Researchers have discovered the molecular mechanism of synaptic facilitation, a process that strengthens synaptic transmission and is thought to be the basis for instantaneous memory. The study, published in the Proceedings of the National Academy of Sciences, reveals that a calcium binding protein called Synaptotagmin 7 plays a crucia...
A new learning mechanism uses natural variability in neural activity to understand how synapses adapt and improve the learning capabilities of brain-inspired devices. The mechanism, called Spike-based Alignment Learning, solves the weight transport problem and matches the performance of existing approaches without unrealistic assumptions.
Researchers at Washington University in St. Louis have developed a new technique to visualize the coupling between neuronal activity and oxygen delivery at the cellular scale. This breakthrough could have profound implications for studying neurodegenerative disease, stroke, and other conditions connected to neurovascular coupling.
The brain convenes ensembles of neurons to distinctly represent and sort options during decision-making, ensuring clarity and preventing interference. After making a decision, new ensembles provide new representations for chosen and unchosen options.
A study found that just 10 minutes of very slow running improves mood and executive function, activating the prefrontal cortex. This suggests that even low-intensity exercise can have cognitive benefits.
Researchers propose an AI framework, called interoceptive AI, that uses internal states to inform learning and decision-making in dynamic environments. This approach treats internal conditions as a continuous source of context, influencing what an agent learns, prioritizes, and does.
Researchers identified a brain circuit that enables comparison between current and previous sensory information to aid judgment. The pulvinar region in the thalamus provides advice on how much sensory information has changed, helping the brain make predictions about what's happening.
Researchers developed a hybrid technology combining human learning and machine learning in noninvasive BCIs, producing rapid and sustained gains in motor imagery control. The study demonstrates significant scientific and technological advancement in BCIs, establishing a scalable pathway toward robust neural interfaces.
Researchers at the University of Groningen found that a clinically approved asthma drug can restore access to social memories disrupted by sleep deprivation. In a study, mice who were sleep deprived after meeting other mice couldn't recognize them later, but the drug roflumilast allowed them to recall their social encounters.
Researchers at NIH have discovered key intracellular signaling processes involved in the weight-loss effects of semaglutide, a GLP-1 drug. The findings may help extend treatment duration and reduce plateaus experienced by patients.
A recent NIH-funded study reveals that oral small-molecule GLP-1 drugs can suppress eating for pleasure and reduce cravings by targeting a deeper brain region, potentially treating other dysfunctions in reward processing. The findings provide insight into the neural mechanisms underlying the effects of these medications.
Genomic Press launches Brain Health, a new peer-reviewed journal dedicated to the science of lifelong brain resilience, featuring research on glial plasticity and recovery from depression. The inaugural issue explores the intersection of fields including cognitive reserve, sleep, aging biology, nutritional psychiatry, and social sciences.
The EBRAINS Roadmap Symposium will bring together the global neuroscience community to shape the EBRAINS 10-Year-Roadmap. A total of 159 submissions from 134 unique contributors across 25 countries have been received, reflecting the momentum of Europe's digital neuroscience landscape.
Researchers at IISc have mapped a neural circuit that links stress to itch. Stress activates specific neurons in the lateral hypothalamic area, which directly regulate itch and reduce scratching behavior. This study provides new insights into the complex relationship between emotional states and sensory perception.
Researchers found that the prefrontal cortex sends customized signals to visual and motor regions, influencing their activity based on arousal levels and movement. The study reveals distinct roles of prefrontal subregions in shaping visual processing, with one region enhancing stimuli detection and another dampening irrelevant stimuli.
Research found that high-fat and high-carbohydrate diets are controlled by separate neural pathways in the brain. Neuropeptide Y neurons activate AMPK-regulated corticotropin-releasing hormone neurons to promote high-carb intake, while inhibiting melanocortin 4 receptor neurons to increase high-fat intake.
Researchers discovered that neurons in the brain's auditory cortex show large bursts of activity tied to specific moments in a task, suggesting a deep connection between behavior and sound processing. This 'tuning' mechanism enables the brain to produce smaller but more distinctive responses to sounds guiding task performance.
Scientists at RIKEN Center for Brain Science found that fruit flies use separate circuits to compute pleasant and unpleasant odors, challenging the idea that 'good' is the opposite of 'bad'. The discovery may contribute to a better understanding of human brain's flavor appreciation mechanisms.
Salk scientists pinpoint gracile nucleus as brain area responsible for differentiating between painful and non-painful touch, with dysfunction leading to chronic pain. Altered neuronal activity in the dorsal column nuclei drives mechanical allodynia, causing the brain to misinterpret innocuous light touch as painful.
