experiencing larger declines in physical abilities. The research highlights the need for policies targeting people with less wealth to reduce health disparities in aging.
The Stein Institute at UC San Diego will serve as the Central Laboratory and Biorepository for the XPRIZE Healthspan Competition. The 10 finalist teams will conduct coordinated clinical trials worldwide to test their treatment approaches, aiming for a decade-long extension of human healthspan.
A cohort study finds that childhood history of maltreatment is associated with increased biological age in late midlife, potentially impacting health outcomes. The study's epigenetic clock analysis sheds light on the long-term effects of early life trauma on aging processes.
A new ACC Scientific Statement highlights the importance of considering cognitive impairment and frailty in cardiovascular care for older adults. The statement outlines practical strategies for prevention, screening, assessment, and management, aiming to improve outcomes such as independence, mobility, and caregiver burden.
Researchers found that exercise-induced molecular changes contribute to neuronal health, improving movement and quality of life in PD patients. Exercise types such as aerobic exercises, resistance training, balance training, and multimodal exercise were found to be helpful in reducing falls, disabilities, and improving brain function.
A cohort study found associations between perinatal factors and changes in brain maturation among adolescents. The study used conditional-longitudinal models to assess individual growth trajectories and mental health symptoms.
The USC Leonard Davis School of Gerontology has received a $7.5 million grant to establish GeroSCORE, a national hub for discovery and collaboration on sex differences in aging. The center will conduct innovative research, develop new tools and analytical methods, and serve as a resource for early-career investigators.
As more Americans with HIV age into Medicare eligibility, costs are expected to increase substantially. The study projects nearly 200,000 beneficiaries by 2035 and $27.3 billion in annual spending. Policy changes like the Inflation Reduction Act could save billions, while generic HIV medications may further reduce costs.
Researchers discovered that depression is associated with a specific area of the hippocampus, independent of Alzheimer's disease risk factors. The study found participants with depression had smaller volumes in the CA23DG region, which plays a crucial role in retrieving memories and distinguishing between similar experiences.
The Boston University-Quantitative Population Science and Healthy Cognitive Aging Research Program (BU-SHARP) aims to better understand how and why Alzheimer's disease manifests among certain populations. The center will fund pilot studies, provide technical assistance, and facilitate access to underutilized datasets.
The LifeAfter90 study found that women 90 and older are at two-fold greater risk for dementia, while Black participants have a 75% greater risk than Asian participants. APOE2's protective effects continue past age 90, reducing risk by 60%, but APOE4 increases the risk among men and Black participants.
A Canadian research team led by Dr. Amanda Grenier is investigating how to address the growing issue of older people falling through the cracks. The AIM BIG initiative will bring together experts, community organizations, and older adults to develop evidence-based resources to support advocacy, decision-making, and service delivery.
Researchers develop first quality-of-life measure specifically designed for Australian aged 65 and over, to improve care and outcomes. The tool will enable consistent monitoring of quality-of-life outcomes across health and aged care settings.
Aging cells become more susceptible to ferroptosis due to elevated levels of acid ceramidase, a previously targeted therapeutic candidate. This vulnerability can be passed to neighboring cells, impacting overall tissue health. The discovery offers new hope for supporting healthy aging and treating age-related diseases.
Researchers found no correlation between SuperAgers' exceptional memory and low inherited Alzheimer's disease risk. Instead, they identified unique biological and psychosocial characteristics associated with SuperAging.
A study published in PLOS Medicine found that people with dementia, mild cognitive impairment, alcohol addiction, or psychiatric disorders like schizophrenia show increased brain aging patterns. The researchers analyzed MRI data from over 45,900 controls and compared them to 2,698 patients with different brain conditions.
Researchers found that females with live offspring had lower late-life frailty, contradicting previous theories on a potential reproductive cost. The study used companion dogs to investigate the relationship between reproduction and aging, revealing a unique link between parity and robustness.
