Articles tagged with Skin Disorders
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Researchers discovered that a gene called ZNF750, active in skin cells, is essential for supporting Langerhans cells and building the body's first line of immune defense. The study found that ZNF750 controls the production of IL-34, a molecule released by skin cells that acts as a survival signal for Langerhans cells.
A revised approach to measuring treatment success for patients with chronic graft-versus-host disease has been proposed by the National Institutes of Health Consensus Project Task Force. The new criteria aim to capture clinically meaningful improvements in skin involvement, leading to better patient outcomes and more effective treatments.
Researchers at Kobe University have identified a specific bacterial strain, Staphylococcus epidermidis and Corynebacterium tuberculostearicum, as the primary causes of foot odor in Nagashima-type palmoplantar keratosis. Topical application of benzoyl peroxide reduces odor by decreasing C. tuberculostearicum levels.
Researchers have developed a new class of light-activatable drug candidates that could serve as a potential treatment for psoriasis. The approach targets the vitamin D receptor, which has been shown to have beneficial effects in psoriasis, but also poses risks due to its role in calcium metabolism.
A new study from North Carolina State University found that neutrophils play a role in the early stages of atopic dermatitis flares in dogs. The researchers compared skin samples from four dogs with house dust mite-induced AD with samples from five healthy, or control, dogs.
A study reports on the underdiagnosis of 'topical steroid withdrawal syndrome' (TSW), a condition triggered by sudden or tapered use of steroid creams for inflammatory skin conditions. TSW can lead to severe symptoms, including skin reddening, burning, itching, and systemic problems like insomnia and depression.
Researchers found that indoor tanning users in their 30s and 40s have more skin mutations than people twice their age, particularly in areas exposed to tanning beds. This can lead to an increased risk of skin cancer, including melanoma.
A 47-year-old man from New Jersey died after consuming beef due to a tick-borne meat allergy caused by the Lone Star tick's alpha-gal sugar. Researchers identified the allergy and its link to fatal anaphylaxis, urging physicians to investigate severe abdominal pain after eating red meat in areas with high Lone Star tick populations.
A new study found that COVID-19 vaccination is associated with a significant reduction in infections and allergic complications among children with atopic dermatitis. The researchers analyzed data from over 5,700 vaccinated and unvaccinated pediatric patients and found lower rates of multiple infections and allergic conditions.
Research suggests that people with allergic conditions like eczema, asthma, and hay fever are more likely to experience complications after surgery, including infections, scar tissue buildup, and implant rupture. These conditions can lead to increased inflammation and immune system changes, making it harder for the body to heal.
Scientists have discovered that immune cells shed their glycocalyx layer to move into tissues, changing the understanding of inflammatory skin diseases like psoriasis. This finding may lead to new approaches in developing drugs targeting immune cell movement and treating infections and inflammatory diseases.
A novel therapeutic candidate has been developed to treat severe cutaneous adverse reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The compound suppresses disease-specific keratinocyte death, demonstrating its efficacy in preclinical studies.
Researchers found that 14.5% of patients with a first episode of psychosis had dermatological symptoms, which were linked to higher levels of depression and risk of suicide. The study suggests that skin conditions may serve as an advance marker for mental health risk, similar to blood tests for cancer or heart disease.
A topical formulation has been shown to reduce the incidence of hand-foot neuropathy in cancer patients undergoing chemotherapy, improving quality of life. The cream, developed at UMH, acts directly on neurosensory pain receptors, reducing hypersensitivity and tolerance to chemotherapy.
A groundbreaking vibroacoustic sensor could provide objective measurements of skin changes, enabling data-driven decisions on treatment effectiveness. The technology aims to reduce years of suffering for patients with eczema and psoriasis, improving health outcomes and reducing healthcare disparities.
A new study reveals that adults with atopic eczema are more likely to experience suicidal thoughts, with factors such as age of onset, obesity, and clinical features strongly associated with increased risk. The study highlights the need for healthcare professionals to better recognize and address these challenges.
A phase 3 clinical trial shows that genetically engineered skin grafts treat severe dystrophic epidermolysis bullosa, reducing pain and healing time. The treatment is part of a larger effort to improve EB patients' treatment options.
A research team at Nanjing University of Chinese Medicine discovered that plant-derived extracellular vesicles can deliver miRNAs across kingdoms to treat psoriasis. The researchers isolated perilla leaf-derived extracellular vesicle-like particles, which demonstrated potent antioxidant and anti-inflammatory activity.
A study found that teenage girls using multiple products on their faces increase the risk of skin irritation and allergy. The average cost of a daily skin care regimen is $168, with some costing over $500.