Researchers discovered that proprioceptive nerve cells for sensing leg motion are deactivated during active movement in fruit flies. This selective suppression may enable the insect to quickly respond to sudden external events. The study advances basic scientific knowledge of sensory feedback and its application to clinical treatments
A new brain training game has shown promise in treating nerve pain, with participants experiencing significant reductions in pain and comparable relief to opioids. The PainWaive technology uses EEG headsets to track brain activity and respond in real time, providing a potential non-invasive alternative for chronic pain management.
A new technique using focused sound waves and microbubbles has shown great promise in treating debilitating brain lesions called cerebral cavernous malformations. The approach has halted the growth of lesions almost entirely, offering a potential paradigm shift in treatment.
Researchers identified CLU protein as a potential strategy to protect against Alzheimer's disease by increasing clusterin protein. Increased CLU protects the brain from amyloid plaques and loss of synapses, while identifying individuals most likely to respond based on their genetics.
A study by Helmholtz Munich researchers found that GIPR agonism and antagonism decrease body weight and food intake via different mechanisms. GIPR agonists use GABAergic neurons to exert their effect, while antagonists rely on the GLP-1 receptor signal.
A harmful form of tau protein directly damages blood vessels in the brain, leading to inflammation and weakening the brain's protective shield. The discovery highlights the importance of focusing on early neurovascular changes mediated by tau to prevent or slow down damage to the blood-brain barrier.
Capsule eliminates I/O overhead and optimizes performance by designing a subgraph loading mechanism and pipelined parallel strategy for large-scale graph neural network training, providing 22.24% memory usage and up to 12.02x performance improvement over existing systems
Researchers at UT Arlington's CIHI are developing innovative solutions to address complex health needs in children with disabilities, behavioral health issues, and medical conditions. The projects aim to improve healthcare services, enhance quality of life, and promote healthier aging through cutting-edge research and model organisms.
Two brain proteins, Imp and Sdc, play a crucial role in preventing seizures by regulating neuronal growth and brain circuit development. Reducing either protein can lead to seizure-prone behavior in flies, highlighting their importance in seizure regulation.
Researchers developed a novel 2D phase-transition memristor leveraging intrinsic ion migration to overcome existing device limitations. The device achieves record-low power consumption, ultrafast switching speed, and exceptional endurance, making it suitable for high-speed computing applications.
Researchers propose a novel machine memory structure and the M2I framework to address excessive data consumption, catastrophic forgetting, and logical reasoning capabilities in large models. The study has potential to revolutionize AI development by mimicking human brain's memory mechanisms.
A novel brain study uncovers the critical role of the HDAC5 enzyme in regulating gene expression and neuronal activity, which can trigger relapse in individuals with substance use disorders. The study highlights a new molecular target for developing novel treatments to reduce relapse risk.
A new study by researchers at Tufts University suggests that a lack of vitamin K may increase inflammation and hamper proliferation of neural cells in the hippocampus, a key region for learning and memory. Vitamin K deficiency was also associated with increased neuroinflammation and reduced neurogenesis, leading to noticeable cognitive...
Researchers have found that people with cannabis use disorder have elevated dopamine levels in a brain region associated with psychosis. This could explain why frequent cannabis use increases the risk of hallucinations and delusions. The study's findings may help doctors educate patients about the potential risks of frequent cannabis u...
A study found that brain activity can predict a person's political affiliation with 80% accuracy when making food purchases. Researchers used fMRI to measure brain activity in Republicans and Democrats, finding distinct neural patterns for each group.
A study using cryo-electron microscopy revealed that autoantibodies in myasthenia gravis disrupt acetylcholine receptor function by blocking or activating the immune system's complement pathway. This knowledge helps explain treatment variability and offers a foundation for personalized therapies targeting specific antibody interactions.
Princeton neuroscientists pinpoint the central amygdala as the brain region responsible for forming lasting memories of food poisoning, which may shed light on PTSD and inform future clinical treatments. The study found that novel flavors can 'tag' specific brain cells to remain sensitive to illness signals.
A research group has uncovered a potential mechanism linking maternal inflammation to delayed neurodevelopment in infants. CD11c-positive microglia, crucial for myelination, play a key role in this process.
Researchers develop a powerful model to study TDP-43 pathology, which accumulates in the cytoplasm and depletes from the nucleus, leading to neuronal death. The 'seeded' protein aggregates recapitulate key features of ALS and frontotemporal dementia.
Researchers discovered that dopamine levels in a specific brain region are closely linked to male sexual behavior transitions. The study found rhythmic dopamine input during intromission was regulated by acetylcholine innervation, directly triggering ejaculation.
A study published in Biological Psychiatry identified the Shisa7 gene as a key driver of heroin addiction. The research team used machine learning to analyze brain tissue from human opioid users and found that modulating this gene's expression influenced heroin-seeking behavior and cognitive flexibility.
