Articles tagged with Neurological Manifestations
A new study highlights the clinical relevance of brain functional connectome uniqueness in identifying biomarkers for major depressive disorder. Researchers found that patients with MDD displayed reduced FC uniqueness, especially in frontoparietal and sensorimotor networks.
Virginia Tech researchers identified a malformed area in the corpus callosum and pattern of bad connections that may help doctors diagnose Leigh syndrome earlier. The study found that developmental defects can be seen before symptoms appear, suggesting potential for earlier intervention.
JMIR Publications' JMIR Neurotechnology journal now accepts submissions on novel technological advances for neurological disorders. Researchers can submit review articles exploring emerging technologies, such as neurofeedback, neurosurgery, and brain-machine interfaces.
A recent study found that the protein TDP43 regulates genes responsible for fixing DNA mistakes, which can lead to cancer when overactive. The discovery could lead to new treatments by controlling overactive DNA repair, offering a therapeutic strategy for diseases such as ALS and dementia.
Poor blood sugar control in adolescence increases the risk of painful future complications for people with type 1 diabetes. Children diagnosed with type 1 diabetes at a young age have trouble controlling their blood sugar as teens and are more likely to develop neuropathy in adulthood.
Researchers have identified a group of cells called Y1 receptor-expressing neurons in the brainstem's lateral parabrachial nucleus as critical for regulating long-term pain states. These neurons integrate information about hunger, fear and thirst, allowing pain signals to be modulated by other brain circuits signaling more urgent needs.
Researchers at NYU Langone Health have developed a new technique using focused sound waves and holograms to activate brain circuits in living animals. The study shows that ultrasound waves can temporarily activate neurons, which can lead to widespread effects on neural networks.
Intra-arterial tenecteplase significantly reduces the risk of symptomatic intracranial hemorrhage and mortality in patients with acute large vessel occlusion. The treatment also improves neurological outcomes at 90 days without increasing complications.
An 11-year-old Asian small-clawed otter developed left-sided paralysis after a fall, but improved with treatment for a suspected fibrocartilaginous embolus. Follow-up MRI showed a diminished lesion one year later.
A new study from the University of Colorado Anschutz Medical Campus identified significant mitochondrial dysfunction in lymphoblast cell lines from children with Dravet syndrome, a severe form of epilepsy. The findings suggest that mitochondrial defects play a role in the metabolic dysfunction observed in Dravet syndrome.
Researchers at Baylor College of Medicine have identified new variants of CDKL2 and CDKL1 genes associated with developmental disorders, including epilepsy. The study proposes a mechanism by which defective variants cause neurological symptoms in affected individuals.
Research reveals nearly 10% of individuals with disabilities misused prescription drugs in the past year, compared to 4.4% without disabilities. Young adults and those with cognitive disabilities are particularly vulnerable to prescription drug misuse.
A new study finds that women with gestational hypertension and preeclampsia are at increased risk of developing new-onset migraine, headache, epilepsy, sleep disorder, or mental fatigue after giving birth. Follow-up care is recommended for these high-risk patients to monitor for neurological symptoms.
A study found that 4.6% of Nigerian participants with COVID-19 experienced neurologic symptoms, with some still experiencing symptoms two years after their initial episode. Researchers plan to treat these patients using similar techniques used in the US, aiming to alleviate their suffering.
A new study by ISGlobal reveals that nearly half of children with severe illnesses in low- and middle-income countries exhibit neurological symptoms before death. The most common causes of death were lack of oxygen, meningitis, and cerebral malaria. However, lumbar punctures are seldom performed, making diagnosis challenging.
Researchers discovered that the blood coagulation protein fibrin causes unusual clotting and inflammation in COVID-19, suppressing the body's ability to clear the virus. A promising therapeutic strategy has been identified, targeting fibrin to combat these deleterious effects.
Researchers found a specific deletion in the spike protein that enhances the virus' ability to infect brains of mice, which could help understand 'long COVID' and develop treatments. The study suggests viruses with this deletion can traffic from the lung to the brain, leading to neurological symptoms.