Researchers explore the psychological impact of chronic illnesses on patients with asthma and allergies, finding that fear, anxiety, and social stigma can greatly interfere with treatment. The American College of Allergy, Asthma, and Immunology discusses ways clinicians can mitigate these effects and provide better care for patients.
A novel topical BRAF inhibitor gel called LUT014 has been shown to significantly reduce the severity of an acne-like rash in patients undergoing anti-EGFR therapies for colorectal cancer. The treatment's safety and effectiveness have been confirmed, offering a potential solution to managing this common side effect.
A clinical trial found that LUT014, a topical BRAF inhibitor, significantly reduced the severity of acne-like skin rashes caused by targeted therapy for colorectal cancer. Patients who received LUT014 had improved quality of life and were able to continue receiving their cancer treatment with reduced side effects.
A study found that a topical formulation combining Kalonji (Nigella sativa) and Sirka (vinegar) showed therapeutic potential in treating mild to moderate acne vulgaris. The formulation was compared with a 5% benzoyl peroxide gel, with promising results but limitations such as a small sample size and short duration.
Researchers have identified a type of immune cell that produces extracellular matrix, strengthening the skin's defensive function and maintaining its integrity. This discovery may lead to new strategies for treating skin diseases, inflammation, diabetes, and age-related conditions.
Tampere University has licensed a drug molecule intended for treating Epidermolysis Bullosa, a group of rare and severe skin disorders. The licensing agreement includes collaboration with Theravia to develop, register and commercialise the drug.
A new study published in Aging found that pioglitazone reduced the frequency of skin ulcers in Werner syndrome patients. The research suggests that pioglitazone's anti-inflammatory properties may help wounds heal faster and prevent ulcers from forming.
Women with infertility are at higher risk of developing SARD, including lupus and Sjögren's syndrome, even after accounting for pre-eclampsia and other pregnancy complications. Infertility treatments do not appear to increase this risk, suggesting that women may be undiagnosed or untreated.
A scoping review found associations between myositis disease activity and gluten exposure in patients with inflammatory myopathies and celiac disease. The study suggests that gluten may act as an exogenous antigen driving myositis in genetically predisposed patients.
The study combines AI with fluorescence photography to enhance skin diagnostics, allowing for earlier detection of skin conditions such as acne, photoaging, and hyperpigmentation. AI can pinpoint early indicators of skin conditions with greater accuracy and monitor changes over time for data-driven decisions.
This study found modestly increased risks of inflammatory bowel disease and bullous skin disorders in hospitalized patients infected with the Omicron variant. Booster vaccination mitigated long-term autoimmune sequelae risk.
Researchers have developed a slow-release system using bamboo vinegar and activated bamboo charcoal to combat acne. The study shows that the refined bamboo vinegar, adsorbed by the bamboo charcoal, exhibits a gradual release rate over two hours, effectively demonstrating its potential as an anti-acne cosmetic raw material.
A large-scale study investigated the relationship between childhood obesity and immune-mediated skin diseases (IMSDs), such as atopic dermatitis and psoriasis. The study found that obese children were more likely to develop these conditions, with changes in body weight affecting their risk of developing these diseases.
A clinical trial shows that JAK inhibitors improve autoimmune conditions such as alopecia areata, atopic dermatitis, and psoriasis in people with Down syndrome. The study also observed improvements in arthritis and decreased biomarkers of autoimmune thyroid disease.
Rashes are a common side effect of antiseizure medications, occurring in 2-16% of patients, with 5% indicating life-threatening reactions. Patients should seek medical treatment immediately if rashes develop, regardless of severity.
Researchers at Rutgers University have developed a unique prototype of a 'living bioelectronic' device that combines advanced electronics, living cells, and hydrogel to treat psoriasis. The patch continuously monitors skin conditions and provides real-time feedback, offering a potential treatment for psoriasis and other skin ailments.
Researchers from Nagoya University have successfully treated rare genetic skin disorders epidermolytic ichthyosis (EI) and ichthyosis with confetti (IWC) by transplanting genetically healthy skin to inflamed areas. Transplantation of healthy skin has been used as a treatment option for severe burn injuries.
A study by Chiba University researchers reveals that a specific variant of the HLA gene can trigger an endoplasmic reticulum stress response in skin cells when exposed to certain drugs, leading to drug eruptions. This newfound knowledge may form the basis for innovative treatment options.
Researchers at Kobe University discovered a new gene, FDFT1, responsible for porokeratosis by identifying epigenetic silencing. Patients with localized lesions didn't have inherited damaged copies, leading to a hypothesis that epigenetic changes are the first hit. The findings have implications for treatment and counseling.
A new study from Aarhus University reveals that only 67% of Danes registered with an ectodermal dysplasia diagnosis actually have congenital ectodermal dysplasia. The study identifies key characteristics, including abnormal teeth, skin issues, and nail problems, highlighting the need for collaboration across healthcare disciplines.