Researchers discover Dscamb protein regulates spacing between color-detecting cells, ensuring perfect arrangement for optimal vision. The protein acts as a 'self-avoidance enforcer' to maintain proper distances between cone cells.
A study by the University of the Basque Country has detected potential biomarkers in the blood that could help predict the risk of developing schizophrenia due to cannabis use. The researchers found significant differences in fatty acid content between cannabis users, individuals with schizophrenia, and those with dual diagnoses.
Researchers found that perceiving prices significantly different from expectations triggers a strong N400 signal in the brain, engaging regions involved in evaluating rewards and learning. This suggests that consumers' perceptions of value are part of automatic cognitive mechanisms activated long before conscious decision-making.
Researchers identified a conserved splicing mechanism controlling the production of different proteins from the same gene, crucial for neuronal function and development. The study sheds light on how neuronal identity is established and maintained through alternative splicing.
The review explores the pathophysiological mechanisms linking obstructive sleep apnea syndrome and metabolic syndrome, highlighting recent advancements in therapeutic strategies. Treatment approaches aim to break the harmful cycle between OSA and MetS, which affects approximately 14% of the global population.
Researchers at Ruhr-University Bochum discovered that the rubber hand illusion reduces perceived pain intensity when a heat stimulus is applied to one hand while simultaneously illuminating a rubber hand. This phenomenon, known as visual analgesia, could potentially be used in treating complex regional pain syndrome.
Researchers at Baylor College of Medicine have identified new variants of CDKL2 and CDKL1 genes associated with developmental disorders, including epilepsy. The study proposes a mechanism by which defective variants cause neurological symptoms in affected individuals.
Researchers from Kyoto University and Cambridge University developed a fluorescent dopamine sensor to monitor dopamine signals in primate brains. The study found that dopamine signals varied depending on the location in the striatum, with distinct patterns observed in the anterior putamen and caudate head.
This study found that electroacupuncture (EA) improved gastric emptying in rats with burn-induced dysmotility by down-regulating cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines. EA also normalized sympathetic hyperactivity and enhanced vagal activity, suggesting a potential therapeutic benefit for burn-induced gastric dysmotility.
Research highlights the interconnected relationship between aging, circadian rhythms, and cancer, with shared mechanisms including genomic instability, cellular senescence, and chronic inflammation. Modulating circadian rhythms may serve as a novel strategy to intervene in age-related functional decline and treat cancer.
A study by Dr. Keum Sehoon's team identified key neural ensembles in the anterior cingulate cortex that encode empathic freezing, a behavioral response to witnessing distress in others. The researchers found that observing another's pain triggers activation in the ACC as if the observer were experiencing pain themselves.
Research finds that certain viral antibodies and genetic risk factors can increase MS risk, with elevated antibody levels combined with a specific gene variant associated with strong increased risk. The study also identifies potential biomarkers for early diagnosis.
Coyotes exhibit genetic monogamy, forming long-lasting social attachments. USU neuroscientist Sara Freeman studies the behavioral, hormonal, and neural basis of coyote pair-bonding behavior.
A study led by Dr. Rodrigo Quian Quiroga has confirmed that individual neurons represent concepts learned in any context, enabling abstract relationships and human intelligence. This finding contradicts previous research on animals, where memories were thought to be stored in different groups of neurons.
Researchers discovered distinct neuronal populations in the ACC process pain and itch information separately, with stimulus-specific neurons receiving differentiated synaptic inputs from the mediodorsal thalamus. Suppressing these neurons reduced corresponding sensations without affecting the other.
Researchers at Kyoto University investigated the effects of two-hit stress on mouse behavior, revealing significant changes in the cerebellum. The study found increased microglia turnover, neuronal loss, and decreased brain connectivity, correlating with anxiety-like behaviors and mental disorders.
Researchers found that brain connectivity related to cognitive control predicted substance use initiation, while cognitive control behavior did not. Stronger connectivity between the dorsal anterior cingulate cortex and dorsolateral prefrontal cortex was associated with delayed substance use onset.
SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateMar 3, 2025
Scientists have identified a new target to prevent cold sores by understanding how the herpes virus triggers its own immune response. The discovery has important implications for genital herpes caused by the same virus, with potential treatments in development.
Researchers from the University of Konstanz challenged long-held hypotheses on collective motion in locust swarms, finding that sensory input and neural representations drive movement decisions. Contrary to previous assumptions, alignment with others is not responsible for coordinating collective motion.
Researchers at Johannes Gutenberg University Mainz have discovered that histone deacetylase 8 (HDCA8) inhibits the conversion of Schwann cells into their repair phenotype, slowing down peripheral nervous system recovery. Removing HDAC8 accelerates regeneration and restores sensory function.