The journal aims to improve understanding of aging to support older adults in aging well. Research articles cover topics such as biological aging, movement behaviors, cognitive functions, and technological advances to enhance aging well.
A new neuroimaging study has identified specific MRI biomarkers that track along with changes in an individual's brain health trajectory over time. These findings demonstrate a holistic, multidimensional index of human performance correlating with physical, measurable changes in brain architecture.
Two Lancet papers call for Japan to redesign its health system and global health strategy by 2040. The country must adapt its approach from a hospital- and service-volume-centred system to one focused on people's lives, health outcomes, and communities.
Subjective olfactory impairment consistently associated with depression, while objective impairment linked to aging and anosmia. The study suggests partly distinct underlying mechanisms for subjective and objective impairments.
Research suggests alcohol interacts with Alzheimer's-related brain circuits in distinct ways, depending on the type of pathological change. Alcohol reduced communication in amyloid-beta models but increased it in tau models, highlighting an important principle in biology.
Recent studies suggest that p16INK4a+ cells, previously thought to be non-beneficial due to their association with aging, actually contribute to tendon regeneration. These mesenchymal cells produce collagen and factors promoting new blood vessel and nerve growth, crucial for normal tendon function.
A study by Rutgers researcher Chien-Chung Huang found that compulsive smartphone habits in older adults can deepen depression. Limited social participation and smartphone addiction were strong predictors of depression, while phone use supporting relationships and interactions was protective.
Research finds that millennials' fear of growing up decreases as they age, while younger generations report higher maturity fears. The study, published by the American Psychological Association, suggests that broader societal factors such as economic uncertainty and social pressures shape how young people view adulthood.
A study found that younger generations are aging faster biologically, increasing their risk of early-onset cancers. The study linked accelerated aging in immune systems and fat tissue to higher risks of lung and colorectal cancer.
A Hiroshima University study finds that practical digital skills, positive financial attitudes, and self-protection are more consistently associated with lower old-age anxiety than traditional financial knowledge alone. The study suggests that financial education may need to move beyond knowledge alone in the digital age.
A large USC-led study found that the main genetic risk factor for Alzheimer's disease may be linked to brain amyloid buildup differently in Hispanic and non-Hispanic white older adults. Hispanic participants generally had lower amyloid levels than non-Hispanic whites with similar characteristics.
A new review suggests that ageing results from overlapping changes occurring simultaneously at many levels of biological organization. This approach is reflected in the concept of the 'hallmarks of ageing', which are interconnected biological characteristics and processes consistently associated with aging.
A study of 585 older adults found that different patterns of depressive symptoms are associated with disability-free survival, differing between men and women. Stronger feelings of 'worthlessness' were a significant risk factor for men, while 'anxiety' was a bigger risk factor for women.
A nationwide survey in Japan found a gradual but steady decline in health-related quality of life among the working-age population over seven years. The study also revealed regional differences in HRQoL across prefectures.
Delirium is a common and preventable complication in older surgical patients, with verified geriatric surgery programs screening nearly every patient. Non-accredited hospitals screen only half of their patients for delirium, leading to a stark gap in care.
A new study found that social connections can help compensate for the loss of mentally stimulating interactions linked to work, with different types of relationships benefiting women and men. The researchers used data from 27 European countries and found that strong social networks appear to buffer the cognitive disadvantage of not wor...
A study of 4,967 community-dwelling adults aged 60+ found that being female, polypharmacy, and unintentional weight loss are associated with fragility fractures. Physical activity was not significantly linked to either fractures or falls, contradicting previous debate.
Researchers identified key factors, including diet, exercise, stress, and social engagement, that contribute to the long lives of Cilento residents. The CIAO Study aims to inform clinical solutions by providing actionable answers on aging and longevity.
Postoperative delirium is a strong predictor of long-term cognitive decline in older adults, according to a new study. Researchers found that delirium was associated with faster cognitive decline than mild cognitive impairment, and rehospitalizations did not explain the effect.