The study found teleneurology to be highly acceptable across various neurological diagnoses, including headache and movement disorders. Patients with additional medical conditions showed increased satisfaction with the telemedicine service.
Children and adolescents with acute SARS-CoV-2 or MIS-C and severe neurological manifestations are at high risk for long-term impairment. Early intervention and screening may be beneficial to assist recovery.
Researchers at Charité - Universitätsmedizin Berlin found that COVID-19 neurological symptoms are caused by inflammation in the body, rather than direct brain infection. The study analyzed brain tissue from 21 deceased patients and found changes in molecular processes in some cells.
A review in the Journal of Neurochemistry suggests a link between COVID-19 and Alzheimer's disease, with age being the largest contributing factor. Emerging evidence may further support this association, with research assessing influences on AD neuropathology.
The journal highlights the complexities of neurological injury and neurodegenerative diseases, emphasizing virtual care as a potential solution. Identifying and treating neuropsychiatric symptoms is crucial for effective rehabilitation.
Rheumatologists are crucial in detecting neurologic Lyme disease due to its broad spectrum of symptoms and signs. Early treatment has a favorable prognosis, but delayed diagnosis can lead to severe symptoms.
Researchers at the University of Texas M. D. Anderson Cancer Center have developed a novel approach to administer intrathecal and intravenous immunotherapy to treat leptomeningeal disease (LMD) in melanoma patients, showing promising results in improving survival rates and quality of life for some patients.
Researchers identified biomarkers that predict severe Covid-19 cases with neurological symptoms, offering potential targets for drug development to prevent consequential damage. They also found a link between impaired blood-brain barrier and excessive immune response.
A randomized controlled trial found that oral ENT-01 significantly improves constipation and possibly neurological symptoms in persons with Parkinson disease. The treatment is safe for up to 25 days, with a dose-dependent effect that persists beyond the treatment period.
A study found that aberrant expression of MAO-B causes both peripheral and neuroinflammation in RA patients, leading to joint pain and cognitive impairment. Administering an MAO-B inhibitor called KDS2010 improved both joint inflammation and cognitive function in a RA animal model.
A study of 219 patients with long COVID and neurologic symptoms found that 64% had an impaired sense of smell. Patients with impaired smell may experience severe and lasting loss of smell, even after recovery from acute COVID-19.
A study by Medical College of Georgia at Augusta University found that fatigue and headache were the most common lingering symptoms after COVID-19, reported by 68.5% and 66.5% of participants, respectively. Cognitive impairment, depression, and anxiety were also prevalent among participants.
In a new study, researchers found that microglia cells are responsible for neuronal death in a mitochondrial disease mouse model. Suppressing these cells with the drug Pexidartinib increased life expectancy and reduced motor problems. Further research is needed to understand the specific process by which microglia attack neurons.
An international study found that nearly 13% of hospitalized COVID-19 patients developed serious neurologic manifestations, including encephalopathy, stroke, and seizures. Patients with these symptoms had poorer outcomes, including longer hospital stays, increased need for ICU interventions, and higher mortality rates.
New research reveals that women with strokes often exhibit generalized symptoms such as confusion and weakness, potentially leading to delayed diagnoses. Women also face worse post-stroke outcomes, including increased institutionalization rates, compared to men.
A study of 181 long COVID patients found that seven in ten experience concentration and memory problems, with many performing worse than their peers on cognitive tests. Cognitive symptoms were more pronounced in people whose overall ongoing symptoms were more severe.
A study found that a subtype of Newcastle disease virus caused the deaths of dozens of pigeons in São Paulo City. The researchers sequenced the viral genome and identified tissue wounds to determine the cause of death, revealing subgenotype VI.2.1.2 as the responsible pathogen. The risk to humans and poultry is considered low.
A new study found that hospitalized children who tested positive for SARS-CoV-2 were more likely to develop neurological symptoms, including headache and altered mental status. The research also showed that these symptoms were more common in kids with MIS-C, a condition characterized by fever, inflammation, and organ dysfunction.