Hemodialysis patients experience itching due to high levels of protein-bound uremic toxins (PBUTs), which are difficult to remove by dialysis therapy. A new study found an association between PBUTs and itching, suggesting improved treatments for this common symptom.
Researchers have gained a deeper understanding of the nuanced roles of JAK inhibitors in inflammation across various cell types and tissues. The study reveals that activating JAK1 signaling has tissue-specific effects, including an unexpected immunoregulatory role in lung sensory neurons, which suppresses lung inflammation.
A new technology has identified a genetic abnormality causing xeroderma pigmentosum (XP)-F, a skin disorder. The technique effectively reversed many cellular phenotypes associated with XP and may be effective for genetic treatments of other diseases.
The study identified two genes, SOX9 and KLF5, that contribute to the development of hidradenitis suppurativa. These genes play a role in hair follicle and epidermal development, respectively, and their mutations may lead to improper development of hair follicles and inflammation.
A large study found a significant link between vitamin D levels and psoriasis severity, with lower levels associated with greater severity. The research suggests that a vitamin D-rich diet or oral supplementation may provide benefits for individuals with psoriasis.
Researchers discovered a novel peptide, T14, that is detectable in human keratinocytes and inversely related to age, with higher levels found in chronically photosensitive individuals. The study suggests that monitoring T14 levels may offer insights into the link between degenerative diseases and epidermal cell profiles.
A UCLA-led team is tracking mpox outbreaks across the US with a new surveillance project called CRASHED. The research aims to identify cases beyond high-risk groups and determine if mpox remains rare or resurges more broadly.
Researchers at Salk Institute discover that mechanical and chemical itch sensations are encoded by different brain pathways, which act together to drive chronic itch. The study reveals key molecules regulating these pathways and opens avenues for new therapies.
A systematic review of 33 randomized controlled trials found that yoga improved gait speed and lower extremity strength in inactive older people. However, it did not offer a benefit for frailty markers compared to exercise or tai chi.
A novel rare mutation in the ABCA12 gene was identified as a cause of Harlequin Ichthyosis through BGI genetic tests. The mutation leads to a severely dysfunctional protein responsible for the disease's serious phenotype.
A new study published in Arthritis & Rheumatology reports significant improvements in disease activity for patients with refractory juvenile dermatomyositis treated with abatacept therapy. The randomized controlled trial demonstrates the potential of abatacept as a treatment option for this rare and debilitating condition.
Patients with moderate to severe atopic dermatitis showed significant improvement in signs and symptoms while taking rocatinlimab, a novel monoclonal antibody therapy. The treatment has the potential to change the genetic makeup of the disease, leading to lasting results without continued use.
Researchers highlight climate-sensitive dermatological manifestations initiated or exacerbated by floods, wildfires, and extreme heat events. These events disproportionately affect marginalized populations, exacerbating existing health disparities.
A large randomized clinical trial demonstrated Octagam 10% as an efficacious and well-tolerated treatment option for adult dermatomyositis patients. The study showed improved outcomes in patients with this rare disease, providing a much-needed treatment alternative.
Researchers explored how differences in skin composition affect susceptibility to diseases like psoriasis and atopic dermatitis. The study found that body site determines skin structure and function, with specific lipids and proteins playing a crucial role in disease diagnosis.
Lenabasum has been shown to improve skin symptoms in patients with amyopathic dermatomyositis, demonstrating significant reductions in inflammation and disease severity. The study's findings suggest that lenabasum is a well-tolerated treatment option for refractory skin disease.
Sensory neurons in human skin have been found to regulate melanocytes, influencing pigmentation and cell survival. The study identified a protein called RGMB as a key factor promoting melanocyte survival and darkness.
A study by Japanese researchers from Fujita Health University sheds light on the molecular mechanisms of contact dermatitis, revealing that neutrophil extracellular traps play a key role in the condition. The team's findings suggest that inhibiting NET formation could be a new therapeutic strategy for treating contact dermatitis.
A case series of six patients reported rare skin reaction complications after receiving the Pfizer/BioNTech COVID-19 mRNA vaccine. The study aims to shed light on these unusual side effects.
Researchers at Scripps Research have identified a protein in sensory nerves that detects mechanical itch, which could lead to better drug treatments for chronic itch conditions. The discovery was made by Ardem Patapoutian and his team, who found that PIEZO1 is expressed in two types of sensory neurons implicated in chemical itch.
New research found that 62% of tinted sunscreens have only one shade option, with tone compatibility being the most important criterion. The study suggests that the beauty industry and dermatologic field need to improve diversity and offer more options for tinted sunscreen formulations tailored to people with skin of color.