A new study published in PLOS ONE found that children born with congenital Zika Virus-related microcephaly have varying levels of neurodevelopmental impairment. The researchers used a routine neurological assessment to track the children's development, revealing differences in cognitive and motor skills. The findings suggest that HINE ...
Chronic light exposure disrupts circadian rhythms in rats, leading to memory deficits and amyloid β accumulation similar to Alzheimer's disease. Fluoxetine treatment prevents these effects, suggesting a potential therapeutic strategy.
A global observational study reveals that COVID-19 patients hospitalized globally exhibit a significant prevalence of neurological manifestations, often associated with higher in-hospital death rates. The findings underscore the importance of considering neurological complications in COVID-19 patients worldwide.
A study of 3,744 hospitalized adult COVID-19 patients found that 82% developed neurological symptoms, with acute encephalopathy being the most common. Patients with preexisting neurological conditions or symptoms are at a higher risk of developing COVID-19-related complications.
Preliminary research found that half of children with MIS-C had neurologic symptoms, including headaches, encephalopathy, and hallucinations. The study also revealed that children with these symptoms were more likely to require ventilator support and drugs to stabilize their blood circulation.
A study found that COVID-19 patients are 2.4 times more likely to experience large vessel occlusion stroke compared to those without the disease. The risk was highest among men and those over 66 years old.
A case series reports neurological symptoms and radiographic findings associated with COVID-19 infection in children. The study presents clinical findings from four children who experienced neurological symptoms, highlighting the potential impact of COVID-19 on pediatric neurology.
A new review reveals COVID-19 poses a global threat to the nervous system, causing neurological manifestations in about half of hospitalized patients. These symptoms include headaches, seizures, and muscle pain, and may appear before fever or cough.
A study published in Radiology reveals that 59% of COVID-19 patients reported an altered mental state, while 31% experienced stroke. The findings suggest that physicians can recognize 'red flags' earlier and potentially provide earlier interventions for patients.
A study investigating neurologic symptoms in hospitalized patients with COVID-19 found notable cases of neurological disorders, including stroke and seizures. The research provides insight into the often-overlooked but serious neurological manifestations of the disease.
A study by Brigham and Women's Hospital found that 77% of patients experienced at least one neurological symptom after CAR-T treatment, which were often temporary. The symptoms included encephalopathy, headache, tremor, weakness, and language dysfunction, with most effects being reversible.
Researchers conclude that 2-hydroxypropyl-β-cyclodextrin (HPβCD) does not cross the blood-brain barrier, which is crucial for addressing neurological manifestations of NPC1. This finding suggests that direct CNS administration may be necessary to achieve therapeutic efficacy.
A new study from the University of South Carolina found a gastrointestinal link to Gulf War Illness, potentially explaining both gastrointestinal inflammation and neurological symptoms. The research suggests that altering the intestinal microbiota may lead to improved treatment options for GWI.
A new study from French Polynesia found a link between Zika virus infection and Guillain-Barré syndrome, a severe neurological disorder. The study analyzed 42 patients diagnosed with GBS during the Zika outbreak and found that most had symptoms of Zika virus infection before developing neurological symptoms.
Research suggests that a high-fat diet can accelerate neurological symptoms in mice genetically predisposed to Parkinson's disease. This diet also causes damage in the brain and affects glucose and insulin regulation.
Flushing out antibodies in people with E. coli infection improves symptoms significantly, according to The Lancet article. Immunoadsorption technique removes circulating immunoglobulins, improving neurological and renal function recovery in patients with severe complications.
Researchers found a significant association between high lifetime exposure to insecticides and neurological symptoms in farmers. Nearly 800 participants reported more than 10 neurological symptoms, while nearly 3,000 had a high lifetime exposure to insecticides.
Research by Mayo Clinic found neurological symptoms account for 31% of in-flight medical complaints, with dizziness/vertigo and seizures being the most common reasons for diversion. The study recommends airlines carry anti-epileptic drugs to improve in-flight care
A study by Ohio State University found that younger farmers are at a higher risk of injury, with 32% of injuries linked to farm equipment. Neurological symptoms such as difficulty concentrating and chemical exposure also correlated with increased injury risk.